Building Blocks

<p>Versatile small molecule scaffold</p>

<p>4-Bromo-2-methylbenzene-1-thiol is a chemical compound that is not found in nature. It can be accessed via the etoricoxib reaction with 4,4'-biphenylsulfonyl chloride in the presence of sodium hydroxide. The compound has anisotropic properties and its magnetic resonance data show methyl sulfonyl groups with Covid-19 at 3.3 ppm and Covid-19 Pandemic at 5.8 ppm as well as intermediates at 2.6 and 2.8 ppm. It also shows resonance peaks for an element at 8.0 ppm and diamagnetic properties at 1.5ppm.</p>

<p>4-Bromo-3-methyl-benzenethiol is an experimental compound that belongs to the class of fluorine compounds. It has a molecular weight of 221.8 and a chemical formula of C6H5BrSCH2. 4-Bromo-3-methyl-benzenethiol contains a methoxy substituent, which is located on the central carbon atom. This compound also contains two bromine atoms, which are located on either side of the central sulfur atom. 4-Bromo-3-methyl-benzenethiol has been shown to have sulfhydryl group in its structure, and can form couplings with other molecules through this group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Hydroxy-cyclohexyl)-acetic acid (1HCAA) is a polystyrene-based monomer that is used in the production of polymers such as vinyl ethers. 1HCAA has been shown to undergo mechanistic reactions with solvents and alkali metal chlorides, which are both required for its synthesis. The 1HCAA molecule can react with water molecules and form monocarboxylic acids, carboxylic acids, or recemic products. 1HCAA also catalyzes cross-linking reactions when it reacts with an oxidizing agent such as iodine.</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Diamidino-benzene dihydrochloride (DABD) is a synthetic, crystalline organic compound that is insoluble in water. This chemical compound has been shown to be a reactive electron donor towards carbamazepine and its derivatives. DABD has also been immobilized on an electrode surface for use as a stable and sustainable electrode material. The immobilization of DABD on an electrode surface was done by covalently binding the DABD molecule to the surface with triazine molecules by covalent bonds. This process resulted in a stable and functional electrode material that can be used for up to 12 hours.</p>

<p>Prop-2-ene-1-sulfonyl chloride is an organic compound that is used as a pharmaceutical intermediate. It has been shown to have potent inhibitory activity against pancreatic lipase, which makes it a potential treatment for inflammatory diseases such as arthritis. The active form of prop-2-ene-1-sulfonyl chloride binds to the receptor site of the molecule and prevents it from binding with other molecules, thereby blocking the inflammatory response. Prop-2-ene-1-sulfonyl chloride also binds to cholesterol esters in cells and prevents them from being transferred. This inhibits cholesterol production and reduces inflammation caused by high levels of cholesterol.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl-(4-methoxy-benzyl)-amine is a chemical compound that has the molecular formula CHNO. It is an organic compound with a nitrate group, which are common in esters and phenolates. This compound can be synthesized by debenzylating benzyl amines and reacting them with nitric acid. Benzyl-(4-methoxy-benzyl)-amine may also be prepared by reacting benzaldehyde with ammonium hydroxide or ammonia gas. The synthesis of this compound is chemoselective, meaning it only reacts at one point on the molecule, rather than two. Benzyl-(4-methoxy-benzyl)-amine is used as a precursor to other compounds such as ammonium nitrate, esters, phenolates, and amides.</p>

<p>2-(4-Chloro-2-formylphenoxy)acetic acid is a chemical compound that is found in microalgae. The compound has been shown to inhibit the growth of bacteria by binding to glucose transporters and inhibiting their ability to absorb glucose. This process leads to a decrease in ATP levels, energy depletion, and cell death. In addition, this compound has been shown to have trophic effects on microalgae. This compound also inhibits the expression of malic enzyme genes and ammonium transporter genes in bacteria. 2-(4-Chloro-2-formylphenoxy)acetic acid is a steerable molecule that can be used for sectioning biological material with ultrafast lasers due to its high fluorescence.</p>

<p>2-{[2-({2-[(2-Hydroxyethyl)sulfanyl]ethyl}sulfanyl)ethyl]sulfanyl}ethan-1-ol is a polymer with a heterocyclic ring that is soluble in organic solvents. It has been used as an activator, coactivator and/or stabilizer for the thermal treatment of inorganic acids to produce imidazolines and halogens. 2-{[2-({2-[(2-Hydroxyethyl)sulfanyl]ethyl}sulfanyl)ethyl]sulfanyl}ethan-1-ol has been shown to be effective in the production of polymeric materials with good stability and low volatility.</p>

