Biochemicals and Reagents

<p>Applications Ethyl β-D-Thiogalactopyranoside (cas# 56245-60-4) is a compound useful in organic synthesis.<br></p>

<p>Applications N-Nitroso-N-methylaniline-d5 labelled compound of N-Nitroso-N-methylaniline (N529925) which is used in the preparation of resin.<br>References Miura, K., et al.: Jpn. Kokai Tokkyo Koho (2020), JP 2020029543 A<br></p>

<p>Applications Disperse Blue 373 have adverse effect on soil and water environment and is a major mutagen in environmental system. This dye is released by textile industry<br>References Watanabe, T., et al.: Env. Sci (Tokyo, Japan), 12, 356 (2005);Carneiro, P.A., et. al.: J. Hazardous Mat., 174, 694 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications Betahistine Methanesulfonate (cas# 54856-23-4) is a useful research chemical.<br></p>

<p>Applications 2-(Hydroxyamino)acetic Acid is a novel lactase inhibitor.<br>References Hattori, M., et al.: J. Insect Physiol., 51, 1359 (2005); Murao, S., et al.: Biosci. Biotech. Biochem., 56, 987 (1992)<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications Taurocholic Acid Sodium Salt Hydrate is a choleretic; Its sodium salt is a lipase accelerator. Also used as a method for the quantitation of conjugated bile acids in dried blood spots using electrospray ionization-mass spectrometry.<br>References Mills, K.A., et al.: Pedatric Res., 43, 3 (1998).<br></p>

<p>Stability Moisture Sensitive<br>Applications Cy 5 is a related compound of CY5 (C951310), a photoswitchable cyanine dye. The photoswitching mechanism was investigated using thiol agents and it was concluded that photoconversion into the dark state is pH and thiol dependent and the dark state product is a cyanine-thiol adduct.<br>References Dempsey, G., et al.: J. Am. Chem. Soc., 131, 18192 (2009)<br></p>

<p>Applications t-Boc-N-amido-PEG3-acid<br></p>

<p>Applications Dodecanedinitrile (cas# 4543-66-2) is a useful research chemical.<br></p>

<p>Applications o-Anisidine, is a highly toxic environmental pollutant and digestive system carcinogen. It is also a toxin that has been identified to be present in cigarettes.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Coggins, C.R.E. et al.: Inhal. Toxicol., 23, 41 (2011); Dracinska, H. et al.: Neuroendorinol. Lett., 27, 9 (2006); Naiman, K. et al.: Neuroendocrinol. Lett., 31, 36 (2010);<br></p>

<p>Applications Glyceryl Monothioglycolate is used as an ingredient of hair permanent wave-setting or straightening agents.<br>References Kuzuhara, A.: Jpn. Kokai Tokkyo Koho (2013), JP 2013249274 A 20131212.; Savaides, A., et al.: U.S. Pat. Appl. Publ. (2014), US 20140261518 A1 20140918<br></p>

<p>Applications 3’-Deoxyguanosine is a derivative of guanosine, a ligand which may be complexe with enzymes such as purine nucleoside phosphorylase and receptors. Potential anti-amoebic agent.<br>References Gaubert, G. et al.: Biochimie., 81, 1041 (1999);<br></p>

<p>Applications Mineral Oil can be used as preferred lubricant for aerosol lubricant and dispensing method. An aerosol container containing a propellant and a highly hydrogenated mineral oil lubricant for the lubrication of gaskets in pipe segments.<br>References Green, R., et al.: U.S., US 7578372 B1 20090825 (2009)<br></p>

<p>Applications Ethyl Olivetolate is used for preparation of crystalline Cannabidiol for pharmaceutical formulations.<br>References Dickman, D., et al.: U.S. Pat. Appl. Publ., (2017);<br></p>

<p>Applications 3-Amino-4-methoxybenzanilide (CAS# 120-35-4) is a useful research chemical compound.<br></p>

<p>Applications Hypocholesterolemic isolated from shiitake mushrooms, effecting phospholipid and linoleic acid metabolisms. Specifically, Eritadenine is a potent inhibitor of S-adenosyl-L-homocysteine hydrolase (SAHH), decreasing total cholesterol levels in plasma.<br>References Fukada, S., et al.: J. Nut., 136, 2797 (2006), Vilar, S., et al.: J. Med. Chem., 49, 1118 (2006), Yamada, T., et al.: Biochem. Pharmacol., 73, 981 (2007), Enman, J., et al.; J. Agric. Food Chem., 56, 2609 (2008),<br></p>

