Toxicology

<p>Stability Moisture Sensitive<br>Applications Fenchlorphos-oxon is a pesticide residue found in fruits and vegetables.<br>References Jadhav, M.R., et. al.: J. Agr. Food Chem., (Ahead of Print) (2015); Li, Y. et. al.: J. Chromatogr. A., 1361, 77 (2014); Li, X., et. al.: Sepu, 32, 268 (2014)<br></p>

<p>Applications Colinesterase inhibitor. Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications Labelled analogue of Propionaldehyde 2,4-Dinitrophenylhydrazone, a dinitrophenylhydrazone (DNPH) derivative of an aliphatic aldehyde found in mainstream cigarette smoke and a breakdown product of lipid peroxidation.<br>References Delgado, B. et al.: J. Liq. Chrom. Rel. Technol., 31, 361 (2008); Miller, J.H. et al.: J. Chrom. Sci., 48, 12 (2010); Enoiu, M. et al.: Anausis, 28, 285 (2000);<br></p>

<p>Applications BUTAN-2-YL 4-HYDROXYBENZOATE (cas# 17696-61-6) is a useful research chemical.<br></p>

<p>Applications Hexadecyl Acetate is a plant sex pheromone.<br>References Brasero, N., et al.: J. Chem. Ecol., 44, 9 (2018); Cuervo, M., et al.: J. Chem. Ecol., 43, 469 (2017)<br></p>

<p>Applications Pretilachlor is a chloroacetanalide herbicide. Pretilachlor is commonly used for weed control in wet seeded rice<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mohankumar, P.D. et al.: J. Trop. Agric., 34, 149 (34, 149 (1996); Ravisankar, N. et al.: Ind. J. Agron., 53, 57 (2008); Singh, S. et al.: Crop Prot., 27, 660 (2008);<br></p>

<p>Applications (E)-Fenpyroximate is an acaricide and an inhibitor of mitochondrial electron transport at Complex I.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hamedi, N. and Fathipour, Y.: BioControl 55, 271 (2010); Sato, M. E., et al.: Appl. Entomol. Zool. 39, 293 (2004)<br></p>

<p>Applications 5-Desthiopropyl-5-hydroxy-ticagrelor is a related compound of ticagrelor (T437700). Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).<br>References Matetzky, S., et al.: Circulation, 109, 3171 (2004), Bassand, J., et al.: Eur. Heart J., 28, 1598 (2007), Jakubowski, J., et al.: Cardiovasc. Drug Rev., 25, 357 (2007),<br></p>

<p>Applications It is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor obtained from the Calabar bean, used to treat glaucoma and delayed gastric emptying.<br>References Engelhart, L., et al.: Arch. Exp. Pathol. Pharmakol., 150, 1 (1930), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 18, 289 (1989),<br></p>

<p>Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).<br>References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),<br></p>

<p>Applications 17-epi-Testosterone Enanthate, is a derivative of 17-epi-Testosterone (T155005).Testosterone and epitestosterone are endogenous steroids that differ in the configuration of the hydroxyl-bearing carbon at C-17. Testosterone is the predominant male sex hormone, whereas the role of epitestosterone is largely unclear. In humans, both androgens are excreted mainly as glucuronide conjugates.<br>References Wudy, S., et al.: Steroids, 66, 759 (2001), Kootstra, P., et al.: Anal. Chim. Acta., 586, 82 (2007), Sten, T., et al.: Drug Metab. Dispos., 37, 417 (2009),<br></p>

<p>Applications Labelled Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.<br>References Srinivasan, et al.: J. Pharm. Pharmacol., 5, 448 (1953), Tu, B., et al.: J .Cell Biol., 164, 341 (2004), Xu, G., et al.: Biochemistry, 44, 9817 (2005), Johnson, J., et al.: Cancer Lett., 255, 170 (2007),<br></p>

