Biochemicals and Reagents

<p>Applications An inhibitor of RNA synthesis (causes premature termination of transcription).<br>References Braedlye, J. and Sporns, O.: Brain Res., 815, 140 (1999), Ljungman, M., et al.: Oncogene, 18, 583 (1999), Roele, R.H., et al.: Oncogene, 18, 5765 (1999)<br></p>

<p>Applications Glycyl-L-Tyrosine Dihydrate is used in process for producing N-Glycyltyrosine. Glycyl-L-Tyrosine Dihydrate is the anhydrous form of Glycyl-L-tyrosine(G720108); which is used in preparation method of high quality Aspartame and Aspartame crystallization-inducing agent.<br>References Mimura, T., et al.: Eur. Pat. Appl., (1999); Gao, Z., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Stability Hygroscopic<br>Applications A mixture of 2 metabolites of Styrene. The 2 regioisomers are in a roughly 3: 1ratio<br>References Ryan, A., et al.: Drug Metab. Dispos., 5, 363 (1977), Delbressine, L., et al.: Xenobiotica, 11, 589 (1981), Truchon, G., et al.: J. Anal. Toxicol., 14, 227 (1990),<br></p>

<p>Applications A potential chiral building blocks for the synthesis of different α -methyl α -amino acids.<br>References Rew, Y., et al.: J. Med. Chem., 45, 3746 (2002),<br></p>

<p>Applications Dehydroabietal is an essential oil and found in the composition of seed extractives from various Abies and Picea species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Falsca, A., et al.: Biochem. Syst. Ecol., 69, 166-175 (2016); Wajs-Bonikowska, A., et al.: Chem. Biodivers., 13, 1194-1201 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications Betahistine Methanesulfonate (cas# 54856-23-4) is a useful research chemical.<br></p>

<p>Applications 3-Aminobiphenyl<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic, Moisture Sensitive<br>Applications A heterobifunctional cross-linker.<br>References Carlsson, J. et al.: Biochem. J., 173, 723 (1978), Neurath, A.R., and Strick, N.J.. : J. Virol. Meth., 3, 155 (1981)<br></p>

<p>Stability Moisture Sensitive: Desiccate<br>Applications A heterobifunctional sulfhydryl cross-linking reagent.<br></p>

<p>Applications (E)-2-chloro-3-imino-N,N-dimethylprop-1-en-1-amine Hydrochloride is an impurity of Etoricoxib (E934100), a selective cyclo-oxygenase-2 (COX-2) inhibitor that is used to improve the signs and symptoms of osteoarthritis and rheumatoid arthritis.<br>References Hunt, R., et al.: Am. J. Gastroenterol., 98, 1725 (2003); Schumacher Jr., H., et al.: Bmj, 324, 1488 (2002)<br></p>

<p>Stability Light Sensitive<br>Applications Acid Red 1, tech. is a synthetic red azo dye used as food additive. Studies have shown that Red Acid 1 is converted to toxic compound aniline and may ultimately interfere with blood haemoglobin. Dyes and metabolites, Environmental Testing.<br>References Ordoudi, S.A., et al.: Food. Add. Contamin., 28, 417 (2011); Ganesan, L., et al.: Biochem. Pharmacol., 81, 810 (2011);<br></p>

<p>Applications Guanosine analog. Used for preparation of nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase.<br>References Eldrup, A.B., et al.: J. Med. Chem., 47, 2283 (2004), Shim, J., et al.: Antiviral Res., 243 (2003), Wang, M., et al.: J. Biol. Chem., 278, 9489 (2003),<br></p>

<p>Applications 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine is used to prepare ppGpp analogs as inhibitors of RelA from Gram-negative/-positive bacteria. It is also used to synthesize guanosine 5'-conjugates as initiator molecules for transcription priming.<br>References Wexselblatt, E., et al.: Bioorg. Med. Chem., 18, 4485 (2010); Wolf, J., et al.:Org. Biomol. Chem., 6, 899 (2008)<br></p>

<p>Stability Hygroscopic<br>Applications Bis(4-hydroxyphenyl) Sulfone O-β-D-Glucuronide is the glucuronide derivative of Bis(4-hydroxyphenyl) Sulfone (B447390); a compound that is commonly used as a reactant in epoxy reactions. It is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012)<br></p>

