Amines

<p>Bosentan is a potent inhibitor of the uptake of organic anions. It is used in the treatment of pulmonary arterial hypertension and has been shown to be effective against pravastatin-resistant HIV protease inhibitors, such as saquinavir, quinidine, and rosuvastatin. Bosentan inhibits uptake by binding to the transporter protein at a site that does not overlap with the binding site for organic anion substrates. This leads to a change in kinetic parameters for substrates, such as pravastatin and saquinavir. The binding site on bosentan may also be elucidated through monolayer experiments with efflux transporters.</p>

<p>Undecafluorohexanoic acid is a perfluoroalkyl carboxylic acid that has been shown to disrupt steroidogenesis in vitro. It may be able to inhibit the transport of cholesterol, fats, and other lipids in cells, which causes disruption in steroidogenesis. This compound also has anti-cancer properties due to its ability to induce apoptosis and arrest cancer cell proliferation. Undecafluorohexanoic acid may also have developmental effects on animals because it can bind to estrogen receptors and disrupt the normal process of estrogen-mediated signaling pathways.</p>

<p>Boc-4-aminopiperidine is a molecule that is used as a substrate in chemical reactions. It reacts with sodium hydroxide solution to form an imine, which is hydrogenated by reducing agents such as NaBH4. This reaction yields the products 4-aminopiperidine and acetaldehyde. Boc-4-aminopiperidine is also utilized as a cholinesterase inhibitor, which inhibits the breakdown of acetylcholine at nerve endings. The inhibitory activity of Boc-4-aminopiperidine can be determined using diagnostic techniques and it can be used to inhibit viruses such as HIV and influenza A virus.</p>

<p>TES, also known as N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid, is a buffering agent that is used in protein assays and forms complexes with DNA and copper ions. The optimal pH range of this zwitterionic buffer is 6.8-8.2 and its pKa is 7.4.</p>

<p>Please enquire for more information about N-(3-Aminopropyl)-2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Dextroamphetamine saccharate is a pharmaceutical drug that belongs to the group of amphetamine derivatives. It is used in the treatment of conditions such as narcolepsy and attention-deficit disorder (ADD). The epidermal growth factor receptor (EGFR) is an important target for the effects of this drug, which has been shown to stimulate growth and proliferation in vitro. Dextroamphetamine saccharate has a complex pharmacokinetic profile and is metabolized by hydrolysis into dextroamphetamine. This drug also binds to voltage-dependent calcium channels, which regulate neurotransmitter release at nerve terminals. The pain relief associated with dextroamphetamine saccharate may be due to its ability to block pro-inflammatory cytokines or inhibit trigeminal nerve activity.</p>

<p>Please enquire for more information about N1-(Pivaloyloxy)methyl-N2-(dimethylamino)methylene 9-deazaguanine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>6-Amino-4-(4-phenoxyphenylethylamino)quinazoline is a potential anticancer drug that has been shown to inhibit the polymerase chain reaction in human osteosarcoma cells. It also inhibits the signaling pathway of nuclear factor-κB (NF-κB), which is involved in cell death and tumorigenesis. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has shown significant cytotoxicity against murine hepatoma cells and bowel disease cells, but not against normal tissue. This drug is also an inhibitor of the drug transporter Pgp. 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline has been shown to be effective in experimental models for cancer, AIDS, and other infectious diseases.</p>

<p>Please enquire for more information about 4-Acetylamino-5-bromo-2-methoxy-benzoic acid methylester including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Isopropyl 2-amino-4-hydroxy-5,8-dihydropyrido[3,4-d]pyrimidine-7(6H)-carboxylate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 4-Amino-6-mercaptopyrazolo[3,4-d]pyrimidine including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Methylaminophenol sulfate is an enzyme substrate that is used in the analytical method for determining the concentration of potassium dichromate. It is prepared by reacting 4-methylaminophenol with sulfuric acid, and its optimum concentration is 0.2 mM. The linear calibration curve was obtained at a pH range of 2 to 5.4 and a temperature range of 25 to 37°C. The analytical method can be applied to human serum samples and has been shown to be applicable for studies on autoimmune diseases and anthelmintics.</p>

