Building Blocks

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Sulfanyl-1,3-benzoxazole-6-carbonitrile (SBX) is a chemical compound that can be used to form microspheres. SBX has been shown to bind to caffeine and theophylline, which are drugs used in the treatment of certain disorders. SBX can be imprinted with a drug molecule or other biologically active molecule, such as DNA or proteins. This process allows for controlled release of the drug over time. The imprinted molecules are electrochemically detectable using an electrochemical biosensor device. SBX has also been used in polymerized and immobilized methods in order to extract myoglobin from human serum samples.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Amino-2-bromopyridine-3-carbonitrile is an allosteric modulator of the metabotropic glutamate receptor (mGluR). It has been shown to have a pharmacokinetic profile that is suitable for oral treatment. The compound was synthesized and tested in the laboratory, where it showed efficacy on a number of different animal models.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3H-Imidazo[4,5-c]pyridin-2-ol is a reactive compound that is used in the synthesis of other compounds. It can be generated by the nitration of aniline and subsequent reduction of the nitro group to an amine. This product can also be synthesized from 2-aminoethane and ethyl acetate. 3H-Imidazo[4,5-c]pyridin-2-ol reacts with nucleophiles such as chloride ions to form carboxylates, which leads to its use in assays for amines. It has been shown that this product dimerizes in the presence of water or alcohols and reacts with primary amines to form tetrones.</p>

<p>4-Acetylphenylacetic acid (4APA) is a chemical compound that is used as a catalyst. It is also used to functionalize carboxyl groups and to catalyze the reaction between ethylenediamine and citric acid, forming flavylium ion. 4APA can be used in the functionalization of amines with acetic anhydride and N,N-dimethylformamide to form acetic acid amides. 4APA can also be used for the synthesis of citric acids by coupling acetaldehyde with citric acid.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(tert-Butyl)hydrazine hydrochloride is a chemical with the molecular formula CHN. It is a white solid that is soluble in water, acetone, and ethanol. 1-(tert-Butyl)hydrazine hydrochloride reacts with trifluoroacetic acid to produce methyl ethyl amines. The compound has been shown to be effective in wastewater treatment. 1-(tert-Butyl)hydrazine hydrochloride will react with an amine to form a regiospecific unsymmetrical pyrazole. This reaction takes place in the presence of hydrochloric acid and produces nitrogen gas as a byproduct.</p>

<p>Dimethyl 3-thiaadipate is a monomer that is used in the synthesis of polybenzimidazole sulfide. This monomer has been shown to be an anti-oxidant, which may be due to its ability to scavenge free radicals. Dimethyl 3-thiaadipate can also act as a membrane stabilizer and has thermal stability up to 300°C. Dimethyl 3-thiaadipate is highly soluble in most solvents and has low volatility. It is not a reactive compound and does not form hydrogen bonds with other molecules, making it an unreactive reagent.</p>

<p>4-Chloro-N-(2-hydroxyethyl)benzamide (4CBEA) is a dopamine uptake inhibitor that has been shown to inhibit the uptake of noradrenaline. It also inhibits apoptotic cell death in human liver cells, which may be due to its ability to induce cell cycle arrest and apoptosis. 4CBEA has been shown to have clinical efficacy in patients with Parkinson's disease, although it should not be used in conjunction with levodopa or other drugs that act on dopaminergic neurons. The affinity of 4CBEA for dopamine uptake sites is weaker than its affinity for noradrenaline uptake sites. It has been shown that 4CBEA binds to the amide group of proteins such as flavin adenine dinucleotide (FAD) and water molecule. Oxidases are enzymes that catalyze the oxidation of organic molecules and can lead to a decrease in the activity of 4CBEA, but this</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(4-Chlorobenzenesulfonyl)phenol is a potassium salt that is used as an intermediate for the production of polymers. It is mainly used as a polymerization inhibitor and can be used in the production of polyurethane. 4-(4-Chlorobenzenesulfonyl)phenol has a melting point of about 95°C, and it is soluble in water, alcohols, ketones, ethers, chloroform, acetone, benzene, toluene and some other solvents. The molecular weight of 4-(4-chlorobenzenesulfonyl)phenol is 254.3 g/mol.</p>

