Toxicology

<p>Applications 4-(2-methyl-1,3-oxazol-4-yl)benzene-1-sulfonyl chloride (cas# 1086376-81-9) is a useful research chemical.<br></p>

<p>Applications Dealkyl Fluticasone Furoate is a Fluticasone Furoate(F599510) raw material impurity which is a synthetic corticosteroid derived from fluticasone for treatment of seasonal allergic rhinitis.<br>References DeWester, J., et al.: Allergy Asthma Proc., 24, 331 (2003), Hughes, S., et al.: Drug Metab. Dispos., 36, 2337 (2008), Meltzer, E., et al.: Clin. Drug Investig., 29, 79 (2009),<br></p>

<p>Applications N-(3-Aminopropyl)-N-methylcarbamic Acid tert-Butyl Ester Hydrochloride is used as a reactant in the synthesis of 8-((dimethylamino)methyl)-1-(3-(dimethylamino)propyl)-1,7,8,9-tetrahydrochromeno[5,6-d]imidazol-2-amine, an inhibitor of the hepatitis C virus.<br>References Dirov, S.M., et. al.: J. Chem. Crystallogr., 43, 235 (2013)<br></p>

<p>Impurity Aztreonam<br>Applications Ethanol Ring-opened Aztreonam is an Aztreonam (A965200) in-house impurity 1. Aztreonam is the first totally synthetic monocyclic β-lactam antibiotic.<br>References Sykes, R.B., et al.: Antimicrob. Agents Chemother., 21, 85 (1982), Florey, K., et al.: Anal. Profiles Drug Subs., 17, 1 (1988),<br></p>

<p>Applications Prothioconazole S-Glucuronide is derived from Prothioconazole (P838830), which is an antifungal metabolite used in agricultural fungicides and herbicides.<br>References Aristimuno Ficoseco, M.E., et al.: Nat. Prod. Res (2016)<br></p>

<p>Applications 2-Butyl-2-(2,4-dichlorophenyl)oxirane is an impurity of Hexaconazole (H293555), a fungicide of the triazole class. Hexaconazole has a broad spectrum antifungal activity and is commonly used in the control of apple, coffee and peanut diseases.<br>References Brown, M.C. et al.: Bright. Crop Prot. Conf. Pest. Dis., 1, 229 (1988); Gozzo, F. et al.: Pest. Biochem. Physiol., 40, 68 (1991)<br></p>

<p>Applications 20(3'-Oxo-caspofungin) Triflate Salt is derived from Pneumocandin B0 (P645300), which is the major analogue of a family of lipopeptides isolated from several species of several different genera, such as Cryptosporiopsis, Glarea and Pezicula. Pneumocandin B0 is a potent antifungal and acts by inhibition of the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.<br>References Schwartz, R., et al.: J. Antibiot., 45, 1853 (1992); Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003), Petersen, L., et al.: Appl. Microbiol. Biotechnol., 62, 263 (2003)<br></p>

<p>Applications 3,4-Dimethoxybenzenesulfonyl Chloride is used in the synthesis of aryl sulfonamides as selective carbonic anhydrase IX and XII inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosatelli, E., et. al.: Bioorg. Med. Chem. Lett., 24, 3422 (2014)<br></p>

<p>Applications 3'-Deoxyadenosine 5’-(2,2,2-Trifluoroacetic Phosphoric Anhydride) is an intermediate in the synthesis of 3'-Deoxyadenosine 5’-Triphosphate Triethylamine Salt (D232070), a salt form of 3'-Deoxyadenosine 5’-Triphosphate(D232070). 3'-Deoxyadenosine 5’-Triphosphate is a nucleotide and was shown to inhibit the replication of hepatitis C virus in human hepatoma cells.<br>References Arnold, Jamie J., et al.: PLoS Pathogens, 8(11), e1003030 (2012)<br></p>

<p>Applications Heterocyclic inhibitor of the RNA-dependent RNA polymerase enzyme transcribed by the Hepatitis C virus.<br>References Dhanak, D., et al.: J. Biol. Chem., 277, 38322 (2002), Liu, Y., et al.: Biochem., 45, 11312 (2006), Tedesco, R., et al.: J. Med. Chem., 49, 971 (2006),<br></p>