<p>3-Propoxypyridine-2-carboxylic acid is a benzene ring containing piperidine with a carboxamide substituent. It has shown to be selective for human eosinophils, and is an antagonist at the benzodiazepine site of GABAA receptors. 3-Propoxypyridine-2-carboxylic acid can also be derivatized to form a potent antagonist of benzodiazepine sites on GABAA receptors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Benzyl propiolate is a molecule that is structurally related to propiolic acid. It has been shown to act as an adrenergic receptor agonist, which leads to platelet aggregation and thrombocytopenia. Benzyl propiolate also forms methyl esters with alcohols and is synthesized by methyl esterification of benzyl alcohol and propionic acid. This compound is electron deficient, which allows it to react with electron-rich substances, such as thromboplastin in the reaction solution for heparin-induced thrombocytopenia.</p>

<p>Benzyl 2-cyanoacetate is an aliphatic hydrocarbon that has been used in the synthesis of various quinoline derivatives. It can be prepared by the reaction of malonic acid with hydrochloric acid, followed by borohydride reduction and the addition of active methylene. Benzyl 2-cyanoacetate is also a precursor to a number of other compounds, including β-amino acids, which are used as pharmaceutical preparations. The chloride ions in benzyl 2-cyanoacetate react with nitro groups to form chloroquinolines. This compound is also an efflux pump inhibitor that blocks bacterial cells from exporting antibiotic molecules out of the cell.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Phenyl-prop-2-ynyl-amine is a primary amine with neuroprotective properties. It can be activated to the corresponding aniline by treatment with a base. Phenyl-prop-2-ynyl-amine has been shown to have neuroprotective effects in a model system of Parkinson's disease. It also possesses ring-opening activity on quinoline derivatives and gold nanoparticles. This reaction is slow, but it can be accelerated by the addition of a carboxylic acid. The use of this method for the synthesis of phenylpropene derivatives provides an efficient route for the construction of complex molecules with functional groups in their skeletons.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Bromopentanenitrile is a medicinal molecule that has been shown to have oral bioavailability. This compound is an antagonist of the chemokine receptor CXCR4 and blocks the binding of SDF-1α and other ligands to this receptor, which inhibits the migration of lymphocytes from bone marrow into peripheral tissues. 4-Bromopentanenitrile has also been shown to inhibit cell proliferation in vitro and in vivo, which may be due to its ability to block DNA replication. 4-Bromopentanenitrile has been tested for its ability to inhibit the growth of cancer cells in mice models.</p>

<p>Versatile small molecule scaffold</p>

<p>(E)-3-(m-Tolyl)acrylic acid is a natural flavonoid compound found in plants. It is an intermediate in the biosynthesis of phenylpropanoids, which are a group of plant secondary metabolites. (E)-3-(m-Tolyl)acrylic acid has been shown to inhibit the production of heterocyclic amines, which are carcinogenic compounds formed during the cooking process of meat and fish. In addition, this compound has been shown to have cytotoxic effects on cancer cells and inhibitory effects on malonic acid production in plants. (E)-3-(m-Tolyl)acrylic acid is synthesized from cinnamic acid derivatives and hydroxyl groups. It is also produced by sulfonation of eugenol with sulfuric acid followed by oxidation with hydrogen peroxide.</p>

<p>3-Chlorocinnamic acid is a potential anticancer agent that has been shown to stimulate the growth of epidermal cells. It inhibits the activity of epidermal growth factor (EGF) and is active against some forms of cancer. 3-Chlorocinnamic acid binds to an activated form of the epidermal growth factor receptor and prevents its activation. 3-Chlorocinnamic acid also inhibits pro-apoptotic protein kinase activities, which may be useful for treating conditions such as tuberculosis. The chemical group in this compound is responsible for its optical properties and its ability to bind to proteins with cinnamoyl groups.</p>

<p>3,5,5-Trimethyl-2-pyrrolidinone is a cyclic hydrocarbon that is produced by the photolysis of acetonylacetone. It undergoes hydrolysis to form 3,5,5-trimethyl-3-oxazolidinone and 2-oxopropanal. The former reacts with nitrones to form oxaziridines and pyrrolidinones. 3,5,5-Trimethyl-2-pyrrolidinone can be used as a protecting group for hydroxyl groups in organic synthesis.</p>