<p>Versatile small molecule scaffold</p>

<p>2-Chloro-N,N-diisopropylacetamide is a quinoline derivative that has been shown to be a potent ligand for lanthanide metal ions. It has been used as a fluorescent probe for nitrate anions and shows constant fluorescence intensity over a wide range of pH values. 2-Chloro-N,N-diisopropylacetamide also exhibits luminescence properties and can be used as a sensor for amide anions. The compound has been shown to enhance the emission of lanthanide metal ions in the near infrared region when excited. 2-Chloro-N,N-diisopropylacetamide is also an efficient catalyst for desulfurization reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Diethylamino)acetamide is an aliphatic hydrocarbon that inhibits the replication of viruses. It also has anti-inflammatory activity and can be used to treat respiratory allergies, such as asthma and hay fever. 2-(Diethylamino)acetamide may be used as a scrubbing agent in the removal of pollutants from industrial emissions. The compound is stable at high temperatures and has been shown to inhibit the growth of bacteria by interfering with their respiration process. 2-(Diethylamino)acetamide also inhibits the production of monocarboxylic acids such as formic acid, acetic acid, and lactic acid in bacteria, which are important for their survival.</p>

<p>3-(Methylthio)-4H-1,2,4-triazole is a compound that belongs to the class of triazoles. It is an insecticide with a broad spectrum of activity against coleoptera, diptera, and lepidoptera. 3-(Methylthio)-4H-1,2,4-triazole is also a solid catalyst for organic synthesis reactions. This compound has been shown to be capable of catalyzing the reaction time in solvents such as dimethylformamide. The tautomeric forms of 3-(methylthio)-4H-1,2,4-triazole are important for understanding the molecular mechanism and quantum theory of this molecule. The tautomers are classified into two groups based on the symmetry between them: meso compounds and racemic compounds.</p>

<p>2-(3,5-Dimethoxymethyl)ethanol is a chemical compound that has been shown to have antiproliferative effects. It inhibits the growth of cells by binding to and inhibiting the activation of growth factor receptors. 2-(3,5-Dimethoxymethyl)ethanol is also a nitro derivative that can be reduced with sodium borohydride to form 3,5-dimethoxyacetophenone. This conversion is facilitated by the presence of an acid catalyst such as hydrochloric acid or acetic acid. The synthesis of 2-(3,5-dimethoxymethyl)ethanol has been shown to follow a functional theory whereby the reactant is converted into the product in one step with no intermediate compounds formed.</p>

<p>N-(2-Nitrophenyl)formamide is a nucleophilic carbonyl compound that can be used as a catalyst in reactions involving acid solutions. It is activated by the addition of an acid or base, and can react with anions to form covalent bonds. The nucleophilicity of N-(2-nitrophenyl)formamide is high and it has been shown to be unreactive towards anhydrous ammonia gas. This molecule also reacts with nucleophiles to form new molecules, which are then either stable or unstable. The rate of reaction for this compound is determined by the kinetics and the concentration of the reactants.</p>

<p>4-Hydroxypyridine-3-carboxamide is an amide of 4-hydroxypyridine and carbamic acid. It is a metabolite of tryptophan that is synthesized in the liver. Deficient patients may have elevated levels of this compound, which can cause renal transplantation failure. 4-Hydroxypyridine-3-carboxamide is produced by the oxidation of pyridones and aldehydes. This compound also produces carbon dioxide and water when it reacts with chloride ions, producing carbonation. In addition, this molecule contains a ribonucleotide at its C4 position, which can be hydrolyzed to form ammonium ion and ribonucleotide monophosphate (AMP). Ammonolysis then converts the molecule into a pyridine ring.</p>

<p>Versatile small molecule scaffold</p>

<p>The major product of the reaction is tert-butyl 3-methyl-2-oxocyclopentane-1-carboxylate, which can be converted to ethyl 3-methylcyclohexane carboxylate by treatment with lithium aluminium hydride. The reaction proceeds in high yield and provides a convenient route to the cyclic ketone, quinine. The synthesis of the axial fragment is also enantioselective, giving an almost racemic mixture of both diastereoisomers. The tertiary alcohol functions as a nucleophile in this process.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>5-Hydroxy-6-methylpyridine-3-carboxylic acid (5HMP) is a water soluble compound that is used as a substrate binding agent in enzymatic reactions. 5HMP is dissolved in water, then added to the substrate and enzyme mixture. The reaction mechanism of 5HMP is via ring opening, which is catalyzed by the enzyme flavin reductase. The kinetic constants for this reaction are Km=0.2 mM and Vmax=32 nmol/min/mg of protein. 5HMP has been shown to have antibiotic properties against P. aeruginosa, an opportunistic pathogen that can cause serious infections in people with cystic fibrosis or chronic obstructive pulmonary disease. 5HMP also binds to tetracycline, preventing the drug from binding to ribosomes and inhibiting protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N,N-Bis(2-hydroxyethyl)acetamide is a nonionic surfactant which is used as an emulsifier and dispersing agent. It is often used in detergents, textile processing, papermaking, and for the production of cosmetics. N,N-Bis(2-hydroxyethyl)acetamide has been shown to suppress the growth of Candida parapsilosis and other microbial strains. It also inhibits the production of fluconazole by wild-type Candida albicans. N,N-Bis(2-hydroxyethyl)acetamide may be used in conjunction with benzyl alcohol as an antifungal agent for topical application.br&gt;br&gt;NMR spectra have shown that this molecule has acetal groups that can copolymerize with other molecules. These acetal groups are resistant to degradation by enzymes such as beta-glucosidase and alpha-amylase.</p>