<p>Please enquire for more information about 5-Amino-4-methyl-4H-1,2,4-triazole-3-thiol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-(5-Aminopentyl) methotrexate amide-LC-biotin is a specialized bioconjugate, derived through the conjugation of methotrexate, an established antifolate drug, with an LC-biotin moiety. This product is synthesized by covalently linking methotrexate, which is known for its role in cancer therapy through the inhibition of dihydrofolate reductase (DHFR), to a biotin moiety via a long-chain spacer. The resultant bioconjugate retains the therapeutic effects of methotrexate, particularly in its ability to interrupt nucleotide synthesis, thereby affecting cell division in rapidly proliferating cancer cells.The inclusion of biotin in the structure allows for facile attachment to avidin or streptavidin-labeled systems, facilitating targeted delivery and enhanced detection in molecular and cellular studies. The primary application of N-(5-Aminopentyl) methotrexate amide-LC-biotin lies in the realm of targeted drug delivery and advanced research into methotrexate metabolism. By leveraging the high affinity of biotin-streptavidin interactions, researchers can effectively study the biodistribution and cellular uptake of methotrexate, advancing cancer therapeutic strategies and providing insights into antifolate drug mechanisms at the molecular level.</p>

<p>[[4-[[2-(4-Cyclohexylphenoxy)ethyl]ethylamino]-2-methylphenyl]methylene]malononitrile (CAS #: 68436-91-7) is a reactive chemical species that has been used as a crosslinking agent and an uv absorption dye. CEM is a styryl dye that absorbs radiation in the uv range, with a maximum absorption at about 275 nm. It is a substrate film for light emission and can be used to measure viscosity. CEM is also chemically related to aromatic hydrocarbons and fatty acids, and can be synthesized from hydroxyl groups.</p>

<p>Please enquire for more information about Ethyl2-(acetylamino)-3-[3,5-diiodo-4-(4-methoxyphenoxy)phenyl]propanoate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>(R)(−)-DOI hydrochloride is a synthetic compound classified as a selective serotonin receptor agonist. It is primarily sourced from chemical synthesis processes designed to explore potential interactions within serotonergic pathways. The compound’s mode of action involves the activation of 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors, which play crucial roles in modulating neurotransmission and signaling pathways within the central nervous system.In research and experimental contexts, (R)(−)-DOI hydrochloride is utilized to investigate the molecular mechanisms of serotonin receptors, contributing to a deeper understanding of their role in neurophysiology and potential implications in neuropsychiatric disorders. Studies often explore its effects on cognition, perception, and mood regulation. Despite its promising role in scientific exploration, (R)(−)-DOI hydrochloride is not intended for therapeutic use and remains predominantly a tool for advancing the field of neuropharmacology through controlled experimental settings.</p>

<p>Please enquire for more information about 5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>7-[(2S,3R)-3-Amino-2-methyl-azetidin-1-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-quinoline-3-carboxylic acid (ABT) is a drug that binds to bacterial enzymes and inhibits their ability to synthesize proteins. ABT is a conjugate of fluoroquinolone and an amino acid. As the drug is degradable by hydrolysis, it has been shown to be less toxic in Sprague Dawley rats than other fluoroquinolones. This drug has been used in diagnostic tests as a ligand for affinity ligands, but has not been approved for human use. The drug also possesses functional groups that are important for binding to reconstituted enzymes.br&gt;br&gt;ABT's ester linkages are degradable by hydrolysis and can be</p>

<p>8-Fluoro-Quinazoline-2,4-Diamine is an organic compound with the formula CHClN. It is a yellow solid that is soluble in organic solvents such as chloroform and toluene. The compound is used to produce dyes and pharmaceuticals. 8-Fluoro-Quinazoline-2,4-Diamine can be obtained by nitrating 2,4-diaminoquinazoline with nitric acid and hydrochloric acid in the presence of carbonate or stannous chloride. This reaction produces two isomers: 8-fluoroquinazoline (8FQ) and 6-fluoroquinazoline (6FQ). The 8FQ isomer has been shown to have a nuclear magnetic resonance spectrum at 300 MHz that contains four signals at 1.3 ppm, 3.5 ppm, 5.6 ppm, and 7.0 ppm, which are assigned to</p>