<p>Applications Phosphoglycolic Acid is used in studies pertaining to biological and metabolic processes. It can be used in the study of human apurinic/apyrimidinic endonuclease (Ape) and its role in double strand break repair. It also has been seen to complex with cPEPCK (cytosolic phosphoenolpyruvate carboxykinase) during the study of its inhibition by various substrate analogues.<br>References Suh, D. et al.: Nucl. Acids Res., 25, 2495 (1997); Stiffin, R. et al.: Biochem., 47, 2099 (2008);<br></p>

<p>Applications Pentanoic-2,2,3,3-d4 Acid (CAS# 1219804-71-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Tryptamine is a monoamine alkaloid found in plants. Tryptamine is commonly used in the preparation of biologically active compounds such as neurotransmitters and psychedelics.<br>References Nichols, D. E., et al.: Curr. Top. Behav. Neurosci., 36, 1(2018); Espinoza, S., et al.: Top. Med. Chem., 23, 175 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications 3-[N-Acetyl-L-cystein-S-yl] Acetaminophen-d5 Sodium Salt (Major) is deuterium labeled 3-(N-Acetyl-L-cystein-S-yl) Acetaminophen Disodium Salt (A172100), which is a metabolite of Acetaminophen (A161220). Acetaminophen is an analgesic and antipyretic agent used as a pain reliever to treat headache, muscle aches, and arthritis (1,2,3).Minimum isotopic incorporation d-3, no d-0 present. 64% isotopic incorporation at the 6-position, 89% at the 4-position.<br>References (1) Chen, C., et al.: J. Biol. Chem., 283, 4543 (2008) (2) Reith, D., et al.: Clin. Exper. Pharmacol. Physiol., 36, 35 (2009) (3) McGill, M. R. and Jaeschke, H. Pharm Res. 30, 2174 (2013)<br></p>

<p>Applications Aristeromycin is an antibacterial adenosine analog.<br></p>

<p>Applications (S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.<br>References Sun, H. et al.: Bioorg. Med. Chem., 21, 856 (2013); Deeb, O., et al.: Chem. Biol. Drug Des., 76, 255 (2010); Sun., et al.: Br. J. Pharmcol., 158, 1302 (2009); Duchowicz, P., et al.: Bioorg. Med. Chem., 14, 5876 (2006); Yamahara, J. et al.: Chem. Pharm. Bull., 24, 1909 (1976)<br></p>

<p>Applications 3-Methyl Adenine is a selective autophagy and phosphoinositide 3-kinase (PI3K) inhibitor (1,2,3). 3-MA inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidylinositol 3-kinases (PI-3K).<br>References (1) Munafo, D., et al.: J. Cell Sci., 114, 3619 (2001) (2) Aggarwal, B., et al.: Biochem. Pharmacol., 71, 1397 (2006) (3) Hayat, M., et al.: Oncologist, 12, 20 (2007)<br></p>

<p>Stability Very Hygroscopic<br>Applications Hydroxyisovaleroyl Carnitine is used as a diagnostic tool to identify the presence of orofacial clefts. Also used in the screening and diagnostics of inborn errors of metabolism.<br>References Denes, J. et al.: Anal. Chem., 84, 10113 (2012); Budner, M. et al.: Arch. Oral. Biol., 58, 459 (2013);<br></p>

<p>Impurity Cholecalciferol EP Impurity A<br>Stability Light Sensitive, Temperature Sensitive<br>Applications 5,6-trans-Vitamin D3 (Cholecalciferol EP Impurity A) is the major photoisomer of Vitamin D3 analog, as an impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bikle, D., et al.: Biochemistry, 25, 1545 (1986), Webb, A., et al.: J. Clin. Endocrinol. Metab., 68, 882 (1989), Baran, D., et al.: J. Cell Biochem., 50, 124 (1992), Tian, X., et al.: J. Biol. Chem., 268, 14888 (1993),<br></p>

<p>Applications N-Hydroxysulfosuccinimide Sodium Salt is a hydrophilic ligand for the preparation of active esters, which can be used for crosslinking agents.<br>References Klibanov, A.L., et al.: Appl. Biochem. Biotechnol., 22, 45 (1989), Marcussen, J., et al.: Anal. Biochem., 198, 318 (1991), Verheul, A.F.M., et al.: Infect. Immun., 59, 843 (1991),<br></p>

<p>Stability Light Sensitive, Temperature Sensitive<br>Applications 9-cis-Retinal is an isomer of all-trans-Retinal (R240000).<br>References Yan, E., et al.: Biochemistry, 43, 10867 (2004), Kukura, P., et al.: Science, 310, 1006 (2005), Ridge, K., et al.: J. Biol. Chem., 282, 9297 (2007),<br></p>