<p>Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.<br>References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)<br></p>

<p>Applications Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.<br>References Iland, C., et al.: J. Pathol. Bacteriol., 58, 495 (1946); Flores, A., et al.: Microbiology, 151, 521 (2005); Livermore, D., et al.: J. Antimicrob. Chemother., 62, 1053 (2008); Tremblay, L., et al.: Biochemistry, 49, 9685 (2010)<br></p>

<p>Applications The microsomal metabolite of Yangonin (Y100550).<br>References Johnson, B., et al.: Chem. Res. Toxicol., 16, 733 (2003), Mathews, J., et al.: Drug Metab. Dispos., 33, 1555 (2005), Zou, L., et al.: Planta Medica, 71, 142 (2005),<br></p>

<p>Applications Streptamine Sulfate is the sulfate salt of streptamine, which is a subunit used in the synthesis of Streptomycin (S687500), an antibiotic substance produced by aerobic fermentation that is also antibacterial (tuberculostatic).<br>References Weiss, et al.: Antibiot. Chemother., 7, 374 (1957), Umezawa, et al.: J. Antibiot., 27, 997 (1974), Mossa, J., et al.: Anal. Profiles Drug Subs., 16, 507 (1986)<br></p>

<p>Applications An intermediate in the preparation of antifungal agents such as Ketoconazole (K186000), Itraconazole (I937500) and Terconazole.<br></p>

<p>Applications A reactant used in the preparation of carbocyclic deoxyguanosine analog with potent and selective anti-hepatitis B virus.<br>References Bisacchi, G. et al.: Bioorg. Med. Chem. Lett., 7, 127 (1997)<br></p>

<p>Applications Ethanolamine is used in the preparation of various pharmaceutical compounds and inhibitors. Substituted carboxamides are synthesized using Ethanolamine that show potent antitumor activity. Also used in the synthesis of aminoquinolones which display anti-plasmodial activity.<br>References Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications α-​(4-​Chlorophenyl)​-​α-​(1-​cyclopropylethyl)​-1H-​1,​2,​4-​triazole-​1-​ethanol is a diastereomer of Cyproconazole (C989070), a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.<br>References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Antibacterial.<br>References Iwahi, T., et al.: Antimicrob. Agents Chemother., 36, 1358 (1992), Miyake, A., et al.: J. Antibiot., 45, 709 (1992),<br></p>

<p>Applications Labelled Eflornithine. Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.<br>References Bacchi, C.J., et al.: Science, 210, 332 (1980), Haegele, K.D., et al.: Clin. Pharmacol. Ther., 30, 210 (1981), Meyskens, F.L., et al.: Clin. Cancer Res., 5, 945 (1999),<br></p>

<p>Applications (2S,4R)-Itraconazole is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications Hexaflumuron-D3 is an isotope labeled compound of Hexaflumuron (H293885). Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.<br>References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);<br></p>

<p>Applications An anti-inflammatory corticosteroid.<br>References Weber, D., et al.: J. Pharm. Sci., 61, 689 (1972), Biagi, G., et al.: J. Med. Chem., 18, 873 (1975),<br></p>

<p>Applications b-Phenylethyl Furoate (cas# 7149-32-8) is a useful research chemical.<br></p>

<p>Applications Cuprous Cyanide-15N is an intermediate in the synthesis of Bictegravir-15N, d2 (B382096), which is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications Ethanol-13C2 is a labelled analogue of Ethanol, which is used in alcoholic beverages in suitable dilutions and as solvent in laboratory and industry, in the manufacture of denatured alcohol, pharmaceuticals, in perfumery, and in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiberg, G.S., et al.: Toxicol. Appl. Pharmacol., 16, 718 (1970); Brown, N.A., et al.: Science, 206, 573 (1979);<br></p>

