Carboxylic Acids

<p>3,4-(Methylenedioxy)cinnamic acid (3-(Benzo[d][1,3]dioxol-5-yl)acrylic acid) is a plant-derived compound first extracted from roots of Asparagus officinalis and</p>

<p>Phenylacetylglutamine (NSC 203800)is a normal constituent of human urine, but other mammals such as the dog, cat, rat, and horse do not excrete this compound.</p>

<p>(S)-2-acetamido-4-amino-4-oxobutanoic acid (Nα-Acetyl-L-asparagine), also known as acasn, is an endogenous metabolite.</p>

<p>Sodium 2-hydroxybutanoate, a by-product of alpha-ketobutyrate, is formed via LDH or alphaHBDH-catalyzed reactions.</p>

<p>Glycylglycine (Diglycine) is a dipeptide used in biochemical research. It is the simplest and is used as a starting template for more complex peptides.</p>

<p>Diaminopimelic acid or DAPA is a lysine-like amino acid derivative that is a key component of the bacterial cell wall.</p>

<p>4,4'-Disulfanediylbis(2-aminobutanoic acid) (DL-Homocystine) is one of the endogenous metabolites, is the double-bonded form of homocysteine.</p>

<p>4-Methyl-2-oxopentanoic acid, an abnormal metabolite and neurotoxin, results from improper branched-chain amino acid metabolism.</p>

<p>(R)-5-Oxopyrrolidine-2-carboxylic acid (D-Pyroglutamic acid) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues.</p>

<p>D-glutamine, an D type stereoisomer of glutamine, is one of the 20 amino acids which is encoded by the standard genetic code.</p>

<p>DL-Valine (H-DL-Val-OH) is 2-amino-3-methylbutanoic acid.It is synthesized in plants via several steps starting from pyruvic acid.</p>

<p>D-(+)-​Phenyllactic acid (D-3-Phenyllactic acid) is an anti-bacterial agent, excreted by Geotrichum candidum, inhibits Gram-positive and Gram-negative bacteria.</p>

<p>Dihydroxyfumaric acid produces superoxide anions, hydroxyl radicals, can inhibit insulin, and converts to hydroxypyruvate or oxaloglycolate.</p>

<p>Applications 1,1-Cyclohexanediacetic acid monoamide is an impurity of Gabapentin (G117250), an amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Gabapentin is used as an anticonvulsant.<br>References Vollmer, K.-O. et al.: Arzneimittel-Forshc., 36, 830 (1986), Saletu, B., et al.: Int. J. Clin. Pharmacol. Ther. Toxicol., 24, 362 (1986)<br></p>

<p>Applications Butyl Acetate, can be used as a synthetic fruit flavoring in foods such as candy, ice cream, cheeses, and baked goods.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ullman's encyclopedia of industrial chemistry, 6th Ed., 1, 170 (2003);<br></p>

<p>Stability Hygroscopic<br>Applications Heptafluorobutyric Acid (HFBA) is used in reversed-phase chromatography.<br> E0<br>References Satake, I., et al.: Biopolymers, 15, 2263 (1976), Aso, K., et al.: Biosci. Biotech. Biochem., 56, 755 (1992), Cecchi, T., et al.: J. Chromatogr., 1216, 1789 (2009),<br></p>

<p>Applications 4-carbamoylfuran-2-carboxylic acid (cas# 1315367-95-3) is a useful research chemical.<br></p>

<p>Applications Empagliflozin Tetraacetate is an Empagliflozin (E521510) impurity and is a reagent used to design and synthesize nitric oxide releasing derivatives of dapagliflozin which has potential antidiabetic and antithrombotic agents.<br>References Zheng, L., et al.: Bioorg. Med. Chem., 26, 3947 (2018)<br></p>

<p>Applications Occurs in unripe fruit and in young green leaves; has also been found in very young sugar beets.<br>References Lelieveld, J., et al.: Nature, 452, 737 (2008), da Silva, G., et al.: Environ. Sci. Technol., 44, 250 (2010),<br></p>

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Applications butyl carbamate (cas# 592-35-8) is a useful research chemical.<br></p>