<p>Stability Stable at RT<br>Applications D-(+)-Cellohexose (cas# 2478-35-5) is a compound useful in organic synthesis.<br></p>

<p>Applications A water soluble sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 10.6 Angstroms<br>References Weltman, J.K., et al.: Biotechniques, 1, 148 (1983)<br></p>

<p>Applications 2-Methoxy-4-nitroaniline is a derivative of 4-Nitroaniline (N491770), which is used in the synthesis of photorefractive polymers, as novel chromophores in analytical study. As well, due to the absorption spectrum associated with 4-Nitroaniline, it is used to determine catechol derivatives in syntheses.<br>References Nagaraja, P. et al.: J. Pharm. Biomed. Anal., 25, 417 (2001);<br></p>

<p>Applications Boc-His(Trt)-OH was used in the study to prepare and study structure-activity relationship of amino acid amides as selective inhibitors for dipeptidyl peptidases.<br>References Senten, K., et al.: J. Med. Chem., 46, 5005 (2003);<br></p>

<p>Applications Antioxidant 1098 (cas# 23128-74-7) is used as a modifier in polymer stabilization.<br>References Li, C.; et al.: J. Appl. Poly. Sci., 134 (2017).<br></p>

<p>Applications L-3-Benzothienylalanine<br></p>

<p>Applications Congo Red is a secondary diazo dye that is used to stain β sheet aggregates. Congo Red can be used to diagnose amyloidosis. Dyes and metabolites, Environmental Testing<br>References Falk, R. H. et al.: N Engl J Med 337, 898 (1997); Ishii, W., et al.: intern Med. May;42, 400 (2003)<br></p>

<p>Stability Moisture and Temperature Sensitive<br>Applications (R,S)-Equol 4’-Sulfate is a sulfated metabolite of isoflavone Daidzein (D103500).<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),<br></p>

<p>Applications Bis[2,5-Dimethoxy-4-(p-nitrophenylazo)benzenediazonium] Chlorozincate can be used for test kits to detect and identify narcotics. It has also been assessed for its suitability as oxygen reduction electrocatalysts and sonoelectrocatalysts.<br>References Callahan, M.D., et.al., U.S., 13,(2017); Sljukic, B., et.al., Electroanalysis, 17,1025-1034,(2005);<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications N-[(Benzyloxy)carbonyl]glycylglycine is a reagent in the synthesis of Glycylglycyl-L-tyrosine (G718500), which is a fungal tyrosinases and their capability to oxidize peptide-bound tyrosine residues is important in a view of applicability of tyrosinases.<br>References Bowness, J., et al.: Biochem. J., 53, 620 (1953), Cuff, M., et al.: J. Mol. Biol., 278, 855 (1998), Kubo, I., et al.: Bioorg. Med. Chem., 12, 5349 (2004),<br></p>

<p>Applications A sulfhydryl cross-linking reagent.<br>References Loo, T., et al.: J. Biol. Chem., 276, 40, 36877 (2001)<br></p>

<p>Applications N1,N3-Bis(2-ethylhexyl)-2-methyl-1,2,3-propanetriamine is a hydrolysis product usually found in preparations of the antimicrobial drug hexetidine.<br>References Mende, P.; Food and Chem. Tox. 31(1), 53-58 (1993)<br></p>

<p>Applications D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011);<br></p>

<p>Applications A labelled metabolite of Malachite Green in seafood products. A labelled triphenylmethane dye with fungicidal and limited antiseptic activity. The term Malachine green applies to the oxalate as well as the chloride. Harmful if swallowed. Avoid release to the environment.<br>References Carter, S.G., et al.: J. Biochem. Biophys. Methods, 7, 7 (1982), Saikan, S., et al.: J. Chem. Phys., 79, 4154 (1983), Clemmensen, S., et al.: Arch. Toxicol., 56, 43 (1984),<br></p>

<p>Applications Dihydrolanosterol, is a derivative of Lanosterol (L174580). It is also one of cytochrome P 450 lanosterol 14α-demethylase (CYP51), which is shown to have an important role in regulating meiosis and reproduction.<br>References Smiljanic, K., et. al.: Lipids, 48, 1069 (2013); Ma, L., et. al.: Food Chem., 139, 503 (2013);<br></p>

