Biochemicals and Reagents

<p>Stability Hygroscopic<br>Applications Betahistine Methanesulfonate (cas# 54856-23-4) is a useful research chemical.<br></p>

<p>Applications Found in animal organs, yeast, patatoes, coffee beans, tea. This drug can be used to relax and widen certain breathing passages of the lungs. It is also found that a large number of derivatives have adenoside receptor antagonist properties.<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>

<p>Applications An acylglycine present in urniary excretion that can be analyzed and be used as diagnostic tool for metabolic disorders, complementary to organic acids and acylcarnitine profiles.<br>References Bonafe, L. et al.: Mol. Genetics Metab., 69, 302 (2000);<br></p>

<p>Applications A fluorescent reagent with a terminal amine for derivatization. 1,5-EDANS has similar spectral properties to the naphthalenesulfonic acids. Fluorescence: max. Abs. 335nm; max. Em. 493nm; e x 10-3: 5.9<br>References Warfield, R., et al.: Org. Biomol. Chem., 4, 3626 (2006), Elston, C., et al.: Anal. Biochem., 368, 87 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications gamma-Polyglutamic acid - sodium salt (cas# 25513-46-6) is a useful research chemical.<br></p>

<p>Applications 20(S)-Ginsenoside Rh2 is a bioactive metabolite of the ginsenoside component of Panax ginseng that has been shown to exhibit antibacterial effects in vitro.<br>References Zhang, J. et al.: Eur. J. Pharm., 740, 277 (2014);<br></p>

<p>Applications Dipropylene Glycol Diacrylate 57472-68-1 (cas# 57472-68-1) is a useful research chemical.<br></p>

<p>Applications 1-Methylpiperazine-2,2,3,3,5,5,6,6-d8 is the labeled version of 1-Methylpiperazine (Imatinib EP Impurity G)(M326495) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug. It is a COVID19-related research product.Is used in preparation of Imidazopyridine compounds for the treatment of inflammatory disorders.<br>References Mallevais, M.L. et al.: Biochimie, 66, 477 (1984); Van der Plas, Steven E., et al.: PCT Int. Appl., (2019);<br></p>

<p>Applications Benzyl Violet C.I. 42640 (cas# 1694-09-3) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications 1,1'-(1,5-Pentanediyl)bis[1-butylpyrrolidinium] Difluoride is the ionic form of 1,1'-(1,5-Pentanediyl)bis[1-butylpyrrolidinium] [CAS#: 805990-74-3 ] which is used for anion detection by electrospray ionization mass spectrometry with dicationic liquids salts.<br>References Armstrong, Daniel W., et al.: PCT Int. Appl., (2009);<br></p>

<p>Applications (+)-cis-Abienol is used in the synthesis of diols as well as in products requiring flavors or fragrances.<br>References Zerbe, P. et al.: J. Bio. Chem., 287, 12121 (2012); Barrero, A.F. et al.: Tetrahedron, 54, 5635 (1998);<br></p>

<p>Applications Suberylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Stability Light Sensitive<br>Applications A labelled vitamin precursor.<br></p>

<p>Applications Potassium p-Nitrophenyl Sulphate (cas# 6217-68-1) is a compound useful in organic synthesis.<br></p>

<p>Applications A amino reactive heterobifunctional crosslinking reagent.<br>References Kraehenbuhl, J.P., et al.: J. Exptl. Med., 139, 208 (1974), Tijssen, P., Kurstak, E.: Viral Immunodiagnosis, P 125, Acad. Press (1974), Galardy, R.E., et al.: J. Med. Chem., 21, 1279 (1978)<br></p>

<p>Applications Carboxymethylcellulose Sodium (cas# 9004-32-4) is a useful research chemical.<br></p>

<p>Applications A labelled metabolite of Toluene.<br>References Gargas, M., et al.: Toxicol. Appl. Pharmacol., 98, 87 (1989), Commandeur, J., et al.: Pharmacol. Rev., 47(2), 271 (1995), Campo, P., et al.: Neurotoxicol. Teratol., 21, 427 (1999), Lohse, C., et al.: J. Agr. Food Chem., 48, 5913 (2000),<br></p>