<p>Stability Light Sensitive<br>Applications Ostruthin imperatorin (cas# 148-83-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Glycerol Monoleate is used to synthesize water soluble drugs in need of sustained-release for drug delivery.<br>References Chang, C. et al.: Int. J. Pharm., 276, 83 (2004); Chang, C. et al.: Int. J. Pharm., 173, 51 (1998);<br></p>

<p>Stability Hygroscopic<br>Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.<br>References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);<br></p>

<p>Applications Ammelide, is a metabolite of Melamine (1) (M208700), which acts as a non-protein nitrogen food additive (2). Also present in pet foods as well (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mast R. et al.: Food Chem Toxicol. 1983 Dec;21(6):807-10. 2. Ehling S. et al.: Food Addit. Contam. 2007 Dec;24(12):1319-25. 3. Vail T. et al.: J Anal Toxicol. 2007 Jul-Aug;31(6):304-12.<br></p>

<p>Applications Dl-valine<br></p>

<p>Stability Hygroscopic, Temperature Sensitive<br>Applications A fluorescent label for the specific and reversible labelling of the outer components of the plasma membrane. The reagent reacts with a fixed number of sites on the surface of cells concerned with anion permeation; does not pass through the osmotic barrier of the membrane; reacts under physiological conditions of temperature, pH and tonicity; and is detectable in small amounts. SEE ALSO NOTES FOR DIDS (CAT#D460600).Fluorescence: max. Abs. l = 336nm, max. Em. l = 436 nm.<br>References Maddy., A.H.: Biochim. Biophys. Acta., 88, 390 (1964), Cabantchik, Z.I., et al.: J. Membrane Biol., 10, 311 (1972); Am. J. Physiol. 262, C803 (1992); J. Biol. Chem. 266, 13355 (1991), Ma, W., et al.: J. Pharmacol. Exp. Ther., 328, 409 (2009),<br></p>

<p>Applications Threonine derivative used in the synthesis of peptide.<br>References Dekker, C.A., et al.: J. Biol. Chem., 180, 155 (1949),<br></p>

<p>Applications Phloxine B acts as the sensitizers of dye-sensitized solar cells. Also, it is a fluorescein photoactive dye. Dyes and metabolites, Environmental Testing.<br>References Ren, P., et al.: Int. J. Photoenergy, 2135847/1-2135847/11 (2016);<br></p>

<p>Applications Tetragalacturonic Acid, is the product of polygalacturonic acid degradation. The mixture of Oligogalacturonic Acids has shown to have shoot growth in cockscomb (Celosia argentea L.) seedlings.<br>References Suzuki, T., et al.: J. Plant Growth Reg., 21, 209 (2003);<br></p>

<p>Applications S-Phenylmercapturic Acid-d5 is the labelled analogue of S-Phenylmercapturic Acid (P335600), an important metabolite of Benzene.<br>References Qu, Q., et al.: Am. J. Ind. Med., 37, 522 (2000); Ghittori, S., et al.: Int. Arch. Occup. Environ. Health, 67, 195 (1995);<br></p>

<p>Applications Benzotriazol-1-yl-oxytripyrrolidinphosphonium Hexafluorophosphate (cas# 128625-52-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-METHYLHYDANTOIN (cas# 616-04-6) is a useful research chemical.<br></p>

<p>Impurity Didanosine EP Impurity C<br>Applications 2'-Deoxyinosine (Didanosine EP Impurity C) is an Inosine (I661000) analog with hypotensive activity. An impurity of the antiviral drug 2’,3’-Dideoxyinosine (D440950).<br>References Maling, S.J. et al.: J. Appl. Biochem., 2, 130 (1980); Rao, D.V.N.S. et al.: J. Pharmac. Biomed. Anal., 45, 516 (2007);<br></p>

<p>Applications 3-Hydroxydodecanoic Acid Methyl Ester is a 3-hydroxyl fatty acid Me ester as methionine regulator.<br>References Akamatsu, Y., et al.: J. Biol. Chem., 245, 709 (1970); Alvarez, L., et al.: Biochem. J., 301, 557 (1994), Varbanova, M., et al.: Plant Cell, 19, 32 (2007), Atsumi, S., et al.: Nature, 451, 86 (2008),<br></p>

<p>Stability Light Sensitive<br>Applications 9-cis-Retinoic Acid Methyl Ester is a cis-Vitamin A derivative.<br>References Englert, G., et al.: Helv. Chimica Acta, 58, 2367 (1975),<br></p>

