Organic Halides

<p>Applications 1-Cyclopropyl-2-(2-fluorophenyl)-2-hydroxy-ethanone is a useful synthetic intermediate in the synthesis of Prasugrel (P701150, HCl); an antiplatelet agent.<br>References Wiviott, S.D., et al.: Circulation, 116, 2923 (2007); Xu, X., et al. Faming Zhuanli Shenqing. CN 102718642 A 20121010. Oct 10, 2012; Wang, G., et al. Faming Zhuanli Shenqing. CN 101402556 A 20090408. Apr 8, 2009<br></p>

<p>Applications (((9H-Fluorene-9,9-diyl)bis(4,1-phenylene))bis(oxy))bis(ethane-2,1-diyl) diacrylate (CAS# 161182-73-6) is a photosensitive compound often found in film curing resins and solutions.<br>References Tanigaki, Y.; et al.: WO 2018181311 (2018).<br></p>

<p>Applications 2-Aminobenzotrifluoride is used as a reagent to synthesize thiohydrazides that act as effective antibacterial remedies for chlamydia. 2-Aminobenzotrifluoride is also used as a reagent to synthesize substituted 2-benzothiazolamines which have anticonvulsant activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hays, S., et al.: J. Pharm. Sci., 83, 1425 (1994); Yarovenko, V., et al.: J. Chem. Chemical Eng., 4, 55 (2010)<br></p>

<p>Applications 2-(2-Chloroethoxy)ethanol is a degradation product of Bis(2-Chloroethyl) Ether. 2-(2-Chloroethoxy)ethanol is a potential genotoxic impurity (PGI) in active pharmaceutical ingredients (APIs).<br>References McClay, K. et al.: Appl. Environ. Microbiol., 73, 6870 (2007); David, F<br></p>

<p>Stability Material darkens in storage with no loss in purity<br>Applications 3-Chlorobenzenamine is used in the synthesis of pyrimidoazepine analogs as serotonin 5-HT2A and 5-HT2C receptor ligands for the treatment of obesity. Also used in the synthesis of novel COX-2 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yang, H. et al.: Eur. J. Med. Chem., 63, 558 (2013); Penning, T. et al.: J. Med. Chem., 40, 1347 (1997);<br></p>

<p>Applications 1-(Bromomethyl)-2-nitrobenzene is a reagent used in the synthesis of 1,3,4-oxadiazole derivatives possessing a benzotriazole moiety leading to anticancer activity. Also used in the preparation of antifungal triazole derivatives.<br>References Zhang, S. et al.: Bioorg. Med. Chem., 21, 3723 (2013); Yu, S. et al.: Arch. Pharm. Res., 36, 1215 (2013);<br></p>

<p>Applications Methyl 4-Chloropicolinate (cas# 24484-93-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Dibromoacetamide is a byproduct produced from water purifciation processes.<br>References Chuang, Y., et al.: Env. Sci. Tech., 53, 3729 (2019);<br></p>

<p>Applications 2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Durban, M. et al.: Eur. J. Lipid. Sci. Tech., 105, 633 (2003);<br></p>

<p>Applications 4-(Trifluoromethyl)benzyl Bromide is a useful building block. It is used in the synthesis of 1-(Substituted benzyl)-2-substituted-5,6-dichlorobenzimidazoles with antiviral activities.It is also used to prepare 2-[(4-diarylmethoxy)phenyl]benzimidazoles as potent inhibitors of hepatitis C virus NS5B polymerase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Porcari, A., et al.: J. Med. Chem., 41, 1252 (1998); Ishida, T., et al.: Bioorg. Med. Chem. Lett., 16, 1859 (2006)<br></p>

<p>Applications Copper Hexafluorosilicate is a useful compound in metal-organic material synthesis.<br>References Nugent, P., et al.: Natrue, 495, 80 (2013);<br></p>

<p>Applications Dimethyldimyristylammonium bromide is a cationic surfactant used in the study of lipid raft domains in membranes.<br>References Uyama, M.; et al.: J. Oleo Sci., 67, 67 (2018).<br></p>

<p>Applications 1-Chlorotetradecane is a useful synthetic intermediate. It is an intermediate used to prepare Dimethyldimyristyl ammonium chloride (D472560), a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991);<br></p>

<p>Applications 2,6-Dichlorobenzoic Acid is an di-halogenated benzoic acid derivative and is used in the synthesis of Lux-S enzyme inhibitor.<br>References Dhimitruka, I., et al.: Organic. Lett., 8, 47 (2006);<br></p>

<p>Applications 2,6-Difluorobenzoylacetonitrile is used in the synthesis of thienodiazepinones which can have poor central nervous system depressant activity.<br>References Binder, D., et al.: Arch. Pharm., 313, 587 (1980)<br></p>

<p>Applications 1-Bromo-2-chlorobenzene is a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists.<br>References Conway, R.J., et al.: Bioorg. Med. Chem. Lett., 22, 2560 (2012)<br></p>

<p>Applications 9-Bromononanol (cas# 55362-80-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Benzo[j]fluoranthene is a polycyclic aromatic hydrocarbon that has tumour initiating activity and can be found in soot, oil, water and soil extracts as a common pollutant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References LaVole, E., et al.: Carcinogenesis, 3, 49 (1982); Nadal, M., et al.: Environ. Pollut., 132, 1 (2004); White, P. &amp; Rasmussen, J.: Mutat. Res., 410, 223 (1998); Wornat, M., et al.: Environ. Sci. Technol., 35, 1943 (2001)<br></p>

