Organic Halides

<p>Applications 1,8-Dibromooctane is used as a reagent in the synthesis of novel 7-aminoalkyl-substituted flavonoid derivatives as potential cholinesterase inhibitors.<br>References Luo, W., et al.: Bioorg. Med. Chem., 24, 672 (2016)<br></p>

<p>Applications Diphenyl Chlorophosphonate, is a building block used for the synthesis of various chemical compounds. It can be used for the synthesis of phosphate esters of polyhedral hydroxyboranes, showing enhanced tumor uptake.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bechtold, R., et al.: J. Med. Chem., 18, 371 (1975);<br></p>

<p>Stability Moisture Sensitive<br>Applications Cyclopropanecarbonyl Chloride is a reagent used in the synthesis of orally bioavailable HCV NS5A inhibitor for the treatment of Hepatitis C virus.<br>References Kang, IJ. Med. Chem., 60, 228 (2017);<br></p>

<p>Applications 2-Bromo-N-[4-chloro-2-(trifluoroacetyl)phenyl]acetamide is an intermediate in the synthesis of novel quinolinones as HIV-1 reverse transcriptase inhibitors.<br>References Patel, M., et al.: Bioorg. Med. Chem. Lett., 11, 1943 (2001);<br></p>

<p>Applications 4-Chloro-2-fluoroaniline is a compound used in the synthesis of 4-Chloro-2-fluoro-3-iodobenzenamine (1000590-87-3).<br></p>

<p>Applications 1,3-Benzothiazole-4-sulfonyl Chloride (cas# 149575-65-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-Dichloro-5-thiazolemethanol (cas# 170232-69-6) is a useful research chemical.<br></p>

<p>Applications 1-Bromo-2,3-dichlorobenzene is a reagent used in the preparation of selective nonpeptidic inhibitors of striatal-enriched protein tryosine phosphatase.<br>References Baguley, T.D., et al.: J. Med. Chem., 56, 7636 (2013)<br></p>

<p>Applications Triethylmethylammonium Chloride (cas# 10052-47-8) is a useful research chemical.<br></p>

<p>Applications 1,3-Dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide1,3-dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide is an intermediate in the synthesis of 2,3,6,7-Tetrachloronaphthalene which is a polychlorinated naphthalene (PCN) with dioxin-like toxic properties that can lead to increased risk of liver disease. It is a potential carcinogen.<br>References McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);<br>Chemical Name: McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);<br></p>

<p>Applications 4-[2,2,2-Trifluoro-1-[4-(phenylmethoxy)phenyl]-1-(trifluoromethyl)ethyl]-phenol is an intermediate used in the synthesis of 4,4'-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bisphenol Mono-β-D-glucuronide (T792735), which is a metabolite of 2,2-Bis-(4-hydroxyphenyl)hexafluoropropane (B447290), which acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.<br>References Matsushima, A. et al.: Environ. Health, Perspect. 118, 1267 (2010);<br></p>

<p>Applications 2-Bromo-4-nitrobenzoic Acid (cas# 16426-64-5) is a compound useful in organic synthesis.<br></p>

<p>Applications O-Toluoyl Chloride is used in the synthesis if quinolinone compounds as SARS CoV 3CLpro inhibitors. Also used in the synthesis of benzooxaboroles as orally active anti-inflammatory agents.<br>References Sun, Y. et al.: Chin. J. CHem., 31, 1199 (2013); Akama, T. et al.: Bioorg. Med. Chem. Lett., 23, 5870 (2013);<br></p>

<p>Applications 2-bromo-N,N-dimethylpropanamide (cas# 54537-47-2) is a useful research chemical.<br></p>

<p>Applications 4-(3-Bromopent-1-yn-1-yl)-6-chloro-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one is the proposed intermediate in the synthesis of (4S)-6-Chloro-4-(3-((4-chloro-2-((S)-4-cyclopropyl-1,1,1-trifluoro-2-hydroxybut-3-yn-2-yl)phenyl)amino)pent-1-yn-1-yl)-4-(trifluoromethyl)-1H-benzo[d][1,3]oxazin-2(4H)-one (Mixture of Diastereomers) (C360045) which is an impurity of Efavirenz (E425000) which is a nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral.<br>References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995),<br></p>

<p>Applications 1-Chloro-2-propanol Phosphorochloridate is an intermediate in the synthesis of metabolite of organic flame retardants.<br>References Schindler, B. et al.: Anal. Bioanal. Chem., 395, 1167 (2009);<br></p>

<p>Applications 2-Amino-5-chloro-α-(cyclopropylethynyl)-4-isopropylsilyloxy-α-(trifluoromethyl)benzenemethanol (cas# 1159977-02-2) is a compound useful in organic synthesis.<br></p>

<p>Applications (S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.<br>References Zhang, X., et al.: Bioorg. Med. Chem., 21, 7988 (2013); Ermoli, A. et al.: J. Med. Chem., 52, 4380 (2009); Pearson, S. et al.: Synthesis, 15, 2503 (2005);<br></p>

<p>Applications 2-(4-Bromo-2-chlorophenyl)ethanol (cas# 916516-90-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Chlorotoluene is used as a reagent to synthesize 4-Arylchromene derivatives, compounds that induce apoptosis and act as anti-cancer agents. 3-Chlorotoluene is also used as an ingredient in deodorant, and is suspected to cause allergic contact dermatitis in humans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rastogi, S., et al.: Contact Derm., 39, 293 (1998); Tsygankova, I. &amp; Zhenodarova, S.: Russ. J. Gen. Chem., 84, 89 (2014)<br></p>