Amides

<p>C2 dihydroceramide is a lipid that belongs to the group of sphingolipids and is involved in neuronal death. It is a precursor for ceramide, which can also induce apoptosis. C2 dihydroceramide has been shown to inhibit axonal growth by interfering with the polymerase chain reaction, as well as inducing autophagy through toll-like receptor 4 signaling. This lipid has also been shown to inhibit intracellular Ca2+ levels, mitochondrial functions, and bowel disease. C2 dihydroceramide was identified in HL-60 cells and may be used as an analytical method for detecting other sphingolipids.</p>

<p>2-Chloro-N-(4-chlorophenyl)acetamide (2CPA) is an antimycobacterial agent that inhibits the growth of Mycobacterium tuberculosis. The antimycobacterial activity of 2CPA has been demonstrated in a dilution method, where it reduced the number of viable cells in cultures of M. tuberculosis and Mycobacterium smegmatis. The antimicrobial activity of 2CPA was confirmed using a fluorescence assay, which showed that this compound is active against M. tuberculosis H37Rv and M. smegmatis at concentrations above 0.1 mM. 2CPA also has a potent bactericidal effect on Staphylococcus aureus with an MIC value of 0.06 mg/mL at 30 minutes and is active against Enterococcus faecalis with an MIC value of 4 mg/mL at 30 minutes.</p>

<p>2-(5-Bromo-1H-indol-3-yl)acetamide is a high quality, reagent, complex compound, useful intermediate and fine chemical. It is also a useful scaffold or building block for the synthesis of speciality chemicals. 2-(5-Bromo-1H-indol-3-yl)acetamide is used in research and development as a versatile building block for the synthesis of new compounds. The CAS number for this compound is 196081-79-5.</p>

<p>2-Phenylbenzamide (2PB) is a drug that belongs to the class of anthelmintics. It binds to the nicotinic acetylcholine receptor and inhibits the release of acetylcholine at neuromuscular junctions, leading to paralysis and death of the parasite. 2PB also has been shown to have anti-inflammatory properties in mice with colitis, which may be due to its ability to inhibit prostaglandin synthesis. The molecular docking analysis showed that 2PB binds covalently with nitro-containing molecules, such as nitrosamines, which are found in cigarette smoke and are known carcinogens. This binding may contribute to the development of cancer through inhibition of DNA repair mechanisms.</p>

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<p>2-Methylbenzamide is an amide with a carbonyl group and an intramolecular hydrogen. It has been shown to have synergic effects when combined with piperonyl butoxide in the treatment of autoimmune diseases. This synergistic effect is due to the inhibition of inflammatory mediator release, which can be achieved by blocking the enzyme cyclooxygenase-2. 2-Methylbenzamide has also been shown to inhibit deuterium isotope effect in cd-1 mice, which could make it beneficial for patients who are unable to tolerate other drugs.</p>

<p>5-(Acetylamino)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide is a reactive iodinated contrast agent that is used in the diagnostic imaging of body cavities and blood vessels. It can be prepared by the acetylation of 5-(acetylamino)naphthalene-2,3-diol with 2,4,6-triiodobenzene dicarboxylic acid using an alkali metal as a base. The yields for this reaction are dependent on the type of solvent used. This chemical has two functional groups: an amide and an acetate group. It reacts with iohexol to form a radiocontrast product that contains both iodine and propanediol. This process is industrially carried out by mixing 5-(acetylamino)naphthalene-2,</p>

<p>N-Methyl-N-vinylacetamide is a colorless liquid with a boiling point of 105.6°C. It is produced by the reaction of acetamide and vinyl chloride in the presence of hydrochloric acid, glycol ether, and methyl ethyl ketone. The viscosity of this compound is low, which makes it an ideal solvent for paints and coatings. N-Methyl-N-vinylacetamide also has genetic damaging effects and can cause mutations in bacteria that are exposed to this compound in high concentrations. This product has an unusual chemical structure due to its hydrogen bonding interactions.br&gt;br&gt;<br>br&gt;br&gt;<br>Hydrogen bonds are weak intermolecular forces between polar molecules, such as water or alcohols, that are formed by the attraction between a partially positive hydrogen atom on one molecule and the negative end of another nearby molecule. Hydrogen bonds stabilize certain molecular structures because they provide partial shielding from electrostatic interactions with</p>

<p>1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-N-methyloctane-1-sulfonamide is a perfluorinated sulfonate that is used as a surfactant in wastewater treatment and to package food. This compound is not water soluble and requires an organic solvent to dissolve it. It has been shown that the use of 1HFAFMS can reduce the amount of phosphates in packaging materials by up to 50%. 1HFAFMS also has been found to be safe for humans and does not accumulate in the environment. It does not bioaccumulate and is rapidly excreted through urine.</p>

