Building Blocks

<p>Versatile small molecule scaffold</p>

<p>2-Bromo-4-fluorobenzamide is a functional group that reacts with other functional groups to form halogenated benzoic compounds. It can be used as a reagent for the halogenation of amides, esters, and substances. 2-Bromo-4-fluorobenzamide can also be used as a chemical transformation agent in organic synthesis. The discovery of this compound was the result of mechanistic chemistry research on the transformation of amides.</p>

<p>5-Iodoquinoline is a serotonin transporter inhibitor that has been shown to have antidepressant properties. The compound competes with serotonin for transport and prevents it from binding to the receptor, which leads to an increase in extracellular serotonin. This active form has been synthesized by the reaction of 5-iodotriphenylenes with cyclobutanones. The pharmacological activity of 5-iodoquinoline was studied in vivo and proved that this drug may be useful for the treatment of depression.</p>

<p>Versatile small molecule scaffold</p>

<p>Alpha-cyclopropylbenzyl alcohol is an organic compound that belongs to the group of carbinols. The most common use of this compound is as a reactant in the Diels-Alder reaction. This reaction involves the formation of a new carbon-carbon bond with two electron-deficient olefins and a dienophile, which can be either an alkene or another diisocyanate. Alpha-cyclopropylbenzyl alcohol reacts selectively with methyl ethyl, isopropyl, and n-propyl groups, which are present in many diisocyanates. The product of this reaction is always a ring-opening adduct containing aldehydes or urethanes. These reactions often produce polyesters as well when alpha-cyclopropylbenzyl alcohol reacts with cyclohexanedimethanol.</p>

<p>N-Methyl-6-oxo-1,6-dihydropyridine-3-carboxamide (NDH) is a water soluble polymer that is synthesized from the reaction of fatty acids and formaldehyde. It can be used as a coagulant to remove suspended particles in wastewater. NDH has shown synergistic effects with other coagulant agents such as aluminium sulphate and ferric chloride. This polymer has been shown to have electrothermal treatment capabilities, which are able to remove organic matter from wastewater on an on-line basis. The kinetic energy of the vibrations in the polymer molecule leads to an increase in its solubility in water, allowing for easier removal of pollutants. This polymer also shows a significant reduction in the amount of dissolved oxygen during treatment, which leads to an increased rate of oxidation and decomposition.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Phenyl-2,4-dihydro-3H-1,2,4-triazol-3-one is a drug that blocks the L type calcium channel. It has been shown to be effective against cervical cancer and cardiac arrhythmias. This drug binds to the l type calcium channels in tumor cells and prevents the influx of calcium ions into the cell, which would normally cause an increase in intracellular levels of cAMP and activation of protein kinase A. 4PHT is a piperazine derivative with an additional triazole group at position 2. It is an amine blocker that can also affect contractility by inhibiting phosphorylation of myosin light chains.</p>

<p>2-(1,3,4-Oxadiazol-2-yl)phenol (ODAP) is a prodrug that can be converted to the active form, estradiol. It has been shown to have anti-inflammatory effects and is used to treat nasal polyps. ODAP is also used as a site specific drug for the treatment of breast cancer. ODAP has been shown to inhibit the growth of bacteria such as Staphylococcus aureus and Helicobacter pylori. ODAP binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division.</p>

<p>Versatile small molecule scaffold</p>

<p>5-Methyl-3-phenyl-1,2-oxazole is a synthetic molecule that is postulated to be an isoxazole derivative. It has been shown to react with sodium chloride in the presence of organic solvents and hydrogen chloride to form a fluorinated salt. The reaction yield for this process was found to be low, however, the product was obtained in high purity. When irradiated or heated, 5-methyl-3-phenyl-1,2-oxazole undergoes thermal isomerization to form 3-(difluoromethyl)-5-(methyl)isoxazole.</p>

