Deuterated Compounds

<p>Applications n-Butyl-4,4,4-d3 Alcohol (CAS# 64156-70-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications rac-threo-Methyl-13C, d3-phenidate Hydrochloride is the labeled analog of rac-threo-Methylphenidate Hydrochloride (M325671), which has shown that the pharmacological activity resides predominantly in the d-threo enantiomer.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961); Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981); Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993); Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993)<br></p>

<p>Applications A labelled trans-4-Hydroxy-L-proline. A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.<br>References Langmaier, F. et al.: Int. J. Cosm. Sci., 24, 273 (2002); Lawrence, C., et al.: Biochem. J., 313, 185 (1996); Mori, H., et al.: J. Bacteriol.; 179, 5677 (1997); Clifton, I., et al.: Eur. J. Biochem., 268, 6625 (2001);<br></p>

<p>Applications DL-Phenyl-d5-alanine-3,3-d2 (CAS# 74228-83-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethanethiol-13C2, is the labeled analogue of Ethanethiol (E676470), is used in the evaluation and application of static headspace-multicapillary column-gas chromatography-ion mobility spectrometry for complex sample analysis.<br>References Denawaka, C., et al.: J. Chromat. A., 1338, 136 (2014)<br></p>

<p>Applications Buramate-d7, is the labeled analogue of Buramate (B689700), used for the synthesis of more complex compounds, having antibacterial activity, and also for the synthesis of new antimalarial compounds.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13 (8), 2881 (2005); Marrero-Ponce, Y., et al.: J. Chem. Info. Model., 45 (4), 1082 (2005);<br></p>

<p>Applications Choline Fenofibrate-d6 is the labeled analogue of Choline Fenofibrate (C432665), a new formulation of fenofibric acid, ABT-335, co-administered with statins.<br>References Athyros, V., et al.: Diabetes Care, 25, 1198 (2002); Sacks, F., et al.: Am. J. Cardiol., 90, 139 (2002); Wierzbicki, A., et al.: Curr. Med. Res. Opin., 19, 155 (2003); Sarwar, N., et al.: Circulation, 115, 450 (2007)<br></p>

<p>Applications N-[2-(Phenylthio)phenyl]-1-piperazine-d8-carboxamide Hydrochloride is the labeled analog of N-[2-(Phenylthio)phenyl]-1-piperazinecarboxamide Hydrochloride, an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.<br>References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)<br></p>

<p>Applications 4-(Methyl-d3-amino)butyric-2,2,3,3,4,4-d6 Acid HCl (CAS# 1219805-36-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (Bromomethyl)cyclohexane-d11 is the isotope labelled analog of (Bromomethyl)cyclohexane. (Bromomethyl)cyclohexane is a reagent that is used in the synthesis of cyano thiouracils as SecA inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chaudhary, A. S., et al.: Bioorg. Med. Chem., 23, 105 (2015);<br></p>

<p>Applications 1,3-Dichloropropene-d4 (cis/trans mixture) (CAS# 202656-23-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-2-Hydroxyhexanoic-6,6,6-d3 Acid (CAS# 1219798-84-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled α-Methyl-1-pyrenemethanol is used in the synthesis of colorimetric and fluorescent ratiometric mercury sensors. This is applicable to the quantification of transition metals in the environment as well as biological systems.<br>References Weng, J. et al.: Tetra., 68, 3129 (2012);<br></p>

<p>Applications Tetrahydrofuran-2,2,5,5-d4 (CAS# 20665-63-8) is a useful isotopically labeled research compound.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 3-​Methylbutyryl-​d9 Chloride is an intermediate for the synthesis of Isovaleryl L-Carnitine-d9 Chloride (I917582), which is labelled Isovaleryl L-Carnitine Chloride (I917580), and it is used to prepare carnitine benzyl esters as neuroprotectant prodrugs.<br>References Gong, X., et al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications Loratadine-d5 (ethyl-d5) (CAS# 1398065-63-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-n-Pentyl-d11-phenol (CAS# 1219805-30-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Nitrobenzyl-d6 Alcohol (CAS# 1219795-18-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexamethyl-d18-disilane (CAS# 61123-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Benzyl- 2-thiophenecarboxylic Acid-d7 is labelled 4-Benzyl- 2-thiophenecarboxylic Acid (B315140) which is a derivative of 2-Thenoic Acid (T343505), used in the synthesis of pharmaceutical and biologically active compounds. 2-Thenoic Acid is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.<br>References huyop, F. Z., et al.: Malaysian J. Biochem. Mol. Bio., 2, 9 (1997)<br></p>