<p>4-Methyl-3-nitrobenzamide is a nitrile that can be synthesized by the reaction of potassium hydroxide and 3-nitrobenzamide. It has been shown to react with dichloroethane to form 4-methyl-3-nitrobenzoic acid. The optimum temperature for this reaction is 120°C, which leads to a high yield of 4-methyl-3-nitrobenzamide. This product is also available in an isotopic form at high purity.</p>

<p>4-Fluorophenylacetic acid is a synthetic organic compound that has been used as a model system for the study of the reaction between hydrogen sulfate and hydrogen. 4-Fluorophenylacetic acid is a fluorinated analog of acetamide, which can be synthesized from sodium borohydride and hydrogen fluoride. It has been shown to inhibit the growth of Mycobacterium tuberculosis in an on-line assay and is also active against Mycobacterium avium complex. 4-Fluorophenylacetic acid also inhibits rat liver microsomes with a second order rate constant of 0.0006 M−1 s−1 at pH 7.4 and 37 °C (pH and temperature not specified). The biological properties of 4-fluorophenylacetic acid are not well understood, but it may bind to hydrophobic regions on proteins or DNA through hydrogen bonding interactions.</p>

<p>2,5-Dichlorobenzamide is a halogenated compound that inhibits topoisomerase and proteasome activity. It has been shown to be cytotoxic against cancer cells in vitro. 2,5-Dichlorobenzamide can also inhibit the growth of tuberculosis bacteria and may be used as an operational agent for weed control. The safety profile of this drug has not yet been fully determined. 2,5-Dichlorobenzamide is available in two crystalline forms, both of which are active with different degrees of potency.<br>2,5-Dichlorobenzamide is a hybridization inhibitor that inhibits the enzyme DNA gyrase and proteasome activity. It binds to bacterial 16S ribosomal RNA and inhibits protein synthesis, leading to cell death by inhibiting the production of proteins vital for cell division.</p>

<p>Ethionamide is a drug that is used for the treatment of tuberculosis. It binds to the enzyme preparations in the bacterial cell wall by competitive inhibition, which prevents formation of an antibiotic-inhibitor complex with the enzyme cell wall synthesis that is required for cell wall biosynthesis, inhibiting protein synthesis and cell division. The sulfoxide form of ethionamide is converted to the sulfone form when it enters the body. This conversion takes place primarily in the liver with assistance from alcohol dehydrogenase, cytochrome P450, and glutathione reductase. The sulfone form has higher potency than its precursor (sulfoxide) because it has lower protein binding affinity and more rapid elimination from plasma.</p>

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<p>4-Hydroxy-3,5-dimethoxybenzamide is a phenolic compound that is soluble in organic solvents. It has been shown to bind to fatty acid sequences and neutral polypeptides in the presence of an acidic or basic environment. 4-Hydroxy-3,5-dimethoxybenzamide has also been shown to have catalytic activity, which may be due to its ability to form a polymeric matrix with other compounds.</p>

<p>Sulfacetamide sodium monohydrate is a sulfa drug that is used in the treatment of infections caused by bacteria that are sensitive to sulfonamides. It is also used to reduce the symptoms of rosacea, a skin condition. Sulfacetamide sodium monohydrate inhibits microbial growth by disrupting microbial fatty acid synthesis and inhibiting bacterial growth through various mechanisms including hydrolysis by hydrochloric acid, metabolic disorders, or changes in water permeability. It has been shown to be an effective treatment for congestive heart failure due to its ability to increase the thickness of the glomerular basement membrane and inhibit erythrocyte adhesion. This drug is also useful as a topical agent for treating mild cases of radiation dermatitis and has high values as an anhydrous sodium sulfate substitute for wastewater treatment.</p>

<p>Lacosamide is a drug that is used for the treatment of epilepsy. It has been shown to inhibit neuronal death in vitro and in animal models, and has been extensively studied for its potential benefits in the treatment of bowel disease. The mechanism of action for lacosamide involves inhibition of the transport of neurotransmitters from the synaptic cleft by binding to the neuronal sodium channels and increasing their recovery rate. Lacosamide has also been found to affect energy metabolism by inhibiting the activity of mitochondrial enzymes such as matrix effect and complex I/III.</p>