<p>1-Phenyl-1H-pyrazol-3(2H)-one is a molecule that has been synthesized in the form of a cyclic compound. It can be used for the synthesis of polymers, which are used as coatings and adhesives. The molecule's structure was determined by x-ray crystallography. The chemical properties of 1-phenyl-1H-pyrazol-3(2H)-one depend on its oxidation state, which can be reversibly oxidized to the corresponding quinone with a cyclic voltammetry strategy. This process involves the use of a solid electrode and nonpolar solvents, such as chloroform or ether. This reaction is irreversible and leads to oxidation of 1-phenyl-1H-pyrazol-3(2H)-one to the quinone form. The molecule has also been synthesized using a solid phase synthesis technique involving methoxy groups as monomers</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-Ethoxy-1H-indole is a synthetic, nucleophilic compound that has been shown to be an effective hydrogenation catalyst. The biological properties of 2-ethoxy-1H-indole have been studied in both animals and humans. In rats, this compound has shown to be an effective analgesic and antiinflammatory agent with few side effects. 2-Ethoxy-1H-indole also has shown efficacy in the treatment of Parkinson's disease in animal models. This drug can be used as a precursor for a variety of compounds including carboximidamides, enecarbamates, amines, or sulfoxides. It is also possible to control the stereocontrol of 2-ethoxy-1H-indole by using chiral reagents or by converting it to its chiral counterpart (2-(2'-ethoxy)-1H-indole).</p>

<p>Versatile small molecule scaffold</p>

<p>Azacycloundecan-2-one is a ring-opening polymerization monomer that exhibits good solubility in organic solvents. It is used as the precursor to polyamides and polymeric matrices. Azacycloundecan-2-one has been shown to form a film with a high degree of viscosity and excellent mechanical properties, which are desirable for films in the food industry. Ring opening polymerization of azacycloundecan-2-one can be achieved by using magnesium salts or diacids as catalysts. The lactam ring structure of azacycloundecan-2-one provides reactive sites for reactions with other compounds, such as amines, alcohols, phenols, and carboxylic acids.</p>

<p>2-(2-Methyl-5-nitro-1H-imidazol-1-yl)acetic acid is an antimicrobial agent that inhibits the growth of bacteria by oxidation. It has been shown to be effective against protozoan parasites and has a good activity against Gram-positive bacteria. The main metabolic pathway for 2-(2-Methyl-5-nitro-1H-imidazol-1-yl)acetic acid is hydrolysis by hydrochloric acid, with a minor route involving hydroxy metabolite formation. This drug also acts as a prodrug for antipyrine, which inhibits bacterial growth via inhibition of protein synthesis.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3,5-Dimethoxy-4-methylbenzaldehyde is a phenylacetic compound that is found in the fructus of plants. It has been shown to have tumor necrosis factor (TNF) and phenolic properties. This molecule also stimulates the inflammatory process by inducing pro-inflammatory cytokines such as TNF-α and IL-1β. 3,5-Dimethoxy-4-methylbenzaldehyde has been found to inhibit the growth of various bacteria, including methicillin resistant Staphylococcus aureus isolates, when used at concentrations of 0.001%.</p>

<p>Versatile small molecule scaffold</p>

<p>1-(Quinolin-2-yl)ethanone is an inhibitor of proteolytic enzymes. It is a triazolopyrimidine that binds to the active site of proteases, thereby inhibiting their activity. 1-(Quinolin-2-yl)ethanone has been shown to be effective against viruses such as herpes simplex virus and Streptococcus faecalis, and bacterial infections such as streptococcus faecalis and Staphylococcus aureus. 1-(Quinolin-2-yl)ethanone also inhibits the production of matrix metalloproteinases, which play an important role in tumor development, by binding to the zinc ion in the enzyme's active site. This compound can also be used synergistically with copper chloride or hydrochloric acid to inhibit protease activity.</p>

<p>Versatile small molecule scaffold</p>

<p>Amiodarone is a drug that is used to treat and prevent certain types of irregular heartbeats. It belongs to the group of drugs called class III anti-arrhythmics. Amiodarone is a long-acting medication that can take up to three weeks for full effect. Amiodarone has been shown to reduce the number of atrial and ventricular arrhythmias in patients with structural heart disease. This drug also has significant cytotoxicity, which means it may affect normal cells as well as cancer cells, and increases the risk of serious side effects such as fibrillation and glucose intolerance. Amiodarone should not be taken with other medications that can cause fibrillation or make it hard for your body to control blood pressure, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen.</p>

<p>2,5-Dihydroxyterephthalaldehyde (2,5-DTPA) is a sugar alcohol that is used in the production of polyester. It can be synthesized by electrochemical methods and is produced as an intermediate in the synthesis of 2,5-dihydroxypentane-1,5-diyldimethanol. The optical properties and chemical stability of 2,5-DTPA are determined by its protonation state. The protonation state depends on the pH of the solution or solvent. 2,5-DTPA has two isomers: one with an intramolecular hydrogen bond and one without. 2,5-DTPA also exists as an enol form at high pH values and as a keto form at low pH values. This compound has been shown to have liver protective effects against cell death induced by oxidative stress in animal models.</p>