<p>Applications 3,5-Di-tert-butyl-4-hydroxybenzoic acid hexadecyl ester<br></p>

<p>Applications 4-Morpholineethanesulfonic Acid is used in the synthesis of nanotechnology and nanoparticles, as potential therapy towards Alzheimer’s.<br>References Liu, G. et al.: Methods. Mol. Biol., 610, 123 (2010); Neugart, F. et al.: Nano. Lett., 7, 3588 (2007)<br></p>

<p>Stability Store Under Argon; Air Sensitive<br>Applications 4-Mercaptobenzoic Acid, Technical Grade (cas# 1074-36-8) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,4-Dioxo-4-phenylbutanoic acid<br></p>

<p>Applications Z-2-Fluoro-3-(3-pyridyl)acrylic Acid (cas# 359435-42-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Bis(2,4,4-trimethylpentyl)phosphinic acid (cas# 83411-71-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-[4-(-Carboxycyclohexylmethyl)]maleamidic Acid (cas# 72748-87-9) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-(4-tert-Butylbenzene)propionic Acid (cas# 1208-64-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Isotope labelled Trifluoroacetic Acid used as a solvent in a variety of organic synthesis and chemical processes. Used in the synthesis of anticancer agents as well as phospholipase D inhibitors.<br> E0<br>References Scott, S. et al.: Nat. Chem. Biol., 5, 108 (2009); Minko, T. et al.: Cancer. Chemother. Pharmacol., 50, 143 (2002);<br></p>

<p>Applications 3,4,9,10-Perylenetetracarboxylic diimide (cas# 81-33-4) is a useful research chemical.<br></p>

<p>Applications β-Formylpropionic Acid is used in the synthesis of potent and orally available nonpeptide antagonist of human gonadotropin-releasing hormone receptor. It is also a reagent in the synthesis of human melanocortin-4 receptor antagonists with a pyrrolidinone moiety.<br>References Chen, C. et al.: J. Med. Chem., 51, 7478 (2008); Jiang, W. et al.: Bioorg. Med. Med. Chem. Lett., 17, 5610 (2007);<br></p>

<p>Applications A metabolite of alkyl carbamate (ethyl or propyl).<br>References Muller, J.P., et al.: J. Chim. Phys. Physicochim. Biol., 71, 893 (1974),<br></p>

<p>Applications (2E)-3-Phenyl-2-propenoic Acid is used in the synthesis of amides and esters through coupling reactions involving carboxylic acids and amines. Also used in the N-methylation of amides and O-methylation of carboxylic acids.<br>References Kunishima, M. et al.: Tetrahedron, 55, 13159 (1999); Xia, Q. et al.: Org. Lett., 15, 3326 (2013);<br></p>

<p>Applications Cyclohexanecarboxylic acid<br></p>

<p>Applications Phenyl N-​(2-​Chloro-​4-​hydroxyphenyl)​carbamate is a reagent used in the prepartion of quinoline-carboxamide compounds including Lenvatinib (L329400), an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.<br>References Wang, N. et al.: Faming Zhuanli Shenqing (2017), CN 106632033 A 20170510.<br></p>

<p>Applications Isophthalic Acid is a useful reagent for preparing semiconductor sealing materials, prepregs, build-up films, solder resists, dry films, and printed wiring boards.<br>References Matsumura, Y., &amp; Nakamura, A.: PCT Int. Appl. (2021), WO 2021006164 A1<br></p>

<p>Applications PERFLUORO-3,6-DIOXAHEPTANOIC ACID (cas# 151772-58-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Isostearic Acid may be a useful reagent in the regioselective preparation of alkenes via photoredox/cobaloxime dual-catalytic decarboxylative elimination of carboxylic acids,<br>References Cartwright, K. C., et al.: Chem. Eur. J., 26, 12454 (2020)<br></p>

<p>Applications 4-GUANIDINOBENZOIC ACID METHANESULFONATE (cas# 148720-07-4) is a useful research chemical.<br></p>

<p>Applications Methyl (S)-N-Tritylaziridine-2-carboxylate (cas# 75154-68-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Dodecylbenzenesulfonic acid<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N,N'-Bis(2,6-diisopropylphenyl)-1,6,7,12-tetraphenoxy-3,4,9,10-perylenetetracarboxylic Diimide has applications in the photosensors and optical detectors.<br>References Wang, Shaojun, et al.: ACS Photonics, 5(6), 2478-2485 (2018);Wang, Hanlin, et al.: Adv. Mat., 29(32), n/a. (2017)<br></p>

