Acids and Synthetic Reagents

<p>Applications 4-(t-Boc-amino)-1-butyl Bromide (cas# 164365-88-2) is a compound useful in organic synthesis.<br>References Bendale, P., et al.: J. Med. Chem., 50, 4585 (2007), Lansdell, M., et al.: Bioorg. Med. Chem. Lett., 18, 4944 (2008), Imaeda, Y., et al.: Bioorg. Med. Chem., 16, 2243 (2008),<br></p>

<p>Applications MK-886 is a potent and selective inhibitor of FLAP and Cox-1.<br>References Gillard, J., et al.: Can. J. Physiol. Pharmacol., 67, 456-464 (1989);<br></p>

<p>Stability Light Sensitive<br>Applications Belinostat is a novel histone deacetylase 3 selective inhibitor, which protects the β cells from cytokine-induced apoptosis.<br>References Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);<br></p>

<p>Applications (-)-B-Methoxydiisopinocampheylborane hydrate is an intermediate used in the synthesis of homoallylic alcohol's and several complex natural products.<br>References Mishra, V. K., et al.: J. Org. Chem., 81, 9728 (2016); Jonnalagadda, S. C., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis 1, (2009); Bailey, A. M., et al.: Angew. Chem. Int. Ed., 55, 639 (2016)<br></p>

<p>Applications γ-Butyrobetaine is a synthetic carnitine related compound used as a transporter substrate in the cloning and sequencing of human carnitine transporter 2 (CT2).<br>References Enomoto, A. et al.: J. Biol. Chem., 277, 36262 (2002);<br></p>

<p>Applications 4-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid (cas# 60875-16-3) is a useful research chemical.<br></p>

<p>Applications 4-Nitrobenzoyl Chloride is used inorganic syntheses such as Michael additions. Also used in the synthesis of polysubstituted furanonaphthoquinoines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, J. et al.: Catal. Comm., 32, 18 (2013); Wu, Z. et al.: Org. Biomol. Chem., 11, 828 (2013);<br></p>

<p>Applications (R)-(+)-3-Methylcyclopentanone (cas# 6672-30-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Di-tert-Butyl Disulfide is a general reagent used in the synthesis of a novel neuropeptide Y (NPY) Y5 receptor antagonist Velneperit) used in the treatment of obesity.<br>References Oda, S. et al.: Org. Proc. Res. Dev., 19, 531 (2015);<br></p>

<p>Applications D-(-)-ASPARAGINE MONOHYDRATE (cas# 5794-24-1) is a useful research chemical.<br></p>

<p>Applications N-(tert-Butoxycarbonyl)-D-prolinol is used to prepare (azetidinyl)methoxy]pyridines and 2-(aryloxymethyl) azacyclic analogs with therapeutic potetials for the treatment of central nervous system (CNS) disorders.<br>References Abreo, M., et al.: J. Med. Chem., 39, 817 (1996); Elliott, R., et al.: Bioorg. Med. Lett., 6, 2283 (1996)<br></p>

<p>Applications Bis(1,5-cyclooctadiene)nickel(0) is a reagent in the synthesis of self-assembled organometallic nickel complexes as catalysts for selective dimerization of ethylene into butene.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulens, P., et al.: Organometallics, 34, 1139 (2015)<br></p>

<p>Applications (S)-(+)-3,3-Dimethyl-2-butylamine is a reagent used in organic synthesis. Used in the synthesis of allosteric modulators in the treatment of schizophrenia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, P. et al.: Org. Lett., 17, 3698 (2015); Turlington, M. et al.: J. Med. Chem., 56, 7976 (2013);<br></p>

<p>Applications AMG 337 is a potent and selective inhibitor of mesencymal epethelial transition factor (MET factor) which has been implicated in several cancers.<br>References Boezio, A. et al.: J. Med. Chem., 59, 2326 (2016);<br></p>

<p>Applications An antineoplastic. A derivative of Cytarabine.<br>References Aoshima, M., et al.: Cancer Res., 36, 2726 (1976), Akiyama, M., et al.: Chem. Pharm. Bull., 26, 981 (1978),<br></p>

<p>Applications Derivatives of 6-Amino-2-thiouracil as novel, potent, and selective A3 adenosine receptor antagonists.<br>References Ji, X., et al.: Drug Dev. Res., 33, 51 (1994), Poulsen, S., et al.: Bioorg. Med. Chem., 6, 619 (1998), Fredholm, B., et al.: Pharmacol. Rev., 53, 527 (2001), Gessi, S., et al.: Clin. Cancer Res., 10, 5895 (2004), Moro, S., et al.: Med. Chem. Res., 26, 131 (2006), Tafi, A., et al.: J. Med. Chem., 49, 4085 (2006),<br></p>