<p>Applications A hydrazine derivative that is a non-selective and irreversible monoamine oxidase inhibitor (MAOI) and also inhibits GABA-transaminase (GABA-T), markedly increasing brain GABA levels. It is an antidepressant and anxiolytic used in the treatment of major depressive disorder (MDD) as well as other neural disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References MacKenzie, E.M. et al.: Neurochem. Res., 33, 430 (2008); Chiche, F. et al.: Mol. Pharmacol., 75, 1052 (2009); McKenna, K.F, et al.: J. Neural Trans., 41, 115 (1994);<br></p>

<p>Applications Tetramethrin is a synthetic pyrethroid pesticide used in large-scale commercial agricultural applications as well as in consumer products for domestic purposes. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anderson, J.F., et al.: J. Economic. Entomol., 105, 1789 (2012); Xu, S.M., et al.: Food. Chem., 135, 161 (2012);<br></p>

<p>Applications Steroid hormone with weak androgenic effects.<br>References Wartman, C., et al.: Aquatic Toxicol., 92, 131 (2009), Gohil, V., et al.: Nat., Biotechnol., 28, 249 (2010), Phapale, P., et al.: Clin. Pharmacol. Ther., 87, 426 (2010),<br></p>

<p>Applications Thifluzamide is a fungicide found in cereals, vegetables and fruits; A succinate dehydrogenase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, C., et al.: Sepu, 35, 487-494 (2017); Sun, H., et al.: Pest Manag. Sci., 73, 896-903 (2017)<br></p>

<p>Applications Dimethyldimyristylammonium bromide is a cationic surfactant used in the study of lipid raft domains in membranes.<br>References Uyama, M.; et al.: J. Oleo Sci., 67, 67 (2018).<br></p>

<p>Applications Chlorfenapyr-d7 is the labelled analogue of Chlorfenapyr (C428500), which is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pest control on cotton. Used as a standard for Pesticide detection. Chlorfenapyr is also useful in cannabis testing kits as a component of pesticide mixes (P698230).<br>References Lovell, J.B. et al.: Bright. Crop Prot. Pests Dis., 1, 37 (1990); Wier, A.T. et al.: J. Agric. Entemol., 11, 311 (1994); Black, B.C. et al.: Pest. Biochem. Physiol., 50, 115 (1994);<br></p>

<p>Applications Benzylmorphine is an opioid alkaloid that is a derivative of Morphine (M652285).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988);<br></p>

<p>Stability Very Moisture Sensitive<br>Applications Chlorotriphenylstannane is used in the synthesis of nanoparticles which bear triamide ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Shariatinia, Z. et al.: Beil. J. Nanotech., 4, 94 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Promazine (P756300). Antipsychotic. Tranquilizer.<br>References Banci, L., et al.: Biochemistry, 38, 3205 (1999), Lawal, O., et al.: Food Chemi., 87, 205 (2004), Shleev, S., et al.: Bioorg. Chem., 35, 35 (2007),<br></p>

<p>Applications Rimsulfuron is used as a pesticide.<br>References Pennington, D., et al.: Environ. Sci. Technol., 39, 1119 (2005), Wang, S., et al.: Food Control., 18, 731 (2007), Wolters, A., et al.: Sci. Total Environ., 405, 269 (2008),<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Insect repellent.<br>References Gilbert, I.H., et al.: J. Econ. Entomol., 48, 741 (1955), Ambrose, A.M., et al.: Toxicol. Appl. Pharmacol., 1, 97 (1959), Blomquist, L., Acta Pharmacol. Toxicol., 41, 235 (1977), Yeung, J.M., et al.: Drug Metab. Dispos., 16, 600 (1988),<br></p>

<p>Applications Asulam-d3 (methoxy-d3) is labelled Asulam (A788750) which is a carbamate herbicide and a folic acid biosynthesis inhibitor.<br>References Cottrell, H.J., et al.: 207, 655 (1965), Smith, A.E., et al.: Pestic. Sci., 8, 449 (1977), Hossain, M.A., et al.: J. Weed Sci. Tech., 43, 10 (1998),<br></p>

