Building Blocks

<p>1,1-Dioxido-1-benzothien-6-ylamine is a cytotoxic drug that inhibits the synthesis of DNA and RNA in cancer cells. It is synthesized from benzo[c]thiophene-2,5-dione by oxidation with nitric acid to give the corresponding dioxido compound. The synthesized product has high lipophilicity (log P = 2.2) and a reactive hydroxy group that can undergo modifications such as esterification or alkylation. 1,1-Dioxido-1-benzothien-6-ylamine shows potent antitumor activity against solid tumours and high lipophilicity that enables it to cross the blood brain barrier very easily. It also induces apoptosis in tumour cells by binding to nucleic acids and inhibiting their synthesis. This drug is cytotoxic at nanomolar concentrations and has been shown to be effective against lung</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Ethyl 4-methylcinnamate is a ligand that binds to diazoacetate, which reacts with ethylene and aldehydes to form ethyl diazoacetate. The reaction rate increases with the addition of alkali, which causes hydrolysis of the acetal group in ethyl 4-methylcinnamate. Impurities may be present in this product, including genotoxic impurities and 8-hydroxyquinoline. Industrialized countries have strict quality control standards for this compound, whereas in developing countries, the purity of this chemical is not regulated.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,4-Dichlorobenzenesulphonamide is a chlorinated benzenesulphonamide compound that has been shown to have anticancer activity. The mechanism of action is not well understood, but it has been suggested that the drug may inhibit mitochondrial membrane potential, leading to cancer cell death. 2,4-Dichlorobenzenesulphonamide has also been shown to induce apoptosis in cervical cancer cells. This drug may be useful for the treatment of carcinomas, as well as other cancers.</p>

<p>5-Methoxy-benzo[b]thiophene is a synthetic compound that has been shown to have antiestrogenic activity. It was synthesized using the acetonitrile technique and has been shown to inhibit the growth of mammary carcinomas in mice. 5-Methoxy-benzo[b]thiophene binds to estrogen receptor protein, which inhibits the binding of estrogen and prevents its effects on breast cancers. This agent also has been shown to be an effective therapy for some human breast cancer cells, which may be due to its ability to block estrogen receptor function.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,2,6-Trimethyl-1,4-cyclohexanedione is a diketone that is produced from the shikimate pathway. It is used in organic synthesis as a carbon source and to produce volatile compounds. 2,2,6-Trimethyl-1,4-cyclohexanedione has been shown to be an attractant for mosquitoes and other insects. This compound also has pheromone activity which may be due to the presence of different isomers. 2,2,6-Trimethyl-1,4-cyclohexanedione can be found in solution form as well as in solid form with a melting point of 156°C. The compound can also be identified using various biochemical markers (e.g., esterase) or by biological studies on subcultures of bacteria or fungi.</p>

<p>4-Hydroxy-2,2,6-trimethylcyclohexan-1-one is a subunit of the nonproteinogenic amino acid, selenocysteine. It is an intermediate in the synthesis of selenocysteine and has been shown to be stereoselective and homologous to other amino acids. 4-Hydroxy-2,2,6-trimethylcyclohexan-1-one is found in corynebacterium and thermophilic species. The enzyme dehydrogenase catalyses the conversion of this compound to 3-(3′hydroxyphenyl)-4-(4′hydroxyphenyl)butanoic acid (4HPPBA). This reaction also produces hydrogen peroxide as a byproduct. 4HPPBA can be converted back into 4-hydroxy-2,2,6-trimethylcyclohexanone by the enzyme reductase. There</p>

<p>2-Chloro-5-(trifluoromethyl)benzamide is a profile that belongs to the group of anti-tuberculosis drugs. It has a high cytotoxic effect against eukaryotic cells and has been shown to have an anti-tuberculosis effect in mice. 2C5BM also inhibits bacterial growth by binding to DNA gyrase and topoisomerases, thereby inhibiting the replication of bacteria. Studies have found that 2C5BM can inhibit the growth of Mycobacterium tuberculosis, but not Mycobacterium avium complex. The therapeutic index for 2C5BM is high, which means it has a wide range of safety margins, with no detectable side effects on healthy human erythrocytes.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Spiro[2.3]hexan-4-one is a reactive, hydrophobic molecule that is synthesized by the reaction of an epoxide with an alcohol. This compound has been shown to undergo photooxidation and thermally induced reactions. It can be used in coatings to provide resistance to environmental effects such as hydrolysis, oxidation, or photooxidation. Spiro[2.3]hexan-4-one can also be used in the production of methylenecyclopropanes, which are used as chemical intermediates for pharmaceuticals and other organic compounds.</p>

