6-membered Rings

<p>Applications 4-Ethylsulfonylphenylboronic acid is used in the discovery of small molecular RIP1 kinase inhibitors for the treatment of pathologies associated with necroptosis.<br>References Harris, P. A,, et al.: ACS Med. Chem. Lett., 4, 1238 (2013)<br></p>

<p>Applications 4-[3-(Hydroxymethyl)phenoxy]benzonitrile can be synthesized from 4-(3-Formylphenoxy)benzonitrile (90178-72-6).<br></p>

<p>Applications An intermediate for the preparation of (+/-)-Taxifolin.<br></p>

<p>Applications Heptylbenzene is a useful synthetic intermediate. It is used in zirconia and titania based stationary phase capillary HTLC, to separate alkyl benzene derivatives using an acetonitrile-water eluent. It can also be used to prepare 3-chloropyridine-stabilized palladium imidazolylidene complexes as catalysts for Suzuki and Negishi cross-coupling reactions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kephart, T., et al.: Anal. Chim. Acta., 414, 71 (2000); O’Brien, C., et al.: Chem. Eur. J., 12, 4743 (2006)<br></p>

<p>Applications 3-(4-Hydroxyphenyl)propionitrile (cas# 17362-17-3) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(Aminosulfonyl)benzoic Acid can be used as reactant/reagent in synthesis and pharmacological activity of γ-(phenyloxamido)- and γ-(phenylsulfonyloxamido)butanoic acids.<br>References Georgiyants, V. A., et al.: Farmatsevtichnii Zhurnal, 2, 34 (2010);<br></p>

<p>Applications ethyl 3,5-dimethylbenzoate (cas# 21239-29-2) is a useful research chemical.<br></p>

<p>Applications N-Octyl 4-Hydroxybenzoate is a useful plasticizer.<br>References Shen, J., et al.: Faming Zhuanli Shenqing (2020), CN 111073279 A<br></p>

<p>Applications 5-Hydroxytetrahydro-2H-pyran-2-one (cas# 33691-73-5) is a useful research chemical.<br></p>

<p>Applications 1-[2-Hydroxy-5-(2-hydroxyethyl)phenyl]-ethanone (cas# 58282-51-2) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Nitro-5-phenylthioaniline is a useful synthetic intermediate. It was used to synthesize methyl 5(6)-phenylsulfinyl-2-benzimidazolecarbamate as a potent anthelmintic.<br>References Averkin, E., et al.: J. Med. Chem., 18, 1164 (1975);<br></p>

<p>Applications 1,1,2,2-tetraphenylethane-1,2-diol (cas# 464-72-2) is a useful research chemical.<br></p>

<p>Applications Phenyl Cyanate (Stabilized with PPE) (cas# 1122-85-6) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Light Sensitive<br>Applications Vinylcyclohexane is a useful reagent in cationic nickel(II)-catalyzed hydrosilylation of alkenes.<br>References Hossain, I., et al.: Organometallics, 39, 3441 (2020)<br></p>

<p>Applications Nitrosobenzene (cas# 586-96-9) is a useful research chemical.<br></p>

<p>Applications Bromodifluoromethyl Phenyl Sulfone can be used to prepare difluoromethyl ethers via difluoromethylation of alcohols.<br>References Xie, Q., et.al.:Angew. Chem. Int., 56, 3206-3210, (2017);<br></p>

<p>Applications 2-(methylamino)benzene-1-sulfonamide (cas# 21639-28-1) is a useful research chemical.<br></p>

<p>Applications 3-[(3-aminophenyl)amino]benzonitrile (cas# 1147094-81-2) is a useful research chemical.<br></p>

<p>Applications 2,5-Dihydroxybenzoic Acid Butylamine Salt [Matrix for MALDI-TOF/MS] (cas# 666174-80-7) is a useful research chemical.<br></p>

<p>Applications 4-Biphenylcarboxylic acid (cas# 92-92-2) is a useful research chemical.<br></p>

<p>Applications 4-Mercaptobenzonitrile is a building block used as a reactant in the synthesis and in vitro anti-hepatitis B virus activities of some ethyl 6-bromo-5-hydroxy-1H-indole-3-carboxylates.<br>References Chai, H., et al.: Bioorg. Med. Chem., 14, 911 (2006);<br></p>

