Heterocycles with Nitrogen (N)

<p>Stability Moisture Sensitive<br>Applications Contains approximately 12% dichloromethane and 8% ethyl acetate<br></p>

<p>Applications 2,5-Di-4-pyridinylpyrazine is a compound used in the preparation of isonicotonic acid derivatives used in the chemotherapy of tuberculosis.<br>References Cymerman-Craig, J., et al.: J Chem Soc., 4315-20 (1955);<br></p>

<p>Applications 1-(pyrimidin-4-yl)piperidine-4-carboxylic acid hydrochloride (cas# 179051-38-8) is a useful research chemical.<br></p>

<p>Applications 2-(3-chlorophenyl)pyrimidine-4-carboxylic acid (cas# 1216604-60-2) is a useful research chemical.<br></p>

<p>Applications 1-(p-Toluenesulfonyl)imidazole 99% (cas# 2232-08-8) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-2-iodopyridine (cas# 129034-38-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(2-bromophenyl)piperazine (cas# 1011-13-8) is a useful research chemical.<br></p>

<p>Applications 3-(2,5-Dioxo-2,5-Dihydro-1h-Pyrrol-1-yl)benzoic Acid (cas# 17057-07-7) is a useful research chemical.<br></p>

<p>Applications 1-(3-Chloro-2-hydroxypropyl)-3,5-bis(2-oxiranylmethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione-d15 is an intermediate for the synthesis of Triglycidyl Isocyanurate-d15 (T793817). Isotope labelled Triglycidyl isocyanurate is a reagent used in the synthesis of N-Benzyl Metaxalone (B285000), which is a muscle relaxant used to relax muscles and relieve pain.<br>References Toth, P.E., et al.: Clin. Ther., 26, 1355 (2004)<br></p>

<p>Applications Used in the preparation of 2-naphthyl substituted diarylpyrimidines (DAPY) analogues.<br>References Gu, S. et al.; Bioorg. Med. Chem. 19, 5117 (2011)<br></p>

<p>Applications A useful synthetic intermediate.<br></p>

<p>Applications 3-Bromo-6-ethynylpyridazine (cas# 1797130-79-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Intermediate in the preparation of Pioglitazone (P471000) impurities.<br>References Kitajima, H., et al.: Bioorg. Med. Chem. Lett., 10, 2453 (2000), Radhakrishna, T., et al.: J. Pharm. Biomed. Anal., 29, 593 (2002),<br></p>

<p>Applications 4-Chloro-2-(trifluoromethoxy)pyrimidine (cas# 1261494-46-5) is a compound useful in organic synthesis.<br></p>

<p>Applications N-[2-(Phenylthio)phenyl]-1-piperazine-d8-carboxamide Hydrochloride is the labeled analog of N-[2-(Phenylthio)phenyl]-1-piperazinecarboxamide Hydrochloride, an impurity of Quetiapine (Q510000), a benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties; used as an antipsychotic.<br>References Stolarczyk, E.U., et. al.: Pharm. Develp. Tech., 14, 27 (2009); Wetzel, H., et al.: Psychopharmacology, 119, 231 (1995)<br></p>

<p>Applications 2,2'-Bipyridine-4,4'-dicarboxylic acid<br></p>

<p>Applications ethyl 4,5,6,7-tetrahydrobenzo[d]isoxazole-3-carboxylate (cas# 1013-14-5) is a useful research chemical.<br></p>

<p>Applications 1-Pyridin-3-yl-piperazine Hydrochloride is a reactant used in discovery of N-aryl Piperazines as selective mGluR5 potentiators. It was also used in the synthesis of piperazine-pyridazinone derivatives that have binding affinity toward α1-, α2-adrenergic and 5-HT1A receptors.<br>References Betti, L., et al.: Bioorg. Med. Chem., 14, 2828 (2006); Zhou, Y., et al.: ACS Med. Chem. Lett., 1, 433 (2010);<br></p>

