Cancer Research Antibodies

<p>LCH-7749944 suppresses human gastric cancer cell growth, induces apoptosis, and inhibits PAK4 with IC50 of 14.93 μM.</p>

<p>Rotenolone (12alpha-HYDROXYROTENONE) is a metabolite of Rotenone which is a natural compound derived from plants of the genera Derris and Lonchocarpus.</p>

<p>SIBA, a synthetic SAH analog, inhibits SAM-dependent transmethylation and blocks HSV-1 replication.</p>

<p>UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild</p>

<p>AZ1495: oral IRAK4 inhibitor (IC50: 5 nM), IRAK1 (23 nM), treats MYD88L265P DLBCL.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human PL. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human PL. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human PL, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human PL in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Mitoxantrone dihydrochloride (NSC-301739) is an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone is a type II topoisomerase inhibitor.</p>

<p>MRTX-1257: selective, irreversible KRAS G12C inhibitor; IC50 of 900 pM; 31% bioavailable in mice; 77% target engagement.</p>

<p>Oxiconazole nitrate (Ro 13-8996) is an antifungal imidazole inhibiting fungal growth by blocking ergosterol synthesis, disrupting cell membranes.</p>

<p>PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) is an orally active inhibitor of VEGFA mRNA</p>

<p>Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR).</p>

<p>Amcenestrant (SAR439859) is an orally active, nonsteroidal and selective degrader of estrogen receptor (SERD). SAR439859 is a potent antagonist of ER.</p>

<p>Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50</p>

<p>Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4</p>

<p>Vecuronium bromide (ORG NC 45) is a synthetic, intermediate-acting mono-quaternary steroid and non-depolarizing neuromuscular blocking agent, with muscle</p>

<p>RAMB4 (PTP1B-IN-9) is a ubiquitin-proteasome system (UPS)-stressor,with anticancer activity.</p>

<p>Niacin is a water-soluble B vitamin with antihyperlipidemic effects, found in food and converted to niacinamide for coenzyme activity.</p>

<p>Crolibulin (EPC2407) is an inhibitor of small molecule tubulin polymerization.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse TRF protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse TRF. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse TRF in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>Orally active SERM, Estrogen receptor modulator 1 (pIC50: 0.46), reverses Tamoxifen-resistant tumors.</p>

<p>Hematin (Ferrihemic acid) is an iron-containing porphyrin.</p>

<p>Inobrodib (CBP-IN-1) is a potent inhibitor of p300/CBP bromodomain.</p>

<p>Azilsartan (TAK-536) is an Angiotensin II Type 1 receptor antagonist that lowers blood pressure.</p>

<p>PHA-M, a lectin from red kidney beans, induces apoptosis by upping Bax protein and activating caspase-3; has anti-tumor effects.</p>

<p>Aspirin (Acetylsalicylic Acid) is a COX inhibitor. Aspirin has anti-inflammatory, antipyretic and analgesic activities. Cost-effective and quality-assured.</p>

Floxuridine (FUDR) is an antimetabolite, floxuridine inhibits thymidylate synthase, resulting in disruption of DNA synthesis and cytotoxicity.

<p>PXR antagonist 70: selective PXR blocker, IC50 = 540 nM, Ki = 390 nM, boosts cancer cell chemosensitivity.</p>

<p>Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor.</p>

<p>Metoprolol Tartrate is a blocker of the cardioselective β-adrenergic receptor.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse INHbB protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse INHbB. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse INHbB in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Human INHbA protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human INHbA. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human INHbA in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>TNIK-IN-5: strong TNIK inhibitor (IC50=0.05μM), halts Wnt signaling, effective against colorectal cancer in vitro.</p>

<p>CWP232228 is a selective Wnt/β-catenin pathway inhibitor targeting β-catenin/TCF binding, halting breast/liver CSC growth and metastasis safely.</p>

<p>The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human MRC1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human MRC1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human MRC1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human MRC1 in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>RUVBL1/2 ATPase-IN-1 inhibits RUVBL1/2 ATPase (IC50: 6.0/7.7 μM); useful in cancer research.</p>