<p>Applications 4-Phenyl-3-buten-2-ol can be used as reagent/reactant for rhodium-catalyzed dynamic kinetic enantio-, chemo- and regioselective allylation of phenols/naphthols/hydroxypyridines with allylic carbonates. It can also be used in biological study for comparative study on quality of soy sauce produced from whole soybeans and defatted soybeans.<br>References Li, C., and Breit, B.: Chemistry- A European Journal, 22, 14655-14663 (2016); Li, X., et al.: Zhongguo Niangzao, 34, 22-26 (2015);<br></p>

<p>Applications Polybutenes is a hydrophobic material that is derivatized to make anti-rust additives and detergents..<br></p>

<p>Stability Hygroscopic<br>Applications A glucosidase inhibitor.<br>References Fellows, L.E.: Pestic. Sci., 17, 602 (1986)<br></p>

<p>Applications 3-(Diethylamino)-7-[2-[4-[[4-[(2,5-dioxo-1-pyrrolidinyl)oxy]-4-oxobutyl]methylamino]phenyl]diazenyl]-5-phenylphenazinium is used in preparation of Peptide derivatives as imaging probes of Cathepsin catalytic activity.<br>References Kindermann, M., et al.: PCT Int. Appl., (2018);<br></p>

<p>Applications n-Butylnitrate (cas# 928-45-0) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications (R)-3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride is an important co-factor of mammalian mitochondrial energy metabolism. It is also a good active ingredient for dry-skin.<br>References Geier, David A., et al.: Neurochem. Res., 38(11), 2336-2341 (2013);Tanno, Osamu, et al.: Fragrance J., 33(8), 82-85 (2005);<br></p>

<p>Applications A potential inhibitor of glutamate carboxypeptidase.<br>References Wolcott, T.G., et al.: Biochem. Biophys. Res. Commun., 57, 709 (1974), Knowles, P.F., et al.: Eur. J. Biochem., 114, 139 (1981),<br></p>

<p>Applications Sudan Blue II;Oil Blue 35 (cas# 17354-14-2) is a useful research chemical. Dyes and metabolites, Environmental Testing<br></p>

<p>Impurity Cholecalciferol EP Impurity D<br>Stability Light Sensitive, Temperature Sensitive<br>Applications Isotachysterol3 (Cholecalciferol EP Impurity D) is a degradation product of Vitamin D3 (V676045). Isotachysterol3 has been shown to stimulate intestinal Ca transport and bone Ca mobilization in anephric rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bolos, J. et al.: Cien. Indust. Farm., 6, 259 (1987); Holick, M.F. et al.: Science, 180, 964 (1973);<br></p>

<p>Stability Hygroscopic<br>Applications Used in peptide N-terminal amino acid determination.<br>References Prota, G., et al.: Biochimie, 53, 51 (1971),<br></p>

<p>Impurity Rabeprazole EP Impurity I<br>Applications Rabeprazole Sulfone N-Oxide (Rabeprazole EP Impurity I) is a potential impurity of Rabeprazole (R070500) sodium.<br>References Fujisaki, H., et al.: Biochem. Pharmacol., 42, 321 (1991), Morri, M., et al.: J. Biol. Chem., 268, 21553 (1993)<br></p>

<p>Applications 5-Hydroxymethylcytidine is a product in DNA hydroxymethylation. The concentrations of 5-Hydroxymethylcytidine in the brain were used to study Alzheimer’s disease.<br>References Chouliaras, L., et. al.: NeuroBiol. Aging, 34, 2091 (2013)<br></p>

<p>Applications Dodecane is used in the synthesis of triblock polymers that deliver nanoparticles to the oil/water interface and degrade non-tocxc non-aqueous liquids. Used in the synthesis of helical folding of alkanes used in a self assembly.<br>References Saleh, N. et al.: Nano. Lett., 2489, 5 (2005); Scarso, A. et al.: J. Am. Chem. Soc., 126, 13512 (2004);<br></p>

<p>Applications N-Carbamyl-L-glutamic Acid has been shown to have protective effects against ammonia intoxication and is used in the treatment of acute hyperammonemia.<br>References Paik, W.K. et al.: Life Sci., 15, 1189 (1974); O'Connor, J.E. et al.: Eur. J. Pediat., 148, 540 (1989); Lee, J.H. et al.: Biochem. Biophys. Res. Chem., 248, 391 (1998);<br></p>

