Antifungals

<p>Diamthazole (Dimazole) is an antifungal agent that can be used in the infection research[1].</p>

<p>Diethofencarb: a fungicide effective against Botrytis cinerea and resistant Botryis strains.</p>

<p>BI-10, paired with fluconazole, hinders fungal growth, increases ROS, decreases MMP, and changes membrane permeability.</p>

<p>Antifungal agent 2 suppresses growth of Cryptococcus, Candida, Aspergillus at ≥0.5 μg/mL.</p>

<p>FBA-IN-1 (2a11) is the first covalent, allosteric CaFBA inhibitor, effective against Azole-resistant strains with a MIC 80 of 1 μg/mL.</p>

<p>Lipoxamycin is an inhibitor of serine palmitoyl-transferase.</p>

<p>41F5: Anti-fungal with MIC50 0.4-0.8 μM and IC50 0.87 μM against Histoplasma; 62x more selective for yeast vs host cells.</p>

<p>Flutolanil: a fungicide targeting R. solani in rice, toxic to zebrafish.</p>

<p>Debneyol exhibits more potent fungicidal activity than validamycin.</p>

<p>1-(6-Amino-3,5-difluoro-2-pyridinyl)-7-[3-[3-[[1-(6-amino-3,5-difluoro-2-pyridinyl)-3-carboxy-8-chloro-6-fluoro-1,4-dihydro-4-oxo-7-quinolinyl]amino]-2-hydroxypropoxy]-1-azetidinyl]-8-chloro-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid is a fluoroquinolone antibiotic, engineered through synthetic chemistry. It is derived from chemical sources involving complex organic synthesis, highlighting its intricate molecular architecture. Its mode of action is distinctive, as it inhibits bacterial DNA gyrase and topoisomerase IV, enzymes crucial for DNA replication and transcription. This interference with bacterial DNA processes results in bactericidal effects, effectively eliminating susceptible bacterial strains.</p>

<p>Rilopirox is a synthetic fungicidal antimycotic with hydrophobic characteristics.</p>

<p>Pramiconazole (R126638), an oral antifungal, treats dermatophyte and yeast infections in seborrheic dermatitis.</p>

<p>Flutrimazole: a dual-action imidazole with anti-inflammatory and antifungal effects; ideal for topical use due to limited skin penetration.</p>

<p>ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes.</p>

<p>Micafungin is an antifungal drug that inhibits the synthesis of ergosterol, a vital component of fungal cell membranes. It is a cyclic peptide with a lipophilic fatty acid chain that has been modified to allow penetration into cells. Micafungin is active against Candida and Aspergillus species and has shown activity against some strains of Cryptococcus neoformans. The MIC (minimum inhibitory concentration) for this drug ranges from 0.06 to 1 microgram/mL, depending on the bacterial strain being tested. Micafungin FR-179642 impurity (acid) is an impurity in micafungin that can be present as trace amounts in the final product and may contribute to hemolytic activity. This impurity is formed by hydrolysis during the synthesis process.</p>

<p>PC945 (Opelconazole) is an antifungal compound that inhibits CYP51A/CYP51B and can be used to study fungal infections of the lungs.</p>

<p>Dihydropenicillin F potassium is a novel antibiotic compound, which is semisynthetic in nature, derived from the penicillin family. It is sourced through the modification of natural penicillins, bringing about enhanced stability and efficacy against certain resistant bacterial strains. The mode of action involves the inhibition of bacterial cell wall synthesis, primarily targeting the penicillin-binding proteins (PBPs). This disruption consequently leads to cell lysis and the eventual bacterial death.</p>

<p>N,O-Diacetyltyramine, isolated from the actinomycete Pseudonocardia endophytica VUK-10, exhibits both antibacterial activity against Gram-positive and Gram-negative bacteria, alongside fungi, and demonstrates cytotoxicity towards MDA-MB-231, HeLa, MCF-7, and OAW-42 cells [1].</p>

<p>Antifungal agent 24 (Compound 6) is an antifungal agent that inhibits Candida albicans (MIC: 0.03 μg/ml).</p>

<p>FR194738 free base inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM. </p>