<p>Versatile small molecule scaffold</p>

<p>4-Methyl-1,5,6,7-tetrahydro-2H-cyclopenta[b]-pyridin-2-one is a cycloalkane that has been shown to have antiinflammatory properties. It has been found to produce phosphoric acid and methanol when heated in the presence of phosphoric acid. 4-Methylcyclohexanone has also been shown to form hydrogen bonds with a variety of molecules including other cycloalkanes, nitro compounds, aromatic hydrocarbons, and heterocyclic compounds. Single crystal x-ray diffraction studies of this compound have revealed that it adopts an anisotropic molecular structure.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Methyloct-3-yn-2-ol is a nucleophile that can be used to make an efficient method for the synthesis of olefinic bonds. This compound is also a ligand, which can form bidentate complexes with electrophilic metal centers. 2-Methyloct-3-yn-2-ol has been shown to react with heterocycles and alkenes in nucleophilic addition reactions. The reaction mechanism is thought to proceed through c–h bond cleavage, followed by dehydration of the resulting olefinic products. This process is reversible and can be driven by acid or base catalysis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-1-methylnaphthalene is the chemical compound with the formula C6H5BrCH2. It is a brominated derivative of naphthalene. This compound is an intermediate in the synthesis of arylboronic acids, which are used as coupling partners in Suzuki and Miyaura cross-coupling reactions. It also has been used as a catalyst for indole synthesis from chlorobenzene and ammonia. 2-Bromo-1-methylnaphthalene can be prepared by treating naphthalene with bromine and potassium t-butoxide at low temperature. The reaction can also be conducted using chloride or potassium instead of t-butoxide.<br>2-Bromo-1methyhnaphthalene is a useful chemical because it can react efficiently with aryl bromides to produce coupling products, such as benzofuran derivatives, in high yield.</p>

<p>Versatile small molecule scaffold</p>

<p>N-Aminobenzenecarbothioamide is a chemical compound that is stable in hydrochloric acid and carbon disulphide. It has been shown to inhibit the growth of skin cells by binding to epidermal growth factor. It also inhibits the production of inflammatory bowel disease, which may be due to its ability to inhibit nitro and nitrite ion. The antimicrobial activity of N-aminobenzenecarbothioamide has not been studied.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Bromo-2-methylpropanoic acid is a colorimetric substrate that is used in the screening of enzymes with propionate as a cofactor. This substrate has been found to be selective for esterases, and can be used as an alternative to octanoate for enzymatic studies. The 3-bromo-2-methylpropanoic acid esters are also hydrophobic and have higher melting points than their corresponding acids, making them more suitable for thermophilic organisms. <br>The 3-bromo-2-methylpropanoic acid esters are chiral compounds that can be synthesized in two forms: (R)-3-bromo-2-methylpropanoic acid methyl ester and (S)-3-bromo-2-methylpropanoic acid methyl ester. The enantiomers of these compounds exhibit different biological activity. For example, the (S)-enantiomer</p>

<p>Ethanol, 2-(phenylsulfonyl)- is a synthetic chemical compound. It is used as an electron donor in the Suzuki coupling reaction and has shown significant cytotoxicity against tumour cell lines. This product also has been used in the synthesis of naphthalene and pulchella. The mechanism for its cytotoxicity involves the desulfurization of tyrosinase, which is an enzyme that catalyzes the conversion of dihydroxyphenylalanine to melanin. This product has also been shown to be effective against glandularia with structural studies showing that it reacts with sulfonic acid groups.</p>