<p>Applications A labelled metabolite of Desipramine.<br>References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981), Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984), Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987),<br></p>

<p>Stability Light Sensitive<br>Applications Acrylonitrile_x000D_(stabilized with 35-45 ppm 4-hydroxy anisole (H750015)) (cas# 107-13-1) is a compound useful in organic synthesis.<br> E0<br></p>

<p>Impurity Levothyroxine EP Impurity D / T4-Acetic Acid (USP)<br>Applications Thyroid hormone analogue. A potent Thyroxine impurity. T4-Acetic Acid (USP).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Horst, C., et al.: Biochem. J., 261, 945 (1989), Kvetny, J., et al.: Horm. Metab. Res., 24, 322 (1992), Yamauchi, K., et al.: J. Biol. Chem., 274, 8460 (1999), Davis, P., et al.: J. Endocrinol. Invest., 25, 377 (2002),<br></p>

<p>Applications Cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists. This is a controlled substance (depressant) in the US but not in Canada. Sedative, hypnotic.<br>References Noble, S., et al.: Drugs, 55, 277 (1998), Musch, B., et al.: Int. J. Clin. Psychopharmacol., 5, 147 (1990),<br></p>

<p>Applications Cyproconazole is a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled antibacterial, a third-generation cephalosporin.<br>References Reiner, R., et al.: J. Antibiot., 33, 783 (1980)<br></p>

<p>Stability Very Hygroscopic<br>Applications S-3-p is the substrate for 5-Enolpyruvoyl-shikimate 3-phosphate synthase (EPSPS) which is the target for the broad-spectrum herbicide N-(phosphonomethyl)glycine(glyphosate).<br>References Chahoua, L., et al.: J. Org. Chem., 57, 5798 (1992)<br></p>

<p>Applications Labelled synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).<br>References Vilchez-Martinez, J.A., et al.: Biochem. Biophys. Res. Commun., 59, 1226 (1974), Sennello, L.T., et al.: J. Pharm. Sci., et al.: 75, 158 (1986), Wheeler, J.M., et al.: Am.J. Obstet. Gynecol., 167, 1367 (1992), Eri, L.M., et al.: J. Urol., 150, 359 (1993),<br></p>

<p>Applications Used as insecticide for terminate control; pre-harvest defoliant; general herbicide. Antimicrobial preservative and fungicide for wood, wood products, starches, textiles, paints, adhesives, leather, pulp, paper, industrial waste systems, building materials; Surface disinfectant. Exposure to PCP is also associated with carcinogenic, renal, and neurological effects. This compound is a contaminant of emerging concern (CECs). One of the new POPs under the Stockholm Convention<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications Octanoyl L-Carnitine-d3 Chloride is a metabolite of Carnitine (C184110, L-Carnitine).<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications A steroid used as a probe in the detection of different viruses.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lin, L. et al., J. Virol. Methods, 171, 91 (2010); Finnegan, C.J. et al., J. Virol. Methods, 121, 223 (2004); Rubio, L. et al., J. Virol. Methods, 114, 105 (2003)<br></p>

<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>

<p>Applications N-(3-Phenylpropionyl)glycine-3C2,15N is a labelled analogue of N-(3-Phenylpropionyl)glycine (P336210), which is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-(3-Phenylpropionyl)glycine is present in the urine of medium-chain acyl-CoA dehydrogenase deficient (MCAD) patients who orally ingested 3-phenylpropionic acid.<br>References Duran, M. et al.: Prog. Clin. Biol. Res., 321, 419 (1988); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000); Ombrone, D. et al.: Anal. Biochem., 417, 122 (2011);<br></p>

<p>Applications Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scordo, M., et al.: Clin. Pharmacol. Ther., 72, 702 (2002), Meijer, W., et al.: Eur. J. Clin. Pharmacol., 60, 57 (2004), Jones, D., et al.: Chem. Res. Toxicol., 23, 939 (2010),<br></p>

