Biochemicals and Reagents

<p>Stability Hygroscopic<br>Applications Labelled N-Acetyl-S-(carbamoylethyl)-L-cysteine (A171870). N-Acetyl-S-(carbamoylethyl)-L-cysteine is the urinary metabolite of Acrylamide (AA). Acrylamide is formed during the heating of food and is classified as a genotoxic carcinogen.<br>References Besaratinia, A., et al.: Mutat. Res., 80, 31 (2005), Bjellaas, T., et al.: Xenobiotica, 35, 1003 (2005), Bjellaas, T., et al.: Food Chem. Toxicol., 45, 1020 (2007), Bjellaas, T., et al.: Toxicol. Sci., 98, 110 (2007),<br></p>

<p>Applications (+)-20-Hydroxyecdysone regulates gene transcription via a genomic pathway through a transcription complex that is formed.<br>References Liu, W. et al.: Endocrinol., 155, 1738 (2014); Wang, Q. et al.: Plant Physiol. Biochem., 84, 1 (2014);<br></p>

<p>Applications C20 Dihydroceramide (cas# 121459-06-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Biotinyl Tyramide is a Biotin (B389040) derivative, a growth factor present in minute amounts in every living cell. Plays an indispensable role in numerous naturally occurring carboxylation reactions. Occurs mainly bound to proteins or polypeptides. The richest sources are liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tumors is higher than that of normal tissue.<br>References Griesser, R. et al.: Biochem., 12, 1917 (1973); du Vigneaud, et al.: J. Biol. Chem., 146, 475 (1942); Traub, et al.: Nature, 178, 649 (1956); Siegel, H., et al.: Experienta, 37, 789 (1981); Vesely, D.L., Science, 216, 1329 (1982); Hugues, M., et al.: Biochemistry, 31, 12 (1992);<br></p>

<p>Applications A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPARγ with a Ki of 1 nM. Displays &gt;800-fold greater selectivity for PPARγ over PPARα and PPARδ (Ki = 0.85 µM and 1.8 µM, respectively). Blocks hormone- and agonist-induced adipogenesis in 3T3-L1 cells. It suppresses interactions between PPARγ and coactivator-derived peptides, while promotes the recruitment of corepressor-derived peptides. Shown to modulate the interaction of PPARγ2 with the cofactor proteins through covalent binding to Cys313 in its ligand-binding domain.<br>References Lee, G., et al: J. Biol. Chem., 277, 19649 (2003), Schaefer, K.L., et al: Cancer Res., 65, 2251 (2005), Masuda, T., et al.: Clin. Cancer Res., 11, 4012 (2005), Raikwar, H.P., et al.: J. Neuroimmunol., 167, 99 (2005)<br></p>

<p>Stability Light Sensitive<br>Applications A labelled vitamin precursor.<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications A constituent of certain mucopolysaccharides.<br>References Hoffman, P., et al.: Science, 124, 1252 (1956), Meyer, K: Biochim et Biophys. Acta, 21, 506 (1956), Cifonelli, J.A., et al.: Federation Proc., 16, 165 (1957), Cifonelli, J.A., et al.: J. Biol. Chem., 233, 541 (1958)<br></p>

<p>Applications Isoleucine-d10 (mixture of diastereomers) (CAS# 29909-02-2) is a useful isotopically labeled research compound and can be used in gas liquid chromatography.<br>References VandenHeuvel, W., et.al., J. Chromatogr., 50, 405-412, (1970);<br></p>

<p>Applications H-GAMMA-GLU-GLU-OH (cas# 1116-22-9) is a useful research chemical.<br></p>

<p>Applications Terbutaline is a beta-adrenoceptor agonist used to treat asthma and premature labor.<br>References O'Byrne, P. M., et al.: Trials, 18, 12 (2017); Vijftigschild, L. A. W., et al.: Eur. Respir. J., 48, 768 (2016); Fang, M., et al.: Xiandai Zhenduan Yu Zhiliao, 25, 4877 (2014)<br></p>

<p>Applications 2,3,5-Triiodobenzoic Acid is a polar auxin transport inhibitor that inhibits and promotes endoreduplication in hypocotyls and cotyledons.<br>References Tanaka, R., et al.: Plant Cell Rep., 35, 2539-2547 (2016)<br></p>