<p>Applications (2S,4R)-4-Hydroxy-L-glutamic Acid is a metabolite of Glutamic acid (G596960).<br>References Hampson, D., et al.: J. Biol. Chem., 274, 33488 (1999), Jensen, A., et al.: Eur. J. Pharmacol., 397, 247 (2000),<br></p>

<p>Applications An impurity of Ketorolac (K235650).<br></p>

<p>Applications UDP-3-O-[R-3-Hydroxymyristoyl]-N-[R-3-hydroxymyristoyl] Glucosamine Tris Salt is the salt version of [2(R),3(R)]-P'-[2-Deoxy-3-O-(3-hydroxy-1-oxotetradecyl)-2-[(3-hydroxy-1-oxotetradecyl)amino]-α-D-glucopyranosyl] Ester Uridine 5'-(trihydrogen diphosphate) (CAS 90293-60-0) which can be used in biological study for reconstruction of metabolic network in bovine mammary gland tissue. Potent drug or API metabolite.<br>References Wang, C., et al.: Mol. Biol. Rep., 39, 7311-7318 (2012);<br></p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ADO. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ADO. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ADO, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ADO in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Applications L-Threonine-2,3-d2 (CAS# 1202936-45-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Indigo is a chemical compound used as a dye in industrial clothing and textile processes. Also used in the synthesis of organic semiconductors. Dyes and metabolites.<br>References He, B. et al.: J. Am. Chem. Soc., 136, 15093 (2014); Pitayatanakul, O. et al.: J. mat. Chem. C., Mat. Op. Elec. Dev., 9311 (2014);<br></p>

<p>Stability Hygroscopic<br>Applications A sulfhydryl reactive homobifunctional crosslinking reagent.Spacer Arm: 13.3 Angstroms<br>References Han, J.C., et al.: Anal. Biochem., 220, 5 (1994)<br></p>

<p>Applications 4,6-Di(methyl-d3)benzen-2,3,5-d3-amine is a useful isotopically labeled research compound.<br></p>

<p>Applications Lanosterol is a sterol cholesterol precursor that maintains a stable concentration in the cortex of rats during aging however concentrations of Lanosterol increases in the liver during aging. Lanosterol is found in Mushroom Inonotus obliquus (I.obliquus) which is known to have anti-inflammatory and anticancer properties.<br>References Smiljanic, K., et. al.: Lipids, 48, 1069 (2013); Ma, L., et. al.: Food Chem., 139, 503 (2013)<br></p>

<p>Stability Light Sensitive<br>Applications Ferroprotoporphyrin IX is a metabolite formed during biosynthesis and is used to evaluate iron nutrition and metabolism. It is also an iron containing cofactor that is involved with a wide range of cellular functions including oxygen transport.<br>References Labbe, R.F., et. al.: Clin. Chem., 45, 146 (1999); Yuan, X., et al.: Proc. Natl. Acad. Sci. USA 113, E5144 (2016);<br></p>

<p>Applications Poly(ethylene Glycol) molecules of an average molecular mass of 6000. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry. Recent research has shown PEG maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals. In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery. It is industrially produced as a lubricating substance for various surfaces to reduce friction. PEG is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.<br>References Borgens, R. et al.: J. Neurosci. Res., 66, 1179 (2001); Stavisky, R. et al.: Neurosci. Lett., 376, 98 (2005); Nalam, P. et al.: Tribiol. Lett., 37, 541 (2010); Steinmetz, N. et al.: J. Am. Chem. Soc., 131, 17093 (2009); Li, X. et al.: J. Am. Chem. Soc., 133, 11147 (2011); Li, L. et al.: Int. J. Pharm., 447, 192 (2013)<br></p>

<p>Applications 1,2-Dipalmitoyl-rac-glycero-3-phosphoethanolamine is a long chain fatty acid, acting as a luminescence marker. Is used in enhancing radiotherapy for cancer treatment<br>References Dotsikas, Y. et al.: Anal. Sci., 28, 753 (2012); Choi, J. et al.: J. Nanomet., 8, 863704, (2012);<br></p>

<p>Applications H-GAMMA-GLU-GLU-OH (cas# 1116-22-9) is a useful research chemical.<br></p>

<p>Applications 2-Phenylbenzothiazole is an organic compound that was detected in water and sediment from sedimentation ponds as a contaminant.<br>References Grung, M., et al.: Sci. Total Environ., 751, 141808 (2021)<br></p>