<p>Applications Dodecane is used in the synthesis of triblock polymers that deliver nanoparticles to the oil/water interface and degrade non-tocxc non-aqueous liquids. Used in the synthesis of helical folding of alkanes used in a self assembly.<br>References Saleh, N. et al.: Nano. Lett., 2489, 5 (2005); Scarso, A. et al.: J. Am. Chem. Soc., 126, 13512 (2004);<br></p>

<p>Applications 6-Methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol is an intermediate used in the preparation of pyridoxine (vitamin B6).<br>References Harris, E. E., et al.: J. Org. Chem., 27, 2705 (1962), Naito, T., et al.: Yakugaku Zasshi, 79, 1277 (1959)<br></p>

<p>Applications (E)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.<br>References Yang, D. et al.: J. Lipid Res., 53, 529 (2012); El-Mekkawy, S. et al.: Nat. Prod. Res., 27, 146 (2013);<br></p>

<p>Applications 1-fluoro-3,3-dimethyl-1$l^{3},2-benziodoxole (cas# 1391728-13-4) is a useful research chemical.<br></p>

<p>Applications Ethyl Cyano(hydroxyimino)acetate is used in peptide synthesis and has shown to suppress racemiztion, has high coupling efficiency in both solution and solid phase synthesis and is a non-explosive alternative to 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt).<br>References Khattab, S.N.: Bull. Chem. Soc. Jpn., 83, 1374 (2010)<br></p>

<p>Applications 2,4'-Bipyridine is used in preparation of Iridium Heterocyclic complexes.<br>References Zhang, X., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications 2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone (cas# 55094-52-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 5,10-Diformyl-5,6,7,8-tetrahydrofolic acid is a derivative of the coenzyme 5,6,7,8-tetrahydrofolic acid which is essential in primary metabolism for reactions involving the transfer of a one-carbon unit at the formic acid, the formaldehyde or the methanol oxidation levels.<br>References Flaks, J.G., et al.: J. Biol. Chem., 228, 215 (1957),<br></p>

<p>Stability Hygroscopic<br>Applications Quaternary ammonium base occurring in tissues of marine animals.<br>References Stein, W., et al.: J. Biol. Chem., 211, 915 (1954), Bystedt, J., et al.: J. Sci. Food Agric., 10, 301 (1959),<br></p>

<p>Applications Labelled analogue of L-Vailne. L-Valine is an essential amino acid and one of 20 proteinogenic amino acids. L-Valine cannot be manufactured by the body and must be acquired through diet or supplementation. L-valine is found in grains, dairy products, mushrooms, meats, peanuts and soy proteins. L-Valine has been used in studies to attenuate arrhythmias and induce hypotensive effects.<br>References Choi, C.W. et al.: Anim. Feed Sci. Technol., 102, 15 (2002); Kolarski, D. et al.: Krmiva, 30, 155 (1988); Oba, M. et al.: J. Dairy Sci., 93, 2044 (2010); Mitrega, K. et al.: Pharmacol. Res., 64, 218 (2011);<br></p>

<p>Applications Boc-L-Nitroarginine, can be used in peptide chemistry. It has been also shown to act as NO synthase inhibitor, and thus used in the study of The effects of methylene blue (MB) for treatment of sepsis induced by bowel perforation.<br>References Galili, Y. Euro. surg. Rese. vol. 29, P:390-395 (19997);<br></p>

<p>Applications Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-α-*induced ICAM-1 expression in human lung epithelial cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Amorati, R., et al.: J Org Chem. (2015) 80:10651-9.(2) Wu, C., et. al.: Inflammation (2014) 37:1957-67<br></p>

<p>Applications 2-Phenylbenzothiazole is an organic compound that was detected in water and sediment from sedimentation ponds as a contaminant.<br>References Grung, M., et al.: Sci. Total Environ., 751, 141808 (2021)<br></p>

<p>Applications 6-Carboxyfluorescein is a useful reagent for the preparation of hydrolytically stable fluorescent conjugates and is a useful starting material for the synthesis of other fluorescein-derived reagents. Dyes and metabolites.<br>References Theisen, P., et al.: Tetrahedron Lett., 33, 5033 (1992); Mattingly, P.: Bioconjgate Chem., 3, 430 (1992); Bertrand, R., et al.: Biochemistry, 34, 9500 (1995);<br></p>