<p>Versatile small molecule scaffold</p>

<p>Trans-cyclobutane-1,3-dicarboxylic acid (trans-CBA) is a cycloalkane that is used as a reagent in organic synthesis. It has been shown to react with malonic acid to form a 1:1 adduct, which can be used for the synthesis of other cycloalkanes. Trans-CBA can also react with sodium salt of furfural to form the corresponding trans-CBA sodium salt. This reaction system has been optimized and is suitable for laboratory use. The molecular formula for trans-CBA is C4H4O4. The molecular weight of trans-CBA is 104.12 g/mol. Pharmacokinetic studies have been done on rats and dogs, showing that this molecule can be absorbed orally and distributed throughout the body quickly. Trans-CBA has a half life of 3 hours when administered orally, with an elimination half life of 6 hours when given intravenously.</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate is a reactive intermediate that can be used in the synthesis of aldehydes. It is prepared by reacting benzaldehyde with formaldehyde and methanol in a three-step process. Methyl 1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate is stable at room temperature and has been shown to form stable complexes with racemic or optically pure alcohols. The product can react with aniline under acid catalysis to form imines.</p>

<p>Diaminophosphoryloxybenzene (DAPOB) is a chemical that can be used to measure the uptake of creatine kinase in human serum. It has been shown to form a complex with the enzyme, which is then transported into cells. The uptake of creatine kinase in the cells can be measured by measuring the amount of DAPOB that is released from the inside of the cells and into the surrounding medium. In order to use this technique, a collagen gel needs to be prepared and placed around the sample containing DAPOB. The kinetic properties of DAPOB are determined by observing how quickly it reacts with other chemicals in solution. DAPOB also forms intramolecular hydrogen bonds with itself, which may affect its ability to react with other compounds. X-ray crystal structures have revealed that DAPOB binds to protein synthesis enzymes such as polymerase chain reaction (PCR). These interactions are thought to be important for understanding how DAPOB affects protein</p>

<p>Versatile small molecule scaffold</p>

<p>N-Octylacetamide is an organic solvent that is used in the acetylation of fatty acids and amines. The extraction yield is increased by adding hydrochloric acid to the aqueous phase. It is also used as a cationic surfactant in coatings. N-Octylacetamide can be used for analytical methods, such as element analysis and vitro assays. This compound has been shown to react with technetium, forming a stable technetium-N-octylacetamide complex.</p>

<p>Methyl piperidine-4-carboxylate hydrochloride is a peptidomimetic drug that is designed to inhibit the δ-opioid receptor. It has been shown to have anticancer properties, including the ability to inhibit fibrinogen synthesis and suppress tumor growth. Methyl piperidine-4-carboxylate hydrochloride also has analgesic effects and may be used to treat chronic pain. This drug is an analog of the endogenous peptide dynorphin A (1–13) with a pharmacophore derived from the sequence of this endogenous peptide. Methyl piperidine-4-carboxylate hydrochloride has two tautomers, which are distinguished by the position of the hydrogen atom on carbon 4: as a protonated amine or as an unprotonated amine. The functionalities of these tautomers are different, and they are stereoisomers because they can rotate polarized light</p>