<p>Applications 2-Chloroethylamine Hydrochloride is used as a reagent in the synthesis of 6-desfluoroquinolones as potential anti-HIV drugs. Also used as a reagent in the synthesis of ellipticine derivatives as anticancer agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sancineto, L., et al.: Bioorg. Med. Chem., 22, 4658 (2014); Mori, R., et al.: Eur. J. Med. Chem., 82, 16 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications N-(2-Chloroethyl)-1,2-ethanediamine Dihydrochloride is an analog of 2-(2-Aminoethylamino)ethanol (A608990); a reagent used in the synthesis of various pharmacologically active compounds and functional groups. Also used in the synthesis of antitumor anthracene-diones and antitumor DNA intercalators. More recently used in the synthesis of ionic liquids with various thermal, dielectric and catalytic properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bair, K. et al.: J. Med. Chem., 33, 2385 (1990); Krapcho, A. et al.: J. Med. Chem., 37, 828 (1994); Karadag, A. et al.: J. Mol. Liq., 177, 369 (2013)<br></p>

<p>Applications 2,4-Dichloro-1-nitrobenzene is used as a reagent in the synthesis of the hepatitis C virus polymerase inhibitor, Deleobuvir (BI 207127).<br>References Zhang, Y., et al.: Org. Lett., 16, 4558 (2014); LaPlante, S.R., et al.: J. Med. Chem., 57, 1845 (2014)<br></p>

<p>Applications Combinations of Bis(trichloromethyl)sulfone, (Hexachlorodimethyl sulfone) and 1,2-Dibromo-2,4-dicyanobutane are shown to have synergistic antimicrobial properties. The synergistic compounds may be used together with a third microbiocide to enhance the compound’s effectiveness against a wide variety of bacteria, molds, and yeasts and other microorganisms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pearl, G., et al.: Curr. Top Med. Chem., 1, 247 (2001), Casalegno, M., et al.: Chem. Res. Toxicol., 18, 740 (2005), Toropov, A., et al.: Bioorg. Med. Chem., 14, 2779 (2006),<br></p>

<p>Applications 1H,1H-Perfluorohexan-1-ol is a reagent in the synthesis of environmentally safer fluoroalkyl ether synthons.<br>References Lazzari, D., et al.: J. Fluorine. Chem., 156, 34 (2013)<br></p>

<p>Applications α-Chloroethyl Chloroformate (cas# 50893-53-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Phosphorus(V) Oxybromide is a reagent used in the preparation of phosphoryl halide for N-protection of amino acids using group assisted purification (GAP). Phosphorus(V) Oxybromide is a brominating agent.<br>References An, G., et al.: Heterocycles, 90, 344 (2015); Guo, J., et al.: Hebei Gongye Daxue Xuebao, 40, 57 (2011); Golding, D., et al.: J. Org. Chem., 12, 293 (1947)<br></p>

<p>Applications 5-Bromo-2-picoline is a halogenated pyridine derivative used is a building block in the preparation of nitrogen containing heterocyclic compounds.<br>References Gallant, M. et al.: Bioorg. Med. Chem. Lett., 18, 1407 (2008);<br></p>

<p>Applications Methyl 5-Aminopentanoate Hydrochloride is used as a reactant to synthesize several compounds with therapeutic potential.<br>References Larson, Peter, et al.: ACS Med. Chem. Let, 8(11), 1148-1152 (2017);Li, Yongtao, et al.: J. of Med. Chem., 61(7), 3166-3192 (2018);Lu, Yuzhi, et al.: ACS Med. Chem. Let., 7(12), 1185-1190 (2016)<br></p>

<p>Applications Triethylamine Trihydrofluoride is used in the synthesis of modified siRNA’s in vivo used to inhibit hepatitis B replication (1). Used in RNA synthesis in the removal of t-butyldimethylsilyl protection (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Marimani M. et al.: Bioorg Med Chem. 2013 Oct 15;21(20):6145-55. 2. Westman, E. et al.: Nucleic Acids Res. 1994 Jun 25;22(12):2430-1<br></p>

<p>Applications 2-(4-CHLOROPHENYL)PROPANOIC ACID (cas# 938-95-4) is a useful research chemical.<br></p>

<p>Applications 2,4,5-Trifluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize quinolone antibacterial agnts.<br>References Sanchez, J., et al.: J. Med. Chem., 31, 983 (1988); Tran, T., et al.: Bioorg. Med. Chem. Lett., 14, 4405 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications 3-[[[2-[(Diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide hydrochloride (cas# 76833-47-1) is a useful research chemical.<br></p>

<p>Applications 2-Fluorobenzamide (cas# 445-28-3) is a useful research chemical.<br></p>

<p>Applications 7-Bromoheptanoic Acid is a reagent that is used in the synthesis of N-Heptanoic Acid Tianeptine Disodium Salt (H281500) which are metabolite of Tianeptine (T436800), having psychostimulant, anti-ulcer and anti-emetic properties.<br>References Malen, C., et al.: Experientia, 28, 811 (1972), Safa, A., et al.: J. Biol. Chem., 262, 7884 (1987), Ford, J.M., et al.: Pharmacol. Rev., 42, 155, (1990), Pierre, A., et a.: Cancer Res., 51, 2312 (1991),<br></p>

<p>Applications 1-Bromo-2-butyne is used in the synthesis of six to eight annulated ring compounds in reactions with indoles. It is also used in the preparation of Pseudopterane (+/-)-Kallolide B, a marine natural product.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrer, C. et al.: Chem. A. Eur. J. et al.: 13, 1358 (2007); Marshall, J. et al.: J. Org. Chem., 60, 796 (1995);<br></p>

<p>Applications Tert-butyl 4-Aminobutanoate Hydrochloride is used as a substance in the prevention of drug-induced memory impairement by immunopharmacotherapy.<br>References Treweek, J. B., et al.: J. Med. Chem., 51, 6866 (2008)<br></p>