<p>Applications Disperse Diazo Black 3BF (cas# 6232-57-1) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications STANNOUS OCTOATE (cas# 301-10-0) is a useful research chemical.<br></p>

<p>Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.<br></p>

<p>Applications D-Serine Methyl Ester Hydrochloride (cas# 5874-57-7) is a compound useful in organic synthesis.<br></p>

<p>Applications D-LEUCYL-L-TYROSINE (cas# 3303-29-5) is a useful research chemical.<br></p>

<p>Applications Leucomalachite Green-​d6 is a labeled analog of leucomalachite green (LMG) (1173021-13-0), a major metabolite of malachite green (M110400). Dyes and metabolites, Environmental Testing.<br>References Mitrowska, Kamila., et al.: J. Chromatogr. A., 1089(1-2), 187 (2005),<br></p>

<p>Stability Moisture, Light Sensitive<br>Applications A fluorescent compound used for the rapid and selective modification of sulfhydryl groups of enzymes.<br>References Stauffer, D.A., and Karlin, A.: Biochemistry, 33, 6840 (1994), Yang, N. et al.: Neuron, 16, 113 (1996), Kuner, T. et al.: Neuron, 17, 343 (1996)<br></p>

<p>Applications Labelled (-)-Norgestrel, an emergency contraceptive. Levonorgestrel is safe, tolerated and effective in emergency contraception in woman.<br>References Fotherby, K., et al.: J. Steroid Biochem., 19(1C), 817 (1983), Stanczyk, F. Z., et al.: Contraception, 42, 67 (1990), Bednarek, P., et al.: Drugs, 67, 2478 (2007),<br></p>

<p>Applications Thymolphthalein Monophosphoric Acid Disodium Salt is a chromogenic substrate for the determination of acid phosphatase and alkaline phosphatase. It is a disodium salt form of Thymolphthalein Monophosphoric Acid which can be used as reactant/reagent in reaction of homodimer and heterodimer subunits of human prostate acid phosphatase.<br>References Lee, H., et al.: Biochem J, 277, 759 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Hydroxymethyl-2’-deoxyuridine acts as a biomarker for the diagnosis for oxidative stress in humans. Used as a diagnostic to for propensitiy for the development of breast cancer.<br>References McAnulty, L. et al.: App. Physiol. Nutr. Metab., 36, 976 (2011); Djuric Z. et al.: Cancer Epidemiol. Biomarkers. Prev., 10, 147 (2001); Frenkel, K. et al.: 7, 49, (1998);<br></p>

<p>Applications 4-Amino-nicotinonitrile<br></p>

<p>Stability Moisture Sensitive: Desiccate<br>Applications A heterobifunctional sulfhydryl cross-linking reagent.<br></p>

<p>Stability Light and Moisture Sensitive<br>Applications A cross-linking, biotin-labelled compound.<br>References Hatanaka, Y. et al: Bioorg. Med. Chem., 2, 1367 (1994); Hatanaka, Y. et al: J. Org. Chem., 59, 383 (1994); Hatanaka, Y. et al: Bioorg. Med. Chem. 2, 1367 (1994)<br></p>

<p>Applications Mineral Oil can be used as preferred lubricant for aerosol lubricant and dispensing method. An aerosol container containing a propellant and a highly hydrogenated mineral oil lubricant for the lubrication of gaskets in pipe segments.<br>References Green, R., et al.: U.S., US 7578372 B1 20090825 (2009)<br></p>

<p>Applications LG 100268 is a potent RXR agonist for evaluation in the treatment of non-insulin-dependent (type II) diabetes mellitus (NIDDM).<br>References Clyne, C., et al.: J. Biol. Chem., 277, 20591 (2002), Santen, R., et al.: J. Clin. Endocrinol. Metab., 87, 3007 (2002), Falender, A., et al.: Endocrinology, 144, 3598 (2003), Sablin, E., et al.: Mol. Cell., 11, 1575 (2003)<br></p>

