Amides

<p>Applications N-Phenylmethanesulfonamide, is a building block used in the synthesis of various compounds.<br></p>

<p>Malonamide is a natural product with biological properties that include anti-inflammatory activity. It is a receptor antagonist that binds to the nicotinic acetylcholine receptors and blocks the binding of acetylcholine, thereby inhibiting muscle contraction. Malonamide has been shown to have good chemical stability and phosphorus pentoxide tolerance. This compound also has high steric interactions with halogens, which allows it to act as an effective antiseptic agent for wounds or skin infections caused by bacteria such as Staphylococcus aureus or Pseudomonas aeruginosa. Malonamide has been shown to be active against both Gram-positive and Gram-negative bacteria, including methicillin resistant strains. Malonamide binds to copper ions and forms an intramolecular hydrogen bond with the nitrogen atoms in the molecule. This interaction stabilizes its conformation and leads to increased chemical stability in comparison with other nitrogen containing drugs.</p>

<p>N-Propyl-N-(2,3-dihydroxypropyl)perfluoro-n-octylsulfonamide is a fine chemical that can be used as a reagent and speciality chemical. It is a versatile building block that can react with other compounds to produce new products. The compound is a complex compound that has been shown to have high quality in the laboratory.</p>

<p>Agonist of D2 dopamine receptors</p>

<p>N-Methylbis(trifluoroacetamide) is a molecule that is used in the preparation of an analytical method. This molecule reacts with human serum and urine to produce a reaction solution. The matrix effect can be seen in metabolic disorders, such as the case of creatine kinase which is not affected by the derivatization. N-Methylbis(trifluoroacetamide) is also used to prepare samples for solid phase microextraction with basic structures that are amines.</p>

<p>Sulfacetamide sodium monohydrate is a sulfa drug that is used in the treatment of infections caused by bacteria that are sensitive to sulfonamides. It is also used to reduce the symptoms of rosacea, a skin condition. Sulfacetamide sodium monohydrate inhibits microbial growth by disrupting microbial fatty acid synthesis and inhibiting bacterial growth through various mechanisms including hydrolysis by hydrochloric acid, metabolic disorders, or changes in water permeability. It has been shown to be an effective treatment for congestive heart failure due to its ability to increase the thickness of the glomerular basement membrane and inhibit erythrocyte adhesion. This drug is also useful as a topical agent for treating mild cases of radiation dermatitis and has high values as an anhydrous sodium sulfate substitute for wastewater treatment.</p>

<p>2-Amino-4-chlorobenzamide is a chemical compound that has been shown to be an effective oxidant in biological systems. It is an oxidative condensation product of 4-chloro-2-nitrobenzoic acid and ammonium chloride, which is formed by the reaction of these two compounds at room temperature. The nature of the functional group on 2-amino-4-chlorobenzamide allows it to be used as a transition state analogue for the study of reactions involving amines and nitrates. This compound can also be used in experiments with isatins, due to its ability to react with ammonia hydroxide to form 2-amino-4,6 dichlorobenzamide.</p>

<p>N-(3-Aminopropylmethacrylamide HCl is a water-soluble optical sensor that has been used in the field of bioanalysis. This compound has been shown to react with propranolol hydrochloride and produce a fluorescent product. The fluorescence intensity depends on the concentration of propranolol hydrochloride, which can be measured using an optical detector. N-(3-Aminopropylmethacrylamide HCl is synthesized from trifluoroacetic acid and 3-aminopropylamine using a solid-phase synthesis technique. This compound has also been used as a ligand for affinity chromatography and as a template molecule in nonsteroidal anti-inflammatory drug research.</p>

<p>Cyanamide is a nitrogen-containing organic compound that is used as a plant nutrient. It has been shown to increase the activity of enzymes in methyl ethyl x-ray crystal structures and locomotor activity in mice. Cyanamide is also used as an herbicide and chemical pesticide, with calcium as its main target. The cyanamide molecule binds to the calcium ion and undergoes a reaction mechanism that results in the release of ammonia gas, which is toxic to plants. In addition, cyanamide can cause kidney damage in humans due to its ability to inhibit protein synthesis.</p>

