Organic Halides

<p>Applications Used for identification of amines, and also in the synthesis and inhibition studies of substituted N-L-histidinylphenylsulfonyl hydrazide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Teng, H., et al.: Biochemistry, 38, 7363 (1999), Abdo, M., et al.: Bioorg. Med. Chem., 15, 4427 (2007),<br></p>

<p>Stability Moisture Sensitive<br>Applications Tert-Butyldimethylsilyl Trifluoromethanesulfonate is a highly reactive silylating agent and lewis acid capable of converting primary, secondary and tertiary alcohols to their respectctive TBDMS. Tert-Butyldimethylsilyl Trifluoromethanesulfonate is also used to covert ketones and lactones into their enol silyl ethers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hua, D.H. et al.: e-ROS Encyc. Reag. Org. Synth., No pp. given (2001); Suzuki, T. et al.: Synthesis, 4, 555 (2001);<br></p>

<p>Applications 4-CHLORO-2-NITRODIPHENYLAMINE (cas# 16611-15-7) is a useful research chemical.<br></p>

<p>Applications Benzyl 4-Fluorophenyl Ketone is used in the preparation and evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.<br>References Singh, S. et al.: Bioorg. Med. Chem., 12, 1881 (2004);<br></p>

<p>Applications 2-BROMO-1-PHENYLPROPANE (cas# 2114-39-8) is a useful research chemical.<br></p>

<p>Applications Hydrofluoric Acid is a common chemical reagent used as a precursor to most pharmaceutical and high volume fluoride compounds as well as in the oil refinery process. Hydrofluoric acid causes skin burns if contact with skin.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yamashita M. et al.; Crit. Care. Med., 29, 1575 (2001); Stahl, K. et al.: Ind. Eng. Chem., 7, 56 (1915);<br></p>

<p>Applications Methyl 2-bromobenzoate<br></p>

<p>Applications 2-Chlorobenzhydrazide<br></p>

<p>Applications 1-Bromo-2,4-difluorobenzene is a reactant used in the preparation of azole derivatives as highly-selective fungal CYP51 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoekstra, W.J., et. al.: Bioorg. Med. Chem. Lett., 24, 3455 (2014)<br></p>

<p>Applications 4-Bromophenethylamine (cas# 73918-56-6) is a useful research chemical.<br></p>

<p>Applications 2-Chloro-3,3,3-trifluoropropene (cas# 2730-62-3) is a useful research chemical.<br></p>

<p>Applications 2-Acetylfluorene (cas# 781-73-7) is a useful research chemical.<br></p>

<p>Applications 2-Bromo-1-(3-fluorophenyl)propan-1-one is an intermediate used to prepare arylalkanol-piperidine derivatives as triple reuptake inhibitors with antidepressant activities.<br>References Zheng, Y., et al.: Eur. J. Med. Chem., 54, 123 (2012)<br></p>

<p>Applications 5-Amino-2-chloro-4-fluorobenzoic Acid is an intermediate in the synthesis of Saflufenacil-d7 (S081802). Saflufenacil-d7 is the labeled version of Saflufenacil (S081800), which is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010)<br></p>

<p>Applications 4-Bromo-α-phenylbenzenemethanol is used in the synthesis of diarylmethylpiperazines as potent and selective nonpeptidic δ-opioid receptor agonists. Is used in the ysnthesis of bronsted acid-catalyzed benzylation of 1,3-dicarbonyl derivatives.<br>References Plobeck, N. et al.: J. Med. Chem., 43, 3878 (2000); Sanz, R. et al.: Org. Lett., 9, 2027 (2007);<br></p>

<p>Stability Moisture Sensitive<br>Applications A synthetic intermediate in the preparation of CNS depressants.<br>References Imamura, S., et al.: J. Med. Chem., 49, 2784 (2006), Barber, C., et al.: Bioorg. Med. Chem. Lett., 19, 1499 (2009),<br></p>

<p>Applications Phenyl chloroformate is a corrosive liquid that is used to synthesize Urazole, a five membered heterocyclic compound that reacts with aldoses to form α and β pyranosides and furanosides. Phenyl chloroformate is also used as a reagent to prepare Sorafenib (S676850), a multikinase inhibitor that targets the tumour and tumour vasculature in patients with melanoma.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boettecher, B. &amp; Meister, A.: Anal. Biochem., 138, 449 (1984); Chai, W., et al.: Tetrahedron Lett., 53, 3514 (20112); Eisen, T., et al.: Brit. J. Cancer, 95, 581 (2006); Kolb, V., et al.: J. Mol. Evol., 38, 549 (1994); Llovet, J., et al.: Engl. J. Med., 359, 378 (2008)<br></p>

<p>Applications An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity.<br>References Tomasi, J., et al.: Chem. Rev., 105, 2999 (2005), Godula, K., et al.: Science, 312, 67 (2006), Davies, H., et al.: Nature, 451, 417 (2008),<br></p>

<p>Applications 1,2,3-Tribromo-5-nitrobenzene is used as a reagent to synthesize various polybrominated biphenyls to use as fire retardents.<br>References Kubiczak, G., et al.: J. Agr. Food Chem., 37, 1160 (1989)<br></p>

<p>Applications 3-Chloro-2,4-dimethyl-benzenesulfonyl Chloride is an intermediate in the synthesis of 3-Chloro-Vortioxetine (C424140) which is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>