<p>Applications α-Methylglyceric Acid is a biogenic secondary organic aerosol used in air quality diagnosis.<br>References Ru, P., et. al.: Environ. Sci. Technol., 48, 8491 (2014); Napelenok, S.L., et. al.: Environ. Sci. Technol., 48, 464 (2014); Stone, E.A., et. al.: Environ. Chem., 9, 263 (2012)<br></p>

<p>Applications Sucrose Monocaprate is a potentially useful biochemical also known as sucrose monodecanoate.<br></p>

<p>Impurity Ramipril EP Impurity E<br>Stability Hygroscopic<br>Applications Ramiprilat (Ramipril EP Impurity E) is a metabolite of Ramipril (R111000), and acts as an ACE inhibitor (1). Reduces the need for dialysis among patients previously on angiotensin-converting-enzyme inhibitors (2). Ramipril is used in stroke prevention. (3)<br>References 1. Teetz, V. et al.: Arzneimittelforschung. 1984;34(10B):1399-401.2. Ruggenenti, P. et al.: Lancet. 1998 Oct 17;352(9136):1252-6.3. Badrinath, P. et al.; BMJ. 2002 Aug 24; 325(7361): 439.<br></p>

<p>Applications A useful linker for biomolecules.<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications Lyral (mixture of isomers) is a suspected fragrance allergen.<br>References Rey, Aurelien, et al.: J. of Chromatography A, 1404, 95-103 (2015);Desmedt, B., et al.: Talanta, 131, 444-451 (2015)<br></p>

<p>Applications L-Valine (1-13c, 99%) (cas# 81201-85-6) is a useful research chemical.<br></p>

<p>Applications n-Butyl Mandelate is a compound used in the exploitation of cofactor versatility to convert a FAD-dependent Baeyer-Villager monooxygenase into a keto ketoreductase.<br>References Xu, J. et al.: Angew. Chem. Int. Ed., 58, 14499 (2019);<br></p>

<p>Applications 2'-Deoxy-N-methyladenosine plays role in catalytic activity and may promote proper folding of A730 loop.<br>References Lafontaine, D. A., et al.: J. Mol. Biol., 323, 23-34 (2002)<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Stability Hygroscoipic, Light and Air Sensitive<br>Applications Dihydrofolic Acid is an intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). Folic acid (FA) and Dihydrofolic acid (FAH2) are substrates of dihydrofolate reductase(s) which reduce them to tetrahydrofolate (THF).<br>References Andres, J., et al.: Bioorg. Chem., 24, 10 (1996), Benkovic, S., et al.: Science, 301, 1196 (2003), ,,,,Williams, D; J Mol Biol 2003, 329, 389,,,Krahn, J., et al.: Biochemistry, 46, 14878 (2007),<br></p>

<p>Applications Danofloxacin is a broad spectrum fluoroquinolone antibacterial compound.<br>References Golet, E., et al.: Anal. Chem., 73, 3632 (2001); Golet, E., et al.: Environ. Sci. Technol., 36, 3645 (2002); Huet, A., et al.: J. Agric. Food Chem., 54, 2822 (2006);<br></p>

<p>Applications (S)-Equol and R-Equol are metabolites of the soy isoflavones Daidzein (D103500) and Genistein. Both have significant biological actions.<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008),<br></p>

<p>Applications N-Acetyl-Tyr-Val-Ala-Asp-7-amido-4-trifluoromethylcoumarin is a substrate whose amino acids are shown as a preferred cleavage site for Caspase-1 and 4. Useful for caspase research.<br>References Talanian, R. et al.: J. Biol. Chem., 272, 9677 (1977); Marcelli, M. et al.: Cancer Res., 58, 76 (1998);<br></p>

<p>Applications Labelled analogue of an essential amino acid found in naturally produced peptides. Unlike its stereoisomer, L-tryptophan, it is not used in structural or enzyme proteins.<br>References Karunakaran, S.et al.: Bochem. J., 414, 343 (2008); Pallaghy, P.K. et al.: Biochem., 38, 11553 (1999);<br></p>

<p>Applications Labelled Sitosterol (S497050). A common sterol in plants. Isolated from wheat germ oil, corn oil. Antilipemic. Used in the treatment of prostatic adenoma.<br>References Tanaka, et al.: J. Biochem., 17, 483 (1933), Nigro, N.D., et al.: J. Natl. Cancer Inst., 69, 103 (1982),<br></p>