<p>4-Amino-2-chlorobenzene-1-sulfonamide is an isoform of the amino acid primary amine. It inhibits carbonic anhydrase and is used in treatment of eye diseases caused by uveitis and glaucoma. The IC50 value for 4-amino-2-chlorobenzene 1-sulfonamide is 2 nM, which falls within the nanomolar range. This drug has been shown to inhibit the activity of mammalian and human carbonic anhydrase. Carbonic anhydrase inhibitors are used as antihypertensive agents, diuretics, and antiepileptics. This drug also inhibits human cytosolic anhydrase II (hCA II).</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>1,4-Dibutylbenzene-1,4-dicarboxylate (DBDC) is a cationic surfactant that reacts with an acid to form a light emitting compound. It has been shown to have optimum concentrations of 0.5% and 1% in the presence of pueraria lobata extract. DBDC has also been used as sealant, hydroxyl group, glycol ester, and fatty acid. DBDC has been found to be a solid catalyst for dehydrocostus lactone with particle size below 10 microns.</p>

<p>3,5-Dimethyl benzo[b]thiophene is a linear molecule containing an unsaturated thiophene ring. This compound is reactive and can undergo bond cleavage reactions with oxygen. It is used in analytical methods such as chromatographic analysis and linear regression analysis. 3,5-Dimethyl benzo[b]thiophene can also be used for the desulfurization of petroleum products and hydrogenated to produce polymers. The molecular descriptors for this compound are C=0, H=1, N=1, O=0, S=0.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>3-Chlorophenylurea is a quinazolinone that inhibits the growth of candida glabrata. This compound has been shown to inhibit efflux pumps, which are proteins that pump out drugs from the cell. 3-Chlorophenylurea has been shown to inhibit the efflux of fluconazole, a drug used to treat fungal infections, and thiourea, a compound that is known for its cytotoxicity. The inhibition of these two compounds suggests that 3-chlorophenylurea could be an efflux pump inhibitor.</p>

<p>Versatile small molecule scaffold</p>

<p>3-Hydroxy-2-(hydroxymethyl)-4H-pyran-4-one is a manganate compound that is used in the synthesis of carboxylic acid derivatives. The reaction is performed in a solvent mixture of methanol, acetone and triethylamine (1:1:1 v/v). The reaction proceeds through an intermediate formation of a tetrahedral ether, which is then hydrolyzed to yield the desired product. This process can be carried out in batch or continuous mode.</p>

<p>Versatile small molecule scaffold</p>

<p>Diethyl succinate (DES) is a chemical compound that has reversible photochromic properties. It absorbs ultraviolet light and converts to 1,3-dimethyl-1H-indole-2-carbaldehyde (DMICA), which can be reverted back to DES by exposure to visible light. DMICA is chemically stable in the absence of oxygen and air, but it decomposes in the presence of strong oxidizing agents. The absorption spectrum of DMICA shows maxima at 230 nm and 270 nm with a peak at 254 nm. Diethyl succinate is an isomer of diethyl malonate, which has a similar structure. Diethyl succinate has no solubility in water, but it dissolves readily in organic solvents such as acetone or ethanol.</p>

<p>4-Cyano-2-methylbenzoic acid is an organic compound with the formula CH3CNOC(O)CH2CO2H. It is a white, water soluble solid that is an intermediate in the conversion of 4-cyanoacetophenone to methyl benzoate. The compound has been used in research as an oxime and has shown biological activity against viruses, bacteria, and tumors. As a result of its antiviral activity, 4-Cyano-2-methylbenzoic acid has been studied for treatment of HIV/AIDS patients. The compound also inhibits insect growth by inhibiting chitin production and can be used as a pesticide or acaricide.</p>