<p>N-(3-Hydroxypropyl)trifluoroacetamide is an alkaline hydrolysis product of 3-hydroxypropyl trifluoroacetate. It is a primary amino compound that can be used as an intermediate in the production of vinyl ethers and acetals. This chemical is used for the synthesis of vinyl acetals, which are important intermediates in the manufacturing of polymers.</p>

<p>3-(4-Methoxyphenyl)propionamide is a compound that belongs to the group of benzene amides. It is synthesized by reacting an excess of 3-bromopropionaldehyde with an amine in the presence of sodium hydroxide. This reaction produces a mixture of products, which are separated by chromatography. The yields for this reaction are approximately 90%. 3-(4-Methoxyphenyl)propionamide has been used as a biomolecular building block, and its traceless nature makes it useful in organic synthesis.<br>3-(4-Methoxyphenyl)propionamide can be used to synthesize alkanesulfonamides and spirolactams, which are important intermediates in chemical synthesis. 3-(4-Methoxyphenyl)propionamide also reacts with phenanthridone to produce chloride derivatives and with arenes to produce linkers.</p>

<p>Chemically a chlorinated salicylanilide, niclosamide is clinically used as an anthelmintic agent. The action of niclosamide has been proven to proceed by inhibiting the STAT3 signaling pathway. Recently, niclosamide, has been considered as an antiproliferative agent in cancer treatment, e.g. melanoma and colorectal cancer. In 2021, niclosamide has been tested for the treatment of COVID-19 patients.</p>

<p>Non-steroidal androgen receptor antagonist</p>

<p>2-Methoxy-5-(2-oxopropyl)benzenesulfonamide is a metal catalyst that can be used in the synthesis of tamsulosin hydrochloride, an alpha blocker that is used to treat benign prostatic hyperplasia. It catalyzes the reaction between 2-methoxybenzenesulfonyl chloride and 3-amino-1,2,4-triazole. The industrial importance of this compound is due to its ability to be used as a catalyst for various chemical reactions.</p>

<p>4-Chloro-3-nitrophenylacetamide is a chemical compound that can be used as a reagent, useful scaffold for research, and a high quality research chemical. CAS No. 5540-60-3, this versatile building block is useful for the synthesis of complex compounds and fine chemicals.</p>

<p>Avenanthramide C is a potent polyphenolic compound that is isolated from the bark of the plant, Avena sativa. It has been shown to be an effective chemotherapeutic treatment for breast cancer and leukemia cells in vitro. Avenanthramide C has a hydroxyl group at its 6th carbon position and is a member of the class of compounds called avenanthramides. The biological properties of this compound have been examined using skin cells and it has been shown to exhibit significant activity against DNA polymerase, DNA binding activity, and enzyme activities. This compound also exhibits chemoattractant protein-like activity, which may be due to its ability to bind with high affinity to specific receptors on leukocytes.</p>

<p>(+/-)-tert-Butylsulphonamide is a synthetic molecule that is a functional group with two aryl halides. It has been shown to inhibit the mitochondrial protein synthesis by preventing the nitrosylation of tyrosine residues in proteins. This inhibition prevents the production of growth factors and other bioactive molecules, leading to an increase in the cell's sensitivity to genotoxic agents. (+/-)-tert-Butylsulphonamide has also been shown to inhibit viral replication and infectivity by targeting viral RNA polymerase, which is responsible for viral transcription. The chloride anion present in (+/-)-tert-butylsulphonamide may have an inhibitory effect on viruses with a low pH environment, such as naphthalene or carbonic acid; however, it does not affect viruses with a neutral pH.END&gt;</p>

<p>Dimethylmorpholine-4-carboxamide (DMMC) is an unsymmetrical, synthetic carbamate that has antiviral properties. The antiviral properties of DMMC are due to its ability to inhibit the synthesis of viral proteins by binding to a site on the enzyme RNA polymerase and blocking the formation of a functional enzyme. This agent also has been shown to inhibit the production of nitric oxide in k562 cells. DMMC is marketed for use as an insecticide, but it has not been approved for this use. In crystallography studies, DMMC was found to have high yield and low melting point.</p>