<p>Stability Hygroscopic<br>Applications α-Aleuritic acid is a major ingredient of shellac and is also a starting reagent in the manufacture of perfumes.<br>References Jakubowska, M., et al.: Polimery ., 15, 295 (1970); Shamsuzzaman, L.A., et al.: Pakistan. J. Biol. Agri. Sci., 11, 68 (1968);<br></p>

<p>Applications 6-(Aminocarbonyl)-3-cyclohexene-1-carboxylic Acid is a useful building block for organic synthesis.<br></p>

<p>Applications 2-(2-carbamoylphenyl)acetic acid (cas# 23362-56-3) is a useful research chemical.<br></p>

<p>Stability Light Sensitive<br>Applications TRANS-2-OCTENOIC ACID (cas# 1871-67-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Formic Acid-d is labelled Formic Acid (F692900). Formic Acid (F692900) is used as a potential energy source in the preparation of fuel cells. Also used in chemical synthesis of various anti-inflammatory and anti-microbial agents.<br>References Yu, X. et al.: J. Power Source., 182, 124 (2008); Bekhit, A. et al.: Bioorg. Med. Chem., 12, 1935 (2004);<br></p>

<p>Impurity Methyl Salicylate USP Related Compound A<br>Applications 4-Hydroxy-isophthalic Acid Dimethyl Ester (cas# 5985-24-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 6-Chlorohexanoic Acid is used as the starting material in the synthesis of 2,6-Dichloro-N-(2,6-dimethylphenyl)hexanamide (D434225); an impurity of the local anesthetic Levobupivacaine (B689546). 6-Chlorohexanoic Acid is also used as a reagent in the synthesis of novel types of polyester glycodendrimers as potential inhibitors of urinary tract infections.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971); Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005); Twibanire, J.K., et al.: New J. Chem., 39, 4115 (2015)<br></p>

<p>Applications 4-(2,2,3-Trimethylcyclopentyl)butanoic Acid is used in preparation of Alicyclic compounds as off-note masking agent in consumables.Is used in preparation of 4-(2,2,3-Trimethylcyclopentyl)butanoic Acid as an off-note masking agent in consumables.<br>References Slack, Jay P., et al.: U.S., (2013); Slack, Jay P., et al.: PCT Int. Appl., (2008);<br></p>

<p>Applications Formamidine Sulfuric Acid is a reagent used in reduction and synthesis reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q. et al.: Carbon, 54, 36 (2013);<br></p>

<p>Applications Isobutylsuccinic Acid was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.<br>References Groutas, W., et al.: Bioorg. Med. Chem., 3, 375 (1995);<br></p>

<p>Applications Diammonium salt of Phosphoric Acid, used in various chemical processes as a phosphorylating compound. Also used in the preparation of prosthetics and collagen nanocomposites due to the bone-like properties.<br>References Ezhova, Z. et al.: Russ. J. Inorg. Chem., 58, 1177 (2013); Wu, Y. et al.: Asian J. Chem., 25, 5881 (2013);<br></p>

<p>Applications Hexacosanoic acid ((1S,2S,3R)-2,3-dihydroxy-1-hydroxymethyl-heptadecyl)-amide is a ceramide found in the moro blood orange (Citrus sinensis). It is a useful building block used in the preparation of 5-thio-α-GalCers as immunostimulators for IFN-​γ production stimulation in mouse NKT cells.<br>References Bi, J.; et al.: ACS Med. Chem. Lett., 6, 476 (2015); Valsecchi, M.; et al.: J. Agric. Food Chem., 60, 10103 (2012).<br></p>

<p>Applications Mesitoic acid can be used for its antioxidant.<br>References Thomas, P.S., et.al.: Medicines, 4, 1-7, (2017);<br></p>

<p>Applications Used in the biological study of differentiation induced by nicotinic acid, nicotinamide and isonicotinic acid in human leukemia cell lines.<br>References Zeilinger, S., et al.: J. Biol. Chem., 271, 25624 (1996), Panagiotou, G., et al.: J. Biotechnol., 118, 304 (2005),<br></p>

<p>Applications 3-(methylamino)-3-oxopropanoic acid (cas# 42105-98-6) is a useful research chemical.<br></p>