<p>Applications 4-Amino-nicotinonitrile<br></p>

<p>Stability Hygroscopic<br>Applications One of the biologically active forms of nicotinic acid. Serves as a coenzyme of hydrogenases and dehydrogenases. NAD usually acts as a hydrogen acceptor, forming NADH which then serves as a hydrogen donor in the respiratory chain. Present in living cells primarily in the reduced form (NADPH) and is involved in synthetic reactions. Occurs in 2 forms, α-NAD and β-NAD, distinguished by the configuration of the ribosyl nicotinamide linkage. Only the β-anomer is bioactive.<br>References Bartlett, G.R., et al.: J. Biol. Chem., 234, 449 (1959), Dixon, M., et al.: Science, 132, 1548 (1960), Heyes, D., et al.: Biochemistry, 43, 8265 (2004), Dietzek, B., et al.: Chem. Phys. Chem., 7, 1727 (2006),<br></p>

<p>Applications Labelled Chenodiol (Chenodeoxycholic acid). A major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Fcilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.<br>References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),<br></p>

<p>Applications Food preservative, having the ability to form complexes with starch, retarding its retrodegradation during storage.<br>References Yu, S., et al.: J. Agric. Food Chem., 54, 4482 (2006),<br></p>

<p>Applications Protected guanine<br>References Tretyakova, N., et al.: Chem. Res. Toxicol., 20, 284 (2007), Rana, S., et al.: Bioorg. Med. Chem. Lett., 19, 670 (2009),<br></p>

<p>Stability Very Hygroscopic<br>Applications Accumulation and excretion of 2-Hydroxyhexanedioic Acid (with 2-ketoadipic and 2-aminoadipic) in urine can be caused by 2-ketoadipic acidemia, probably without adverse phenotypic effects , due to deficiency of 2-ketoadipic dehydrogenase.<br>References Svendsen, J., et al.: J. Chromatogr., 337, 9 (1985); Przyrembel, H., et al.: Clin. Chim. Acta 58, 257 (1975).<br></p>

<p>Applications 5-Aminolevulinic Acid Methyl Ester Hydrochloride, is the methyl ester of Aminolevulinic Acid (ALA) (A611780), which has been shown to have higher lipophilicity, and to be highly efficient at inducing protoporphyrin IX (PpIX) production in cell culture.<br>References Morrow, D. I. J., et al.: J. Pharmac. Sci., 99, 3486 (2010); Peng, Q., et al.: Cancer, 79, 2282 (1997);<br></p>

<p>Applications A fluorogenic substrate in the assay of α-galactosidase.<br></p>

<p>Applications 17α-Dydrogesterone is an isomer of Dydrogesterone (D826000), a synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid .beta.-endorphin. Progestogen.<br>References Bernardi, F., et al.: Eur. J. Endocrinol., 138, 316 (1998); Rupprecht, R., et al.: Steroids, 64, 83 (1999); Uzunova, V., et al.: Brain Res., 976, 1 (2003); Pluchino, N., et al.: J. Steroid Biochem. Mol. Biol., 102, 205 (2006)<br></p>

<p>Applications 4-Phenylazophenol is a diaryl-azo derivative with potential use as potential antifungal agents. 4-Phenylazophenol is an azo dye with toxic effects as well as a being a soil contaminant. Dyes and metabolites.<br>References Xu, H. et al.: Bioorg. Med. Chem., 20, 4193 (2010); Spadaro, J.T. et al.: Appl. Environ. Microbiol., 58, 2397 (1992);<br></p>

<p>Applications 5-Ethynyl-2’-deoxyuridine is an extensively used nucleoside analog used as a probe for DNA synthesis. 5-Ethynyl-2’-deoxyuridine is known as an toxic anti-metabolite, which potentially causes DNA instabiliy, necrosis and cell-cycle arrest, therefore it is often used for short-term DNA synthesis in tissue culture and living organisms where prolonged cell survival is not required.<br>References Neef, A.B., et al.: P. Natl. Acad. Sci.., 108, 20404 (2011); Gristwood, T., et al.: Nucleic. Acids. Rsch., 40, 5487 (2012);<br></p>