<p>iFSP1, a potent, selective, and glutathione-independent ferroptosis suppressor protein 1 (FSP1) (AIFM2) inhibitor with an EC50 of 103 nM, sensitizes diverse</p>

<p>Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B</p>

<p>Gefitinib (ZD1839) is an EGFR first-generation inhibitor with oral activity that inhibits the EGFR 19 Del and L858R mutations.</p>

<p>Cyproterone acetate (Cyproterone 17-O-acetate) binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation in target tissues and</p>

<p>CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay).</p>

<p>Aliskiren hemifumarate (CGP60536B) is an orally active nonpeptide renin inhibitor with antihypertensive activity.</p>

<p>AR antagonist 1 is a potent antagonist of the androgen receptor.</p>

<p>Carboxyamidotriazole Orotate (L-651582 Orotate) is a cytostatic inhibitor of non-voltage-operated calcium channels and calcium channel-mediated signaling</p>

<p>MD-224 is a highly potent and efficacious MDM2 degrader based on the proteolysistargeting chimera (PROTAC) concept,and as a new class of anticancer agent.</p>

<p>L-Selenomethionine is a natural amino acid boosting cell growth and antioxidant enzyme levels.</p>

<p>Bosutinib (SKI-606) is a synthetic quinolone derivative and dual kinase inhibitor that targets both Abl (IC50: 1 nM) and Src (IC50: 1.2 nM) kinases.</p>

<p>L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant.</p>

<p>Lentinan, isolated and purified from a hot water extract of Lentinula edodes fruit bodies, is a fungal polysaccharide immunomodulator with anti-tumor effects.</p>

<p>Minocycline HCl: tetracycline antibiotic, treats bacterial infections and acne, may cause acute or chronic hepatitis.</p>

<p>Ibuprofen, an NSAID, reduces pain, inflammation, and fever by limiting prostaglandin production.</p>

<p>Isosulfan blue, a blue dye used in lymphangiography and sentinel node biopsies, may cause allergies.</p>

<p>Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Mouse PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>This assay employs the competitive inhibition enzyme immunoassay technique. The microtiter plate provided in this kit has been pre-coated with Rat PP protein. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat PP. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Rat PP in the samples is then determined by comparing the OD of the samples to the standard curve.</p>

<p>BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).</p>

<p>Bicalutamide (ICI-176334), a synthetic, nonsteroidal antiandrogen, competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the</p>

<p>Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.</p>

<p>Letrozole (CGS 20267) is an Aromatase Inhibitor. The mechanism of action of letrozole is as an Aromatase Inhibitor.</p>

<p>Dyclonine hydrochloride (Dyclonine HCl) , an over the counter throat lozenge, is found in Sucretswith local anesthetic effect .</p>

<p>L-2-Hydroxyglutaric acid disodium may affect epigenetics and contribute to renal cancer, inhibiting Mi-CK (Km 2.52 mM, Ki 11.13 mM).</p>

<p>Hexylresorcinol (4-Hexylresorcinol) is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.</p>

<p>Sulfisoxazole: a short-acting antibacterial targeting gram-positive/negative bacteria and inhibits breast cancer exosome by affecting endothelin receptor A.</p>

<p>Silodosin (KAD 3213) is an alpha-Adrenergic Blocker. The mechanism of action of silodosin is as an Adrenergic alpha-Antagonist.</p>

<p>AMG 487: potent CXCR3 antagonist, blocks CXCL10/CXCL11 binding, IC50s: 8.0/8.2 nM.</p>

<p>Azido-PEG10-alcohol is a PEG-based PROTAC linker that can be used in PROTAC synthesis[1].</p>

<p>4-Hydroxynonenal (4-HNE) (4-HNE) is an oxidative/nitrosative stress biomarker. It is a substrate and an inhibitor of acetaldehyde dehydrogenase 2 (ALDH2).</p>

