Organic Halides

<p>Applications 2,3-Dibromo-1-propanol is a metabolite of the flame retardant tris(2,3-dibromopropyl) phosphate (T775560), previously shown to be a mutagen and carcinogen in experimental animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pandith, A.H., et al.: Org. Chem. Int., 17, (2010); Dixon, D., et al.: Toxicol. Pathol., 36,428 (2008);Eustis, S.L., et al.: Toxiciol. Sci., 26, 41 (1994);<br></p>

<p>Applications Methyl Pentadecafluoroheptyl Ketone 754-85-8 (cas# 754-85-8) is a useful research chemical.<br></p>

<p>Applications 2-Iodobenzyl Alcohol (cas# 5159-41-1) is a useful research chemical.<br></p>

<p>Applications 4-(Chloromethyl)benzoyl Chloride is used in the synthetic preparation of various compounds and pharmaceuticals. 4-(Chloromethyl)benzoyl Chloride was used in the synthesis of several imidazo[2,1-b]thiazoles.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bratulescu, G., et al.: Asian. J. Chem., 24, 350 (2012);<br></p>

<p>Applications 9-Chloro-dibenzo[b,f][1,4]thiazepin-11(10H)-one is an intermediate in the synthesis of 9-Chloro Quetiapine (C366040). 9-Chloro Quetiapine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.<br>References Kumar, K., et al.: Org. Chem.: An Indian Journal, 8, 164 (2012); Raju, I., et al.: Chromatographia, 70, 545 (2009)<br></p>

<p>Impurity Clemastine EP Impurity C<br>Applications 1-(4-Chlorophenyl)-1-phenylethanol (Clemastine EP Impurity C) is used in the synthetic preparation of rhodium-catalyzed arylation of nitriles, ketones and imines with tetrafluoroborate or arylboronic acids<br>References Ueura, K., et al.: J. Organomet. Chem., 691, 2821 (2006); Ueda, M., et al.: J. Organomet. Chem., 595, 31 (2000)<br></p>

<p>Applications 1-Bromodecane is used to react with Mg to prepare Grignard reagents which play an important role in formation of carbon-carbon bond. It is also used in preparation of biodegradable cationic gemini surfactants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rogers, R., et al.: J. Org. Chem., 39, 857 (1975); Talaba, P., et al.: J. Carbohyd. Chem., 16, 573 (1997); Jain, T., et al., J. Mater. Chem. C: Materials for Optical and Electronic Devices, 2, 994 (2014)<br></p>

<p>Applications 4-Fluorothiophenol is primarily used in wet chemistry as a capping ligand for various metal nanostructures so that they don’t aggregate in solution. 4-Fluorothiophenol is also capable of creating a self-assembled monolayer, which is used to improve the interface properties of metal electrodes with hydrophobic layers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bakr, O., et al.: Angew. Chem., 121, 6035 (2009); Boev, V., et al.: Solid State Sci., 8, 50 (2006); Li, G., et al.: Mat. Chem. Phys., 129, 1011 (2011); Yang, L., et al.: Appl. Surf. Sci., 254, 5055 (2008)<br></p>

<p>Applications 2-Propyloxybenzamidine Hydrochloride (cas# 57075-84-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Dichloroacetyl Chloride is a reagent used in the synthesis of substituted benzothiazoles exhibiting antitumor and anticancer activity.<br>References Chua, M. et al.: J. Med. Chem., 42, 381 (1999);<br></p>

<p>Applications 2,3,4-Trichloronitrobenzene is a useful synthetic intermediate that is mainly used as the starting material in the synthesis of third generation quinolone antibacterial drugs, such as Lomefloxacin (L469415, HCl) and Ofloxacin (O245750). 2,3,4-Trichloronitrobenzene is also used as the starting material in the synthesis of Aclonifen (A190200); a compound used as a pesticide and herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, Y., et al.: Guangdong Huagong, 36, 20 (2009); Laini, A., et al.: Sci. Total Environ., 438, 312 (2012); Fantke, P., et al.: Enviorn. Int., 49, 9 (2012)<br></p>

<p>Applications 8-Bromooctanoic Acid (cas# 17696-11-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Ethoxyoxalyl Chloride has been used as a reactant in the preparation of oxyoxalamide derivatives as epoxide hydrolase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kim, I., et. al.: Bioorg. Med., 22, 1163 (2014)<br></p>

<p>Applications 3-Chloro-2,4-dimethyl-benzenesulfonyl Chloride is an intermediate in the synthesis of 3-Chloro-Vortioxetine (C424140) which is an impurity of Vortioxetine (V766000), a multimodal serotonergic agent. Vortioxetine inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT.<br>References Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011); Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012); Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>

<p>Applications 2-Fluoro-4-(3-trifluoromethyl)-3H-diazirin-3-ylbenzyl Benzoate (cas# 1391052-78-0) is a compound useful in organic synthesis.<br></p>

<p>Stability Moisture Sensitive<br>Applications Chloromethoxysulfonyl Chloride is a useful intermediate for organic synthesis. Chloromethoxysulfonyl Chloride is a useful reagent for the preparation of HIV-attachment inhibitor BMS-663068, and in the synthesis of water soluble benzimidazole derivatives useful for treatment of fasciolosis.<br>References Fox, R. J., et al.; Org. Process Res. Dev., 21, 1095 (2017); Flores-Ramos, M., et al.: Bioorg. Med. Chem. Lett., 24, 5814 (2014); Zheng, B., et al.: Org. Process Res. Dev., 16, 1827 (2012)<br></p>

<p>Applications 2’,8-Bis(trifluoromethyl)-10H-3,10'-biphenothiazine is an intermediate for the synthesis of 2-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol (B586700), an impurity of Fluphenazine Decanoate (F598350) which is used in psychotropic drug treatments like those relating to schizophrenia.<br>References Frasch, K. et al.: Pharmacopay., 45, 138 (2012); Aggarwal, N. et al.: J. Clin. Psychopharmacol., 32, 323 (2012)<br></p>

<p>Applications Manganese Chloride Tetrahydrate is an inorganic chemical reagent used in oxidation studies and reactions.<br>References Huynh, M. et al.: J. Am. Chem. Soc., 136, 6002 (2014); Gupta, Y. et al.: Res. J. Chem. Env., 16, 48 (2012);<br></p>

<p>Applications Ethyl 2-bromobutyrate is used in synthetic chemistry as a polymerization initiator. Ethyl 2-bromobutyrate is also used as a reagent to synthesize Efaroxan, an imidazoline α 2-antagonist that stimulated insulin secretion in rat pancreatic cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ball, A., et al.: Pharm. Res., 42, 575 (2000); Bibiao. J. et al.: Eur. Polym. J., 42, 179 (2006); Chan, S. &amp; Morgan, N.: Eur. J. Pharm., 176, 97 (1990); Xu, W., et al.: Eur. Polym. J., 39, 1349 (2003)<br></p>

<p>Applications Hexachloropropanone is a useful synthetic intermediate. It is a reagent used for the conversion of nucleoside-3′-phosphonates to the corresponding phosphates and for the polymerization of vinyl compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Garegg, P., et al.: J. Chem. Soc. Perkin Trans. I, 6, 1269 (1972); Deming, T., et al.: 26, 7089 (1993)<br></p>