Biochemicals and Reagents

<p>Applications 1-Methylpiperazine-2,2,3,3,5,5,6,6-d8 is the labeled version of 1-Methylpiperazine (Imatinib EP Impurity G)(M326495) is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug. It is a COVID19-related research product.Is used in preparation of Imidazopyridine compounds for the treatment of inflammatory disorders.<br>References Mallevais, M.L. et al.: Biochimie, 66, 477 (1984); Van der Plas, Steven E., et al.: PCT Int. Appl., (2019);<br></p>

<p>Applications Isodeoxycholic Acid is used for comprehensive bile acid profiling in hereditary intrahepatic cholestasis.<br>References Liu, T., et al.: Liver Int. 38, 1676 (2018)<br></p>

<p>Impurity Ursodeoxycholic Acid EP Impurity A<br>Applications Chenodeoxycholic Acid (Ursodeoxycholic Acid EP Impurity A) is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion. Facilitates fat absorption in the small intestine by micellar solubilization of fatty acids and monoglycerides. Anticholelithogenic. Epimeric with Ursodiol.<br>References Danzinger, et al.: N. Engl. J. Med., 286, 1 (1972), Iser, J.H., et al.: Drugs, 21, 90 (1981), Tint, G.S., et al.: Gastroenterology, 91, 1007 (1986),<br></p>

<p>Applications H-L-METHR-OH (cas# 2812-28-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Israel, et al.: J. Med. Chem., 7, 710 (1964), Janne, J., et al.: Biochim. Biophys. Acta, 473, 241 (1978). Theoharides, T.C., et al.: Life Sci., 27, 703 (1980), Horn, Y., et al.: Cancer Res., 42, 3248 (1982),<br></p>

<p>Applications Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neuburger, M., et al.: Eur. J. Biochem., 267, 2882 (2000), Krijt, J., et al.: Clin. Chem., 47, 1821 (2001), Yen, T.-Y., et al.: J. Mass Spectrom., 37, 15 (2002),<br></p>

<p>Applications A fluorinated DOPA analog.<br>References Leete, E., et al.: Phytochemistry, 10, 2687 (1971), Garnett, E., et al.: Nature, 305, 137 (1983),<br></p>

<p>Applications Davis Oxaziridine is an oxidizing agent used in the preparation of wide variety of pharmaceutical compounds.<br>References Davis, F. et al.: J. Org. Chem., 49, 3241 (1984); Cruz-Almanza, R. et al.: Tetrahed. Lett., 38, 183 (1997);<br></p>

<p>Applications Thioflavine S is a reagent also known as Direct Yellow 7; potentially useful as an amyloid plaque stain. Dyes and metabolites.<br></p>

<p>Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.<br></p>

<p>Applications 6-Methoxynicotinamide<br></p>

<p>Applications A biomarker of metabolic responses to hepatotoxicants and carcinogens.<br>References Broadhurst, D., et al.: Metabolomics, 2, 171 (2006), Shi, J., et al.: Nat. Biotechnol., 25, 930 (2007),<br></p>

<p>Applications Sodium Decyl Sulfate is emulsifier; used in preparation of super wear-resistant foamed Styrene Butadiene rubber.<br>References Zhou, J., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications A water soluble pH dependent bifunctional fluorogenic reagent for the sensitive and specific detection of protein thiols. ABD-F is highly reactive and specific for protein thiols, and its selectivity is superior to that of other sulfhydryl-reactive fluorophores such as fluorescein maleimide, 5-iodoacetamidofluorescein, 5-I-AEDANS, dansylaziridine, and bimane. Fluorescence: max Abs. l = 385nm, max Em. l = 520nm; Molar Abs. &gt; 4.5x103 (ca. 315nm)<br>References Hiratsuka., T.,: J. Biol. Chem., 268, 24742 (1993), Treuheit, M.J., et al.: Anal. Biochem., 212, 138 (1993), Takeda., S., et al.: Trans. Mater. Res. Soc. Jpn., 15A, 509 (1994), Tukushima, T., et al.: Biomed. Chromatogr., 9, 10 (1995), Takeda., S., et al.: J. Biochem., 117, 267 (1995)<br></p>

<p>Applications An enzyme inhibitor.<br></p>

<p>Applications 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin is a thiol-reactive fluorescent probe. 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM) is a thiol-reactive fluorescent probe. CPM selectively forms Michael adducts in the presence of hyperreactive sulfhydryls. CPM has been used to monitor the release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining. Dyes and metabolites.<br>References 1. Sippel, T.O. 1981. J. Histochem. Cytochem. 29: 1377-1381. PMID: 73204962. Liu, G., et al. 1994. J. Biol. Chem. 269: 33028-33034. PMID: 78065313. Liu, G., et al. 1994. Mol. Pharmacol. 45: 189-200. PMID: 81146704. Feng, W., et al. 1999. Mol. Pharmacol. 55: 821-831. PMID: 102205605. Han, M.S., et al. 2004. J. Org. Chem. 69: 2853-2855. PMID: 150749386. Ptak, C.P., et al. 2005. Biochemistry. 44: 62-71. PMID: 156288467. Khersonsky, O., et al. 2006. Chembiochem. 7: 49-53. PMID: 16329153<br></p>

