Toxicology

<p>Applications Methyl 3-(Hydroxymethyl)benzoate is used in the synthetic preparation of N-acylhydrazone derivatives as lactate dehydrogenase A inhibitors.<br>References Rupiani, S., et al.: J. Med. Chem., 101, 70 (2015)<br></p>

<p>Applications Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.<br>References Iland, C., et al.: J. Pathol. Bacteriol., 58, 495 (1946); Flores, A., et al.: Microbiology, 151, 521 (2005); Livermore, D., et al.: J. Antimicrob. Chemother., 62, 1053 (2008); Tremblay, L., et al.: Biochemistry, 49, 9685 (2010)<br></p>

<p>Applications 3,4-Dihydroquinoline-2-one 6-Oxoacetic Acid is a derivative of 3,4-Dihydro-2-quinolone (D450600), which is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthetisze substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.<br>References Molteni, V., et al.: Bioorg. Med. Chem. lett., 14, 1477 (2004); Webber, R., et al.: J. Med. Chem., 41, 96 (1998)<br></p>

<p>Applications Malathion-d7 (dimethyl-d6; 3-d1) (CAS# 352438-94-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(Dimethylamino)-4-pyridinyl-boronic Acid can be used to synthesize N-biaryl quinolone carboxylic acids as selective M1 positive allosteric modulators.<br>References Yang, F., et al.: Bioorg. Med. Chem. Lett., 20, 531 (2010)<br></p>

<p>Applications N-Benzoyl-2'-deoxy-2',2'-difluorocytidine 3’-Benzoate is an intermediate in the synthesis of Gemcitabine (G305000) metabolites.<br>References Baraniak, J., et al.: Bioorg. Med. Chem., 22, 2133 (2014); Labrioli, M.A., et al.: Bioorg. Med. Chem., 22, 2303 (2014);<br></p>

<p>Applications Flufenoxuron-d3 (2,6-difluorobenzoyl-d3) is a useful isotopically labeled compound of Flufenoxuron (F435100), which is a known insecticide and acts as an insect growth regulator by inhibiting chitin synthesis.<br>References Abbaszadeh, G., et al.: Pesticide. Res. J., 23, 52 (2011); Yang, A., et al.: Food. Control., 28, 99 (2012);<br></p>

<p>Applications (S)-1-Amino-3-chloro-2-propanol Hydrochloride is used in biological studies as an orally active male antifertility agent which is mediated by an effect on epididymal and vas deferens sperm.<br>References Coppola, J. A., et al.: Contraception, 9, 459 (1974);<br></p>

<p>Applications ((((R)-1-(6-((((5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)amino)methyl)amino)-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid is impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications Cholic Acid (C432600) derivative.<br></p>

<p>Applications Diethyl 2-(methylthio)-4,5-pyrimidinedicarboxylate<br></p>

<p>Impurity Lopinavir EP Impurity K<br>Applications Lopinavir D-Valine Diastereomer (Lopinavir EP Impurity K) is a metabolite of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product.<br>References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)<br></p>

<p>Applications 4-[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenylamine, is an intermediate for the synthesis of Itraconazole (I937500), an Antifungal.<br></p>

<p>Applications Testosterone (T155000) derivative. Inhibits estrogen biosynthesis. A steroid ligand for the cytosol androgen receptor (AR) of rat prostate.<br>References Ojasoo, T. et al.; J. Steroid Biochem. 27, 255 (1987); Schwarzel, W. et al.; Endrocrinology 92, 866 (1973);<br></p>

<p>Applications 4-Chloro-thiamethoxam is an over chlorinated impurity of thiamethoxam (T344180), which is a neonicotinoid insecticide. Reports show that when exposed to neonicotinid pesticides honeybees have problems returning home after foraging and bumblebee colonies grow poorly and produce fewer queens.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010), Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010), Chem. and Eng. News 90: 10 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Sodium salt of Fenoprofen (F248825), acts as an anti-inflammatory; analgesic.<br>References Rubin, et al.: J. Pharm. Sci., et al.: 60, 1797 (1971), Ward, C.K., et al.: Anal. Profiles Drug Subs., 6, 161 (1977); Hirsch, C. et al.: J. Pharm. Sci., 67, 231 (1978);<br></p>

<p>Applications 4-(Trifluoromethoxy)benzoic Acid is a substituted benzoic acid used in the preparation of a various biologically active compounds such as antifungal and antimalarial agents.<br>References Jiang, Y. et al.: Bioorg. Med. Chem. Lett., 21, 4471 (2011); Herrin, T.R. et al.: J. Med. Chem., 18, 1216 (1975);<br></p>

<p>Applications N'-Boc,N,N'-Desethylene Iso Gatifloxacin Anhydride with Diacetyl Borate is an impurity of Gatifloxacin (G250000), an antibacterial agent.<br>References Bauernfeind, A.: J. Antimicro. Chemother., 40, 639 (1997), Fukuda, H., et al.: Antimicrob. Ag. Chemother., 42, 1917 (1998),<br></p>

<p>Stability Light and Temperature Sensitive<br>Applications Δ2-Cefadroxil is a derivative of Cefadroxil (C235750), a semi-synthetic cephalosporin antibiotic. Antibacterial.<br>References Buck, R.E., et al.: Antimicrob. Agents Chemother., 11, 324 (1977)<br></p>