<p>Applications 4-Acetamidobenzene-d4-sulfonyl Chloride is the deuterium labelled form of 4-(Acetylamino)benzenesulfonyl Chloride (A170950), which is a sulfanilamide derivative of Chitosan with antifungal properties.<br>References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008); Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009);<br></p>

<p>Applications 2,4,6-Trimethyl-1,3-benzenediamine-15N2 is the isotope labelled analogue of 2,4,6-Trimethyl-1,3-benzenediamine, a compound used in the synthesis of various polymers.<br>References Fritsch, D., et al.: Macromolec. Chem. Phys., 197, 701 (1996);<br></p>

<p>Applications Ethyl-1,2,2,2-d4 Alcohol (CAS# 22544-43-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-(Ethyl-d2)-N-(propyl-d2)benzenemethanamine is an intermediate in the synthesis of N-Ethyl-N-nitroso-1-propanamine-d4 (E817997) and isotope labelled version of N-Ethyl-N-nitroso-1-propanamine. N-Ethyl-N-nitroso-1-propanamine is a derivative of N-Nitrosodiethylamine (N525465),a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver.<br>References Shirakami, Y., et al.: Bitamin, 87, 156 (2013); Fujii, Y., et al.: Toxicol., 305, 30 (2013); Uehara, T., et al.: Toxicol. Sci., 132, 53 (2013);<br></p>

<p>Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.<br>References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)<br></p>

<p>Applications 1,4-Butane-d8-dithiol (CAS# 1219805-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Glyceryl Tri(octanoate-d15) (CAS# 352431-24-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 6-Nitro-1-pyrenol is a urinary hydroxylated metabolites used as a biomarkers of exposure of polycyclic aromatic hydrocarbons. This is the labeled analog.<br>References Toriba, A., et al.: J. Health. Sci., 53; 631 (2007); Chae, Y.H., et al.: Cancer Res., 59, 1473 (1999);<br></p>

<p>Applications n-Nonylbenzene-d24 (CAS# 1219799-13-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.<br>References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)<br></p>

<p>Applications 1-Iodopentane-5,5,5-d3 (CAS# 920502-31-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pentanone-d6 is labelled 3-Pentanone (P273600) which is a simple, symmetrical dialkyl ketone. It is mainly used as a solvent in paint and a precursor to vitamin E. It is a useful synthetic intermediate. It can be used as a reagent to synthesize Ethyl 2-Cyano-3,3-diethylacrylate (E907600) by Knoevenagel condensation. It also shows anticonvulsant effect in several types of mouse seizure models.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hasebe, N., et al.: Eur. J. Pharma., 642, 66 (2010); Siegel, H., et al.: Ullmann's Encyclopedia of Industrial Chemistry, (2002)<br></p>

<p>Applications 2,3-Butane-1,1,1,4,4,4-d6-diol (CAS# 344750-80-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Acetyl-2,6-dichlorodiphenylamine-d5 is labelled N-Acetyl-2,6-dichlorodiphenylamine (A173570) which is an impurity of diclofenac (D436450, Na salt), a nonsteroidal anti-inflammatory compound and decycloxygenase (COX) inhibitor.<br>References Kenny, J. R., et al.: J. Med. Chem., 47, 2816 (2004); Sasaki, A., et al.: J. Pharmacol. Sci., 108, 266 (2008); Dalvie, D., et al.: Chem. Res. Toxicol., 22, 357 (2009)<br></p>

<p>Applications Iodoacetic Acid 2-13C is labelled Iodoacetic Acid (I685520) which is used as a general reagent in acylation reactions. It is also a byproduct formed in treated waters, and found in marine life.<br>References Zuckermann, R.N. et al.; J. Am. Chem. Soc., 115, 10646 (1992); Bull, R., et al.: Toxicol. Appl. Pharmacol., 182, 55 (2002); Mitch, W., et ;l.: Water Sci. Technol., 2, 191 (2002)<br></p>

<p>Applications Labelled Azilsartan (A926900). An analgesic and antiinflammatory drugs containing angiotensin II antagonists.<br>References Kohara, Y. et al.: J. Med. Chem., 39, 5228 (1996); Plomgaard, P. et al.: Diabetes, 54, 2939 (2005); Fenton, C. et al.: Drugs, 2005, 65, 537;<br></p>

<p>Applications 2-hydroxy-3-(methyl-d3)-Butanoic-2,3,4,4,4-d5 Acid is a useful chemical reagent.<br></p>