<p>Applications Systemic post-emergence herbicide for use in food crops and mesquite.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pik, A.J., J. Agric. Food Chem., 25, 1054 (1977), Bovey, R.W., et al.: Weed. Sci., 33, 349 (1985),<br></p>

<p>Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.<br>References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Thionazin is a highly toxic organophosphorus pesticide used to protect crops and gardens from microorganisms and pests (such as the glasshouse whitefly and wireworms).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Critchley, B.: Bull. Entomol. Res., 62, 327 (1972); French, N., et al.: Plant Pathol., 22, 99 (1973); Griffiths, D.: Entomol. Exp. Appl., 10, 171 (1967); Lloyd, G. &amp; Bell, G.: Analyst, 91, 808 (1966)<br></p>

<p>Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Applications O,O-Di(Ethyl-d5)phosphate Sodium Salt is labelled Diethyl Phosphate Sodium Salt (D444720) which is used in a cosmetic composition for treating keratin materials, for example, keratin fibers such as the hair.<br></p>

<p>Applications Riociguat is used in the treatment for pulmonary hypertension.<br>References Frey, R. et al.: J. Clin. Pharmacol., 51, 1051 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of L-Carnitine (C184110).<br>References Millington, D., et al.: J. Inherit. Metab. Dis., 13, 321 (1990), Chace, D., et al.: Clin. Chem., 49, 1797 (2003),<br></p>

<p>Applications Bromoxynil is a nitrile herbicide. Bromoxynil is effective in post-emergent control of broad leaf weeds in cereal, corn, sorghum, onions, flax, mint, turf, and on non-cropland.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhattacharya, S.P. et al.: Pesticides, 22, 7 (1988); Culpepper, A.S. et al.: Weed Technol., 12, 554 (1998); Rosales-Robles, E. et al.: Weed Technol., 19, 385 (2005);<br></p>

<p>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Limaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tsuboi, T., et al.: Arch. Int. Pharmacodyn., 247, 89 (1980), Adaikan, P.G., et al.: Prostaglandins Med., 6, 449 (1981), Kottegoda, S.R., et al.: Prostaglandins Leukotrienes Med., 8, 343 (1982), Ishizaki, T., et al.: Chest, 85, 382 (1984),<br></p>

<p>Applications A labelled semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic.<br>References Ringel, I., et al.: J. Natl. Cancer Inst., 83, 288 (1991), Extra, J.-M., et al.: Cancer Res., 53, 1037 (1993)<br></p>

<p>Applications Isotope labelled Acephate (A130850) acts as a contact and systemic insecticide in agriculture through pesticide formulations. Through perinatal exposure studies, it has been linked to hyperglycemia, changes in lipid metabolism and type 2 diabetes (1). Acephate exposed Drosophila melanogaster potentially display an L-ascorbic acid mediated defense (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants. Standard for Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ribeiro, T., et al.: Toxicology, 372, 12-21 (2016); Rajak, P., et al.: J. Hazard. Mater., 321, 690-702 (2017)<br></p>

<p>Applications Fenoxaprop-P is an agro-product, used in pesticide formulations.<br>References Han, Y. et al. et al.: J. Sep. Sci., 40, 878 (2017);<br></p>

<p>Applications Thiobencarb is used as a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishihara, T., et al.: J. Health Sci., 46, 282 (2000); Paya, P., et al.: Ana;. Bioanal. Chem., 389, 1697 (2007)<br></p>

<p>Applications 2-Naphthylacetic acid can be used to synthesize hydrolase inhibitors. It can also be utilized for developing γ-dipeptide derivatives that can bind human somatostatin receptors.<br>References Tarzia, G., et al.: J. Med. Chem. 46, 2352 (2003); Seebach, D., et al.: Angew. Chem. Int. Ed. 42, 776 (2003)<br></p>

