Toxicology

<p>Applications Pyrimethanil-d5 (phenyl-d5) (CAS# 2118244-83-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Adrenalone is a ketone derivative of Epinephrine (E588585) and a potential dopamine β oxidase inhibitor.<br>References Goldstein, M., et al.: Nature, 192, 1081 (1961)<br></p>

<p>Stability Moisture Sensitive<br>Applications Naled is a cholinesterase inhibitor. Insecticide; acaricide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.B., et al.: Toxicol. Appl. Pharmacol., 14, 515 (1969),<br></p>

<p>Applications Demephion is used in pesticidal compositions. A pesticide, and an organophosphate insecticide.<br>References Iacob, N., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, Academia de Stiinte Agricole si Silvice, 16, 357 (1981); Dimitrov, A., et al.: Bulgarski Tyutyun, 25, 16 (1980); Babrikova, T., et al.: Nauchni Trudove - Vissh Selskostopanski Institut--Plovdiv, 25, 31 (1980)<br></p>

<p>Applications Azafenidin is a weed controlling herbicide used in various crops.<br>References Chandran, R.S., et al.: Weed. Technol., 14, 556 (2000); Sharma, S.D., et al.: Bull. Environ. Contamin. Toxiciol., 67, 594 (2001);<br></p>

<p>Applications 1-(1-Ethylpropyl)-5,6-dimethyl-7-nitro-1H-benzimidazole is a metabolite of Pendimethalin(P221900). Pendimethalin herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010)<br></p>

<p>Stability Moisture Sensitive, Unstable in Solution<br>Applications Bensulfuron-methyl inhibits the growth of Anabaena azotica. ALS inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liao, J. Z., et al.: Fresenius Environ. Bull., 25, 5000 (2016)<br></p>

<p>Applications Pyruvic Acid-13C3 is labelled Pyruvic acid (P998900).Pyruvic acid is an Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001); Martinez., et al.: Development, 6, 851 (2002); Nakayama, K., et al.: J. Biochem., 146, 757 (2009); Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009)<br></p>

<p>Applications Taurine (1,2-13c2, 98%) (cas# 70155-54-3) is a useful research chemical.<br></p>

<p>Applications (S)-(+)-Methoprene is used as an insect growth regulator. May be used to inhibit metamorphosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Koureas, Mi. et al.:Sci. Total Env., 496, 358 (2014); Knaus, M. et al.: Veterin. Parasitol., 202, 40 (2014);<br></p>

<p>Applications A metabolite of Bromethalin rodenticide found in the blood and liver of treated animals.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Van Lier, R.B.L., et at.: Fundamental Appl. Toxicol., 11, 664 (1988),<br></p>

<p>Applications Benoxacor is a herbicide used as a part of pesticidal compositions.<br>References Portoles, T. et al.: Chemosphere., 179, 242 (2017); Hong, J. et al.: Food Contr., 79, 134 (2017);<br></p>

<p>Applications Levofloxacin-d3, is the labeled analogue of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.<br>References Kato, M., et al.: Arzneim.-Forsch., 42, 365 (1992), North, D.S., et al.: Pharmacotherapy, 18, 915 (1998), Hwang, D.G., et al.: Br. J. Ophthalmol., 87, 1004 (2003),<br></p>

<p>Applications Labelled Cefuroxime (C248050). Antibacterial.<br>References O’Callaghan, C.H., et al.: Antimicrob. Agents Chemother., 9, 511 (1976), Norrby, R., et al.: J. Antimicrob. Chemother., 3, 355 (1977), Brogden, R.N., et al.: Drugs, 17, 233 (1979), Wozniak, J.R., et al.: Anal. Profiles Drug Subs., 20, 209 (1991),<br></p>

<p>Applications NN703 (Tabimorelin) is an orally active growth hormone (GH) secretagogue intended for use as an alternative to daily injections of GH. In vitro studies in human liver microsomes have indicated that NN703 is a mechanism-based inhibitor of CYP3A4.<br>References Fabre, G., et al.: Biochem. Pharmacol., 37, 4389 (1988), Thummel, K., et al.: Clin. Pharmacol. Ther., 59, 491 (1996), Yu, D., et al.: J. Clin. Pharmacol., 39, 1203 (1999),<br></p>

<p>Applications Labelled Folpet (F402000). Agricultural fungicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, S., et al.: Crit. Rev. Toxicol., 40, 531 (2010), Wong, J., et al.: J. Agric. Food Chem., 58, 5884 (2010),<br></p>

<p>Applications A β1 selective aryloxypropanolamine andrenergic antagonist. Used in the treatment of a variety of cardiovascular disorder.<br>References McGourty, J.C., et al.: Br. J. Clin. Pharmacol. 20, 555 (1985), Lennard, M.S., et al.: Biochem. Pharmacol., 35, 2757 (1986),<br></p>