<p>Applications 1,4-Dichloro-2-butyne used in the synthesis of 1,4-disubstituted 1,2,3-triazoles. Also, it is used in the approach of the 20S-camptothecin family of antitumor agents.<br>References Feldman, A. et al.: Org. Lett., 6, 3897 (2004); Josien, H. et al.: Chem. Eur. J., 4, 67 (1998);<br></p>

<p>Applications 5-Methylindole is used in the synthesis of novel protein kinase inhibitors.<br>References Guengerich, F. et al.: J. Med. Chem., 47, 3236 (2004);<br></p>

<p>Applications SP 2509 reduces the effect of the LSD1 binding to CoREST, resulting in increased methylation of H3K4 and driving increased expression of p21, p27 and CCAAT/enhancer binding protein α in acute myeloid leukemia cells. Anti-leukemia agent.<br>References Sorna, V. et al.: J. Med. Chem., 56, 9496 (2013); Fiskus, W. et al.: Leukemia, 11, 2155 (2014);<br></p>

<p>Applications 2-Fluoroiodobenzene is used as a reagent in various organic reactions. It is used in the synthesis of spirocyclic [1,2,3]-triazolooxazine nucleosides which have antiviral properties.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dell'Isola, A., et al.: Chem-Eur. J., 20, 11685 (2014)<br></p>

<p>Applications (1S)-[1,1'-Binaphthalene]-2,2'-diol is used in the stereoselective synthesis of Peloruside A. Also used in the synthesis of BINAP-based aminophosphines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raghavan, S. et al.: Tetrahedron, 69, 4835 (2013); Anstiss, C. et al.: Mol., 18, 2788 (2013);<br></p>

<p>Applications Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity.<br>References Sampath, C. et al.: Phosphor. Sulfur Silicon. Rel. Elem., 191, 95 (2016);<br></p>

<p>Applications TETRAMETHYLAMMONIUM BOROHYDRIDE (cas# 16883-45-7) is a useful research chemical.<br></p>

<p>Applications 4-Aminoresorcinol Hydrochloride is a reactant in the preparation of diethers with antiviral activity against group A and B human Rhinoviruses.<br>References Bernard, A.M., et. al.: Bioorg. Med. Chem., 22, 4061 (2014)<br></p>

<p>Applications 1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.<br>References Neyyarapally, A.T. et al.: Ind. J. Chem., 11, 325 (1973); Jones, C.D. et al.: J. Med. Chem., 27, 1057 (1984); Nakata, K. et al.: Molecules, 15, 6773 (2010);<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Bromobenzenesulfonyl Chloride is an intermediate used to prepare sulfonamide-substituted cyclooctylpyranones as nonpeptidic HIV protease inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Skulnick, H., et al.; J. Med. Chem., 40, 1149 (1997)<br></p>

<p>Applications methyl 5-(chloromethyl)-2-furoate (cas# 2144-37-8) is a useful research chemical.<br></p>

<p>Applications LGK 974 is a potent and specific small molecule Porcupine (PORCN) inhibitor.<br>References Liu, J., et. al.: Roc. Natl. Acad. Sci. USA, 110, 20224 (2013)<br></p>

<p>Applications Benzenecarbothioic Acid is used in the preparation of anti-leishmanial activity. Also used in the preparation of agents for the treatment against Alzheimer’s disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Andrews, P. et al.: Aus. J. Chem., 66, 1297 (2013); Linning, P. et al.: Org. Biomol. Chem., 10, 8216 (2012);<br></p>

<p>Applications Ethyl 2,4-Dioxovalerate is an analog of Ethyl Pyruvate (P998915) and exhibits anti-inflammatory properties in vivo and/or in vitro. It is a potential antifungal agent that inhibits the growth of Candida albicans and Microsporum canis.<br>References Sappington, P.L., et al.: Biochem. Pharmacol., 70, 1579 (2005); Burch, H.A., et al.: J. Med. Chem., 15, 429 (1972)<br></p>

<p>Applications o-Chloramine T (cas# 110076-44-3) is a useful research chemical.<br></p>