<p>1-Amino-1,2,3,4-tetrahydropyrimidine-2,4-dione is an alkynyl amine that is used in the agricultural industry as a binding agent for acid. It has been shown to bind to cyanoalkyl, haloalkyl and aminouracil groups. The compound also has a variety of other uses in the pharmaceutical industry including use as a nerve toxin. 1-Amino-1,2,3,4-tetrahydropyrimidine-2,4-dione is also used as a spectrum diluent and can be used in refluxing reactions with nitro compounds.</p>

<p>2-(Acetyloxy)-4-methylbenzoic acid (AMBA) is a compound that is used in the field of health care. It has been shown to have neuroprotective effects and to reduce neuronal apoptosis, which may be due to its ability to attenuate proinflammatory responses. AMBA has also been shown to inhibit the formation of amyloid plaques in Alzheimer's disease. This compound has also shown anti-inflammatory properties and can be used as a treatment for neuroinflammation. AMBA inhibits the activation of caspases, which are responsible for initiating the apoptosis pathway by cleaving proteins necessary for cell survival, such as PARP1 or Bcl-2. The mechanism of action is not fully understood but it appears that AMBA alters mitochondrial function and reduces intracellular calcium levels.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Benzoyl-2H-1,2,3,4-tetrazole is a pyrazole compound that can be synthesized by reacting an aliphatic azide with a sulfoxide. The reaction of the sulfoxide with potassium hydroxide and dimethylbenzoyl chloride produces the desired product. 5-Benzoyl-2H-1,2,3,4-tetrazole is used in research as a short term substrate for enzymes such as diazo compounds and tetrazole. It has also been shown to be capable of forming covalent bonds with alkali metal ions such as sodium and potassium. This compound is also useful for the synthesis of 2H-1,2,3,4-tetrazoles via diazotization.</p>

<p>5H,6H,7H,8H-Imidazo[1,5-c]pyrimidin-5-one is a marine alkaloid that belongs to the family of histamine. It is found in the sponge pseudoceratina and has been shown to have antifouling properties. 5H,6H,7H,8H-Imidazo[1,5-c]pyrimidin-5-one can be used as a treatment for hyperhistaminemia and may inhibit tyrosine hydroxylase activity.</p>

<p>8-Hydroxy-4-quinolinecarboxaldehyde is an alkaloid that is found in the bark of Broussonetia papyrifera, a tree native to Asia. Alkaloids are nitrogenous organic compounds that contain basic properties. 8-Hydroxy-4-quinolinecarboxaldehyde can be synthesized by reacting oxime with hydroquinone. This compound has been studied using spectroscopic methods and can be used as a starting point for the synthesis of other alkaloids.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[4.5]dec-6-en-8-one is a natural product isolated from the leaves of plants in Madagascar. It has an inhibitory effect on insects and was sampled by researchers at the University of Florida. Spiro[4.5]dec-6-en-8-one can be extracted from camphene, naphthalene, and solenopsis. The compound inhibits the growth of insects through its inhibitory effects on protein synthesis by binding to ribosomal RNA. This activity is more pronounced in insect cells than in human cells, which may be due to a lower expression of ribosomal RNA in human cells.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(2,6-Dimethylphenoxy)acetohydrazide is a herbicide that inhibits the growth of monocotyledon and dicotyledon plants. It is used to control weeds in fields of soybeans, rice, corn, wheat, oats, barley and rye. The compound was found to be the most effective herbicide for the control of weeds in bioassays conducted with various types of plants. 2-(2,6-Dimethylphenoxy)acetohydrazide has been shown to inhibit the growth of Brassica species such as cabbage and broccoli by interfering with phenol synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 3-Fluorophenylacetate is an alkali, cyclopropene carboxamide that has a nucleophilic functionality. It is positioned strategically in biomolecular chemistry and biomolecular function. Methyl 3-Fluorophenylacetate has been used as a building block to synthesize bioactive molecules such as peptides and polymers. In addition, it can be used as a fluorescent probe for the identification of nucleophilic functionalities.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Acetyl-1,2,3,4-tetrahydroquinolin-4-one is a chemical compound that can be prepared by nitration of quinolin-4-one with concentrated sulfuric acid. This chemical has the following constants:</p>