<p>Applications 4,4'-(ETHYNE-1,2-DIYL)DIBENZOIC ACID (cas# 16819-43-5) is a useful research chemical.<br></p>

<p>Applications 3-(1-Cyanoethyl)benzoic Acid is an intermediate for the synthetic preparation of various pharmaceutical compounds. 3-(1-Cyanoethyl)benzoic Acid was used in studies examining the enantioselectivity of nitrile hydratases.<br>References Rzeznicka, K., et al.: App. Microbiol. Biotechnol., 85, 1417 (2010); Van Pelt. S., et al.: Org. Biomole. Chem., 9, 3011 (2011);<br></p>

<p>Applications Boric Acid, Pinacol Ester was a useful reagent in the study of hydrogen peroxide inducible DNA croslsinking agents as anticancer prodrugs.<br>References Kuang, Y., et al.: J. Am. Chem. Soc., 133, 19278 (2011);<br></p>

<p>Applications Bromochloroacetic acid is a halogenated disinfection byproduct commonly found in drinking water, fruit juice, and cheese. Bromochloroacetic acid has been shown to cause mesothelioma, fibroadenomas, and adenomas in rats<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hang, C., et al.: Sci Total Environ. 543, 425 (2016); Cardador, M. J. and Gallego, M.: Food Chem. 173, 685 (2015); Natl Toxicol Program Tech Rep Ser. 549, 1 (2009)<br></p>

<p>Applications (3E,7E)-4,8,12-Trimethyl-3,7,11-tridecatrienoic Acid is a compound involved in a study on ligand-controlled regiodivergent Ni-catalyzed reductive carboxylation of allyl esters with CO2.<br>References Moragas, T., et al.: J. Am. Chem. Soc., 136, 17702-17705 (2014)<br></p>

<p>Applications 2-(4-Hydroxycyclohexyl)acetic acid (cas# 99799-09-4) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxyphenylacetic Acid (cas# 614-75-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Azidobenzoic Acid (cas# 31162-13-7) is a useful research chemical.<br></p>

<p>Impurity Orlistat USP Related Compound B<br>Applications Orlistat USP Related Compound B<br></p>

<p>Applications Nonadecanedioic Acid (cas# 6250-70-0) is a useful research chemical.<br></p>

<p>Applications 3-Hydroxytetradecanoic Acid is used in the preparation of liposomes coated with N-acylated molecular-weight. Also used in the synthesis of pseudomycin side-chain analogs. Also used in the study of Lipid A, a major constituent of the lipopolysaccharides, which are responsible for the toxicity of gram negative bacteria.<br>References Naberezhnykh, G. et al.: Chem. Nat. Comp., 46, 852 (2011); Chen, S. et al.: Bioorg. Med. Chem. Lett., 10, 2107 (2000); Carillo, S. et al.: Marine Drugs., 11, 184 (2013);<br></p>

<p>Applications 1,3-Adamantanedicarboxylic acid, is a monomer that can be used in polymer science, self assembly and lithography.<br></p>

<p>Applications A naturally occurring chelation agent.<br>References Boonme, P., et al.: J. Biomed. Nanotechnol., 5, 373 (2009), Noh, J., et al.: Bioorg. Med. Chem., Lett., 19, 5586 (2009), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications 6-[(6-Aminohexyl)amino]-6-oxo-hexanoic acid is a nylon oligomer with flame retardant properties.<br>References Zahn, Helmut et al.: Chemische Berichte, 92, 1381 (1959)<br></p>

<p>Stability Air Sensitive<br>Applications Levopimaric Acid is a major component of pine oleoresin. It is an abietane-type of diterpene resin acid and has antibacterial, cardiovascular, and antioxidant properties.<br>References Kersten, P. J., et al.: J. Chem. Ecol., 32(12), 2679-85 (2006)<br></p>

<p>Applications 4-(Methylsulfonyl)phenylacetic Acid is an intermediate used to prepare heterocyclic diaryl compounds as selective COX-2 inhibitors. It is also used to synthesize hydroxyfuranones as antioxidants and antiinflammatory agents.<br>References Eren, G., et al.: Bioorg. Med. Chem., 18, 6467 (2010); Weber, V., et al.: Bioorg. Med. Chem., 13, 4552 (2005)<br></p>

