Organic Halides

<p>Applications 4-Chloro-3-nitro-5-sulfamoylbenzoic Acid Ammonium Salt is a useful intermediate and a salt form of 4-Chloro-3-nitro-5-sulfamoylbenzoic Acid(C369580).<br>References Feit, P., et al.: J. Mem. Biol., 103, 135 (1988),<br></p>

<p>Applications 2-(4-Chloro-3-nitrobenzoyl)benzoic Acid is an intermediate used in the synthesis of indanthrone derivatives. It is related to Chlorthalidone (C427500).<br>References Bradley, W., et al.; J. Chem. Soc., 2177 (1951)<br></p>

<p>Applications Cyclohexanecarbonyl Chloride is used to prepare 1,2,3-triazoles as inhibitors of human immunodeficiency virus type 1 protease. It was also used to synthesize benzothiazole as potent antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Whiting, M., et al.: J. Med. Chem., 49, 7697 (2006); Yoshida, M., et al.: Bioorg. Med. Chem. Lett., 15, 3328 (2005)<br></p>

<p>Applications 3-Bromopropionitrile acts as a reagent in the preparation of bisindole maleimide derivative useful as α-glucosidase inhibitors for the treatment of diabetesis. Also used in the study of the structure activity relations between alkyl nucleophilic chemicals causing duodenal ulcer and adrenocortical necrosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szabo, S., et al.: J. Pharm. Exp. Ther., 223, 68 (1982); Zhu, W., et al.: Faming Zhuanli Shenqing (2016); CN 106146487 A 20161123;<br></p>

<p>Applications 1,7-Dibromoheptane is a useful synthetic intermediate. 1,7-Dibromoheptane can be used in the synthesis of random thermotropic liquid crystalline copolyether and ternary copolyether. It can also be used in the synthesis of thermotropic liquid crystalline dendrimer exhibiting a nematic phase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Percec, V., et al.: J. Polym. Sci. A Polym. Chem., 25, 1943, 1987; Percec, V., et al.: Macromolecules 23, 5 (1990); Percec, V., et al.: Macromolecules, 25, 3843 (1992)<br></p>

<p>Applications 2-Bromo-4,5-dimethoxybenzoic Acid 2,3-Dimethoxyphenyl Ester is an intermediate in the synthesis of Urolithin D (U847020) used in biological studies to evaluate DNA gyrase inhibitory activity of ellagic acid derivatives.<br>References Weidner-Weels, M. A., et al: Bioorg. Med. Chem. Lett., 8, 97 (1998)<br></p>

<p>Stability Moisture Sensitive<br>Applications 2-Bromoacetyl Bromide, is a builidng block used for various organic synthesis. It can be used for the synthesis of novel biofunctional molecules for target-selective photodegradation of proteins and carbohydrates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Toshima, K., et al.: Yuki Gosei Kagaku Kyokaishi, 70, 1187 (2012);<br></p>

<p>Applications 3,4-Difluoroaniline was used to prepare thiourea-containing sorafenib analogs or fluorinated 2-(4-aminophenyl)benzothiazoles as potential antitumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yao, J., et al.: Bioorg. Med. Chem., 20, 2923 (2012); Hutchinson, I., et al.: J. Med. Chem., 44, 1446 (2001)<br></p>

<p>Applications 1,2,3-Tribromo-5-nitrobenzene is used as a reagent to synthesize various polybrominated biphenyls to use as fire retardents.<br>References Kubiczak, G., et al.: J. Agr. Food Chem., 37, 1160 (1989)<br></p>

<p>Applications 2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.<br>References Liu, J., et al.: Synthesis., 45, 943 (2013); Rambabu, D., et al.: Bioorg. Med. Chem. Lett., 23, 1351 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications trans-1,3-Dichloropropene is used in a biological study to evaluate the fumigant emission and distribution in relation to soil moisture and texture.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Qin, R., et al.: Chemosphere, 90, 866 (2013)<br></p>

<p>Applications 2,3-Dibromo-2-(4-bromophenyl)propionic Acid (cas# 112595-55-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Iodoanisole is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.<br>References Chu, X., et al.: J. Med. Chem., 49, 6549 (2006); Thevenin, M., et al.: Bioorg. Med. Chem., 21, 4885 (2013)<br></p>

<p>Applications O-Toluoyl Chloride is used in the synthesis if quinolinone compounds as SARS CoV 3CLpro inhibitors. Also used in the synthesis of benzooxaboroles as orally active anti-inflammatory agents.<br>References Sun, Y. et al.: Chin. J. CHem., 31, 1199 (2013); Akama, T. et al.: Bioorg. Med. Chem. Lett., 23, 5870 (2013);<br></p>

<p>Applications Diphenyliodonium chloride &gt;=98.0% (AT) (cas# 1483-72-3) is a useful research chemical.<br></p>

<p>Impurity Bupropion (S)-Hydroxy Propanone Impurity<br>Applications Bupropion intermediate.<br>References Kelley, J., et al.: J. Med. Chem., 39, 347 (1996), Musso, D., et al.: Bioorg. Med. Chem. Lett ., 7, 1 (1997)<br></p>

<p>Applications 1-Bromo-2,4-difluorobenzene is a reactant used in the preparation of azole derivatives as highly-selective fungal CYP51 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoekstra, W.J., et. al.: Bioorg. Med. Chem. Lett., 24, 3455 (2014)<br></p>

<p>Applications 4-Fluoro-3-nitroaniline (cas# 364-76-1) is a useful research chemical.<br></p>

<p>Stability Not stable in Solution<br>Applications 3-Chloro-1-(N,N-dimethyl)propylamine is a genotoxic impurity in drug samples of rizatriptan benzoate. Also, it is the side chain of Chlorpromazine and Amitriptyline.<br>References Rao, K. L., et al.: Anal. Chem. Lett., 7, 248-260 (2017); Wang, Q., et al.: Huagong Shikan, 28, 35-37 (2014)<br></p>

<p>Applications 1,3-Dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide1,3-dihydro-5,6-dichlorobenzo(c)thiophene-S,S-dioxide is an intermediate in the synthesis of 2,3,6,7-Tetrachloronaphthalene which is a polychlorinated naphthalene (PCN) with dioxin-like toxic properties that can lead to increased risk of liver disease. It is a potential carcinogen.<br>References McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);<br>Chemical Name: McKinney, J.D. et al.: Safe Handl. Chem. Carcinog., Mutagens, Teratog. Highly Toxic Subst., 2, 421 (1980); Blankenship, A.L. et al.: Env. Sci. Technol., 34, 3153 (2000);<br></p>