Halogenated Compounds

<p>Applications 6-Fluoro-3-(trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is a useful research chemical.<br></p>

<p>Applications 2-iodo-4-methylphenol is a useful research chemical for organic synthesis and other chemical processes.<br>References Liu, Y., et al.: RSC Advances, 8, 28637 (2018); Xu, S., et al.: Mol. Catal., 452, 264 (2018); Alonso-Maranon, L., et al.: J. Org. Chem., 83, 7970 (2018)<br></p>

<p>Applications 1-Phenyl-2-methyl-6-chlorobenzimidazole is a useful research chemical.<br></p>

<p>Applications (3,5-Dichloropyrazin-2-yl)methanamine is a reagent used in the preparation of triazolopyrazines and related bicyclic nitrogen heterocycles as Ahr modulators for treatment of diseases.<br>References Beck, H. P. et al.: PCT Int. Appl. 86 pp. (2019)<br></p>

<p>Applications 4-Iodopyrimidine is used as a reactant in the preparation of 1,3,8-triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.<br>References Vachal, P., et. al.: J. Med. Chem., 55, 2945 (2012)<br></p>

<p>Applications 2-Bromo-3-methoxybenzoic acid (cas# 88377-29-1) is a useful research chemical.<br></p>

<p>Applications 2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin is an intermediate in the synthesis of N-Dides(2-chloroethyl) N-(2-Hydroxyethyl),N-(2-ethoxyethyl) Cyclophosphamide (C984610) which is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.<br>References Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)<br></p>

<p>Applications 4,5-Dibromo-1,2-cyclohexanediol is an intermediate in the synthesis of Conduritol A (C645000). Conduritol A (cas# 526-87-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(1-oxooctadecyl)-1-piperazinyl]-3-quinolinecarboxylic Acid is used in biological studies as a modifier or additive for the sustained release of norfloxacin.<br>References Dong, M. et al.: Fam. Zhu. She. (2016)<br></p>

<p>Applications 2,5-Bis(2,2,2-trifluoroethoxy)-1,4-benzenedicarboxylic Acid is used in the synthesis of new fluorinated ethers of aromatic acids and diesters.<br>References Ritter, J. C., et al.: From PCT Int. Appl. (2011), WO 2011028852 A2 20110310<br></p>

<p>Applications [5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (cas# 345637-71-0) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Octafluoro-4,4'-biphenol (cas# 2200-70-6) is a useful research chemical.<br></p>

<p>Applications (1,2-Dibromo-3,3-dimethylbutyl)trimethylsilane is an intermediate in the synthesis of 1-Bromo-3,3-dimethyl-1-butene (B740080) which is used as a reagent in the preparation of bromo(dimethyl)butenes via elimination of dibromo(dimethyl)butane in the preparation of alkynes.<br>References Sydnes, L. K., et al.: Monatsh. Chem., 136, 1737 (2005)<br></p>

<p>Applications 4,4-Dibromo-2,4-dihydro-5-methyl-3H-pyrazol-3-one is used in the preparation of antimoebic compounds such as thiosemicarbazide derivatives. Also used in the preparation of triazine molecules displaying antifungal activity.<br>References Singh, S. et al.: Eur. J. Pharm. Sci., 25, 255 (2005); Tewari, A. et al.: Indian. J. Chem. B., 41B, 664 (2002);<br></p>

<p>Applications 1,1-Dimethylethyl Ester N-(3-Iodopropyl)carbamic Acid (cas# 167479-01-8) is a useful research chemical.<br></p>

<p>Applications 6'-Bromo-2',3'-dihydro-spiro[imidazolidine-4,1'-[1H]indene]-2,5-dione has 5,5-Tetramethylenehydantoin in its structure. 5,5-Tetramethylenehydantoin is used in preparation of substituted heteroaryl compounds which are useful in the treatment of cognitive dysfunction and CNS disorders.<br>References Toop, H., et al.: PCT Int. Appl., (2020);<br></p>

<p>Applications 3,5-Dichlorobiphenyl-2',3',4',5',6'-d5 (CAS# 1276197-28-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Chlorohexadecane-d33 (CAS# 352431-13-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-(4-Bromophenyl)piperazine Hydrochloride is useful in the synthesis of large bifunctional heterocycles use in targeted degradation of rapidly accelerated fibrosarcoma polypeptides<br>References Crew, A., et al.: U.S. Pat. Appl. Publ., 1094 (2020)<br></p>

<p>Applications 4-(Bromomethyl)nonane can be used as both a reagent and is incorporated into anionic surfactants.<br>References Jin, Z., et al.: J. Dispersion. Sci. Technol., 32, 898-902 (2011)<br></p>