<p>Phenoxybenzamine hydrochloride: non-selective, irreversible alpha-blocker; antihypertensive, vasodilator, may cause tachycardia, potential carcinogen.</p>

<p>Genistin (Genistoside) is the major isoflavonoid of soybeans and soy products.It has been reported to possess various therapeutic effects, including anti-</p>

<p>Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.</p>

<p>A unique collection of xnum histone modification related compounds for high throughput screening (HTS) and high content screening (HCS);</p>

<p>A unique collection of 1772 natural products with known anti-cancer activity for high throughput screening (HTS) and high content screening (HCS);</p>

<p>FAK-IN-7 has potential antiproliferative activity and is a FAK inhibitor.</p>

<p>Contains xnum active small molecules for research related to post-translational modifications (PTMs);</p>

<p>CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.</p>

<p>A unique collection of xnum mouse metabolites, which can be used for HTS and HCS;</p>

<p>KIF18A-IN-2 is an inhibitor of mitotic kinesin Kif18A with IC50 of 28 nM and can be used in studies about chromosomal instability-associated vulnerabilities.</p>

<p>xnum methylation-related compounds that can be used for high-throughput and high-content screening.</p>

<p>Befotertinib (D-0316) is an inhibitor of EGFR tyrosine kinase and can be used for studies about EGFR T790M-positive non-small cell lung cancer.</p>

<p>A collection of 79 phosphatase inhibitors with known activity;</p>

<p>A unique collection of 2238 pancreatic cancer related compounds can be used in HTS and HCS;</p>

<p>Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy.</p>

<p>A unique collection of xnum compounds targeting NF-κB signaling for high throughput screening and high content screening;</p>

Erythromycin (E-Mycin) is a Macrolide and Macrolide Antimicrobial. The physiologic effect of erythromycin is by means of Decreased Sebaceous Gland Activity.

<p>IPI-9119 is an orally active, selective and irreversible FASN inhibitor (IC50 = 0.3 nM).</p>

<p>MST-312, a telomerase inhibitor derived from green tea's EGCG, has research potential in cancer, including MM.</p>

<p>A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;</p>

<p>Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) exhibits antidiabetic, anti-inflammatory and antitumor activities.</p>

<p>xnum types of active small molecules associated with pyroptosis for high-throughput and high-content screening.</p>

<p>Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.</p>

<p>A unique collection of xnum promising or approved mitochondria-targeted compounds including Idebenone, the only approved drug targeting mitochondria, for</p>

<p>A unique collection of 1336 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；</p>

<p>A unique collection of 1760 apoptosis-related compounds for apoptosis research, research in tumorigenesis, and anti-cancer drug screening;</p>

<p>A unique collection of 492 compounds targeting lipid metabolism, can be used for high-throughput screening (HTS) and high-content screening (HCS).</p>

<p>A unique collection of 193 endoplasmic reticulum stress (ER stress) related compounds used for high throughput screening (HTS) and high content screening (HCS);</p>

<p>A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-</p>

<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50&lt;1 μM).</p>

<p>Well-chosen 953 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new</p>

<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>

<p>3',4'-Dimethoxyflavone is a standard compound of flavonoids with numerous medicinal activities.</p>

<p>NMS-E973 is a potent and selective Hsp90 inhibitor with DC50 of &lt;10 nM for Hsp90 binding, no activiy against a panel of 52 diverse protein kinases.</p>

<p>Antiproliferative agent-13 is a compound with antiproliferative activity.</p>

<p>A unique collection of xnum glutamine metabolism related compounds can be used for high throughput screening (HTS) and high content screening (HCS), and also is</p>

<p>A unique collection of xnum GPCR-active agents for high throughput screening and high content screening for GPCR drug discovery, and new GPCR target</p>

<p>A unique collection of 365 compounds targeting MAPK signaling for drug discovery in MAPK related diseases;</p>

<p>CS1: BODIPY-based sensor detects Cu+ selectively in bio samples; visible via all fluorescence microscopes.</p>

<p>Mouse Anti Glutathione-S-transferase (GST)</p>