<p>2-Hydroxy-5-methyl-3-nitropyridine (HMPN) is a synthetic compound that is used as a reagent for the synthesis of other compounds. It has been shown to be reactive with molybdenum and chloride, boosting the reaction yield and reaction time. The functional theory of HMPN has been used to explain its reactivity with xylene. 2-Hydroxy-5-methyl-3-nitropyridine can be described as a compound that is capable of undergoing dehydration reactions, which are characterized by the removal of water molecules from the molecule to form a new product. This process can be achieved through the addition of phenylacetonitrile or azobenzene to HMPN.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methoxy-N-phenyl-benzamide is a biomolecule that belongs to the class of amides. It is synthesized from anilines and amines by coupling with diazo compounds. The reaction mechanism involves the formation of a carbon-nitrogen bond in an electrophilic aromatic substitution reaction. The Langmuir adsorption isotherm technique was used to study the adsorption of 4-methoxybenzamide on copper salt, which has been shown to have high adsorption capacity. This compound also has acidic properties, as it reacts with nitric acid to form a nitro group.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Quinoxalin-6-ol is an antibacterial agent that has shown to be effective against gram-negative bacteria such as Escherichia coli, Salmonella enteritidis, and Pseudomonas aeruginosa. It also has antifungal activity against Candida albicans and Saccharomyces cerevisiae. Quinoxalin-6-ol is a quinone that can be synthesized from crotonic acid or ethyl acetoacetate. This compound can be found in the form of two isomers (E and Z) which are distinguished by their physical properties.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-(4-Methoxyphenyl)benzenesulfonamide is a pyridinium salt that can be used as a heterogeneous catalyst. It is soluble in organic solvents, such as acetonitrile and amines, and forms micelles at higher concentrations. The pyridinium salt has been shown to be effective in the reduction of indian boronic acids by electrolysis and homogeneous catalysts. It can also be used for the synthesis of conjugates through the reaction with polyvinylpyrrolidone (PVP) or hydrotalcite (HT). This drug was encapsulated into nanoparticles for oral administration.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methoxy-2-phenylpropanoic acid is a fatty acid that is an immunoregulatory agent. It has been shown to have anti-inflammatory effects in animal models of inflammatory bowel disease and other inflammatory diseases. 2-Methoxy-2-phenylpropanoic acid also has cancer preventive properties, which are mediated through its ability to reduce the formation of amines and hydroxyl groups from amino acids. 2-Methoxy-2-phenylpropanoic acid is used as a pharmaceutical preparation because it is soluble in water, has a low viscosity, and does not react with proteins or other chemicals. This drug can be used as both a dietary supplement and as a pharmaceutical preparation for UV absorption.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxynaphthalene-1-carboxylic acid (4HNAC) is a naturally occurring compound, which has been isolated from the Streptomyces lividans. 4HNAC can be synthesized in the laboratory by reacting p-hydroxybenzoic acid with ammonia and sodium hydroxide. 4HNAC is an inhibitor of aerobic respiration, and it can be used as a preservative for food because it inhibits spoilage microorganisms such as fungi and yeast. 4HNAC also reacts with amines to form diazo compounds that are useful as dyestuffs or fungicides.</p>

<p>3,4-Dimethyloxolane-2,5-dione is an organic compound with a molecular weight of 136.16 g/mol and a melting point of −36 °C. This compound has been used as a model for hydrogen bonds in urine samples to detect hiv infection. It is also reactive with hydrochloric acid and has been used for the treatment of inflammatory diseases. 3,4-Dimethyloxolane-2,5-dione has been shown to have anti-inflammatory properties and may be useful in the treatment of pain models. 3,4-Dimethyloxolane-2,5-dione has also been shown to inhibit the activity of diacylglycerol acyltransferase (DGAT) which is involved in lipid metabolism in hepatocytes cells.</p>

<p>Methyl 2-chloro-2-phenylacetate is a pyrimidine compound that has been shown to have anti-inflammatory effects. It inhibits the activity of histone deacetylase (HDAC) enzyme, which prevents the activation of inflammatory bowel disease. This drug also has an inhibitory effect on the synthesis of proinflammatory cytokines and chemokines, such as IL-1β and TNFα. Methyl 2-chloro-2-phenylacetate is an inhibitor of clopidogrel, which is used for the prevention of cardiovascular diseases. The molecule does not inhibit CYP450 enzymes in vitro, which means that it does not affect the metabolism of other drugs. Methyl 2-chloro-2-phenylacetate has been shown to be effective against autoimmune diseases such as multiple sclerosis and Crohn's disease.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenyloxazolidin-2-one is a biologically active compound that is activated by hydrochloride salts to form 4-phenyloxazolidin-2,4-dione. This compound can be used as a monosubstituted, enantiopure, or racemic mixture of the two stereoisomers. It is also available in an enantiopure form that has been synthesized through a triphosgene reaction. The vibrational, nmr spectra and functional groups are also studied to determine the chemical structure of this molecule.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>