6-membered Rings

<p>Applications N-Ethyl-3-phenylpropylamine is an intermediate in the synthesis of 4-Hydroxy Alverine (H827950), a metabolite of Alverine (A575780) in plasma.<br>References Bouvier, M., et al.: Gastroenterol. Clin. Biol., 16, 334 (1992), Mitchell, S., et al.: Aliment. Pharmacol. Ther., 16, 1187 (2002), Hayase, M., et al.: Br. J. Pharmacol., 152, 1228 (2007),<br></p>

<p>Applications 5-(3-Benzyloxyphenyl)nicotinic acid<br></p>

<p>Applications 5-(Diphenylphosphinyl)pentanoic Acid, can be used for the preparation of praseodymium coordination polymers with diphenylphosphorylvalerate ligand. It is also a by product in the preparation of prostaglandin analogs.<br>References Spichal, Z., et al.: Polyhedron, 48, 99 (2012); Zhao Y. et al.: PCT Int. Appl. 43pp.Patent, 2016<br></p>

<p>Applications 2H-1,3-benzodithiole-2-thione (cas# 934-36-1) is a useful research chemical.<br></p>

<p>Applications 3-Trimethylstannyl Benzoic Acid (cas# 161767-56-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Ethyl 3,5-dichloro-4-hydroxybenzoate (cas# 17302-82-8) is a useful research chemical.<br></p>

<p>Applications Benzofuran-3(2H)-one is a useful research chemical, an intermediate used in the catalytic asymmetric synthesis of chiral benzofuranones.<br>References Li, Y., et al.: Adv. Synth. Catal., 356, 1172 (2014); Huang, Z., et al.: Org. Lett., 19, 3524 (2017)<br></p>

<p>Applications 3-PHENYLISONICOTINIC ACID (cas# 104096-15-3) is a useful research chemical.<br></p>

<p>Applications Ethyl 3,4-dihydro-2H-pyran-2-carboxylate (cas# 83568-11-0) is a useful research chemical.<br></p>

<p>Applications 1-Cyclohexylethanone is used in the synthesis of thiosemicarbazide derivatives which exhibits biological activity.<br>References Venkatesh, K., et al.: J. Chem. Pharm. Res., 7, 437-445 (2015)<br></p>

<p>Applications p-Anilinoaniline is an antioxidant that has shown to cause a reduction of NOx emissions from soybean biodiesel powered DI diesel engines but has increased CO and HC emissions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Varatharajan, K., Cheralathan, M.: Fuel Process Technol., 106, 526 (2013)<br></p>

<p>Applications 2-CYCLOPENTYL-2-PHENYLACETIC ACID (cas# 3900-93-4) is a useful research chemical.<br></p>

<p>Applications N-(2-acetyl-1-benzofuran-3-yl)-2-chloroacetamide (cas# 855715-46-7) is a useful research chemical.<br></p>

<p>Applications 4-phenyloxolan-2-one (cas# 1008-73-7) is a useful research chemical.<br></p>

<p>Applications 4-Hydroxyphenylacetone (cas# 770-39-8) is a useful research chemical.<br></p>

<p>Applications 1-Benzyl-5-(dicyclohexylcarbodiimido)glutarate (cas# 887352-83-2) is a compound useful in organic synthesis.<br></p>

<p>Applications Can be used in the preparation of pyrrolylphenylsulfonates as dopamine D3 antagonists as well as in the preparation of substituted amidothiophene derivatives for use as 11-β-HSD1 inhibitors.<br></p>

<p>Applications Glycidyl 4-Toluenesulfonate is used in the development and validation of a chiral HPLC method for rapid screening of allylic alcohol asymmetric epoxidation processes. Glycidyl 4-Toluenesulfonate is a reagent for organic displacement, additional and ring-opening reactions.<br>References Morante-Zarcero S., et al.: Analytica chimica acta, 618, 102 (2008); Bittman, R., et al.: e-EROS Encyclopedia of Reagents for Organic Synthesis; 1, (2001)<br></p>