<p>Applications 2-Amino-5,5-dimethyl-5,6-dihydro-4h-benzothiazol-7-one<br></p>

<p>Applications Ethyl 4-acetylbenzoate is used as a reagent to synthesize pyrazoles (e.g. 1H-Pyrazole [P842195]). Ethyl 4-acetylbenzoate is also used as a reagent to synthesize chiral hydrazines (e.g. (S)-[2-(Benzyloxy)propylidene]hydrazinecarboxaldehyde [B288000]) from the catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones.<br>References Heller, S. &amp; Natarajan, S.: Org. Lett., 8, 2675 (2006); Yoshikawa, N., et al.: Org. Lett., 12, 276 (2010)<br></p>

<p>Applications (1R,2S,4S)-rel-1,2,4-Trimethylcyclohexane is a reagent in the thermal cracking of kerosine. Present in coal-derived liquids light fractions.<br>References Van Camp, C. et al.: Ind. Eng. Chem. Proc. Design. Dev., 23, 155 (1984); Kumar, P. et al.: Fuel., 66, 1036 (1987);<br></p>

<p>Applications 1,2,4-Triacetoxybenzene, can be used in preparation of two marine aminated hydroxynaphthazarins, echinamines A and B.<br>References Pokhilo N. D., et al.: Journal of natural products, 69(8), undefined (2006-8-29);<br></p>

<p>Stability Hygroscopic<br>Applications 1-Amino-3-Hydroxybenzene is used in the preparation of inhibitors of mammalian carbonic anhydrase isoforms. Also used in the preparation of quinoline tethered fluorescent carbon dots for regulated anticancer discovery.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carta, F. et al.: Bioorg. Med. Chem., 21, 1564 (2013); Karthik, S. et al.: Chem. Comm., 49, 10471 (2013);<br></p>

<p>Applications Intermediate in the production of Gallic Acid derivatives.<br>References Dodo, K., et al.: Bioorg. Med. Chem., 16, 7975 (2008), Dodo, K., et al.: Chem. Pharm. Bull., 57, 190 (2009),<br></p>

<p>Applications 5-Bromo-2-ethoxy-benzenesulfonyl chloride<br></p>

<p>Applications 4-Biphenylacetonitrile is a useful synthetic intermediate. It was used to study the adsorption orientation of the biphenyl derivatives on the Au colloidal surfaces with α-cyclodextrins. 4-Biphenylacetonitrile on condensation reaction with ethyl phenyl propiolate yields biphenyl derivatives of acetylenic β-ketocyanide.<br>References Lee, J., et al.: Bull. Korean. Chem. Soc., 30, 1637 (2009); Al-Jallo, H., et al.: J. Chem. Eng. Data, 17, 513, (1972)<br></p>

<p>Applications p-(Allyloxy)benzyl Alcohol is an intermediate in the synthesis of 2-amino-nicotinic acid benzyl ester derivatives as agrochemical fungicides.<br>References Jpn. Kokai Tokkyo Koho (2015), JP 2015089883 A 20150511.<br></p>

<p>Applications Benzyl Isocyanate is a general reagent used in the synthesis of complex bisindolylmethanes. Also used in the preparation of urea derivatives of thiazol-2-ethylamines for their anti-trypanosomal activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Patrick, D. et al.: Bioorg. Med. Chem., 24, 2451 (2016);<br></p>

<p>Applications (1R)-2-(methylamino)-1-phenylethan-1-ol (cas# 495-42-1) is a useful research chemical.<br></p>

<p>Applications A useful synthetic intermediate for the preparation of novel antiinflammatory agents.<br></p>

<p>Applications PROPYL 3,5-DICHLORO-4-HYDROXYBENZOATE (cas# 101003-80-9) is a useful research chemical.<br></p>

<p>Applications Ethylene Glycol Monobenzoate, is a reagent that can be used as an intermediate in a variety of chemical and biochemical reactions. It is used as an intermediate in the preparation of 1,2-Ethanediol Disodium Salt (E890125), which is the result of the nucleophilic attack on its carbonyl group.<br>References Khouri, F. et al.: J. Am. Chem. Soc., 108, 6683 (1986);<br></p>