<p>Trifluoromethanesulfonamide is a strong acid that has been shown to inhibit the proteolytic activity of human secretase. It binds to a specific site on the enzyme and prevents it from cleaving the substrate. This inhibition slows down the progression of Alzheimer's disease, Parkinson's disease, and other related disorders. Trifluoromethanesulfonamide has also been shown to bind to metal hydroxides, such as iron hydroxide, which may be due to its ability to form hydrogen bonds with these metals. Structural analysis reveals that trifluoromethanesulfonamide contains a pyrazole ring and two chlorine atoms, one in the para position and one in the meta position.</p>

<p>4-Amino-N-((2R,3S)-3-amino-2-hydroxy-4-phenylbutyl)-N-isobutylbenzenesulfonamide is an amide that is used to treat HIV infections. It has been shown to have potent anti-viral activity against HIV infected cells in the laboratory and can inhibit the replication of HIV by interfering with the virus's ability to use the reverse transcriptase enzyme. 4ABAB has been shown to bind to the enzyme ribonuclease H (crth2), which is responsible for breaking down viral RNA. This binding prevents crth2 from cleaving viral RNA, thus inhibiting DNA synthesis and preventing cell death. 4ABAB also interferes with a hydrogen bond between ethyl group and the hydroxyl group on crth2, leading to a decrease in activity.</p>

<p>DL-Leucine amide hydrochloride is a fine chemical that can be used as a building block for research chemicals, as a reagent for the preparation of other compounds, and as a speciality chemical. DL-Leucine amide hydrochloride has been shown to be effective in the synthesis of complex compounds. The compound is also versatile and can be used as an intermediate or scaffold in the synthesis of other compounds. DL-Leucine amide hydrochloride is useful in reactions such as condensation, substitution, elimination, and Grignard reactions. It is also used in peptide synthesis and polymerization reactions.</p>

<p>N-(n-Butyl)thiophosphoric triamide is a triamide herbicide that inhibits the plant enzyme fatty acid synthase. It has been shown to inhibit the uptake of glycol ethers, such as glycol esters, into plants by acting on the glycol ester hydroxyl group. This chemical also inhibits the synthesis of fatty acids in plants and reduces lipid content in perennial ryegrass and solanum tuberosum. N-(n-Butyl)thiophosphoric triamide also inhibits nitrous oxide emissions from wastewater treatment plants.</p>

<p>2-((4-Methylphenyl)sulfonyl)ethanamide is an amide that has been shown to have antibacterial activity. It binds to the DNA of bacteria, inhibiting its replication and transcription. This drug also inhibits the growth of influenza virus in cell culture. 2-((4-Methylphenyl)sulfonyl)ethanamide is a sensor for chloride ions, which may be used as treatments for bacterial infections. This drug is also able to inhibit the replication of bacteria that are resistant to other antibiotics, such as penicillin. The unsaturated alkyl group on this molecule allows it to be activated by radiation treatment, which may be useful in the treatment of cancer cells or viral infections.</p>

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<p>2-Methoxybenzamide is an amide with a p-hydroxybenzoic acid moiety. It has been shown to be an effective inhibitor of the enzyme histone deacetylase, which is involved in the regulation of gene expression. 2-Methoxybenzamide also has antiinflammatory activity and has minimal toxicity. This drug is used as a research tool for studying the immune system and its effects on hyperproliferative diseases such as cancer and autoimmune diseases. 2-Methoxybenzamide can also be used to treat metabolic disorders and physiological effects. The drug binds to intracellular targets through intermolecular hydrogen bonds that are mainly found in protein structures, including cytochrome P450s, protein kinases, DNA polymerases, transcription factors, and proteases.</p>

<p>2-Veratramide is a drug that belongs to the group of amides. It is a highly soluble, water-soluble and lipophilic molecule. The molecular modeling study revealed that it has a hydroxyl group in its structure and a hydrogen bond with the intramolecular hydrogen atom. 2-Veratramide has been observed to inhibit protein synthesis and cellular proliferation by binding to cancer cells or inflammatory cells. It also binds to dopamine receptors, inhibiting uptake of dopamine and subsequent activation of downstream signaling pathways. 2-Veratramide is an inhibitor of nitric oxide synthase (NOS), which plays an important role in inflammation, vascular tone, neurotransmission, and cell proliferation.<br>2-Veratramide inhibits NOS by competitively binding to the heme moiety at the active site of the enzyme, thereby blocking access to substrate arginine.</p>

<p>3-(4-Methoxyphenyl)propionamide is a compound that belongs to the group of benzene amides. It is synthesized by reacting an excess of 3-bromopropionaldehyde with an amine in the presence of sodium hydroxide. This reaction produces a mixture of products, which are separated by chromatography. The yields for this reaction are approximately 90%. 3-(4-Methoxyphenyl)propionamide has been used as a biomolecular building block, and its traceless nature makes it useful in organic synthesis.<br>3-(4-Methoxyphenyl)propionamide can be used to synthesize alkanesulfonamides and spirolactams, which are important intermediates in chemical synthesis. 3-(4-Methoxyphenyl)propionamide also reacts with phenanthridone to produce chloride derivatives and with arenes to produce linkers.</p>