<p>Applications (4-Bromo-1h-pyrazol-1-yl)acetic acid<br></p>

<p>Applications Methyl 4-[(Pyridine-3-carbonylamino)methyl]benzoate (CAS# 554407-47-5) may be a derivative of 4-​[[(3-​Quinolinylcarbonyl)​amino]​methyl]​-​benzoic Acid Methyl Ester (CAS# 591217-99-1), which is an antitumor agent.<br>References Maeda, T., et al.: Bioorg. Med. Chem., 12, 4351 (2004)<br></p>

<p>Applications 5-Cyano-1-methylbenzoimidazole<br></p>

<p>Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1H-1,2,4-Triazole-3-carboxylic acid, 1-ethyl-, methyl ester (cas# 1034197-43-7) is a useful research chemical.<br></p>

<p>Applications 2-Amino-3-hydroxypyridine (cas# 16867-03-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl (αS)-α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxothieno[3,2-c]pyridine-5(4H)-acetate is the essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>

<p>Applications 4-BROMO-2-PYRIDINECARBOXAMIDE (cas# 62150-46-3) is a useful research chemical.<br></p>

<p>Applications (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate is used in the preparation of indole-derivative serotoninergic receptor agonists.<br></p>

<p>Applications 2,4-Diamino-6-hydroxypyrimidine-15N3 (cas# 1638736-04-5) is a compound useful in organic synthesis.<br></p>

<p>Applications dimethyl 4-hydroxy-1H-pyrazole-3,5-dicarboxylate (cas# 23705-85-3) is a useful research chemical.<br></p>

<p>Applications 6-Amino-5-formylpyridine-3-carbonitrile is a useful research reagent<br>References Babaev, E.V., et al.: J. Am. Chem. Soc., 115, 2416 (1993)<br></p>

<p>Stability Light Sensitive<br>Applications 4-(1-Naphthylvinyl)pyridine (cas# 16375-56-7) is a useful research chemical.<br></p>

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol-d3 is the isotope labelled analog of α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol (D473780); a reagent in the synthesis of Medetomidine (M203250) which is an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications A useful synthetic intermediate<br></p>

<p>Applications 5-Methoxyoxazole-2-carboxylic Acid Methyl Ester,is a oxazole-containing compound, that can be extensively used in medicinal chemistry. The oxazole group is a key element of a number of biologically active natural products.<br>References Thalhammer, A., et al.: Tetrahedron Lett., 50, 1045 (2009);<br></p>

<p>Applications 4-(2-Oxopyrrolidin-1-yl)butanoic acid (cas# 6739-80-6) is a useful research chemical.<br></p>

<p>Applications 2,3-Diamino-4-chloropyridine<br></p>

<p>Applications 5-Hydroxy-3H-imidazole-4-carboxamide (cas# 56973-26-3) is a compound useful in organic synthesis.<br></p>

<p>Applications N-1H-Imidazol-2-yl-formamide is used as a reagent in the synthesis of N-pyridinyl-2-[(thienylcarbonyl)amino]benzamides and its analogs as anticoagulants.<br>References Arnaiz, D.O., et al.: U.S. US 6140351 A 20001031. Oct 31, 2000<br></p>

<p>Applications (4S3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl)amino][4-[(trimethylsilyl)oxy]phenyl]methyl]-1-oxo-5-[(trimethylsilyl)oxy]pentyl]-4-phenyl-2-oxazolidinone is used in the synthesis of Ezetimibe (E975000), an antihyperlipoproteinemic; a cholesterol absorption inhibitor.<br>References Bankowski, K., et. al.: Przemysl Chemiczny, 91, 289 (2012); van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997); van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications Pyrrole-d5 (CAS# 18430-85-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-benzenamine is one of the key reactants with N-[1-(4-Aminophenyl)-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide used in the synthesis of a pyrrolo[3,2-c]pyridine derivative [N-[1-[4-[[[[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]-1H-pyrrolo[3,2-c]pyridin-4-yl]benzamide (I)], an anticancer diarylurea derivative with multiple-kinase inhibitory effect; Also, it is an intermediate used in the synthesis of N-[4-[(4-Ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-N'-[4-[[6-(methylamino)-4-pyrimidinyl]oxy]phenyl]urea (E926495), which is an inhibitor of RET, FLT3, KDR, c-Abl and c-Kit. Also, it prevent the growth of human thyroid cancer cells.<br>References El-Gamal, M. I., et al.: Bull. Korean Chem. Soc., 33, 1571-1576 (2012); Weisberg, E., et al.: Genes Cancer, 1, 1021-1032 (2010);<br></p>

