Cancer Research Antibodies

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Human EGF. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Human EGF. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Human EGF, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Human EGF. You can calculate the concentration of Human EGF in the samples by comparing the OD of the samples to the standard curve.

This ELISA kit uses the Sandwich-ELISA principle. The micro ELISA plate provided in this kit has been pre-coated with an antibody specific to Mouse IL-12 p40. Samples (or Standards) are added to the micro ELISA plate wells and combined with the specific antibody and biotinylated detection antibody specific for Mouse IL-12 p40. Then Avidin-Horseradish Peroxidase (HRP) conjugate are added successively to each micro plate well and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain Mouse IL-12 p40, biotinylated detection antibody and Avidin-HRP conjugate will appear blue in color. The enzyme-substrate reaction is terminated by the addition of stop solution and the color turns yellow. The optical density (OD) is measured spectrophotometrically at a wavelength of 450 nm. The OD value is proportional to the concentration of Mouse IL-12 p40. You can calculate the concentration of Mouse IL-12 p40 in the samples by comparing the OD of the samples to the standard curve.

<p>Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.</p>

<p>UUN44923: FTO inhibitor, potential treatment for obesity, MS, T2D, Alzheimer's, various cancers.</p>

<p>VY-3-135 is an orally active, stable and specific acetyl-CoA synthetase 2 (ACSS2) inhibitor.Cost-effective and quality-assured.</p>

<p>Alloxazine (Isoalloxazine) is an A2 receptor antagonist, which is approximately 10-fold more selective for the A2B receptor than for the A2A receptor.</p>

<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>

<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>

<p>Astaxanthin, a keto-carotenoid and xanthophyll, offers antioxidant benefits, present in red aquatic species, and used as a colorant in animal feed.</p>

<p>Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor.</p>

<p>ZCL278 is a selective Cdc42 GTPase inhibitor.</p>

<p>Pinoresinol ((+)-Pinoresinol) has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury</p>

<p>ARV-471 (Vepdegestrant) is a orally active Cereblon -based estrogen receptor (ER) PROTAC degrader. ARV-471 is developed for the research of breast cancer.</p>

<p>Pitstop2 is an amphipathic protein-bound inhibitor of the clathrin terminal domain. Pitstop2 has antitumor activity. Cost-effective, quality assurance.</p>

<p>ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity</p>

<p>SKF-96365 hydrochloride (SKF96365) , a SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y</p>

Niraparib (MK-4827), a PARP inhibitor, boosts DNA breaks to trigger genomic instability and apoptosis, offering anti-cancer effects.

<p>L189 is a human DNA ligase inhibitor, inhibits hLigI/III/IV (IC50: 5/9/5 μM).</p>

<p>GNF-5, non-ATP Bcr-Abl inhibitor (IC50: 0.22±0.1 uM, wild-type), improves upon GNF-2 with better pharmacokinetics.</p>

<p>Xevinapant (Debio-1143) is a potent Smac mimetic and an antagonist of IAP, binding to XIAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3.</p>

<p>M2N12 selectively inhibits Cdc25C (IC50=0.09μM) and has anti-tumor properties, affecting Cdc25A and B as well.</p>

<p>Hamamelitannin, from Hamamelis virginiana bark, is cytotoxic, disrupts biofilms, enhances antibiotic effectiveness, and protects cells from peroxide damage.</p>

<p>UNC2025 (mrx-6313)(IC50 of 0.74 nM and 0.8 nM) is a potent and orally bioavailable dual MER/FLT3 inhibitor.</p>

<p>Buformin hydrochloride, an oral biguanide antidiabetic, activates AMPK, enhances insulin sensitivity, and inhibits hepatic glucose production.</p>

<p>FLTX1, a Tamoxifen derivative, fluoresces to mark estrogen receptors and acts as a strong antiestrogen in breast cancer without affecting the uterus.</p>

<p>CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity</p>

<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>

<p>NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.</p>

<p>SC-236 (Sc 236) is an orally active and selective inhibitor of COX-2 (IC50 of 0.005 μM and 17.8 μM for COX-2 and COX-1, respectively).</p>

