Ketones

<p>Applications Used in the preparation of benzopyran derivatives for their antiinflammatory properties.<br></p>

<p>Applications 1-​(3-​Hydroxyphenyl)​-​1-​propanone is a reactant used to synthesize tricyclic fused pyridines, a family of alkaloids with antimalarial activity.<br>References Zheng, L., et al.: J. Org. Chem., 81, 8911-8919 (2016)<br></p>

<p>Applications Benzyl p-Toluylketone (cas# 2001-28-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wu, Z., et al.: Bioorg. Med. Chem. Lett., 18, 2211 (2008), Gadad, A., et al.: Bioorg. Med. Chem., 16, 276 (2008),<br></p>

<p>Applications 4-(Morpholin-4-yl)cyclohexanone is a useful synthetic intermediate. It was used to synthesize diastereomeric 3,6-diaminobicyclo[3.1.0]hexane derivatives.<br>References Vilsmaier, E., et al.: Synthesis, 12, 1142 (1991)<br></p>

<p>Applications 1-[3,4-Bis(phenylmethoxy)phenyl]ethanone is an intermediate in synthesizing Arbutamine (A766300). It is a cardiac stimulant. Arbutamine stimulates adrenergic receptors.<br>References Sinusas, A., et al.: J. Nucl. Med., 35, 664 (1994); Sansoy, V., et al.: Circulation, 92, 994 (1995); Elhendy, A., et al.: Eur. J. Nucl. Med., 23, 1354 (1996);<br></p>

<p>Applications (5Z,9Z,13Z)-Geranylgeranylacetone is the structural analogue of Teprenone (T103500), an anti-ulcerative. Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.<br>References Murakami, M., et al.: Arzneim.-Forsch., 31, 799 (1981); Nishizawa, Y., et al.: Xenobiotica, 17, 575 (1987)<br></p>

<p>Applications 7-Hydroxy-1-indanone (cas# 6968-35-0) is a useful research chemical.<br></p>

<p>Applications 9-HEPTADECANONE (cas# 540-08-9) is a useful research chemical.<br></p>

<p>Applications Cyclopropyl Methyl Ketone is a chemical reagents used in the synthesis of PDE4 inhibitors. Also used in the synthesis of α-trifluoromethyl-amines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ferrer, M. et al.: Tetrahedron Lett., 54, 4821 (2013); Radchenko, D. et al.: Tetrahedron Lett., 54, 1897 (2013);<br></p>

<p>Applications 1-(2,5-Dihydroxyphenyl)ethanone is an intermediate used in various synthetic preparations of pharmaceutical goods, 1-(2,5-Dihydroxyphenyl)ethanone was untilized in the synthesis of new flavonoid fatty acid esters with anti-adipogenic and glucose consumption enhancing activities.<br>References Zhao, W., et al.: Bioorg. Med. Chem., 19, 3192 (2011); Jayashree, B.S., et al.: Asian. J. Chem., 22, 1055 (2010); Benites, J., et al.: Bioorg. Med. Chem., 16, 862 (2008);<br></p>

<p>Applications iso-Butyl Vinyl Ketone is a major component in the secretion of Iporangaia pustulosa and Neosadocus maximus.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rocha, D.F., et. al. J. Nat. Prod., 74, 658 (2011)<br></p>

<p>Applications 4,4-Dimethyl-1,3-cyclohexanedione (cas# 562-46-9) is a useful research chemical.<br></p>

<p>Applications (2R,​3S,​4S,​5S)-5-Hydroxy-2,3,4-tris(phenylmethoxy)-5-[(phenylmethoxy)methyl]-cyclohexanone was used in the synthetic preparation of N-substituted valiolamine derivatives.<br>References Fukase, H., et al.: J. Org. Chem., 57, 3642 (1992);<br></p>

<p>Applications 1-Cyclohexylethanone is used in the synthesis of thiosemicarbazide derivatives which exhibits biological activity.<br>References Venkatesh, K., et al.: J. Chem. Pharm. Res., 7, 437-445 (2015)<br></p>

<p>Stability Moisture Sensitive<br>Applications (3R,4R)-Dihydro-3,4-bis(phenylmethoxy)-2,5-furandione is an intermediate in the synthesis of N-alkenylsuccinimide derivatives.<br>References Ohwada, J., et al.: Bull. Chem. Soc. Jap., 63, 287 (1990);<br></p>

<p>Applications PBD-5,11-dione (cas# 18877-34-4) is a useful research chemical.<br></p>

<p>Applications Cyclopentanone-2-carbonitrile (cas# 2941-29-9) is a useful research chemical. It acts as a reagent in the preparation of quinolines<br>References Larsen, R. D., et al.: Science of Synthesis, 15, 389 (2005)<br></p>

<p>Applications 2-NONADECANONE (cas# 629-66-3) is a useful research chemical.<br></p>