<p>Applications (Methyl)triphenylphosphonium Iodide is the precursor to a wittig reagent.<br></p>

<p>Applications Benzyltrimethylammonium dichloroiodate is used in the mechanism of oxidation.<br>References Srinivasan, N., et al.: Tetrahedron, 30, 419 (1974), Sankhla, R., et al.: J. Chem. Res., 0465 (2002),<br></p>

<p>Applications 2-(3-Butynyloxy)tetrahydro-2H-pyran is used as a reagent in the synthesis of Phomoidride D, a bridged, polycyclic, natural compound that has the ability to inhibit squalene synthase and can be used as an antihypercholesterolemic agent. 2-(3-Butynyloxy)tetrahydro-2H-pyran is also used as a reagent to prepare Rugulactone, a natural compound that is isolated from Cryptocarya rugulosa.<br>References Allais, F., et al.: Synthesis, 2010, 2787 (2010); Biller, S., et al.: Curr. Pharm. Des., 2, 1 (1996); Chen, C., et al.: J. Am. Chem. Soc., 122, 7424 (2000); Murphy, G., et al.: J. Org. Chem., 78, 477 (2013)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-(N,N-Dimethylaminosulfonyl)phenylboronic acid pinacol ester<br></p>

<p>Applications 9-(2-(Benzyloxy)ethyl)-2-((2-(benzyloxy)ethyl)amino)-1H-purin-6-(9H)-one is an intermediate used in the synthesis of 9-(2-Hydroxyethyl)guanine (H942035), which is an impurity of the antiviral agent Acyclovir (A192400). 9-(2-Hydroxyethyl)guanine is a nucleoside phosphotransferase acceptor.<br>References Kamimura, A. et al.: Agric. Biol. Chem., 37, 2037 (1973);<br></p>

<p>Applications N-Octyl 4-Hydroxybenzoate is a useful plasticizer.<br>References Shen, J., et al.: Faming Zhuanli Shenqing (2020), CN 111073279 A<br></p>

<p>Applications 5-Hydroxytetrahydro-2H-pyran-2-one (cas# 33691-73-5) is a useful research chemical.<br></p>

<p>Applications 4-Mercaptobenzonitrile is a building block used as a reactant in the synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.<br>References Chai, H., et al.: Bioorg. Med. Chem., 14, 911 (2006);<br></p>

<p>Applications 1-Nitro-2-[(1E)-2-nitroethenyl]-4-(phenylmethoxy)-benzene is an intermediate used in the synthesis of 5-Hydroxyindole-3-acetic acid (H953605), which is an impurity of chlorpheniramine (C424300), an antihistaminic agent.<br>References Josko, J., et al.: Annal. Acad. Med. Siles., 66, 13, (2012); Carson, R.P., et al.: Human. Molec. Genetics., 22, 140 (2013);<br></p>

<p>Applications N-(4-amino-2-chlorophenyl)-5-chloro-2-hydroxybenzamide (cas# 10558-45-9) is a useful research chemical.<br></p>

<p>Applications 4-Biphenylacetonitrile is a useful synthetic intermediate. It was used to study the adsorption orientation of the biphenyl derivatives on the Au colloidal surfaces with α-cyclodextrins. 4-Biphenylacetonitrile on condensation reaction with ethyl phenyl propiolate yields biphenyl derivatives of acetylenic β-ketocyanide.<br>References Lee, J., et al.: Bull. Korean. Chem. Soc., 30, 1637 (2009); Al-Jallo, H., et al.: J. Chem. Eng. Data, 17, 513, (1972)<br></p>

<p>Applications Benzyltributylammonium Chloride (cas# 23616-79-7) is a useful research chemical.<br></p>