<p>Applications (7Z)​-7-​Hexadecenoic acid is a fatty acid that may be useful for determining the specific genus of a bacterial population present in a variety of natural environments.<br>References Kneif, C., et al.: Environ Microbiol., 5, 1155-67 (2003)<br></p>

<p>Applications Polybutenes is a hydrophobic material that is derivatized to make anti-rust additives and detergents..<br></p>

<p>Applications L-Thioproline is used to create a monolayer on gold electrodes for the determination Copper(II). L-Thioproline has shown to be an effect inhibitor of proline absorption in Saccharomyces chevalieri.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cui, X., et. al.: Sci. China Chem., 53, 257 (2010); Magana-Schwenchke, N., Schwencke, J.: BBA-Biomembranes, 173, 313 (1969)<br></p>

<p>Applications N-Acetyl-DL-aspartic acid (cas# 2545-40-6) is a useful research chemical.<br></p>

<p>Applications Indene is an organic building block that has been used in the synthesis of isatins as selective inhibitors of carboxylesterases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hyatt, J.L., et. al.: J. Med. Chem., 50, 1876 (2007)<br></p>

<p>Applications L-Glutamic Acid α-tert-Butyl Ester is an ester of L-Glutamic Acid used in the synthesis of enantiopure isotopomers of amino acids.<br>References Chauvel, E., et al.: J. Med. Chem., 37, 2950 (1994),<br></p>

<p>Applications 4-[(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoic Acid is used in the preparation of pentamethylnaphthylmethylbenzoates as a selective retinoid X receptor ligands that induce apoptosis in leukemia cells.<br>References Boehm, M.F., et al.: J. Med. Chem., 38, 3146-55 (1995); Furmie, J.K., et al.: ChemMedChem, 7, 1551-66 (2012)<br></p>

<p>Applications Direct Brown 95, Techincal Grade is an azo dye used in PET/cotton blended fabrics as well as other textiles. Environmental reproductive toxin.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list. Dyes and metabolites, Environmental Testing<br>References Pielesz, A., et al.: J. Mol. Struct., 511, 337 (1999); Galloway, S., et al.: Env. Mol. Mutagen., 10, 1 (1987)<br></p>

<p>Stability Light and Moisture Sensitive<br>Applications Fluorescent labeling reagent for proteins. Used in the fluorescent antibody technique for rapid identification of pathogens. Dyes and metabolites.<br>References Riggs, H.J.L., et al.: Amer. J. Pathol., 34, 1081 (1958), Mann, K.G. and Fish, W.W., Methods in Enz., 26, 28 (1972),<br></p>

<p>Applications L-Threonolactone is formed in the autoxidation of L-Ascorbic acid (A786990), a compound that is essential for numerous enzymatic reactions in the body and is also responsible for scavenging free radicals to prevent oxidative damage to cells.<br>References Miyake, N., et al.: Biosci. Biotech. Bioch., 61, 2069 (1997); Kvernberg, P. &amp; Pedersen, B.: Acta Chem. Scand., 48, 646 (1994); Tsukaguchi, H., et al.: Nature, 399, 70 (1999)<br></p>

<p>Applications Teneligliptin Hydrobromide (2:5) is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.<br>References Goda, M. &amp; Kadowaki, T.: Drugs Today, 49, 615 (2013); Kishimoto, M.: Diabetes Metab. Syndr. Obes., 6, 187 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications A labelled metabolite of Methyl isocyanate.<br>References Slatter, J. G., et al.: Chem. Res. Toxicol., 4, 157 (1991),<br></p>

<p>Applications JTV 519 Fumarate is a useful intermediate.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications DL-Cystine-2,2',3,3,3',3'-d6 (CAS# 352431-53-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Azo Rubine is an synthetic red food dye and is used for the purposes where food is heat-treated after fermentation. Dyes and metabolites, Environmental Testing<br>References Abu, S., et al.: Sensor. Lett., 10, 894 (2012); Harp, B. P., et al.: Food. Add. Contamin., Chem. Anal. Control. Expo. Risk. Assess., 29, 886 (2012); Zohoori, S., et al.: Asian. J. Chem., 24. 1541 (2012);<br></p>

<p>Applications Solvent Red 25 (cas# 3176-79-2) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>