<p>Applications 1,1'-[1]Benzothieno[3,2-b][1]benzothiophene-2,7-diylbis[1-octanone] is the intermediate in the synthesis of C8-BTBT (C015010), which is a soluble organic semicoductor used in solution-processed organic field-effect transistors.<br>References Ebata, H., et al.: J. Am. Chem. Soc., 129, 15732 (2007); Izawa, T., et al.: Adv. Mat., 20, 3388 (2008)<br></p>

<p>Applications 1,1'-(1,4-phenylene)bis-Ethanone can undergo oxidative C-C Bond Cleavage to synthesize an aryl carboxylic acid with an iodine catalyst . 1,1'-(1,4-phenylene)bis-Ethanone is also capable of Suzuki-Miyaura coupling.<br>References Xu, L.; et al.: Synlett, 29, 1505 (2018). Xia, Y.; et al.: J. Am. Chem. Soc., 140, 5347 (2018).<br></p>

<p>Applications 1-(2-AMINO-5-HYDROXYPHENYL)ETHANONE (cas# 30954-71-3) is a useful research chemical.<br></p>

<p>Stability Moisture Sensitive<br>Applications 4,7-dimethyl-1,3-dihydro-2-benzofuran-1,3-dione (cas# 5463-50-3) is a useful research chemical.<br></p>

<p>Applications 1,2-Cycloheptanedione is a reagent in the synthesis of 3,3’-Polymethylene-2,2’-bibenzo[b]-1,10-phenanthrolines.<br>References Rahman, A. F. M., et al.: Heterocycles, 75, 871-877 (2008)<br></p>

<p>Applications 2-Hexylidenecyclopentanone is a compound that is found in fragrance.<br>References Scognamiglio, J., et al.: Food Chem. Tox., 3, S577 (2012)<br></p>

<p>Applications 3,​3-​Dimethyl-​2,​4-​pentanedione is used in asymmetric hydrosilation of ketones.<br>References Kuwano, R., et al.: Bull. Chem. Soc. Jpn., 73, 485 (2000).<br></p>

<p>Applications (Z)-1-(Benzo[b]​thiophen-​2-​yl)ethanone Oxime is an isomer of N-​(1-​Benzo[b]​thiophen-​2-​yl-​ethyl)​-​hydroxylamine a reagent used in the preparation of Zileuton, an anti-asthmatic drug.<br>References Guinchard, X. et al.: J. Org. Chem., 73, 2028 (2008)<br></p>

<p>Stability Volatile<br>Applications Cyclobutanone is a member of cycloketone compounds that have potential genotoxic and cytotoxic effects and are most commonly found in irradiated food.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anandon, A., et al.: EFSA Journal, 9, 1930 (2011); Delincee, H., et al.: Radiat. Phys. Chem., 63, 431 (2002); Obana, H. ,et al.: J. Health Sci., 52, 375 (2006)<br></p>

<p>Applications 1,3-Indandione is one of the starting materials in the one-pot multi-component synthesis of indenone-fused heterocyclic derivatives. Also it acts as electron-withdrawing end group used for organic photovoltaic cell application.<br>References Bayayt, M., et al.: Tetrahedron, 73, 1196-1204 (2017); Lim, E.: Mol. Cryst. Liq. Cryst., 635, 94-101 (2016);<br></p>

<p>Applications 5-Acetoxy-3-chloro-2-pentanone (cas# 13051-49-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 5-[(4-Fluorobenzylidene]-2,4-thiazolidinedione (cas# 262601-87-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Phenylcyclohexanone is used in the synthesis of CCR2 antagonists for the treatment of rheumatoid arthritis, atherosclerosis and other disease states. Also used in the preparation of coumarins via dehydrogenation and Heck coupling reactions.<br>References Subasinghe, N. et al.: Bioorg. Med. Chem. Lett., 23, 1063 (2013); Kim, D. et al.: Chem. Comm., 49, 4021 (2013);<br></p>

<p>Applications 5-[1-Hydroxy-2-(2,4,5-trifluorophenyl)ethylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione is an impurity of the DPP-IV inhibitor Sitagliptin (S491000).<br>References Ye, F. et al.: Hech. Huax., 18, 767 (2010); Ahn, J.H, et al.: Bioorg. Med. Chem. Lett., 17, 2622 (2007);<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-(2-oxopropyl)-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione (cas# 57384-79-9) is a useful research chemical.<br></p>

<p>Applications 4-Cyanocyclohexanone is used to prepare nicotinamides as PDE4 D isoenzymes inhibitors. It is also used as an anthranilic acid replacement in niacin receptor agonist.<br>References Marfat, A., et al.: PCT Int. Appl. (1998), WO 9845268 A1 19981015; Schmidt, D., et al.: Bioorg. Med. Chem. lett., 20, 3426 (2010)<br></p>