Nicotine and Nicotine Derivatives

<p>Applications A major metabolite of Nicotine in humans. Carcinogen.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994), Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996), Corringer, P., et al.: J. Neurosci., 18, 648 (1998),<br></p>

<p>Stability Hygroscopic<br>Applications rac-Cotinine-d3 N-β-D-Glucuronide is a labelled racemic analogue of Cotinine N-β-D-Glucuronide (C725175), a major metabolite of Nicotine (N412420) in humans. Carcinogen.<br>References Benowitz, N., et al.: Clin. Pharmacol. Ther., 56, 483 (1994), Nakajima, M., et al.: Drug Metab. Dispos., 24, 1212 (1996), Messina, E., et al.: J. Pharmacol. Exp. Ther., 282, 1608 (1997), Oscarson, M., et al.: Hum. Mutat., 20, 275 (2002),<br></p>

<p>Applications A nicotinic receptor agonist; brain rubidium efflux pharmacol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alkondon, M., et al.: J. Pharmacol. Exp. Ther., 271, 494 (1994); Wang, F., et al.: J. Biol. Chem., 271, 17656 (1996); Corringer, P., et al.: J. Neurosci., 18, 648 (1998);<br></p>

<p>Applications (R)-Anabasine is a minor tobacco alkaloid from Nicotiana tabacum that is known to have nicotinic receptor agonist activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lee, S.T., et al.: Neurotoxicol. Teratol., 28, 220 (2006); Ayers, J.T., et al.: AAPS J., 4, E752 (2005)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications Labelled Myosmine (M835000). Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.<br></p>

<p>Applications (S)-1-Methylnicotinium Iodide exhibits antinociceptive activity. A nicotinic receptor antagonist and a metabolite of Nicotine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aceto, M. D., et al.: Br. J. Pharmacol., 79, 869-876 (1983); Wilkins, L. H., et al.: J. Pharm. Exp. Ther., 304, 400-410 (2003); Seeman, J.I. and Whidby, J.F.: J. Org. Chem., 41, 24, 3824 (1976), Oldendorf, W.H., et al.: Proc. Natl. Acad. Sci., USA, 90, 307 (1993)<br></p>

<p>Applications A metabolite of Nicotine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seeman, J.I. and Whidby, J.F.: J. Org. Chem., 41, 24, 3824 (1976), Oldendorf, W.H., et al.: Proc. Natl. Acad. Sci., USA, 90, 307 (1993)<br></p>

<p>Stability Light Sensitive<br>Applications A metabolite of Nicotine in humans. Used for internal standardization for routine biomonitoring of nicotine metabolites.<br>References Sugasawa, S., et al.: Pharma. Bull., et al.: 2, 39 (1954), Thompson, J.A., et al.: J. Chromatog., 231, 53 (1982); Seeman, J.I., et al.: J. Org. Chem., 51, 1548 (1986)<br></p>

<p>Applications Nudifloramide is a metabolite of Niacin (or Nicorinic acid).<br>References Felsted, R., et al.: J. Biol. Chem., 242, 1274 (1967), Igel, M., et al.: Eur. J. Clin. Pharmacol., 57, 357 (2001), Kashyap, M., et al.: Am. J. Cardiol., 89, 672 (2002), Bottorff, M., et al.: Am. J. Cardiol., 97, 27 (2006),<br></p>

<p>Applications Labelled Nicotinic acid. It is a precursor of the coenzymes NAD and NADP. Widely distributed in nature; appreciable amounts are found in liver , fish, yeast and cereal grains. Dietary deficiency is associated with pellagra. The term “niacin” has also been applied to nicotinamide or to other derivatives exhibiting the biological activity of nicotinic acid. Vitamin (enzyme cofactor).<br>References Darby, W.J., et al.: Nutr. Rev., 33, 289 (1975), Black, A., et al.: Eur. J. Clin. Nutr., 54, 395 (2000), Cole, T., et al.: Br. Med. J., 320, 1240 (2000), Forshee, R., et al.: J. Nutr., 134, 2733 (2004),<br></p>

<p>Applications A metabolite of nicotine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1-(3-Pyridyl)-1-butanol-4-carboxylic Acid Na+/NH4+ Salt is a metabolite of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) (M325750), which is a major carcinogen, found in cigarette smoke.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hecht, S., et al.: Chem. Res. Toxicol., 11, 559 (1998); Hecht, S., et al.: Carcinogenesis, 23, 907 (2002); Sasco, A., et al.: Lung Cancer, 45, S3 (2004);<br></p>

<p>Applications Nicotine Salicylate is used for treatment of smoking withdrawal syndrome.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eneroth, P., et al.: Med. Biol., 55, 158 (1977),<br></p>