<p>Applications Ethyl 3-Mercaptopropanoate is a useful synthetic intermediate. It can be used to prepare acylaminobutyldecahydroisoquinolines with HIV protease-inhibiting activities. It can also be used to prepare new anti-MRSA cephalosporins (cephalosporins C zinc salt, C258750).<br>References Ghosh, A., et al.: J. Med. Chem., 37, 1177 (1994); Cho, A., et al.: Bioorg. Med. Chem. Lett., 11, 137 (2001)<br></p>

<p>Applications 3-Sulfobenzaldehyde Sodium Salt, can be used for the preparation of a series of novel sulfonamide derivatives, as inhibitors of the enzyme histone deacetylase (HDAC) as a novel approach to the treatment of cancer.<br>References Finn, P., et al.: Helvetica Chimica Acta, 88 (7), 1630 (2005);<br></p>

<p>Applications ((2R,5S)-5-(4-Amino-5-fluoro-2-oxopyrimidin-1(2H)-yl)-1,3-oxathiolan-2-yl)methyl hydrogen ((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonate is an impurity of Emtricitabine (E525000), a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications Mycophenolic Acid Carboxybutoxy Ether Dimethyl Ester is a metabolite of Mycophenolic Acid (M831500).<br>References Wieland, E., et al.: Clin. Biochem., 33, 107 (2000), Shipkova, M., et al.: Ther. Drug Monit., 25, 1 (2003),<br></p>

<p>Applications Erythromycin Cyclocarbonate is a derivative of Erythromycin (E649950), an antibcterial agent working on the 50S ribosomal subunit.<br>References Champney, W. et al.: Curr. Microbiol., 38, 342 (1999); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Applications A labeled derivative of Amoxicillin (A634235), a semi-synthetic antibiotic related to penicillin. Antibacterial.<br>References Brogden, R.N., et al.: Drugs, 18, 169 (1979), Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994),<br></p>

<p>Applications (2E)-3-(2-Thiazolyl)-2-propenoic Acid is a useful synthetic intermediate. It is used as an intermediate for HIV-1 protease inhibitor.<br>References Baloglu, E., et al.: PCT Int. Appl. (2014), WO 2014085607 A1 20140605<br></p>

<p>Applications 4-Bromo-2-(ethyl-d3)pyridine is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications A triazine herbicide.<br>References Schenck, F., et al.: Bull Environ. Contam. Toxicol., 73, 24 (2004),<br></p>

<p>Applications (1H-Indol-3-yl)methanamine is an indolic Tryptophan-derived metabolite with antifungal defense properties against Arabidopsis mlo2 mutant.<br>References Consonni, C., et al.: Plant Physiol., 152, 1544 (2010), Mahboobi, S., et al.: Archiv der Pharmazie , 327, 105 (1994)<br></p>

<p>Applications Cefotaxime Sodium Impurity G-d3 is the isotope labelled analog of Cefotaxime Sodium Impurity G (C242955); an impurity of Cefotaxime Sodium (C242950) which is a broad spectrum third generation cephalosporin antibiotic.<br>References Wise, R., et al.: Antimicrob. Agents Chemother., 14, 807 (1978); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 11, 139 (1982)<br></p>

<p>Applications 6-Chloro-2-cyclohexyl-2,3-dihydro-1,3-dioxo-1H-isoindole-5-sulfonamide is an intermediate in the synthesis of Chlorexolone (C327080), a sulfonamide based antibiotic.<br></p>

<p>Applications Useful as vasodilators, antihypertensives, and spasmolytics.<br></p>

<p>Applications 1-Cyclopropyl-8-ethoxy-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid is an impurity in the synthesis of Moxifloxacin (M745000), a fluorinated quinolone antibacterial.<br>References Woodcock, J.M., et al.: Antimicrob. Ag. Chemother., 41, 101 (1997), Stass, H., et al.: Antimicrob. Ag. Chemother., 42, 2060 (1998)<br></p>

<p>Applications Labelled analogue of Cyhexatin, a derivative of tricyclohexyltin and an effective acaricide used in the control of spider mites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeppson, L.R. et al.: J. Econ. Entomol., 61, 1502 (1968); Rudd, J.A. et al.: Exp. Appl. Acarol., 21, 615 (1997);<br></p>

<p>Applications Emtricitabine Isopropyl Carbamate is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Applications Ursodeoxycholic Acid-24-13C is the labeled compound of Ursodeoxycholic Acid (U850000). It is used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.<br></p>

<p>Applications A labelled analog of Ezetimibe (E975000). SCH 58053 is a potent, rapid, and selective inhibitor of lymphatic cholesterol transport in the intestine.<br>References Ly, H., et al.: Biochem. J., 286, 937 (1992), Dujovne, C., et al.: Am. J. Cardiol., 90, 1092 (2002), Repa, J., et al.: J. Lipid Res., 43, 1864 (2002), Knopp, R., et al.: Eur. Heart J., 24, 729 (2003), Altmann, S., et al.: Science, 303, 1201 (2004),<br></p>