<p>Applications L-Argininic Acid is a guanidino compound, of which accumulation in tissue can cause Hyperargininemia.<br>References Deignan, J., et al.: Mol. Gen. Metab., 93, 172 (2008); Balz, D., et al.: Intl. J. Develop. Neurosci., 21, 75 (2003); Wyse, A., et al.: Brain Res., 923, 50 (2001)<br></p>

<p>Applications Lyral (mixture of isomers) is a suspected fragrance allergen.<br>References Rey, Aurelien, et al.: J. of Chromatography A, 1404, 95-103 (2015);Desmedt, B., et al.: Talanta, 131, 444-451 (2015)<br></p>

<p>Applications A fat-metabolism stimulator. Antioxidant.<br>References Plotzker, R., et al.: Am. J. Med. Sci., 283, 79 (1982), Evans, J., et al.: Diabetes Technol. Ther., 2, 401 (2000), Konrad, D., et al.: Diabetes, 50, 1464 (2001), Lockhart, B., et al.: Brain Res., 855, 292 (2000),<br></p>

<p>Applications Erythrosin B is an organoiodine compound that is a useful biological stain. Suggested to be effective in vital exclusion staining in monolayer culture. Dyes and metabolites.<br></p>

<p>Applications A fluorescent reagent with a terminal amine for derivatization. 1,5-EDANS has similar spectral properties to the naphthalenesulfonic acids. Fluorescence: max. Abs. 335nm; max. Em. 493nm; e x 10-3: 5.9<br>References Warfield, R., et al.: Org. Biomol. Chem., 4, 3626 (2006), Elston, C., et al.: Anal. Biochem., 368, 87 (2007),<br></p>

<p>Applications Isometheptane Mucate is a compound included in pain and migraine relief formulations. Oral administration.<br>References Lyris, E. et al.: J. Chrom. Anal. Tech. Biomed. Life. Sci., 827, 199 (2005); Plakogiannis, F. et al.: J. Pharm. Sci., 66, 604 (1977);<br></p>

<p>Applications Thionin Acetate Salt is a metachromic cationic histology dye. It can also be used in biological use and engineering or chemical process of controlled design and fabrication of SERS-SEF multifunctional nanoparticles for nanoprobe applications. Dyes and metabolites.<br>References Chang, S., et al.: J Phys Chem C, (2017)<br></p>

<p>Applications 4-(Dimethylaminobenzylidene)rhodanine is a useful research chemical in analytical techniques such as electrochemistry that investigate adsorption and corrosion inhibition by metals.<br>References Solmaz, R. et al.: Corrosion. Sci., 79, 169 (2014);<br></p>

<p>Applications Z-VAL-MET-OH (cas# 108543-82-4) is a useful research chemical.<br></p>

<p>Applications 6-Dimethylaminopurine-9-riboside (cas# 2620-62-4) is a compound useful in organic synthesis.<br>References Elion, G.B., et al.: JACS, 74, 411-414 (1952), Kelley, J.L., et al.: J. Med. Chem., 32, 1020-1024 (1989)<br></p>

<p>Applications 4-n-Nonylphenol-2,3,5,6-d4 is the labelled isotope compound of 4-Nonyl Phenol(N650430) which is used in the process for the manufacture of 5-nonyl salicylaldoxime, which is used for the selective purification and concentration of copper ions.<br>References Bhikulal, P. S., et al.: From Indian Pat. Appl. (2005) IN 2005MU01163 A 20051118<br></p>

<p>Applications 8-Hydroxypyrene-1,3,6-trisulfonic Acid, Trisodium Salt is or 6358-69-6), a fluorescent pH indicator. It is a salt form of 8-Hydroxypyrene-1,3,6-trisulfonic Acid (CAS 27928-00-3) which can be used in biological study of phenylene vinylene macrocycles as artificial transmembrane transporters. Dyes and metabolites, Environmental Testing.<br>References Hu, X., et al.: Chem Commun, 52, 5848 (2016)<br></p>

<p>Applications L-Alanine-d3 is the labeled analogue of L-Alanine (A481500), which is used to make in-vivo measurement of glucose and alanine metabolism in studies of patients with diabetes. L-Alanine is a non-essential amino acid for human development. L-Alanine is one of the 20 amino acids encoded by the genetic code.<br>References Bier, D.M. et al.: Diabetes, 26, 1005 (1977); Capaldo, B. et al.: J. Clin. Endocrinol. Metab., 71, 1220 (1990); Giacca, A. et al.: Diabetes, 47, 1763 (1998)<br></p>

<p>Applications 6-Deoxy-6-fluoro-D-galactose (cas# 447-25-6) is a compound useful in organic synthesis.<br></p>