<p>Applications PROPYL 3,5-DICHLORO-4-HYDROXYBENZOATE (cas# 101003-80-9) is a useful research chemical.<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications Ethyl 5-amino-1-benzofuran-2-carboxylate is used as an synthetic intermediate in the preparation of indolebutylpiperazines, a class of dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. Ethyl 5-amino-1-benzofuran-2-carboxylate was also used as a potential radiolabelled analog for melanoma imaging and targeted radiotherapy.<br>References Chezal, J.M., et al.: J. Medn. Chem., 51, 3133 (2008); Heinrich, T., et al.: J. Medn. Chem., 47, 4684 (2004);<br></p>

<p>Applications 4-(ethenesulfonyl)benzonitrile (cas# 1154397-48-4) is a useful research chemical.<br></p>

<p>Applications Methyl 2-(Isocyanatosulfonyl)benzoate is an intermediate in the synthesis of Metsulfuron (M227745), a powerful herbicide used in the control of pests and protection of crops and produce.<br>References Anderson, J. et al.: J. Agric. Food Chem., 37, 1429 (1989); Ivany, J. et al.: Can. J. Plant Sci., 67, 1083 (1987);<br></p>

<p>Applications 4-(2,4,4-trimethylpentan-2-yl)benzene-1,2-diol (cas# 1139-46-4) is a useful research chemical.<br></p>

<p>Applications 4-(3,4-dipropoxyphenyl)-4-oxobutanoic acid (cas# 568553-00-4) is a useful research chemical.<br></p>

<p>Applications 1-(2-AMINO-5-HYDROXYPHENYL)ETHANONE (cas# 30954-71-3) is a useful research chemical.<br></p>

<p>Applications 3,5-Dimethoxytoluene (cas# 4179-19-5) is a useful research chemical.<br></p>

<p>Applications Bis(p-aminophenyl) Ether is a reagent used in the preparation of polyimide-silica composite membranes for gas separation techniques. In addition, it is used in the synthesis of polymer films for electrolyte membranes. Dyes and metabolites, Environmental Testing<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lua, A. et al.: React. Funct. Polym., 73 756 (2013); Song, Y. et al.: J. Pow. Souce., 238, 236 (2013); Saito, K. et al.: React. Funct. Polym., 73, 756 (2013);<br></p>

<p>Applications A potent γ-ketoaldehyde scavenger that has been shown to protects cardiac sodium channel (NaV1.5) from oxidant-induced inactivation<br>References Zagol-Ikapitte, I. et al.: Pharmaceutics, 2, 18 (2010); Nakajima, T. et al.: J. Mol. Cell. Cardiol., 48, 352 (2010); Davies, S.S. et al.: Biochem., 45, 15756 (2006);<br></p>

<p>Applications α-(Aminomethyl)-2-(trifluoromethoxy)benzenemethanol is an analog of α-(Aminomethyl)-3-(trifluoromethoxy)benzenemethanol (A630745); a compound that is used as a reagent in the synthesis of potent and selective ethanolamine inhibitors of bacterial phenylalanyl tRNA synthetase. It is also used as a reagent in the synthesis of 1-aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase.<br>References Jarvest, R.L., et al.: Bioorg. Med. Chem. Lett., 15, 2305 (2005); Keith, J.M., et al.: Bioorg. Med. Chem. Lett., 24, 1280 (2014)<br></p>

<p>Applications Methyl Phenylacetate is used as a reagent in the synthesis of various organic reactions, one of which is the synthesis of Vulpinic Acid (V850000); a lichen metabolite with anti-inflammatory properties.<br>References Shachak, M., et al.: Science, 236, 1098 (1987); Froberg, L., et al.: Lichenologist, 25, 83 (1993); Hesbacher, S., et al.: J. Chem. Ecology, 21, 233 (1995)<br></p>

<p>Applications 4-N-OCTYLOXYBENZOIC ACID (cas# 2493-84-7) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Acetamido-2-hydroxy-3-(2-oxoethyl)benzoate is a useful research chemical for organic synthesis and other chemical processes.<br>References Kakigami, T., et al.: Chem. Pharm. Bull., 46, 42 (1998)<br></p>

<p>Stability Air Sensitive<br>Applications Can be used as a building block for chiral ligands.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,3-Cyclohexanediol (cas# 504-01-8) is a useful research chemical.<br></p>