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<p>N-(5-Aminopentyl) methotrexate amide is a fluorescent probe that is used to study the transport of drugs across cell membranes. It binds to the plasma membrane of cells and can be visualized with a fluorescence microscope. N-(5-Aminopentyl) methotrexate amide has been shown to bind to leukemia cells in murine leukemia models. It has a high affinity for drug-resistant cells, which makes it useful for studying drug resistance mechanisms. This probe can be used at nanomolar concentrations for imaging studies, as well as for measuring the uptake of drugs into cancer cells by flow cytometry.</p>

<p>6-Aminonicotinamide is an experimental drug that has shown promising results in animal studies. This compound may be useful for the treatment of cancer, due to its ability to inhibit reactive oxygen species and maintain mitochondrial membrane potential. 6-Aminonicotinamide also has a protective effect against radiation-induced cell damage, as it prevents oxidative injury to DNA and protein. In addition, 6-aminonicotinamide can stimulate the proliferation of pluripotent cells, which are cells that have the ability to differentiate into any type of cell in the body. Finally, this compound was shown to have antitumor effects by inhibiting squamous carcinoma tumor growth in experimental models.</p>

<p>(S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide (MBI-23) is a potential antineoplastic agent that has been shown to induce regression of bladder cancer in mice. MBI-23 induces apoptosis by inhibiting the proliferation of cancer cells and inducing differentiation of cancer stem cells. It is also shown to inhibit tumor growth and progression in glioma and prostate cancer models. MBI-23 binds to the KDR receptor subtype, which is activated by organic acids and inhibited by inorganic compounds. This binding leads to constitutive activation of the KDR receptor, thereby inducing apoptosis. The tautomers and stereoisomers of MBI-23 have not been fully elucidated yet.</p>

<p>N-Allyl-N-(4-cyano-2-chlorophenyl)acetamide is a high quality reagent that has been used as an intermediate in the synthesis of fine chemicals, useful scaffolds and building blocks. It is also a versatile building block that can be used to synthesize high quality compounds with a wide range of functionalities. N-Allyl-N-(4-cyano-2-chlorophenyl)acetamide is a speciality chemical that can be used for research purposes. This compound has been shown to produce reactions with other compounds, such as nitrobenzene, to generate useful products.</p>

<p>4-Amino-2,5-diethoxyphenyl)benzamide is a small molecule that inhibits the enzyme activity of polymerase chain reaction (PCR), DNA topoisomerase I, and DNA gyrase. It has been shown to inhibit the growth of human leukemia cells in culture. 4-Amino-2,5-diethoxyphenyl)benzamide also inhibits rat liver microsomes and can be used for the treatment of neurodegenerative diseases.</p>

<p>Tris[N-ethyl-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8-heptadecafluoro-N-(2-hydroxyethyl)-1-octanesulfonamide] phosphate is a sulfonate that has been mixed with other chemicals. It is used as a chemical substance for the production of other substances. Tris[N-ethyl-1,1,2,2,3]3,[4],4,[5],5,[6],6-[7],7,[8],8-[heptadecafluoro-N-(2-hydroxyethyl)-1-octanesulfonamide] phosphate has not been classified by the International Agency for Research on Cancer (IARC).</p>

<p>Heptadecafluoro-N,N-Bis(2-Hydroxyethyl)Octanesulphonamide is a lubricant that is used in the manufacture of polyester films. It is insoluble and has excellent compressive properties. This compound is soluble in both organic solvents and water, and can be applied as a transfer agent or to obviate the need for a separate lubricant. Heptadecafluoro-N,N-Bis(2-Hydroxyethyl)Octanesulphonamide is an inorganic material that does not react with other materials. It also has good deformation resistance and low hardness. The particle size of this compound is between 5 and 10 microns.</p>

<p>4-Benzylpiperazine-1-carboximidamide sulfate is a versatile building block that can be used in the synthesis of complex compounds. It is a useful intermediate that can be used in the production of research chemicals and speciality chemicals. 4-Benzylpiperazine-1-carboximidamide sulfate is also an excellent reagent for reactions involving complex substrates, such as high quality and useful scaffolds.</p>