<p>RGX-202 (β-GPA) is an orally active inhibitor of the SLC6A8 transport protein. RGX-202 is a creatine analog that alters skeletal muscle energy expenditure.</p>

<p>Desmethylanethol trithione (ADT-OH), a synthetic H2S donor, modulates tPA effects, reduces stroke damage, and improves recovery in mice.</p>

<p>Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51.</p>

<p>MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.</p>

<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>

<p>Rasarfin inhibits Ras and ARF6.</p>

<p>MTOB, a CtBP substrate, inhibits CtBP-linked cancer activity in cells/mice and regulates TCF-4, affecting CSC proliferation.</p>

<p>Cyasterone (Cyasteron), a natural EGFR inhibitor, can inhibit the growth of A549 and MGC823 cells, via regulating EGFR signaling pathway, it may be a promising</p>

<p>AG-270 is an allosteric and orally active inhibitor of MAT2A.</p>

<p>View and buy STM2457 from TargetMol.STM2457 is a first-in-class, highly potent, selective and orally active inhibitor of METTL3.Cited in 2 publications.</p>

<p>1. Liensinine, a kind of isoquinoline alkaloid, can antagonize the ventricular arrhythmias.</p>

<p>Elacridar (GG918) is a potent inhibitor of P-glycoprotein and BCRP.Cost-effective and quality-assured.</p>

<p>O6-Benzylguanine is a guanine analog with antineoplastic activity,and is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.</p>

<p>FR054 inhibits PGM3, a key enzyme in the HBP, significantly reducing breast cancer cell growth and survival.</p>

<p>TL-895 is a potent, selective ATP-competitive BTK inhibitor (IC50 = 1.5 nM, Ki = 11.9 nM).</p>

<p>ML141 (CID-2950007) is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).</p>

<p>Ganoderic acid D, a Ganoderma component, inhibits HeLa cell growth with an IC50 of 17.3µM after 48h.</p>

<p>Rhapontin may reduce liver fat and better blood sugar/lipids, showing potential for treating type 2 diabetes.</p>

<p>ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.</p>

<p>(E/Z)-Zotiraciclib ((E/Z)-TG02) inhibits CDK2, JAK2, and FLT3 effectively with IC50s of 13, 73, and 56 nM, respectively.</p>

<p>Tetramethylcurcumin is a novel curcumin analog, is an effective inhibitors of STAT3 phosphorylation, DNA binding activity, and transactivation in vitro.it also</p>

<p>Obtusifolin is an antioxidant that combats diabetes, bone-resorption, diabetic retinopathy, pain, and cognitive decline.</p>

<p>Addition of the Rhamnose (6-Deoxy-L-mannose)-rich polysaccharide, RROP-1, to normal human dermal fibroblasts (NHDFs) and human endothelial cells produced a dose</p>

<p>Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).</p>

<p>PIK-75, a DNA-PK and PI3K inhibitor, suppresses DNA-PK(IC50=2 nM), p110α(IC50=5.8 nM) and p110γ(IC50=76 nM).</p>

<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>

<p>Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.</p>

<p>Glumetinib (SCC244) (SCC 244) is a novel potent and selective inhibitor of c-Met kinase (IC50: 0.42 nM).</p>

<p>WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)</p>

<p>NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-</p>

<p>HUHS015 is a potent PCA-1/ALKBH3 inhibitor.</p>

<p>MSX-130 is CXCR4 Antagonist.</p>

<p>Methyl caffeate (Methyl caffeate acid) acid</p>

<p>MSX-127 elicites positive response in peptide CXCR4.</p>

<p>Rosiglitazone hydrochloride (BRL-49653 HCl) is a blood glucose-lowering drugs, stimulating insulin secretion by binding to the PPAR receptors in fat cells.</p>

<p>(6R)-FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect.</p>

<p>Pellitorine (Pellitorin) is an extract of Tetradium daniellii, and acts as a TRPV1 antagonist.</p>

<p>Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (</p>

<p>Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).</p>

<p>J-14, a reversible sulfiredoxin inhibitor (IC50: 8.1 μM), triggers oxidative stress and cancer cell death.</p>