<p>Applications Eprazinone Dihydrochloride is a drug used to improve pulmonary function in patients with chronic bronchitis.<br>References Thrail, R.S., et. al.: Exp. Lung Res., 18, 409 (1992)<br></p>

<p>Applications Selective serotonin reuptake inhibitor (SSRI).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feret, B., et al.: Formulary, 40, 227 (2005),<br></p>

<p>Applications Pyoluteorin is a pesticide used in the protection of crops from bacteria.<br>References Bakthavatchalu, S. et al.: J. Biol., 37, 289 (2013); Kumar, A.. et al.: Env. Microbiol., 15, 764 (2013);<br></p>

<p>Applications Bazedoxifene Acetate is a nonsteroidal selective estrogen receptor modulator (SERM). Bazedoxifene Acetate is used as an antiosteoporotic.<br>References van Hoorn, W., et al.: J. Med. Chem., 45, 584 (2002); Neubauer, B., et al.: Cancer Res., 63, 6056 (2003); Yan, X., et al.: Biochemistry, 43, 909 (2004);<br></p>

<p>Applications A metabolite of Amonafide.<br>References Felder, T.B., et al.: Drug Metab. Dispos., 15, 773 (1987), Frei, E., et al.: Cancer Res., 48, 6417 (1988), Liu, Y., et al.: Bioorg. Med. Chem., 14, 2935 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications 4-Hydroxyestradiol 4-O-β-D-Glucuronide Sodium Salt, is a glucuronide derivative of 4-Hydroxy-17β-estradiol (H941895); a metabolite of Estradiol (E888000) which is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985); Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991); Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998); Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000); Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)<br></p>

<p>Applications Carbamate fungicide used in the agriculture industry<br>References Judelson, H., et al.: Mol. Plant Pathol., 7, 17 (2005), Grunwald, N., et al.: Phytopathol., 96, 1397 (2006), Celik, L., et al.: Chem. Res. Toxicol., 21, 2195 (2008),<br></p>

<p>Applications Esfenvalerate is the most potent insecticidal isomer of Fenvalerate (F279450), a pyrethroid insecticide used to control insects from food crops, animal feed and cotton products.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakayama, I. et al.: Adv. Pestic. Sci., Plenary Lect. Symp. Pap. Int. Congr. Pestic. Chem., 2, 174 (1979); Mikami, N. et al.: Pest. Sci., 16, 46 (1985); Palmquist, K.R. et al.: Environ. Toxicol. Chem., 27, 1721 (2008);<br></p>

<p>Applications Its application as nitrification inhibitor of nitrogen fertilizers.<br>References Williams, B., et al.: J. Soil Sci., 34, 113 (1983), Leinweber, P., et al.: Biol. Fertil. Soils, 20, 17 (1995),<br></p>

<p>Applications Cortisol 21-m-Maleimidobenzoate is a derivative of Cortisol which is a topical corticosteroid (1), more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland (2). Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis (3); suppress the immune system; and aid in fat, protein and carbohydrate metabolism.<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Carnitine.<br>References Huang, Z., et al.: Anal. Biochem., 199, 98 (1991), Friolet, R., et al.: J. Clin. Invest., 94, 1490 (1994), Rashed, M., et al.: Pediatr. Res., 38, 324 (1995), Costa, C., et al.: J. Lipid Res., 38, 173 (1997),<br></p>

<p>Applications A labelled selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in the treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998), Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000), Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000),<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>

<p>Applications (Z)-Hexadec-11-en-1-ol is a pheromone antagonist that regulates optimal mating time in moth Helicoverpa armigera.<br>References Chang, H., et al.: Curr. Biol., 27, 1610 (2017); Du, M., et al.: Insect Biochem. Mol. Biol., 87, 154 (2017)<br></p>

<p>Applications The S-enantiomer of Clobenzorex (C583000), an anorexic.<br>References Thomasset, M., et al.: Experienta, 26, 692 (1970), Glasson, B., et al.: Arzneim.-Forsch., 21, 1985 (1971),<br></p>