<p>Applications Labelled Sudan I. A food azo-dye, a liver and urinary bladder carcinogen for rodents and a potent contact allergen and sensitizer for humans. Genotoxic and carcinogenic. Dyes and metabolites, Environmental Testing.<br>References Skog, K., et al.: Carcinogenesis, 14, 2027 (1993), Slob, W., et al.: Toxicol. Sci., 84, 167 (2005),,, Slob, W; Food and Chemical Toxicology 2006, 44, 933<br></p>

<p>Stability Hygroscopic<br>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications Magnolol is the bioactive phytochemicals found in Magnolia officinalis (1). Magnolol has been used to treat anxiety, cough, headache and allergies (2). It also inhibits tumor necrosis factor-α-*induced ICAM-1 expression in human lung epithelial cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Amorati, R., et al.: J Org Chem. (2015) 80:10651-9.(2) Wu, C., et. al.: Inflammation (2014) 37:1957-67<br></p>

<p>Applications Ethylmalonic Acid is used as a diagnostic agent used in the diagnosis of Ethylmalonic encephalopathy which is a rare autosomal recessive inborn error of metabolism.<br>References Baertling, F. et al.: Eur. J. Pediat., 173, 1719 (2014); Sudo, Y. et al.: Hu,am Genome Var., 1, 15016 (2014);<br></p>

<p>Applications N-Hydroxyl-tryptamine is used in plant growth regulator composition for improved efficacy. It is also used in compositions for use as chemical thinning agents.<br>References Williams, R., et al.: PCT Int. Appl. 57pp. (2010); Williams, R., et al.: U.S. Pat. Appl. Publ. (2012)<br></p>

<p>Applications tert-Butoxycarbonyl-D-proline is Boc protected D-proline (P755990). It is used to prepare trichostatin A and trapoxin B analogs as histone deacetylase inhibitors. It is also used to prepare potent and selective nonpeptide inhibitors of caspases 3 and 7.<br>References Jung, M., et al.: Bioorg. Med. Chem. Lett., 7, 1655 (1997); Lee, D., et al.: J. Med. Chem,, 44, 2015 (2001)<br></p>

<p>Applications Antibiotic substance belonging to the actinomycin complex, produced by several Streptomyces spp. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Manaker, et al.: Antibiot. Ann., 55, 853 (1954), Jain, S., et al.: J. Mol. Biol., 114, 317 (1977), Nakajima, K., et al.: Pept. Chem., 19, 143 (1981), Shereda, R., et al.: J. Biol. Chem., 282, 19247 (2007),<br></p>

<p>Applications Higenamine is a chemical compound found in a variety of plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, and Nelumbo nucifera<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications A cross-linking sulfhydryl spin label.<br>References Kalai, T., et al.: Synthesis, 6, 973 (1999)<br></p>

<p>Applications Used in treatment of seborrhoeic dermatitis includes topical treatments such as corticosteroids, antifungals, metronidazole and pimecrolimus.<br>References Miyachi, Y., et al.: Br. J. Dermatol., 114, 231 (1986), Rallis, E., et al.: Drugs Exp. Clin. Res., 30, 191 (2004), Ozcan, H., et al.: Eur. J. Dermatol., 17, 313 (2007),<br></p>

<p>Applications Plant hormone; natural steroid containing a seven-membered B-ring lactone, that promotes both cell elongation and cell devision. Over ten brossinosteroids have been isolated and characterized from sources such as pollen, seedling, leaf. Used as plant growth regulator.<br>References Grove, M.D., et al.: Nature, 281, 216 (1979), Schlagnhaufer, C., et al.: Physiol. Plant., 60, 347 (1984), Wada, K., et al.: Agric. Biol. Chem., 48, 719 (1984),<br></p>

<p>Applications o-Dianisidine (cas# 119-90-4) is a useful research chemical. Dyes and metabolites, Environmental Testing.<br></p>

<p>Applications Triglycol is used in a mixture with 2-amino-2-methyl-1-propanol in a CO2 absorption-regeneration process.<br>References Zheng, C., et. al.: Ind. Eng. Chem. Res., 51, 11236 (2012)<br></p>

<p>Applications N-Phenylpyrimidin-2-amine is used in preparation of Nitrogen-containing Heterocyclic Hexafluoroborate.<br>References Cui, Y., et al.: Faming Zhuanli Shenqing, (2019);<br></p>

<p>Applications (4-Hydroxyphenyl)glycine, is a key intermediate for the synthesis Cefpiramide (C243400), used as a β-lactam antibiotic.<br>References Xiao, R. Q., et al.: Guangzhou Huagong, 41, 111 (2013);<br></p>