<p>Applications 6-Methyl-5-hepten-2-one-1,1,1,3,3-d5 is an intermediate used in the synthesis of Geraniol-D5 (G367003), which is a deuterium labelled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications Isotope labelled Ethyl Octanoate used in the preparation of β-cyclodextrins as nano-drug delivery encasements. Also used in the synthesis of second generation biodiesels via palladium catalysis.<br>References Gervaise, C. et al.: New J. Chem., 36, 2417 (2012); Han, J. et al.: Green Chem., 12, 463 (2010);<br></p>

<p>Applications Sodium Methanesulfonate-d3,13C is an intermediate used in the synthesis of Methanesulfonyl Chloride-d3,13C (M258847), which is a labeled analogue of Methanesulfonyl Chloride (M258845). Methanesulfonyl Chloride used in the synthesis of phosphodiesterase 9A Inhibitors, used in treatments for Alzheimer’s disease. It is also used in the preparation of sulfonamide derivatives showing antibacterial activity.<br>References Reddy, N. et al.: J. Chem. Sci., 124, 723 (2012); Claffey, M. et al.: J. Med. Chem., 55, 9055 (2012);<br></p>

<p>Applications Bis(1-ethylpentyl) Phthalate-d4, is the labeled analogue of Bis(1-ethylpentyl) Phthalate (B433990), one of the phthalate esters, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products.<br>References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications Uracil-6-d1 (CAS# 24897-51-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(2-Aminophenyl)-2-chloroethanone-13C8 is an intermediate in the synthesis of Indole-3-carboxaldehyde-13C8 (I614993), the labelled version of Indole-3-carboxaldehyde (I615020) which is a tryptophan (T947200) metabolite from Streptomyces staurosporeus and it is chemical constituent from Inula wissmanniana. Indole-3-carboxaldehyde and other tryptophan metabolites play an important role in mammalian gut immune homeostasis.<br>References Yang, S., et al.: J. Nat. Prod., 60, 44 (1997); Cheng, X. et al.: Chem. Nat. Compd., 49, 815 (2013); Zelante, T., et al,: Immunity, 39, 372 (2013)<br></p>

<p>Applications A labelled isomeric impurity of 7-(2-Hydroxypropyl)guanine (H952590).<br></p>

<p>Applications 1,3-Dibromo-5-fluorobenzene-d3 (CAS# 1219805-87-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Deferasirox Ethyl Ester-d5 is the isotope labelled analog of Deferasirox Ethyl Ester (D228655); a derivative of Deferasirox (D228650) which is an orally active tridentate iron chelator.<br>References Hershko, C., et al.: Blood, 97, 1115 (2001); Galanello, R., et al.: J. Clin. Pharmacol., 43, 565 (2003); Nick, H., et al.: Curr. Med. Chem., 10, 1065 (2003)<br></p>

<p>Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications A trapping agent used in the desulfenylation of 3-indolyl sulfides.<br>References Miller, C., et al.: Environ. Sci. Technol., 43, 8548 (2009), Mecinovic, J., et al.: Anal. Biochem., 393, 215 (2009), Zarghi, A., et al.: Bioorg., Med., Chem., 17, 5369 (2009),<br></p>

<p>Applications (±)-2-Ethylhexanoic-d15 Acid (CAS# 352431-38-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl Octanoate-d15 (CAS# 1219798-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Extremely Volatile<br>Applications 1-Hexene-d3, an isotopically labelled 1-Hexene, is used in the synthesis of ethylene polymers and copolymers. An olefin used to synthesize diols through oxidation reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tao, X. et al.: Organometal., 32, 4185 (2013); Clerici, M. et al.: J. Catal., 140, 71 (1993);<br></p>

<p>Applications Glyceryl Tri(octadecanoate-d35) (CAS# 125941-88-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 22-Oxacalcitriol-d6 is the labeled analogue of 22-Oxacalcitriol (O752350), the noncalcemic analogue of vitamine D and was found to suppress parathyroid hormone synthesis and secretion.<br>References Aoshima, Y., et al.: Nephrol. DIalysis. Transplan., 27, 1800 (2012); Hemant. P.. et al.: Adv. Res. Pharma. Biol., 1, 10 (2011); Adachi, M., et al.: Clin. Nephrol., 76, 266 (2011); Kubrusly, M., et al.: Kidney. Int., 44, 551 (1993)<br></p>