<p>Stability Hygroscopic<br>Applications An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Sandri, G., et al.: Eur. J. Pharm. Biopharm., 62, 59 (2006), Rosenthal, R., et al.: J. Ocular Pharmacol. Ther., 22, 440 (2007), Sabio, S., et al.: J. App. Oral Sci., 16, 280 (2008),<br></p>

<p>Applications Antiarrhythmic (class IA). Sodium channel blocker.<br>References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),<br></p>

<p>Applications Labelled Vorizonazole (V760000), used as an antifungal (systemic). An Ergosterol Biosynthesis inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanati, H., et al.: Antimicrob. Ag. Chemother., 41, 2492 (1997),<br></p>

<p>Stability Light Sensitive<br>Applications A highly sensitive reagent for α-keto acids. A fluorometric labeling reagent. Dyes and metabolites.<br>References Kajihara, Y., et al.: Carb. Res., 331, 455 (2001)<br></p>

<p>Applications 2,2',3,3',4,4',5,5',6,6'-Decachlorobiphenyl is a polychlorinated biphenyl (PCB) congeners. A halogenated organic contaminant and a pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ballschmiter, K., et al.: Fresenius J Anal Chem., 302, 20 (1980); Hawker, Darryl W., et al.: Environ Sci Technol., 22, 382 (1988); Souza, A. C., et al.: Mar. Pollut. Bull., 133, 436 (2018); Siddiqi, H. A., et al.: J. Chem.Soc. Pakistan, 39, 851 (2017)<br></p>

<p>Applications Fenbuconazole is a conazole based fungicide used as a spray for the control of leaf spot, yellow and brown rust, powdery mildew and net blotch on wheat and barley and apple scab, pear scab and apple powdery mildew on apples and pears.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reiss, R., et al.: Food. Chem. Toxicol., 50, 4421 (2012); Loos, M. et al.: Environ. Sci. Technol., 46, 9830 (2012);<br></p>

<p>Applications Pre-emergence herbicide used for grass control in crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Robens, J.F., et al.: Vet. Hum. Toxicol., 22, 328 (1980),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Loperamide, which is used as an antidiarrheal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973), Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990),<br></p>

<p>Applications Herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010), Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Acrylamide.<br>References Bjellaas, T., et al.: Toxicol. Sci., 100, 374 (2007), Doerge, D., et al.: Toxicol. Lett., 169, 34 (2007), Hartmann, E., et al.: J. Agric. Food Chem., 56, 6061 (2008),<br></p>

<p>Applications A metabolite of halopropanes.<br>References Barnsley, E.A.: Biochem. J., 100, 362 (1966)<br></p>

<p>Applications Flupyradifurone, can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications Isotope labelled Famoxadone, a known fungicide used in the protection of agricultural products against various fungal diseases and other biotic stresses such as pests.<br>References Speck- Planche, A., et al.: Excotoxicol. Enviro. Safety., 80. 308 (2012)<br></p>

<p>Applications Bacitracin is a peptide antibiotic effective against gram-postive bacteria. Bacitracin is an inhibitor of peptidoglycan synthesis. Bacitracin disrupts bacterial cell wall synthesis by inhibiting dephosphorylation of lipid pyrophosphate. Bacitracin also strongly inhibits proline endopeptidase from human muscle.<br>References Ward, J.B. et al.: Biochem. J., 141, 227 (1974); Anastasi, A. et al.: Biochem. J., 290, 601 (1993); Daly, D.J. et al.: Biochem. Soc. Trans., 13, 1161 (1985); Weinberg, E.D. et al.: Antibiot. Ber., 90, (1967);<br></p>

<p>Applications Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell lines, including melanoma cell lines expressing BRAFV600E or other mutant BRAF proteins altered at codon 600. Potent B-Raf inhibitor<br>References Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010); Yang, H. et al.: Cancer Res., 70, 5518 (2010); Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010);<br></p>