<p>Applications Hexamoll is one of the new plasticizers being used, which shows a structure similar to the most commonly used o-phthalates. It is favoured to substitute DEHP by DINCH as plasticizer for flexible poly(vinyl chloride).<br>References Crespo, J., et al.: J. Appl. Polym. Sci.,104, 1215 (2007).<br></p>

<p>Applications MG-101 (ALLN) is a potent inhibitor of cysteine proteases including caplains and cathespins. Used in the treatment of genotoxic agents or replication stress of cells. Neuroprotective product.<br>References Wang, H. et al.: Biochem., 54, 5781 (2015); Fukunaga, Y. et al.: Neurosci. Res., 101, 6 (2014);<br></p>

<p>Applications N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.<br>References Saheki, T. et al.: J. Biochem., 77, 659 (1975); Rivas, J. et al.: Acta Biol. Med. Ger., 36, 1673 (1977); Zollner, H.: Biochim. Biophys. Acta, 676, 170 (1981);<br></p>

<p>Applications The deamination product of Guanosine. Potential biomarker for detecting radiation exposure. Used in the amplification of DNA isothermal strand displacement.<br>References Magasanik, B, et al.: J. Bio. Chem., 206, 83 (1954).<br></p>

<p>Applications Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver.<br>References Rotig, A., et al.: Lancet, 356, 391 (2000), Forsgren, M., et al.: Biochem. J., 382, 519 (2004), Johnson, A., et al.: J. Biol. Chem., 280, 31397 (2005), Horvath, R., et al.: Neurology, 66, 253 (2006), Mollet, M., et al.: J. Clin. Invest., 117, 765 (2007),<br></p>

<p>Applications A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.<br>References Niall, et al.: Proc. Natl. Acad. Sci., 71, 384 (1974); Dobnig,T., et al.: Endocrinol., 138, 4607 (1997); Manabe. et al.: Bone., 40, 1475 (2007);<br></p>

<p>Applications Secondary metabolite of Cholesterol.<br>References Notaro, G., et al.: J. Nat. Prod., 55, 1588 (1992), Aydogmus, Z., et al.: Nat. Prod. Res., 18, 43 (2004), Mao, S., et al.: J. Nat. Prod ., 69, 1209 (2006), Shoji, T., et al.: J. Agric. Food Chem., 54, 884 (2006),<br></p>

<p>Applications N6-(Hydroxymethyl)adenosine is an intermediate with modified ribonucleoside formed by chemical oxidation of N6-methyladenosine (M275895) mediated by bicarbonate-activated hydrogen peroxide. N6-(Hydroxymethyl)adenosine is also reported as active mutagen.<br>References Alderson, T.: Mutat. Res-Rev. Genet., 154, 101 (1985); Wu, J., et al.: Chem. Sci., 6, 3013 (2015);<br></p>

<p>Applications N6-​[Bis(ethylamino)​methylene]​-D-​lysine is an intermediate in preparation of analogs of transforming and epidermal growth factor fragment.<br>References Nestor, John J., et al.: U.S., (1987);<br></p>

<p>Applications Lucifer Yellow CH dipotassium salt is a highly fluorescent dye useful in marking nerve cells. It can also be utilized in technical or engineered material use in effect of swelling on multiple energy transfer in conjugated polymer nanoparticles.<br>References Groff, L. C., et al.: J Phys Chem, 121, 7549 (2017)<br></p>

<p>Applications A halogenated uridine derivative used in pharmaceutical compositions.<br>References Brammer, K., et al.: Biochim. Biophys. Acta, 72, 217 (1963), Uesugi, S., et al.: Chem. Pharm. Bull., 26, 3040 (1978)<br></p>

<p>Applications Trimedlure (cas# 12002-53-8) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications A nucleotide of nicotinic acid which is produced from quinolinic acid by quinolinate phosphoribosyltransferase via transfer of a phosphoribose group. It is an intermediate of nicotinic acid adenine dinucleotide (NaAD) which is then converted to NAD via amidation and in turn converted to NADPH.<br>References Petrelli, R. et al.: Curr. Med. Chem., 18, 1973 (2011); Shibata, K. et al.: J. Chrom. B Biomed. Sci. Appl., 749, 281 (2000); Evans, C. et al.: BMC Chem. Biol., 10, 2 (2010);<br></p>