<p>Applications A synthetic musk fragrance compound (polycyclic musk) used in personal care products, and can be found in the environment and the human body.<br>References Mori, T. et al.: Env. Sci., 14, 195 (2007); Int. J. Hygiene Env. Health, 123, 124 (2010); Yamauchi, R. et al.: Aquatic Toxic., 90, 261 (2008);<br></p>

<p>Applications Taurocholic Acid Sodium Salt Hydrate is a choleretic; Its sodium salt is a lipase accelerator. Also used as a method for the quantitation of conjugated bile acids in dried blood spots using electrospray ionization-mass spectrometry.<br>References Mills, K.A., et al.: Pedatric Res., 43, 3 (1998).<br></p>

<p>Applications Fluorescent label<br>References Forster, Y., et al.: Anal. Biochem., 209, 9 (1993),<br></p>

<p>Stability Hygroscopic<br>Applications Urolithin B is an intestinal microbial metabolite of ellagitannis and exhibits potent anti-oxidant and pro-oxidant activies depending on the assay system and conditions. Urolithin B can also display estrogenic and/or anti-estrogenic activity.<br>References Kallio, T., et al.: J. Agr. Food Chem., 61, 10720 (2013); Nealmongkol, P., et al.: Tetrahedron, 69, 9277 (2013); Larrosa, M., et al.: J. Agr. Food Chem., 54, 1611 (2006); Bialonska, D., et al.: J. Agr. Food Chem., 57, 10181 (2009)<br></p>

<p>Applications Disperse Yellow 3 is an azo disperse dye which is water insoluble. Disperse Yellow 3 can be used to dye polyester and acetate fibers. Dyes and metabolites, Environmental Testing.<br>References Nishida, K., et al.: J. Soc. Dyers Colour., 105, 112 (1989); Akkurt, F., et al.: Trends Chem. Eng., 11, 73 (2008)<br></p>

<p>Stability Moisture Sensitive<br>Applications Used in conjunction with Isothiocyanate to conduct partial Edman Degradation on biologically active peptides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Heidenreich, O., et al.: J. Biol. Chem., 269, 2131 (1994), Kothe, U., et al.: Anal. Biochem., 356, 148 (2006), Thakkar, A., et al.: Anal. Chem., 78, 5935 (2006),<br></p>

<p>Applications 1-Arachidoyl-sn-glycero-3-phosphocholine is a derivative of sn-Glycero-3-phosphocholine (G598700) and can be used as a biomarker in biological studies.<br>References Tang, C.,et al.: J. Chromatogr. B, 879, 2095 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications gamma-Polyglutamic acid - sodium salt (cas# 25513-46-6) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications An anthraquinone derivative that is a potent and selective protein kinase CK1 delta inhibitor. Studies suggest that it has potential solar cell applications. Used in studies as a potential competitive non-peptidic inhibitor of HIV-1 proteinase. Dyes and metabolites, Environmental Testing.<br>References Cozza, G. et al.: Bioorg. Med. Chem. Lett., 18, 5672 (2008); Brovelli, F. et al.: Polym. Bull., 58, 521 (2007); Brinkworth, R.I. et al.: Biochim. Biophys. Acta, Prot. Struct. Mol. Enzymol., 1253, 5 (1995);<br></p>

<p>Applications 2,5,5-trimethyl-1,3-dioxane (cas# 766-33-6) is a useful research chemical.<br></p>

<p>Applications A red glucosidal hydroxyanthrapurin, it is produced naturally within some insects as a defense mechanism. Dyes and metabolites, Environmental Testing.<br>References Enoch, S., et al.: Chem. Res. Toxicol., 23, 1547 (2010), Valianou, L., et al.: Anal. Bioanal. Chem., 396, 3115 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications 2,3,5-Triiodobenzoic Acid is a polar auxin transport inhibitor that inhibits and promotes endoreduplication in hypocotyls and cotyledons.<br>References Tanaka, R., et al.: Plant Cell Rep., 35, 2539-2547 (2016)<br></p>

<p>Applications Disperse Orange 37 is an orange azo dye used in plastics. Dyes and metabolites, Environmental Testing.<br>References Okada, Y. et al.: Color. Tech., 126, 127 (2010); Alicilar, A. et al.: Chin. J. Chem. Phys., 23, 368 (2010);<br></p>

<p>Applications Used for fragrance compositions and perfumes with long-lasting fragrance.<br>References Ternes, T., et al.: Sci. Total Environ., 225, 81 (1999), Simonich, S., et al.: Environ. Sci. Technol., 36, 2839 (2002) Metcalfe, C., et al.: Environ. Toxicol. Chem., 22, 2872 (2003),<br></p>

<p>Applications N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.<br>References Miura, G. et al.: Nat. Chem. Biol., 11, 903 (2015); Deng, X. et al.: Nucl. Acids Res., 43, 6557 (2015); Chem. and Eng. News, p.35, Feb. 18, 2019<br></p>