<p>Eliglustat is an oral medication used as a substrate reduction therapy for Gaucher disease type 1, which is an inherited lysosomal storage disorder. This product is a small-molecule inhibitor derived via chemical synthesis. Its primary mode of action involves the selective inhibition of glucosylceramide synthase, an enzyme responsible for the first committed step in glycosphingolipid biosynthesis. By reducing the production of glucosylceramide, eliglustat decreases the substrate accumulation that contributes to the pathophysiology of Gaucher disease.</p>

<p>Non-steroidal androgen receptor antagonist</p>

<p>L-Alaninamide is a protonated amino acid that reacts with the bacterial cell membrane and causes it to rupture. L-Alaninamide is synthesized by hydrolysis of the ester bond between butyric acid and serine protease in the presence of immobilized d-alanine. The reaction is carried out at a pH of 5.5, and the release of pressor is observed. This reaction takes place in an aqueous solution containing fatty acids as solvents. The type strain of this amino acid is E. coli.</p>

<p>Phthalimidoyl-N-(methyltosyl)hexanamide is a fine chemical that can be used as a versatile building block and reaction component. It is an intermediate in the production of a variety of products, including pharmaceuticals and pesticides. Phthalimidoyl-N-(methyltosyl)hexanamide is also used as a reagent for the preparation of other compounds. This compound has high purity and quality, making it suitable for research purposes. The CAS number for this compound is 183828-04-7.</p>

<p>N-Chloro-4-toluenesulfonamide sodium (NCTS) is a disinfectant that is used to treat wastewater and as a preservative for water. It has been shown to be effective against bacteria, fungi, and viruses. NCTS is an antimicrobial agent that reacts with the matrix in which it is applied to form chloramines-T (NHClO). The chloramines-T inhibits the activity of enzymes such as those involved in DNA synthesis and protein synthesis. This reaction also generates an electric current due to the redox potentials of the reactants. The presence of aziridines in NCTS leads to crosslinking between proteins, which enhances its effectiveness as a disinfectant.<br>NCTS has been shown to have no adverse effects on human erythrocytes or DNA when used at concentrations up to 100 µg/mL.</p>

<p>Nipecotamide is a water-soluble drug that inhibits the activity of α1-acid glycoprotein, which is a blood protein that regulates the concentration of hydrogen ions in the body. It has been shown to inhibit the growth of amyloid protein and decrease camp levels in erythrocytes. Nipecotamide is used as an inhibitor for infectious diseases, such as leprosy, tuberculosis, and malaria. The chemical structure of nipecotamide contains nitrogen atoms and an amide bond with carbonyl oxygens. It is also an inhibitor binding to hydrochloric acid and hydrogen bonds with amide groups.</p>

<p>N-(2-Oxo-2-phenylethyl)-N-phenylbenzamide is a fine chemical that can be used as a versatile building block and reagent for the synthesis of complex compounds. This compound has been shown to react with both amines and alcohols in the presence of acid to produce useful products. It is also an intermediate for the synthesis of other compounds, such as pharmaceuticals, pesticides, and herbicides. N-(2-Oxo-2-phenylethyl)-N-phenylbenzamide is soluble in organic solvents and can be purified by recrystallization or column chromatography. The purity of this compound can be confirmed by nuclear magnetic resonance spectroscopy (1H NMR) or mass spectrometry (MS).</p>

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<p>4-Aminobenzamide is a compound that is used as an anti-tuberculosis drug. It inhibits the activity of aminotransferase, which is an enzyme responsible for converting amino acids into other compounds. 4-Aminobenzamide has been shown to have antimicrobial properties against bacteria, fungi and protozoa. It also has a protective effect on human liver cells, but can cause damage to rat liver cells in vitro. 4-Aminobenzamide also shows some activity against microbial metabolism and can be hydrolyzed by hydrochloric acid to form phenylacetic acid and ammonia. This compound has been shown to inhibit the nervous system disease progression of Huntington's disease in mice.</p>

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<p>Coenzyme B12, also known as vitamin B12, is a coenzyme that participates in the metabolism of amino acids and fatty acids. It is required for the conversion of homocysteine to methionine, which is an important step in the synthesis of S-adenosylmethionine (SAM), a major methyl donor. Coenzymes are required for many different reactions in cells, but they are not consumed during these reactions. Instead, they are regenerated and reused. Coenzyme B12 is synthesized by bacteria and archaea but not by animals. The cobalamin form of this coenzyme is made from cobaltous chloride or cobaltous sulfate and cyanide. This coenzyme has been shown to bind to riboswitches in bacteria and to ATP-binding cassette transporters in humans. Coenzyme B12 can exist in two different forms: adenosylcobalamin and methylcobalamin.</p>

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<p>Marker for Farber disease diagnosis</p>

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