<p>Applications 2-Acetamido-5-fluorophenylboronic acid, pinacol ester<br></p>

<p>Applications 2,6-Dichlorobenzyl Bromide is used in the preparation of potent epoxide hydrolase inhibitors. Has shown thus far to relieve hypotension in lipopolysaccharide deficient murine models. As well they have been used in the synthesis of anti-HIV drugs based on diaryltriazine (DATA) analogues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hwang, S. et al.: J. Med. Chem., 50, 3825 (2007); Ludovici, D. et al.: Bioorg. Med. Chem. Lett., 11, 2229 (2001);<br></p>

<p>Applications 2-Bromophenylethylamine is an intermediate used to prepare potent antagonists of antiapoptotic protein XIAP for treatment of cancer. It is also used in the synthesis of aryl aminosulfonamide derivatives as potent 5-HT6 receptor antagonists.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oost, T., et al.: J. Med. Chem., 47, 4417 (2004); Nirogi, R., et al.: Bioorg. Med. Chem. Lett., 20, 4440 (2010)<br></p>

<p>Applications N-Boc-6-hydroxyhexylamine (cas# 75937-12-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Calcium Sulfate Dihydrate is obtained from gypsum, a naturally occurring compound. Also used in the preparation of calcium sulfate and calcium sulfoaluminate.<br>References Strydom, C. et al.: J. Therm. Anal., 49, 1501 (1997); Winnefeld, F. et al.: DGCh-Monograph., 44, 30 (2011);<br></p>

<p>Applications 5-Methyltryptamine is a methylated derivative of tryptamine. 5-Methyltryptamine is a weak antagonist of 5-Hydroxytryptamine (H974990) with weak potency as stimulants of the cardiac sympathetic nerves. 5-Methyltryptamine is also used in the preparation of inhibitors of kinesin spindle protein (KSP), a promising class of anticancer agents.<br>References Fozard, J.R. et al.: Naun.-Schmied. Arch. Pharmacol., 301, 223 (1978); Slotkin, T. et al.: Mol. Pharmacol., 15, 607 (1979); Liu, F. et al.: Bioorg. Med, Chem., 18, 4167 (2010);<br></p>

<p>Applications 2,5-Dimethoxythiophenol is a thiophenol derivative used in the preparation of dihydrofolate reductase inhibitors and potential antitumor agents.<br>References Gangjee, A. et al.: J. Med. Chem., 52, 4892 (2009); Gangjee, A. et al.: Biiorg. Med. Chem., 18, 953 (2010);<br></p>

<p>Applications Mercury(II) acetate is a reagent that is used in the investigation of diastereoselective acyclic α-alkoxydithioacetal substitutions involving thiacarbenium intermediates.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Prevost, M., et al.: J. Org. Chem. 79, 10504 (2014);<br></p>

<p>Applications 1,5-Difluoro-2,4-dinitrobenzene acts as an oleanolic acid NO-releasing derivative used towards the treatment of colon cancer. Also used in the synthesis of beta blockers used as bronchodialators.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, J. et al.: RSC. Adv., 5,19445 (2015); Bhushan, R. et al.: Anal. Lett., 47, 202 (2014);<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 5-Nitrothiophene-2-carboxaldehyde is a reagent that is used in the activity of mefloquine-oxazolidine derivatives against multidrug-resistant Mycobacterium tuberculosis.<br>References Goncalves, R. S. B., et al.: Bioorg. Med. Chem., 20, 243 (2012);<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-Morpholinylsulfur Trifluoride is a chemical reagent used in the preparation of proline analogs. Also used in the preparation of difluoropiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mykhailiuk, P. et al.: Tetrahedron 67, 3091 (2011); Surmont, R. et al.: Synlett., 12, 1933 (2009);<br></p>

<p>Applications Entinostat is an emerging HDACi (histone deacetylase inhibitor). Entinostat is used for treatment of solid tumors and hematologic malignancies. Potent Histone deacetylase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hu, E., et al.: J. Pharmacol. Exp. Ther., 307, 720 (2003), Maggio, S., et al.: Cancer Res., 64, 2590 (2004), Gojo, I., et al.: Blood, 109, 2781 (2007), Xu, W; Oncogene, 26, 5541 (2007),<br></p>

<p>Applications N-Acetyl-DL-Valine is an amino acid.<br>References Hirschmann R., et al.: Science, 265, 234 (1994); Gu Z. T., et al.: J. Magn. Reson., 140, 340 (1999); Bodalo, A., et al.: Enzyme Microb. Technol., 24, 381 (1999)<br></p>