<p>3-Phenyl-cyclopentanone is a conformational chiral reagent that is used in the synthesis of enantiomerically pure compounds. It is a substrate for many enzymatic reactions, such as alkylation, and can be used to prepare one of the two possible stereoisomers. 3-Phenyl-cyclopentanone has been shown to show positive dichroism in the visible region and negative dichroism in the near infrared region. This compound also has potential for use as an analytical reagent due to its ability to separate solutes based on their chromatographic properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(iodomethyl)-1,4-dioxane is a cytotoxic moiety that binds to the capsid protein of a virus. It has been shown to be an antiviral agent against HIV-1 and other retroviruses. 2-(iodomethyl)-1,4-dioxane is hydrophobic, connecting and binds to hydrophobic regions in proteins. The compound was also observed to have antiviral activity against HIV-2 and SIV. 2-(iodomethyl)-1,4-dioxane was found to form hydrogen bonds with the capsid proteins of both HIV-1 and HIV-2, which are important for viral infectivity. This compound has been used as a linker for attaching cytotoxic molecules such as doxorubicin or camptothecin to liposomes or nanoparticles.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,3-Dithian-5-one is a carbonyl compound that contains an aromatic ring. It has been used as a herbicide and bactericide. Spectroscopic data has shown that the carbonyl group in 1,3-dithian-5-one is responsible for its spectra. These spectral data also show that it is an antisymmetric molecule with a carbonyl group at the center of the molecule. The carbonyl group absorbs light in the visible range, which can be seen in its spectrum. This compound also has gas phase equilibrium interactions with sulfur.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Oltipraz-d3 is a chemopreventive agent that has been shown to inhibit the production of reactive oxygen species and inflammatory cytokines. Oltipraz-d3 inhibits the activation of the nuclear factor kappa B (NF-κB) pathway by preventing phosphorylation and degradation of IkappaBα, which is an inhibitor of NF-κB. It also reduces oxidative stress in the cell by increasing glutathione levels. Oltipraz-d3 has been shown to reduce DNA damage in human cells exposed to aflatoxin and may be useful for treating chronic liver diseases, such as cancer or injury.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Chloropyrimidine-4-carboxylic acid is a herbicide that is used in weed control. It has a broad spectrum of activity, which includes grasses and broadleaf weeds. This herbicide is also used in the treatment of soil contaminated with phenyl. 5-Chloropyrimidine-4-carboxylic acid inhibits the growth of weeds by inhibiting the synthesis of amino acids from their corresponding amino acid precursors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-methyl-1H-pyrrole-2-carboxamide is a heterocycle that has been shown to interact with specific DNA sequences. It is a conformational analog of the natural nucleoside guanosine, which has been shown to be a key component in the development of oligonucleotide drugs. 1-methyl-1H-pyrrole-2-carboxamide can be synthesized by the condensation of 1,2-diaminopropane and pyrrole. This compound also has magnetic properties, which allow it to be used in magnetic resonance imaging (MRI).</p>

<p>Versatile small molecule scaffold</p>

<p>1,2,4-Benzotriazine-3-carboxylic acid is a reagent that is used in organic chemistry to produce diazonium salts. It reacts with borohydride to form tetrachloropalladate, which can be reacted with thiazoles to form the corresponding benzothiazoles. 1,2,4-Benzotriazine-3-carboxylic acid also reacts with sodium borohydride in the presence of carbonyl compounds to form the corresponding triazoles. The compound can also be alkylated using alkyl halides or tricyclic compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>The thiophene-3-sulfonamide is a potent inhibitor of the enzyme carbonic anhydrase. It has been shown to inhibit the calcium ion's entry into cells, leading to a decrease in intracellular calcium ion concentration. The thiophene-3-sulfonamide has also been shown to bind to the endothelin receptor and block its function. The binding of this compound to the endothelin receptor blocks the effects of endothelin on vascular smooth muscle cells, which leads to vasodilation and increased blood flow.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Cyclodepsipeptide is a natural product that belongs to the family of linear peptides. It is a hydrophobic amino acid with a configuration. The cyclodepsipeptide inhibits bacterial growth by binding to the active site of hydrolases, enzymes that catalyze hydrolysis reactions. Cyclodepsipeptide binds to the ester bonds present in lipids and inhibits their hydrolysis. This prevents bacterial growth and leads to cell death by depriving cells of essential building blocks for cellular functions such as protein synthesis and membrane formation.</p>

<p>Versatile small molecule scaffold</p>

<p>1-Cyano-1-(phenylamino)cyclohexane is a ketone that can be used as a nucleophile in organic synthesis. It is catalyzed by acid and has been shown to be effective in the reduction of various carbonyl groups. The reaction mechanism is based on the formation of an imine, followed by nucleophilic attack of the ketone on the imine. 1-Cyano-1-(phenylamino)cyclohexane also has magnetic properties and can be used in techniques such as magnetic resonance imaging (MRI). It is also useful for synthesizing nanostructured materials with aliphatic amines and amines. The yield for this reaction is about 30%.</p>