<p>Applications Methyl 5-chloro-2-hydroxy-1-oxo-2,3-dihydro-1H-indene-2-carboxylate (cas# 144172-24-7) is a useful research chemical. It is an intermediate in the synthesis of IN-KG 433 (I627995). IN-KG 433 is an impurity of Indoxacarb (I654000), an oxadiazine pesticide that acts against lepidopteran larvae and is the active ingredient in a number of household insecticides including cockroach baits.<br>References Wang, H., et al.: Water. Sci. Technol., 61, 2733 (2010); Shono, T., et al.: Pesticide. Biochem. Physiol., 75, 1 (2003);<br></p>

<p>Applications DL-2-aminobutyric acid<br></p>

<p>Applications 3-Amino-4-(carboxymethyl)benzoic acid<br></p>

<p>Applications 2,2-Diphenylpentanoic Acid (cas# 841-32-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Phenylglyoxylic Acid (cas# 611-73-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,3-Dihydro-1,3-dioxo-5-isobenzofurancarboxylic Acid is an analog of Trioctyl Trimellitate (T804400) which is a plasticizer that was evaluated for endocrine disrupting activities through estrogen receptor alpha binding assay.<br></p>

<p>Applications 2-Benzoylbenzoic Acid is a reagent that is used in the synthesis of BzATP Triethylammonium Salt, which is a selective P2X purinergic agonist. It is more potent than ATP at homodimeric P2X7 receptors.<br>References Abou-Seri, S. M., et al.: Eur. J. Med. Chem., 107, 165 (2016);<br></p>

<p>Applications Benzyl Acetate, is found naturally in many flowers, It has pleasant sweet aroma reminiscent of jasmine, and thus is used widely in perfumery industry, and also as a flavouring agent. It is also used as a solvent.<br>References Schiestl, F. P., et al.: J. Chem. Ecology, 29 (2004); Qian-qian, M., et al.: Jingxi Huagong, 30, 442 (2013);<br></p>

<p>Applications m-Toluic acid is used as a reagent in the preparation of hybrid molecules containing oxadiazole and thiadiazole bearing Schiff base moiety as it has antitumor activities.<br>References Zhang, K., et al.; Bioorg. Med. Chem. Lett., 24, 5154 (2014);<br></p>

<p>Applications Phosphoric acid, ammonium salt (1:1) is a useful reagent for organic synthesis.<br></p>

<p>Stability Hygroscopic<br>Applications A phosphonic acid derivative for development of biologically active compounds.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ma, Q.F., et al.: Biochemistry, 29, 1412 (1990), Soti, C., et al.: Eur. J. Biochem., 270, 2421 (2003), Barabas, O., et al.: J. Biol. Chem., 279, 42907 (2004),<br></p>

<p>Applications Phthalanilic acid is a compound that is useful in the production of fertilizers.<br>References Liang, S., et al.: Faming Zhuanli Shenqing.,4 (2019)<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications (2E,6E)-3,7,11-Trimethyldodeca-2,6,10-trien-1-yl Acetate is an intermediate in the synthesis of JHSB3 (J211030). JHSB3 is an acyclic sesquiterpenoid that regulates many aspects of insect physiology. Juvenile Hormone regulate development, reproduction, diapause, and polyphenisms.<br>References Kotaki, T., et al.: Org. Let., 11, 5234 (2009); Riddiford, L.: Adv. Insect Physiol., 24, 213 (1994); Wyatt, G., Davey, K.: Adv. Insect Physiol., 26, 1 (1996); Nijhout, H.: Insect Hormones (Princeton Univ. Press, Princeton) (1994)<br></p>

<p>Applications Perfluorohexanoic Acid is a perfluorinated compound (FPC) that can cause acute toxicity to humans and the environment. Perfluorohexanoic Acid is also used as a reagent in the synthesis of 3,3,4,4,5,5,6,6,7,7,7-Undecafluoro-2-heptanol (U787500).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Latala, A., et al.: Environ. Toxicol. Phar., 28, 167 (2009); Mulkiewicz, E., et al.: Environ. Toxicol. Phar., 23, 279 (2007)<br></p>

<p>Applications Opianic Acid is a reagent used in the synthesis of novel 5-arylidene (thio)barbituric acid displaying urease activity.<br>References Vosooghi, M. et al.: J. Iran. Chem. Soc., 12, 1487 (2015);<br></p>