Toxicology

<p>Applications A metabolite of Zopiclone (Z700500).<br>References Fernandez, C., et al.: Clin. Pharmacokinet., 29, 431 (1995), Nordgren, H., et al.: Ther. Drug Monit., 24, 410 (2002),<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications A mixture of 2 labelled metabolites of Bbutadiene. The isomeric ratio has been determine to be approximately 1:1 based on proton nmr integration.<br>References Barnsley, E.A., et al.: Biochem. J., 100, 362 (1966),<br></p>

<p>Applications 2,2,2-Trichloro-acetic Acid is an acetic acid analogue used for the precipitation of macromolecules including proteins, DNA and RNA as well as for cosmetic treatments.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wiley D. et al.: Clin. Infect. Dis., 35m S210 (2002);<br></p>

<p>Stability Hygroscopic<br>Applications Papain is used in the induction of T helper type 2 (Th2) immunity in the genital mucosa. Papain-functionalized gold nanoparticles as heterogeneous biocatalyst for bioanalysis and biopharmaceuticals analysis. Also used in the elucidation of the anti-proliferative activity of bovine blood hydrolyzates towards cancer cells including, lymphoma, breast cancer, hepatocytes and epithelial colorectal adenocarcinoma cells in cultureBiochem/physiol ActionsA cysteine protease that cleaves peptide bonds of basic amino acids, leucine, or glycine.pH optimum 6.0-7.0Also hydrolyzes esters and amides.Papain papaya latex has antifungal activity against C. albicans. It is a cysteine protease that cleaves peptide bonds of basic amino acids, leucine, or glycine.. The pH optimum is 6.0-7.0. Papain hydrol<br>References Oh, J. E.,et al.: Proc. Natl. Acad. Sci. USA, 114, 1188 (2017); Liu, S., et al.: Analytica Chimica Acta, 963, 33 (2017); O'Sullivan, S. M., et al.: Int. J. Food Sci. Technol., 52, 1049 (2017)<br></p>

<p>Applications Phenylmercuric acetate is a compound that is widely used as a fungicide and a disinfectant. Phenylmercuric acetate’s antibacterial action is a result of its interference with sulphydryl groups of organisms.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Matsumura, F., et al.: Science, 173, 49 (1971); Tonomura, K., et al.: Nature, 217, 644 (1968)<br></p>

<p>Applications Labelled Cefetamet is a third-generation cephalosporin antibiotic and the active agent of Cefeamet pivoxil (C242780) after hydrolysis.<br>References Bryson, H.M., et al.: Drugs., 45, 589 (1993); Sharma, R.K., et al.: Asian. J. Biochem. Pharmaceut. Res., 1, 443 (2011); Waters, N.J., et al.: Drug. Metabolism. Disposit., 38, 1159 (2010);<br></p>

<p>Applications Deuterated Ketoconazole, an inhibitor of cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986), Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1989), Nardone, P.A., et al.: . Surg. Res., 44, 425 (1988), Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)<br></p>

<p>Applications Usnic Acid Sodium acts as an antibacterial and antifungal agent, and are often seen used in cosmetics and facial application chemicals.<br>References Ferrarese, L. et al.: Cosm. Tech. et al.: 11, 25 (2008); Coiffard, C. et al.: Annal. Pharm. Dranc., 57, 392 (1999);<br></p>

<p>Applications An analog of labelled Sildenafil; a novel pyrazolopyrimidinethiones as PDE5 inhibitor.<br>References DeBono, R., et al.: Pharm. Technol., 26, 72 (2002), Blok-Tip, L., et al.: Food Addit. Contam., 21, 737 (2004), Liang, Q., et al.: J. Pharm. Biomed. Anal., 40, 305 (2006),<br></p>

<p>Applications 3,4-Dichloroaniline is used in the preparation of the herbicide propanil (P760840).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavir<br>References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>

<p>Applications The major metabolite of Ethionamide.<br>References Rivera-Marrero, C., et al.: Microb. Pathog., 25, 307 (1998), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Cole, S., et al.: Nature, 409, 1007 (2001), Liang, X., et al.: Bacteriology, 183, 843 (2001),<br></p>

<p>Applications Alodane (cas# 2550-75-6) is a compound useful in organic synthesis.<br></p>