<p>Applications Labelled Des[(5-Methyl-1,3,4-thiadiazol-2-yl)thio] Cefazolin-3-methanol is an impurity of Cefazolin (C242500). Cefazolin impurity X3.<br>References Kidwai, M., et al.: Chem. Lett., 6, 487 (1999), Kidwai, M., et al.: Bioorg. Med. Chem., 8, 69 (2000),<br></p>

<p>Applications 1,2-Dihydro-oseltamivir is the impurity of the anti-viral drug Oseltamivir Phosphate (O701000), which is an orally active inhibitor of influenza virus neuraminidase. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000); Kalashnikov, A., et al.: Russ. Chem. Bull., 62, 163 (2013);<br></p>

<p>Applications Pefloxacin-d3 is deuterium labelled Pefloxacin, which is a fluorinated quinolone antibacterial; analog of Norfloxacin.<br>References Barre, J., et al.: J. Pharm. Sci., 73, 1379 (1984); Contrepois, A., et al.: J. Antimicrob. Chemother., 14, 51 (1984)<br></p>

<p>Applications An aminopyridine derivative with potential herbicidal activity.<br>References Xiao, Y. et al.: Nongyao, 42, 15 (2003);<br></p>

<p>Applications Sodium Methanesulfonate-d3,13C is an intermediate used in the synthesis of Methanesulfonyl Chloride-d3,13C (M258847), which is a labeled analogue of Methanesulfonyl Chloride (M258845). Methanesulfonyl Chloride used in the synthesis of phosphodiesterase 9A Inhibitors, used in treatments for Alzheimer’s disease. It is also used in the preparation of sulfonamide derivatives showing antibacterial activity.<br>References Reddy, N. et al.: J. Chem. Sci., 124, 723 (2012); Claffey, M. et al.: J. Med. Chem., 55, 9055 (2012);<br></p>

<p>Applications 6-Methylmercaptopurine Riboside-d3 is the isotope labelled analog of 6-Methylmercaptopurine Riboside (M321035); a thiopurine prodrug used as potential treatment for patients with inflammatory bowel disease.<br>References Haglund, S., et al.: Therap. Drug. Monitor., 33, 200 (2011); Arendt, C.S., et al.: J. BIol. Chem., 285, 6024 (2010); Fotoohi, A.K., et al.: Biochem. Pharmacol., 72, 816 (2006)<br></p>

<p>Applications Serotonin-13C215N Hydrochloride, is a labelled Serotonin (S274980). Serotonin is a monoamine neurotransmitter.<br></p>

<p>Applications Adrenocortical/mineralocorticoid Steroid.<br>References Quigley, J., et al.: Clin. Exper. Pharmacol. Physiol., 36, 724 (2009),<br></p>

<p>Applications Protected Morphine, a principal alkaloid of opium.<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988),<br></p>

<p>Applications 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic Acid-13C4 Ethyl Ester is an isotope labelled derivative in the synthesis of Flucloxacillin (F419200), a new semisynthetic penicillin with broad spectrum of antibacterial activity.<br>References Macsari, I., et al.: Bioorg. Med. Chem. Lett., 21, 3871 (2011); Cui, Y., et al.: Curr. Sci., 89, 531 (2005);<br></p>

<p>Applications Dimethrin is a pesticide, a pyrethroid insecticide. An acaricide for agricultural purposes.<br>References Ford, M G.: Pestic. Sci., 10, 39 (1979); Gan, W., et al.: Zhonghua Yufang Yixue Zazhi, 35, 13 (2001); Wright, F. C.: Southwestern Entomol., 5, 222 (1980);<br></p>

<p>Applications Labelled analogue of (R)-Linezolid, an enatiomeric impurity of Linezolid (L466500).<br>References Bednarek, E. et al.: J. Chrom. A, 1193, 164 (2008); Nirogi, R. et al.: J. Chrom. Sci., 46, 764 (2008);<br></p>

<p>Applications Stearoyl Ethanolamide-d4 is the labelled analogue of Stearoyl Ethanolamide (S686608), which is a prolific fatty acid ethanolamide produced by PLD hydrolysis of membrane phospholipids.<br>References Kasatkina, L. A., et al.: Biochem. Pharmacol. 174, 113783 (2020)<br></p>