<p>Versatile small molecule scaffold</p>

<p>3-tert-Butylcyclobutanone is an organocatalyst that is used for the asymmetric synthesis of cyclobutanones. It has been shown to be a chiral, stereoselective and catalytic mediator in the Baeyer–Villiger oxidation of enones. 3-tert-Butylcyclobutanone also exhibits self-assembly properties and can form dimers with other molecules. This compound is also capable of catalyzing cycloadditions between electron deficient alkenes and electron rich dienes. The dimers of 3-tert-butylcyclobutanone are formed by hydrogen bonding interactions between the keto groups on adjacent molecules.</p>

<p>3,3-Dimethyl-5-oxohexanoic acid is a peroxide with the chemical formula C10H16O4. It is synthesized by the ozonolysis of isophorone. 3,3-Dimethyl-5-oxohexanoic acid can be used as a dehydrating agent and has been shown to be effective in the production of esters, such as methyl esters. The dehydration of this compound gives rise to hydrogen peroxide and acetone. The hydrolysis of 3,3-dimethyl-5-oxohexanoic acid with water yields acetic acid and methyl alcohol. This reaction has been shown to be stoichiometric.</p>

<p>1-(2-Methoxy-5-methylphenyl)ethanone is a volatile, synthetic compound. It is used as a chemical intermediate in the production of picotamide and esterification products. Methoxyphenylacetic acid (1) is methylated with methanol in the presence of hydrochloric acid to form 2,5-dimethoxybenzoic acid (2). The latter is then esterified with methanol and acetic anhydride to yield picotamide (3).</p>

<p>Versatile small molecule scaffold</p>

<p>3-Ureidobenzoic acid is an organic compound that can act as a reducer or bidentate ligand. The reductive properties of 3-ureidobenzoic acid are due to its ability to accept electrons from other molecules, which can be used to reduce metal ions. The ligand properties of 3-ureidobenzoic acid are due to the formation of a covalent bond with other molecules, often metal ions. 3-Ureidobenzoic acid is also known to be a synthetase, which catalyzes the formation of peptide bonds in proteins by joining amino acids together. This compound has been found in cytochrome P450 enzymes, where it is believed to play a role in electron transfer and activation reactions. It has also been shown to be involved in supramolecular hydrogen bonding, which stabilizes certain compounds and plays an important role in enzyme activity and intermolecular reactions.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-Butyl-4-nitrobenzene is an environmental pollutant that is a byproduct of coal combustion and industrial processes. It can be chlorinated to produce 1,2,3-trichloropropane, which is used in the production of various chemicals. The chemical transformation of 1-butyl-4-nitrobenzene yields a variety of products including nitroarenes and anilines. The mechanistic pathways for the production of these compounds are not completely understood but it has been shown that isotope effects may play a role in the formation of certain product yields.</p>

<p>2,2-Dimethylpentanenitrile is a solvent that can be used in the polymerization of cellulose acetate. It has been shown to have reactive sites and be resistant to radiation and heat. 2,2-Dimethylpentanenitrile has also been used as a polymerization initiator for cationic polymers, which are water vapor-resistant and bond cleavage resistant. This compound is an experimental infection agent that is used against enteritidis, which is an antibiotic-resistant bacterium. 2,2-Dimethylpentanenitrile has also been shown to be effective as an electrophotographic developer for particle suspensions and gaseous emissions.</p>

<p>2-Methyl-4-phenyl-1,3-oxazole is an organic compound that is a white solid. It has a molecular weight of 222.2 g/mol and chemical formula C6H5NO2. 2-Methyl-4-phenyl-1,3-oxazole can be synthesized by reacting phenylmagnesium bromide with methyl iodide in an ether solvent at room temperature. The reaction produces a product in high yield, which is soluble in both water and organic solvents. The product is stable to air and light for up to two months at room temperature.<br><br>The following are the properties of 2-methyl 4 phenyl 1,3 oxazole:<br><br>• White solid<br>• Molecular weight of 222.2 g/mol<br>• Chemical formula C6H5NO2 <br>• Soluble in both water and organic solvents <br>• Synthesized by reacting phenylmag</p>

<p>Versatile small molecule scaffold</p>

<p>Methyl 4,4-dimethylpent-2-enoate is a natural product that has been isolated from the fungus Candida albicans. It has been shown to inhibit the growth of Aspergillus niger and Candida albicans.</p>