<p>Applications Isotope labelled N-1-Naphthylethylenediamine Dihydrochloride, is an organic building block used for the chemical synthesis. It can also be used as highly selective organic fluorescent probe for azide ion.<br>References Sahana, A., et al.: Analyst , 137, 1544 (2012);<br></p>

<p>Applications Homotaurine-d6 is the isotope labelled analog of Homotaurine (H656200). Homotaurine is an important GABA mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid.<br>References Riv. Farmacol. Ter., 7, 155 (1976), Neuropharmacology, 17, 13 (1978), Br. J. Pharmacol., 59 373 (1977)<br></p>

<p>Applications Hexadecanoic-13,13,14,14,15,15,16,16,16-d9 Acid (CAS# 1173022-49-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Succinic Acid (D6, 98%) (cas# 21668-90-6) is a useful research chemical.<br></p>

<p>Applications Clemastine N-Oxide-d5 is the isotope labelled analog of Clemastine N-Oxide (C568505); a metabolite of Clemastine Fumarate (C568500) which is a H1 histamine receptor antagonist and antihistaminic.<br>References Froehlich, L., et al.: Pharmazie, 51, 409 (1996); Weidmann, et al.: Boll. Chim. Farm., 106, 467 (1967); Gober, B., et al.: Pharmazie, 43, 539 (1988); Breccia, A., et al.: Curr. Ther. Res., 49, 622 (1991); Schran, H., et al.: J. Clin. Pharmacol., 36, 911 (1996)<br></p>

<p>Applications L-Homocitrulline-2,6,6-d3 is a labeled compound of L-Homocitrulline (H590900) which is an amino acid present in milk products.<br>References Evered, D. &amp; Vadgama, J.: Br. J. Nutr., 49, 35 (1983); Paik, W., et al.: Int. J. Biochem., 8, 317 (1977)<br></p>

<p>Applications Methylcyclohexane-D14 (D, 99.5%) (cas# 10120-28-2) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications O-Desaryl Ranolazine-d5 is the isotope labelled analog of O-Desaryl Ranolazine (D422050); a metabolite of Ranolazine (R122500).<br>References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)<br></p>

<p>Applications Benzyl Octyl Adipate-d17, is the labeled analogue of Benzyl Octyl Adipate (B285580), which is used as plasticizer. It can also be used for the synthesis of orally effective acid prodrugs of the β-Lactamase inhibitor Sulbactam (S699185).<br>References Sorokin, G. A., Plasticheskie Massy, 25 (1976); Kraus, A., Farbe + Lack,60, 185 (1954); English, A. R., et al.: J. Med. Chem., 33, 344 (1990);<br></p>

<p>Applications 1,3-Dichlorobenzene (D4, 98%) (cas# 2199-70-4) is a useful research chemical.<br></p>

<p>Applications N-1-Butyl-d9-1-demethylethyl Torsemide is labelled N-1-Butyl-1-demethylethyl Torsemide (B692375) which is an impurity of Torsemide (T548750), diuretic.<br>References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),<br></p>

<p>Applications 2-Chloropropane-2-d1 (CAS# 53778-42-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Volatile<br>Applications N-Hexane (D14, 98%) (cas# 21666-38-6) is a useful research chemical.<br></p>

<p>Applications Labelled Methyl Methanethiosulfonate (M321500). Used for the rapid and selective modification of sulfhydryl groups of enzymes. Useful for mapping the pore-lining regions of the ryanodine receptor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996), Ehrlich, B.E., et al.: J. Gen. Physiol., 109, 255 (1997), Dunten, R.L., et al.: Biochemistry, 32, 3139-3145 (1993)<br></p>

<p>Applications 3-Hydroxypropionic Acid-13C3 Sodium Salt is isotope labelled analogue of 3-Hydroxypropionic Acid Sodium Salt (H952480), which is beta hydroxy acid derived from plants and crops such as corn. 3-Hydroxypropionic Acid is used in the preparation of acrylates and biodegradable polymer polyester.<br>References Wang, Y. et al.: Biomacromol., 3, 828 (2002); Jiang, X. et al.: Appl. Microbiol. Biotech., 82, 995 (2009);<br></p>

<p>Applications 2,2'-Bipyridyl-d8 was a useful compound in the NMR study of soft porous nanocrystal and a bulk crystal.<br>References Hijikata, Y., et al.: Chem. Commun. (Cambridge, UK), 47, 7632 (2011)<br></p>

<p>Applications n-Dodecyl-d25-phosphocholine (CAS# 861924-55-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropylmethyl-d2 Alcohol (CAS# 90568-07-3) is a useful isotopically labeled research compound.<br></p>