<p>Applications 4-Amino-1,5-dimethylpyrazole is used in the preparation of pyridine compounds as focal adhesion kinase inhibitors.<br></p>

<p>Applications tert-Butyl 2-cyanopiperazine-1-carboxylate (cas# 1053656-76-0) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of various enzymatic inhibitors<br>References Poeckel, D., et al.: Mol. Pharmacol., 70, 1071 (2006), Wigle, T., et al.: Bioorg. Med. Chem. Lett., 17, 3249 (2007),<br></p>

<p>Applications An intermediate in the production of labelled Enrofloxacin.<br>References Chao, Q., et al.: J. Med. Chem., 52, 7808 (2009), Bebbington, D., et al.: Bioorg. Med. Chem. Lett., 19, 3586 (2009),<br></p>

<p>Applications (±)-N-(2,6-Dimethylphenyl)-1-iso-propyl-d7-2-piperidinecarboxamide (CAS# 1276197-11-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Piperidinemethanol, is a building block that can be used for the synthesis of selective inhibitors of sphingosine kinase 1 (SK1), that may serve as therapeutic agents for proliferative diseases, including hypertension.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baek, D., et al.: Chem.l Commun., 49, 2136 (2013);<br></p>

<p>Applications 5-Pyrimidinemethanamine (cas# 25198-95-2) is a compound useful in organic synthesis.<br></p>

<p>Applications methyl 1-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyrazole-5-carboxylate (cas# 929899-20-7) is a useful research chemical.<br></p>

<p>Applications 5-Hydroxy-N-methyl-2-pyrrolidinone-d3 is an isotopically labelled analogue of the metabolite of N-methylpyrrolidone (NMP, M326120).<br>References Payan, J., et al.: Drug Metab. Dispos., 30, 1418 (2002), Carnerup, M., et al.: Food Chem. Toxicol., 43, 1441 (2005), Angerer, J., et al.: Toxicol. Sci., 93, 3 (2006),<br></p>

<p>Applications Pyrrole-2-carboxylic Acid is a reagent used in the synthesis of potent small molecule inhibitors of severe acute respiratory syndrome (SARS) coronavirus. Also used in the synthesis of [2,3-c]pyridine-7-one scaffolds.<br>References Jacobs, J. et al.: 56, 534 (2013); Nechayev, M. et al.: Mol. Div., 16, 749 (2012);<br></p>

<p>Applications 4-(Dimethylamino)pyridin-1-ium ((2-Nitrophenyl)sulfonyl)(phenoxycarbonyl)amide is an intermediate used in the synthesis of Monosulfuron (M567185), which is a sulfonylurea herbicide that inhibits Acetohydroxyacid synthase enzyme.<br>References Wang, J., et al.: J. Comput. Aided Mol. Des., 19, 801 (2005);<br></p>

<p>Applications 5-(Difluoromethyl)-1h-pyrazol-3-amine<br></p>

<p>Applications Pyrazinoic Acid Ethyl Ester (cas# 6924-68-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-phenyl-1H-pyrrole-2-carboxylic acid (cas# 802052-63-7) is a useful research chemical.<br></p>

<p>Applications N-(Benzoyl)piperazine-2,2,3,3,5,5,6,6-d8 (CAS# 1219805-49-8) is a useful isotopically labeled research compound.<br></p>