<p>Versatile small molecule scaffold</p>

<p>Methanesulfonylpropan-2-ol is a sulfonic acid that is used in clinical chemistry for the measurement of the concentration of mercaptans. This liquid has an acidic character, which distinguishes it from other sulfonic acids. Methanesulfonylpropan-2-ol also has a magnetic property and can be used to detect the presence of this substance in urine or blood samples. <br>Methanesulfonylpropan-2-ol is excreted by the kidneys and intestines and is diluted when mixed with water. This substance can be detected using chromatographic science, such as gas chromatography, to identify its presence in biological samples. Methanesulfonylpropan-2-ol may have anticancer properties due to its ability to inhibit cell growth and proliferation. It binds to DNA, disrupting the production of new cells. The intestinal absorption of this drug leads to an increased concentration in the intestine, which may lead to anticancer effects</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>4-Hydroxy-9H-fluoren-9-one is a byproduct of the oxidation of fatty acids in soil microorganisms. It inhibits bacterial growth and has been shown to have synergistic effects with aromatic hydrocarbons. 4-Hydroxy-9H-fluoren-9-one can inhibit the production of enzymes such as acetyl coenzyme A carboxylase, which are necessary for cellular respiration and carbon metabolism. This compound also inhibits the dioxygenation of propionate to acetate and butyrate, which are important substrates for microorganisms. 4-Hydroxy-9H-fluoren-9-one is produced by bacteria in deionized water when exposed to dioxygen. It can be used as a carbon source for bacterial growth and can inhibit the activity of enzymes that metabolize aromatic compounds, such as biphenyl.</p>

<p>Versatile small molecule scaffold</p>

<p>4-(1-Phenylethyl)phenol is an organic solvent that has been used as a corrosion inhibitor, an antioxidant, and an alkylating agent. It has been shown to be a good catalyst for the production of styrene from ethylene. 4-(1-Phenylethyl)phenol is also used in the production of polyvinyl chloride, polyvinyl acetate, and other chemical products. It is used as a chemical intermediate in the production of nonyl and nitrate modifiers. 4-(1-Phenylethyl)phenol is also a reagent for the preparation of ketones and nitrates.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Cyclopentyl-(1-phenyl-ethyl)-amine is a cavity-forming molecule that can be used as a molecular probe. It has been shown to interact with the amine groups in polymers and form chains, which can be used for template molecules. Cyclopentyl-(1-phenyl-ethyl)-amine has been shown to have selectivity for interactions with amines over other moieties, such as nitrobenzene or water. The steric interactions of cyclopentyl-(1-phenyl-ethyl)-amine are also important when considering its interactions with other molecules, such as polymers. Cyclopentyl-(1-phenyl-ethyl)-amine has been shown to form molecular structures that could be used as templates for the synthesis of other molecules.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Potassium trifluoromethoxytrimethylborate is a boronic acid. It is used in organic chemistry as an oxidant and nucleophile. It reacts with alcohols, iodides, and aldehydes to form the corresponding potassium salt and alcohol or the corresponding potassium salt and iodide or the corresponding potassium salt and aldehyde. Potassium trifluoromethoxytrimethylborate has been used for the synthesis of fluoxetine hydrochloride. The reaction time is dependent on the substrate chosen, but typically ranges from 5-12 hours.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(1H-Pyrazol-3-yl)acetamide (2PZA) is a nitroheterocyclic compound that exhibits anticancer activity by inhibiting the growth of cancer cells. It has been shown to inhibit cell growth and induce apoptosis in vitro. 2PZA also interacts with DNA and inhibits nucleotide synthesis, which leads to inhibition of protein synthesis. The functional theory for this compound is based on its ability to undergo hydrogen bonding interactions with aromatic amino acid residues. 2PZA also has significant antioxidant properties and can be used as a magnetic resonance imaging contrast agent for brain tumors.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2-(Benzylamino)butan-1-ol is an organic compound that is a chiral amine. It can be used as a solvent for chemical reactions, and has been shown to be useful in the preparation of catecholamines and other biologically active compounds. The crystal structure of 2-(benzylamino)butan-1-ol has been determined using x-ray diffraction techniques. The molecule exists as a racemic mixture of two enantiomers, one with a melting point at 56°C and the other at 53°C. These enantiomers have different solubilities in nonpolar solvents such as benzene, which makes them useful as phase transfer catalysts or antisolvents to separate chiral molecules by liquid chromatography.</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>Versatile small molecule scaffold</p>

<p>2,4-Dichloro-6-phenylpyrimidine is a nucleophilic reagent that has been used to synthesize pyrimidine derivatives. It has been shown to react with cyanoacetic acid and malononitrile in the presence of an organolithium reagent to form 2,6-dichloro-2,4-dihydroxypyrimidine. This compound reacts with chlorine gas to give 2,4-dichloro-6-(chloromethyl)pyrimidine. This reaction is regioselective and does not affect the other substituents on the ring. The reaction proceeds via a nucleophilic attack on the carbon atom adjacent to the nitrogen atom.</p>

<p>Versatile small molecule scaffold</p>