<p>Applications methyl 4-(bromomethyl)-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate (cas# 1626407-50-8) is a useful research chemical.<br></p>

<p>Applications (1S,3R,4S)-Ethyl 4-Amino-3-((tert-butoxycarbonyl)amino)cyclohexanecarboxylate Oxalate has been used as a reactant for the preparation of oxadiazole compounds containing cyclohexanediamine moiety.<br></p>

<p>Applications Ethyl 6-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylate is an intermediate in the synthesis of rac Ketorolac 6-Benzoyl Isomer (K235620). rac Ketorolac 6-Benzoyl Isomer (Ketorolac EP Impurity C) is an isomeric impurity of Ketorolac (K235620).<br></p>

<p>Stability Moisture Sensitive<br>Applications (3R,4R)-Dihydro-3,4-bis(phenylmethoxy)-2,5-furandione is an intermediate in the synthesis of N-alkenylsuccinimide derivatives.<br>References Ohwada, J., et al.: Bull. Chem. Soc. Jap., 63, 287 (1990);<br></p>

<p>Impurity Lubiprostone Impurity VI<br>Applications 7-((1R,2R,3R)-3-(cyclohexylmethoxy)-2-(4,4-difluoro-3-oxooctyl)-5-oxocyclopentyl)heptanoic Acid is a useful chemical reagent.<br></p>

<p>Applications 2,4-Dihydroxy-5-((4-sulfophenyl)diazenyl)benzoic Acid is an intermediate in the synthesis of Acid Orange 24 (A189835), which is used in trickling biofilters for wastewater treatment. Acid Orange 24 is used in suncare compositions. It also serves as a raw material for cosmetics. Mutagenicity test for dye compositions in cosmetics.<br>References Garzon-Zuniga, M. A., et al.: Water Environ. Res., 83, 107 (2011); Anon.: IP.com Journal, 11, 5 (2011); Muzzall, J. M., et al.: Mutat. Res., Genet. Toxicol. Testing, 67, 1 (1979)<br></p>

<p>Applications N-(1-Chloro-2-oxo-2-phenylethyl)benzamide is an amidophenacylating reagent used in various organic reactions, e.g. in the synthesis of thiohydantoin derivatives.<br>References Balya, A.G., et al.: Russ. J. Gen. Chem., 78, 1427 (2008); Belyuga, A.G., et al.: Zhurnal Organichnoi ta Farmatsevtichnoi Khimii, 2, 25 (2004)<br></p>

<p>Applications 1,4-Phenylenediamine-13N2 is the isotope labelled analogue of 1,4-Phenylenediamine (P319845), an organic compound that is a derivative of aniline and a main ingredient for the production of polymers and hair dyes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Chugh, K., et al.: J. Med., 13, 131 (1982), Baud, F., et al.: J. Toxicol. Med., 4, 279 (1984), Ashraf, W., et al.: Human Exp. Toxicol., 13, 167 (1994),<br></p>

<p>Applications Triethylene Glycol Monobenzyl Ether is used in the preparation of self-assembled monolayers with multiple binding sites and biocompatible imprinted cavities for biosensor application. Also used in the synthesis of novel ethoxylated inositol surfactants.<br>References Zhang, X. et al.: J. Am. Chem. Soc., 135, 9248 (2013); Catanoiu, G. et al.: J. Colloid. Inter. Sci., 371, 82 (2012);<br></p>

<p>Applications 4-Nitrobenzenesulfonamide (cas# 6325-93-5) is a useful research chemical.<br></p>

<p>Applications 2-Isopropoxy-2-phenylacetic acid<br></p>

<p>Applications 4-​Morpholinocyclohex-​1-​en-​1-​yl Trifluoromethanesulf​onate is a reagent used in the preparation of inhibitors of c-Jun N-terminal kinase in the treatment of neurodegenerative disorders and autoimmune diseases.<br>References Graczyk, P. et al.: PCT Int. Appl. (2010), WO 2010015803 A1 20100211.<br></p>