<p>PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].</p>

<p>Talazoparib (LT-673) is a new-type PARP inhibitor (IC50: 0.58 nM), It similarly binds to PARP1/2 (Kis: 1.2/0.85 nM).</p>

<p>LP-261 is a novel tubulin targeting anticancer agent that binds at the colchicine site on tubulin, inducing G2/M arrest.</p>

<p>Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit</p>

<p>Barasertib-HQPA (AZD2811) is a highly selective Aurora B inhibitor (IC50: 0.37 nM) and demonstrates ~3,700-fold greater selectivity than Aurora A.</p>

<p>Aucubin (Rhinanthin) is an iridoid glycoside with anti-inflammatory, anti-microbial, anti-algesic as well as anti-tumor activities.</p>

<p>NPD8733 is an inhibitor of cancer cell-enhanced fibroblast migration. It specifically binds to valosin-containing protein (VCP)/p97.</p>

<p>Supinoxin (RX-5902) is an oral anti-cancer drug targeting p68 RNA helicase, inducing apoptosis in TNBC cells (IC50: 10-20nM).</p>

<p>Songorine (Napellonine) shows anti-tumor activity in preliminary pharmacological verification trials including cell proliferation and molecular docking assays.</p>

<p>AKR1C3-IN-4: potent, selective AKR1C3 inhibitor, IC50 = 0.56 μM, potential for CRPC research.</p>

<p>BRD4 Inhibitor-24 is a BRD4 small molecule inhibitor with antitumor activity.</p>

<p>NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway</p>

<p>Alflutinib (ASK120067) is an inhibitor of EGFR, and its targets including EGFR activating mutations and T790M, thus leading to tumor growth inhibition.</p>

<p>Benzyl butyl phthalate (1,2-benzenedicarboxylic acid) is used as a plasticizer for PVC.</p>

<p>Palbociclib is an oral CDK4/6 inhibitor, halts Rb phosphorylation, arrests cell cycle, and curbs tumor growth.</p>

<p>DCLK1-IN-1 is a selective, in vivo compatible chemical probe of the kinase domain of doublecortin-like kinase 1 (DCLK1).Cost-effective and quality-assured.</p>

<p>Millepachine is a natural product found in the Chinese herbal medicine with strong antitumor effects against numerous human cancer cells.</p>

<p>TRPM4-IN-1 (4-chloro-2-(2-(2-chlorophenoxy)acetamido)benzoic acid) is a potent and selective inhibitor of TRPM4 with an IC50 of 1.5 μM.</p>

<p>Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) is a substrate for affinity chromatography of heme-binding proteins.</p>

<p>AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).</p>

<p>PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).</p>

<p>Leptomycin B: potent CRM1 inhibitor, blocks protein nuclear export and cell cycle, antifungal, modifies cysteine.</p>

<p>Denosumab is a monoclonal antibody given subcutaneously that inhibits osteoclast activity by targeting the RANK ligand</p>

<p>Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) &amp; EZH1 (IC50: 392 nM).</p>

<p>Almonertinib (HS-10296) is an inhibitor of EGFR activation mutation and tolerant mutation of EGFR T790M, which has only limited activity against wild-type EGFR.</p>

<p>Acetylalkannin (Alkannin acetate), an isohexenylnaphthazarin pigment extracted from Arnebia euchroma, exhibits antimicrobial and cytotoxic properties.</p>

<p>Galloflavin is a lactate dehydrogenase inhibitor. Galloflavin inhibits both human LDH isoforms (type A and type B).Cost-effective and quality-assured.</p>

<p>MAT2A Inhibitor 4 acts as an inhibitor targeting the catalytic subunit of methionine S-adenosyltransferase-2 (MAT2A), offering potential utility in cancer</p>

<p>AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.</p>

<p>Ketorolac (Acuvail) is an NSAID that blocks prostaglandin synthesis, related to heterocyclic acetic acids.</p>

<p>Nirogacestat (PF 03084014) is a specific γ-secretase inhibitor (IC50: 6.2 nM, in a cell-free assay).</p>

<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>