<p>1-Methyl-1,4-dihydronicotinamide (1MDNA) is a flavine adenine dinucleotide analog that has been shown to be a potent inhibitor of the enzyme catalase. 1MDNA binds to the active site of the enzyme and prevents hydrogen peroxide from being converted into water and oxygen. This inhibition slows down or stops the reaction, which leads to reduced production of reactive oxygen species. 1MDNA inhibits other enzymes in a similar manner, including transferases and kinases. The kinetic properties of 1MDNA have been studied by performing kinetic studies on model systems at different temperatures. X-ray crystal structures have also been obtained for 1MDNA bound to catalase and ferredoxin.</p>

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<p>3-Oxo-2-phenyl butanamide is an amphetamine that has been shown to be a potential marker for wastewater. 3-Oxo-2-phenyl butanamide is one of the many intermediates in the synthesis of amphetamine from phenylacetone and can be found in wastewater as an impurity. This compound has also been used as a marker for wastewater treatment malfunctioning. 3-Oxo-2-phenyl butanamide is excreted into the environment through urine, and its presence can be measured in water samples by gas chromatography/mass spectrometry or liquid chromatography/mass spectrometry.</p>

<p>2,2'-(Diazene-1,2-diyl)bis(2-methylpropanimidamide) dihydrochloride (BPDC) is a synthetic compound that is used as an analytical reagent and a model system for oxidative injury. It has significant cytotoxicity on human cells in cell culture. BPDC induces oxidative damage to proteins and DNA by increasing the production of reactive oxygen species such as hydrogen peroxide, superoxide, and hydroxyl radicals. The mechanism of action is not well understood but may be due to Toll-like receptor signalling pathways. This compound has been shown to inhibit the activity of antioxidant enzymes such as glutathione peroxidase and catalase. It also inhibits the activity of proinflammatory cytokines such as IL-6 and IL-8. BPDC is being investigated for its potential use in bowel disease treatment.</p>

<p>Hydroxy tolbutamide is a drug with an unknown mechanism of action. It has been shown to inhibit the transcription-polymerase chain reaction and human serum in vitro. This drug may be used as a marker for renal disease, as it has been shown to increase the level of magnesium in urine and reduce the rate of protein synthesis in rat liver microsomes. Hydroxy tolbutamide also inhibits receptor activity, which may be due to its ability to inhibit the metabolic rate.</p>

<p>2-Chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)acetamide (CPA) is a chemical compound that belongs to the class of phenyl pyrazoles. It has a thermal stability and is soluble in organic solvents. CPA crystallizes in the monoclinic system with the space group P21/c, with the following unit cell parameters: a = 8.943(4) Å, b = 7.878(3) Å, c = 17.834(6) Å, α = 90°, β = 112° and γ = 90°. In this crystal structure, there are two molecules of chloride per molecule of CPA. The crystal x ray diffraction pattern showed that this compound forms dimers in solution at room temperature and can be dissolved</p>

<p>Cinnamamide is a natural compound that is structurally related to the amino acid lysine and has been shown to regulate skin cell proliferation. Cinnamamide has also been found to be an effective inhibitor of the mitochondrial membrane potential in human erythrocytes. It has been shown to inhibit the production of reactive oxygen species (ROS) and reverse oxidative damage in cells, which may reduce the risk of developing autoimmune diseases. Cinnamamide is also able to prevent cell death caused by epidermal growth factor (EGF) withdrawal and induce apoptosis in HL-60 cells.</p>

<p>2-Phenyl-2-(2-piperidyl)acetamide is an enantiomeric amide that can be used as a chiral building block for the synthesis of other organic compounds. It is synthesized by reacting phenylacetic acid with piperidine. 2-Phenyl-2-(2-piperidyl)acetamide is a primary amide and has been shown to have analgesic properties.</p>

<p>2-Chloro-N,N-diphenylacetamide is a functional theory that has been shown to have antimicrobial activity against mammalian cells. It is an acetamide derivative with a formyl group and two chloro substituents. 2-Chloro-N,N-diphenylacetamide inhibits the growth of Mycobacterium tuberculosis by binding to the ribosomal protein P0, which inhibits the production of proteins vital for cell division. This drug also has antifungal properties, inhibiting the synthesis of ergosterol in filamentous fungi such as Candida albicans.<br>2-Chloro-N,N-diphenylacetamide is also known to inhibit the growth of other bacteria by binding to their ribosomes and interfering with protein synthesis. This drug may also be active against viruses due to its ability to bind chloride ions.</p>