<p>Applications 4'-Dimethylaminophenyl acetylene<br></p>

<p>Applications Ethyl 4-[[(methylphenylamino)methylene]amino]benzoate<br></p>

<p>Applications 1-​Biphenyl-​4-​yl-​propan-​2-​one is a reactant used in the preparation of potent inhibitors of metalloproteinases 2 and 9 (MMP-2, MMP-9). This affects such processes such as homeostatic regulation, tumor progression, etc.<br>References Nicolotti, O. et al.: Eur. J. Med. Chem., 58, 358 (2012);<br></p>

<p>Applications 2-amino-6-hydroxybenzoic acid (cas# 567-62-4) is a useful research chemical.<br></p>

<p>Applications Intermediate in the preparation of Trimebutine metabolites.<br></p>

<p>Applications 4,5-Dihydro-1-benzoazepin-2(3H)-one (cas# 4424-80-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Formylbenzene-1,2-disulfonoic Acid is derived from 5,6-Difluoro Anthranilic Acid (D445550), which is used in the preparation of 2-[[2-(phenylamino)-1H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]benzamide derivatives as inhibitors of IGF-1R and IR receptor tyrosine kinase as anticancer agents.<br>References Rubinstein, E., et al.: Chemotherapy, 47, 3 (2001), Grohs, P., et al.: Antimicrob. Agents Chemother., 47, 3542 (2003),<br></p>

<p>Applications Ethynyl-2-d-benzene is a useful labeled building block for organic synthesis.<br></p>

<p>Applications 5,7-Bis-(benzyloxy)-2-(4-(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one (cas# 23405-70-1) is a compound useful in organic synthesis.<br>References Smith, J., et al.: Bioorg. Med. Chem., 15, 5018 (2007),<br></p>

<p>Applications 6-AMINO-2,2-DIMETHYL-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE (cas# 105807-84-9) is a useful research chemical.<br></p>

<p>Applications 1-Isocyanato-3-phenoxybenzene (cas# 87873-72-1) is a useful research chemical.<br></p>

<p>Applications 4-(ethenesulfonyl)benzonitrile (cas# 1154397-48-4) is a useful research chemical.<br></p>

<p>Applications 1-(2H-1,3-benzodioxol-5-yl)prop-2-en-1-ol (cas# 5208-87-7) is a useful research chemical.<br></p>

<p>Applications N-(furan-3-ylmethyl)cyclohexanamine (cas# 462068-58-2) is a useful research chemical.<br></p>

<p>Stability Air and Moisture Sensitive<br>Applications [Bis(trifluoroacetoxy)iodo]benzene is a reagent that is used in the preparation of XEN907, which is a spiro-oxindole blocker of Nav1.7 for the treatment of pain.<br>References Chowdhury, S., et al.: Bioorg. Med. Chem. Lett., 12, 3676 (2011);<br></p>

<p>Applications Phosphorylating reagent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moris, M., et al.: J. Med. Chem., 48, 1251 (2005), Kline, T., et al.: Bioorg. Med. Chem. Lett., 18, 1507 (2008),<br></p>

<p>Applications 4-(3,4-dipropoxyphenyl)-4-oxobutanoic acid (cas# 568553-00-4) is a useful research chemical.<br></p>

<p>Applications 4-Nitrotoluene is an explosive material.<br>References Wollseifen, Rainer, et al.: Separation, 35(1), 28-30 (2015);Cao, Anping, et al.: Nano Letters, 17(1), 1-7 (2017)<br></p>

<p>Applications Methyl Dimethylbenzeneacetate (cas# 57625-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1-(1,3-Benzodioxol-5-yl)-1-hexanone is an intermediate used in the synthesis of 1-(1,3-benzodioxol-5-yl)-2-(1-pyrrolidinyl)-1-Hexanone (B207110), which is also known as MDPHP, is a synthetic cathinone.<br>References Fowble, K. L.; et al.: Talanta, 179, 546 (2018).<br></p>

<p>Applications 1-(2-AMINO-5-HYDROXYPHENYL)ETHANONE (cas# 30954-71-3) is a useful research chemical.<br></p>

<p>Applications Benzyl (2S)-2-carbobenzyloxyamino-6-hydroxyhexanoate (cas# 84246-49-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(dimethylamino)-3-nitrobenzoic Acid (cas# 28096-56-2) is a useful research chemical.<br></p>

<p>Applications 3,4-dihydro-2H-1-benzopyran (cas# 493-08-3) is a useful research chemical.<br></p>