<p>Applications 4'-Bromopropiophenone is an electron-deficient aryl bromide that has the ability to self-polymerize using binary palladium catalyst. 4'-Bromopropiophenone is also used as a reagent in the synthesis of substituted 2-aminothiazoles (e.g. 2-Aminobenzothiazole [A593500]), compounds that are inhibitors of neuronal degeneration in patients with Alzheimer’s disease.<br>References Bensaid, S., et al.: Tetrahedron Lett., 52, 1383 (2011); Lagoja, I., et al.: Eur. J. Pharm. Sci., 43, 386 (2011); Matsubara, K., et al.: J. Organom. Chem., 691, 3693 (2006)<br></p>

<p>Applications N-(Benzyloxycarbonyl)ethylenediamine Hydrochloride is a reagent used to synthesize new opioid ligand as an analgesics with mixed agonist and antagonist properties to induce tolerance and dependence.<br>References Salvadori, S., et al.: Bioorg. Med. Chem., 15, 6876-6881 (2007);<br></p>

<p>Applications 4-Fluorobenzyl Bromide is a substituted benzyl bromide reagent used in the preparation of wide range of biologically active compounds such as bronchodialators, neurochemicals and antibacterials.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hardtmann, G.E. et al.: J. Med. Chem., 18, 447 (1975); Bartl, V. et al.: Coll. Czechoslov. Chem. Comm., 45, 3182 (1980);<br></p>

<p>Applications AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.<br>References Yeh, T., et al.: Clin. Cancer Res., 13, 1576 (2007), Meng, J., et al.: Cancer Biol. Ther., 8, 2073 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications 9-Mesityl-10-methylacridinium Tetrafluoroborate can be used for the synthesis of γ-butyrolactones, γ-lactams and pyrrolidines. 9-Mesityl-10-methylacridinium Tetrafluoroborate has been reported by Nicewicz et al. to mediate myriad transformations through Photoredox Catalysis. The applications include the anti-Markovnikov hydroamination of alkenes and addition of carboxylic acids to alkenes and the hydrotrifluoromethylation of styrenes using the Langlois reagent S673690.<br>References Gesmundo, N. J. et al.: Org. Lett. 17, 1316 (2015); Zeller, M. A., et al.: Org. Lett. 16, 4810 (2014); Nicewicz et al., J. Am. Chem. Soc., 135 (26), 9588–9591(2013)<br></p>

<p>Applications (4R,5R)-2,2-Dimethyl-α,α,α',α'-tetra-2-naphthalenyl-1,3-dioxolane-4,5-dimethanol, is a privileged ligand analogue of TADDOLs. It can be broadly used in asymmetric synthesis. It is also shown that the titanium TADDOLate catalysts have broad application towards carbonyl addition and cycloaddition.<br>References Seebach, D., et al.: Ange. Chem. Inter. Ed., 40, 92, (20010;<br></p>

<p>Stability Hygroscopic<br>Applications Magnesium acetate tetrahydrate (cas# 16674-78-5) is a useful research chemical.<br></p>

<p>Applications 1-Acetyl-1H-pyrazole-4-boronic acid, pinacol ester<br></p>

<p>Applications ethyl 3-aminobutanoate (cas# 5303-65-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Lithium Trifluoromethylsulfonate has been shown to improve the cycling performance of lithium-oxygen batteries.<br>References Nasybulin, E., et. al.: J. Phys. Chem. C, 117, 2635 (2013)<br></p>

<p>Applications 4-Fluoro-α-methylstyrene is used in the synthesis of Paroxetine (P205750), which is a selective serotonin reuptake inhibitor. Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lassen, J.B.: Eur. J. Pharmacol., 47, 351 (1978), Lund, J., et al.: Acta Pharmacol. Toxicol., 51, 351, (1982),<br></p>

<p>Applications Bismuth Citrate is a reagent used in the preparation of nano-array wires and nanotubes. Also used in the preparation of collidal bismuth subcitrate with ulcer healing properties.<br>References Chen, R. et al.: Chem. Commun (Camb)., 21, 2265 (2006); Asato, E. et al.: Inorg. Chem., 34, 2447 (1995);<br></p>

<p>Applications Precursor to Kifunensine.<br>References Kayakiri, H., et al.: Chem. Pharm. Bull., 39, 1378 (1991),<br></p>

<p>Applications 5-Amino-2-methylene-1,3,3-trimethylindoline (cas# 6872-05-5) is a compound useful in organic synthesis.<br></p>