<p>Applications Anidulafungin, is a semisynthetic echinocandin that inhibits glucan synthase, an enzyme important in the formation of (1→3)-β-D-glucan, a major fungal cell wall component, and thus is used as antifungal drug.<br>References Denning, D. W., et al.: J. Antimicrob. Chemother, 40, 611 (1997); Vazquez, J. A., et al.: Clin. Ther., 27(6), 657 (2005);<br></p>

<p>Applications Bictegravir-15N, d2 is the labeled version of Bictegravir, which is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications 2'-O-Methyl Uridine-d3 is an isotope labelled compound of 2'-O-Methyl Uridine (M338200), a uridine analog used for the preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.<br>References Gratzner, H., et al.: Science, 218, 474 (1982), Jarvis, T., et al.: J. Biol. Chem., 271, 29107 (1996), Pavco, P., et al.: Clin. Cancer Res., 6, 2094 (2000),<br></p>

<p>Applications Metyrapone acts as a glucocorticoid synthesis inhibitor, maintaining stress-hormone levels.<br>References Keller, C. et al.: Drug. Alc. Dep., 133, 405 (2013); Vilela, F. et al.: Neuroendocrinol., 97, 322 (2013);<br></p>

<p>Applications The active labelled metabolite of the antibacterial dye, Sulfamidochrysoidine. Inhibits folic acid synthesis in prokaryotes. Antibacterial.<br>References Colebrook, L., et al.: Lancet, 233, 1291 (1937), Dye, C., et al.: Nat. Rev. Microbiol., 7, 81 (2009), Isik, S., et al.: Bioorg. Med. Chem., 17, 1158 (2009),<br></p>

<p>Applications (+)-Irinotecan is a Topo I inhibitor.<br></p>

<p>Applications Antiepileptic agent with anxiolytic and antimanic properties. Anticonvulsant.This is a controlled substance (depressant).<br>References Blum, et al.: Arzneim.-Forsch., 23, 377 (1973), Winslow, W.C., et al.: Anal. Profiles Drug Subs., 6, 61 (1977)<br></p>

<p>Applications Triflumizole is an conazole fungicide is an imidazole fungicide used on many food and ornamental crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haralson, J.C., et al.: Crop. Protect., 44, 1 (2013); Leroux, P., et al.: Pest. Manage. Sci., 69, 15 (2013);<br></p>

<p>Applications Pirimicarb is a pesticide which is useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Cyhexatin is a derivative of tricyclohexyltin and an effective acaricide used in the control of spider mites.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jeppson, L.R. et al.: J. Econ. Entomol., 61, 1502 (1968); Rudd, J.A. et al.: Exp. Appl. Acarol., 21, 615 (1997);<br></p>

<p>Applications Anticonvulsant; hypnotic.Controlled substance (depressant).<br>References Rieder, et al.: Arzneim.-Forsch., 23, 212 (1973), Kangas, L., Acta Pharmacol. Toxicol., 45, 16 (1979), Aboul-Enein, H.Y., et al.: Anal. Profiles Drug Subs., 9, 487 (1980).<br></p>

<p>Applications Imazapic can be used in analytical and biological studies of residue analysis and determination of imidazolinone herbicides in sunflower and soil by GC-MS.<br>References Ozcan, C., et al.: Chromatographia, 80, 941 (2017)<br></p>

<p>Applications A mixture of 2 metabolites of butadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.<br>References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),<br></p>

<p>Applications Piperonyl Butoxide-d9 is a deuterated analog of Piperonyl Butoxide an Insecticide synergist, especially for pyrethroids and rotenone. Also used in Cannabis testing.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jiang, W., et al.: J. Econ. Entomol., 103, 1365 (2010), Markussen, M., et al.: Pest. Biochem. Physiol., 98, 50 (2010),<br></p>

<p>Applications Tetradifon is an acaricide and ovicide. Also, Tetradifon possessed nephrotoxic by promoting kidney morphometric and functional damage and depleting renal antioxidant defense system in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Badraoui, R., et al.: Exp Toxicol Pathol., 64, 645-50 (2012);<br></p>

<p>Applications Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leather, G.R., et al.: Pestic. Biochem. Physiol., 7, 437 (1977),<br></p>

<p>Applications Spinetoram L is an impurity of Spinetoram (S683650), Spinetoram belongs to spinosyn family of insecticides and shows potential of natural products research.<br>References Kirst H. A.: J. Antibiot., 63, 101-111 (2010)<br></p>

<p>Applications Pyrethrin is a pesticide most commonly used around homes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hudson, N.L., et. al.: Am. J. Ind. Med., 57, 15 (2014)<br></p>

<p>Applications 1H-1,2,4-triazole-3-sulfonamide (cas# 89517-96-4) is a useful research chemical.<br></p>