<p>N-Cyclopentylcyclopentanamine is a cyclic amine that has a carboxylate and an amino function. It can be used as a substrate film for reaction rate studies and to investigate the effect of surface active agents on the patterning of the polymer. The compound is also used as a primary amino reactant in reactions with hydrocarbon groups, amines, and silicone. This substance is soluble in organic solvents such as acetone, ether, chloroform, and benzene.</p>

<p>3-Methyl-1,2,3,4-tetrahydroquinoline is a synthetic molecule that has been shown to have adjuvant activity in the treatment of cancer. 3-Methyl-1,2,3,4-tetrahydroquinoline inhibits bacterial growth by alkylating DNA and RNA. It binds to nucleic acids and prevents transcription and replication. The molecular structure of 3-methyl-1,2,3,4-tetrahydroquinoline was elucidated by FTIR spectroscopy and XRPD analysis. This compound has also been shown to inhibit the growth of Staphylococcus aureus strains.</p>

<p>6,7-Dimethylquinoline is a chemical that is used as a research tool in the study of the uptake of drugs into tissues and their excretion by the body. 6,7-Dimethylquinoline is used as an internal standard for gas chromatography to measure the uptake rate of drugs into tissues. This chemical has also been shown to have significant cutaneous absorption and may be metabolized to glucuronide conjugates in humans. It has been shown to bioconcentrate in muscle tissue and may be metabolized by biotransformation products. 6,7-Dimethylquinoline is excreted primarily in the bile and its whole-body half-life ranges from 3.2 hours to 5.3 hours.</p>

<p>7,8-Dimethylquinoline is an electrophilic agent that has been shown to be active against a variety of fungi. 7,8-Dimethylquinoline is a phenolic compound that can be used as an antifungal agent and has been shown to possess narcotic properties. 7,8-Dimethylquionline is not toxic to mammals but may cause toxicity in other organisms. It also has potential to inhibit membrane transport processes in fungi.</p>

<p>Methyl 2-acetamido-5-chlorobenzoate is a chemical compound that belongs to the group of organic compounds. It has a crystal structure with orthorhombic and isotropic properties. The radiation used in the measurement of this compound is atomic and it has been measured using a Bruker instrument.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1-(4-Bromophenyl)-3-methylurea is a nitrosourea that has been shown to be carcinogenic in experiments. It is an alkylating agent that may also have genotoxic properties. 1-(4-Bromophenyl)-3-methylurea can react with DNA, forming DNA adducts. This chemical is a potent inhibitor of the enzyme nitrite reductase, which reduces nitrite to nitric oxide and water. Nitric oxide is important for blood vessel dilation and vasodilation, as well as the regulation of vasoconstriction. The inhibition of this enzyme leads to increased blood pressure by blocking these effects. 1-(4-Bromophenyl)-3-methylurea is commonly used in the laboratory to induce papillomas on the skin of animals or fish, as well as carcinogenic activity in vitro.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-(Butylamino)-3-nitrobenzoic acid is a compound that has a coplanar, nitro group and a nitro group. It has the conformation of 4-(butylamino)-3-nitrobenzoic acid and is also asymmetric. The geometry of the molecule is planar with an angle of 120 degrees. The nitro group resides in the coplanar structure. The hydrogen bond is formed between the nitrogen atom and the carboxyl group in the chain, which creates an asymmetric effect. The hydrogen bonds are also present in this molecule due to its benzene ring. 4-(Butylamino)-3-nitrobenzoic acid is found in natural products such as plants, fruits, and vegetables.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>N-Carbobenzoxypropargylamine (CBPA) is an isoxazole that has been shown to bind to the integrin receptor, which is a type of protein found on the surface of cells. CBPA binds to the ligand-binding site of the integrin receptor and inhibits its activation by connecting it with a peptide fragment. This results in a loss of cell adhesion and reduced proliferation. CBPA has a nanomolar range and can be used as a potential drug candidate for cancer treatment because it has high affinity for cells and high frequency of occurrence. The pharmacophore model for CBPA was generated using aspartic acid, which is one of the most abundant amino acids in proteins.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>