<p>2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-benzenesulfonamide is a drug that belongs to the class of sulfonamides which is used in pharmaceutical formulations. It has been shown to have potent antihypertensive effects, and it also lowers blood pressure by inhibiting an enzyme called carbonic anhydrase. 2CCHIB binds to the chloride channel in kidney tubule cells and prevents the reabsorption of chloride ions in these cells. This leads to more water being excreted from the body, which reduces blood volume and pressure. The low density lipoprotein (LDL) cholesterol levels are also reduced when this drug is taken orally. 2CCHIB increases high sensitivity C reactive protein (hsCRP), a marker for inflammation, but it can also have antioxidant effects.</p>

<p>4-Methoxybenzenecarbothioamide is a urea nitrogen analogue that inhibits the synthesis of urea and other nitrogenous compounds. It is an inhibitor of the enzyme pyruvic transaminase, which converts pyruvate to alanine. The drug is also an inhibitor of the enzyme lactam synthetase, which catalyzes the formation of lactams from amino acids. This activity results in decreased production of cancer cells and renal toxicity. 4-Methoxybenzenecarbothioamide has been shown to have anticancer activity in vitro against a number of human cancer cell lines, including A549 lung carcinoma cells and MCF-7 breast cancer cells.</p>

<p>Cyclotheonamide A is a cyclopeptide, which is a type of secondary metabolite composed of non-standard amino acids arranged in a cyclic structure. It is naturally sourced from marine sponges, particularly Theonella sp., which are known for their rich and diverse repertoire of bioactive compounds. Cyclotheonamide A functions through the inhibition of serine proteases, a class of enzymes that play a significant role in numerous biological processes, including digestion, immune response, and blood coagulation.</p>

<p>Dimethylphosphonoacetamide (DMPPA) is a phosphorus-containing compound that is used as an intermediate in the synthesis of fatty acids. DMPPA can be synthesized by the reaction of ethylene diamine and phosphorus pentoxide, which is a common reagent for preparing phosphorus compounds. The reaction mechanism has been studied using electrochemical impedance spectroscopy. This study revealed that DMPPA can be converted to a water-soluble product by treatment with water vapor or by adding cotton. In addition, the kinetic data obtained from this study showed that the reaction rate was affected by temperature and the type of solvent used. The frequency shift observed during this study indicated that nitrogen atoms are involved in the reaction mechanism.</p>

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<p>Prothionamide is a drug that belongs to the group of drugs called sulfonamides. It is used to treat bowel disease by inhibiting the growth of bacteria and fungi. Prothionamide inhibits bacterial growth by binding to bacterial DNA and preventing it from synthesizing new proteins. This drug also has a matrix effect, which means that it binds to the inside of the bacterial cell wall and prevents the production of new cells, leading to cell death. Prothionamide has been shown to be effective against tuberculosis in mice, although there are few data on its use in humans. The most common side effects associated with prothionamide are nausea and vomiting.</p>

<p>2,4,6-Trimethoxybenzamide is a triggered compound that reacts with lithium to form an efficient regiospecific lithium 2,4,6-trimethoxybenzamide complex. This reaction occurs at low temperatures and has been shown to be more efficient than other methods for the synthesis of acridones. The reaction has not been shown to be reversible and requires the use of a strong base such as lithium.</p>

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<p>3-Cyanobenzamide is an organic compound with the formula CHC(N)NH. It is a white crystalline solid that can be obtained by reacting benzamide with cyanoacetylene. There are three possible isomers of 3-cyanobenzamide: 3-cyano-1-(substituted phenyl)benzamide, 3-cyano-2-(substituted phenyl)benzamide, and 3-cyano-3-(substituted phenyl)benzamide. The optimal reaction conditions for the synthesis of 3-cyanobenzamide are in the presence of hydrogen bonding, such as n-hexane, amide, and phase equilibrium. Studies have determined that 3-cyanobenzamide has the potential to cause cancer or liver toxicity in humans. In addition, this chemical has been shown to be an effective inhibitor of alpha glucosidase enzymes in vitro and in vivo.</p>