Serotonin–Norepinephrine Reuptake Inhibitors (SNRI)

<p>Milnacipran, an SNRI with 85% bioavailability, treats fibromyalgia and is well absorbed orally.</p>

<p>Impurity Venlafaxine EP Impurity E<br>Applications 5-(4-Methoxyphenyl)-3-methyl-1-oxa-3-azaspiro[5.5]undecane Hydrochloride (Venlafaxine EP Impurity E) is a useful building block in the synthesis of various pharmaceuticals.<br></p>

<p>Applications (E)-N-Methylcinnamylamine is an 3-amino-1-phenyl-prop-1-ene derivative with potential to inhibit and inactivate monoamine oxidase.<br>References Williams, C.H. et al.: Biochim. Biophys. Acta Prot. Struc. Mol. Enzymol., 119, 111 (1992);<br></p>

<p>Impurity Venlafaxine EP Impurity B<br>Applications Ethyl α-(p-Methoxyphenyl)-β-(dimethylamino)propionate (Venlafaxine EP Impurity B) is an impurity of Venlafaxine (impurity B).<br></p>

<p>Applications rac,trans-Milnacipran Hydrochloride is an impurity of rac-Milnacipran Hydrochloride (M344600), an antidepressant and a selective norepinephrine and serotonin reuptake inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Moret, C., et al.: Neuropharmacology, 24, 1211 (1985), Palmier, C., et al.: Eur. J. Clin. Pharmacol., 37, 235 (1989), Spencer, C.M., et al.: Drugs, 56, 405 (1998)<br></p>

<p>Impurity Venlafaxine EP Impurity D; Venlafaxine USP Related Compound A<br>Applications 1-[1-(4-Methoxyphenyl)-2-(methylamino)ethyl]cyclohexanol Hydrochloride (Venlafaxine EP Impurity D; Venlafaxine USP Related Compound A) is a metabolite of Venlafaxine (V120000), which is a selective serotonin noradrenaline reuptake inhibitor, used as an antidepressant.<br>References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000);<br></p>

<p>Applications (±)-Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>

<p>Applications A phenethylamine alkaloid with antibacterial and antibiotic properties found mainly in plants from the cactaceae family. It showed effects similar to Cytosine (C998950) and acted as a depressant on the central nervous system (CNS) during animal testing.<br>References Aliev, K.U. et al.: Med. Zhur. Uzbek., 8, 71 (1966); Ghosal, S. et al. Planta Medica, 22, 434 (1972); Starha, R. et al.: Biochem. Sys. Ecol., 27, 839 (1999);<br></p>

<p>Applications A optically active metabolite of Tramadol.<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>

<p>Applications A optically active metabolite of Tramadol.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lintz, V.W., et al.: Arzneim.-Forsch./Drug Res., 31, II, 11, 1932 (1981)<br></p>

<p>Stability Hygroscopic<br>Applications An analgesic. Used in the treatment of urinary incontinence.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Raffa, R.B., et al.: J. Pharmacol. Exp. Ther., 267, 331 (1993)<br></p>

<p>Applications Desmethyl Sibutramine is a metabolite of Sibutramine (S422500), a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998); Woolard, J., et al.: J. Pharmacol. Exp. Ther., 308, 1102 (2004); Geranton, S., et al.: Neuropharmacol., 46, 511 (2004)<br></p>

<p>Applications (±)-Venlafaxine-d6 HCl (N,N-dimethyl-d6) (CAS# 1062606-12-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications A selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.<br>References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992), Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)<br></p>

<p>Applications rac N-Methyl Atomoxetine Oxalate is a derivative of Atomoxetine which acts as a norepinephrine reuptake inhibitor.<br>References Farid, N.A., et al.: J. Clin. Pharmacol., 25, 296 (1985), Gehlert, D.R., et al.: J. Neurochem., 64, 2792 (1995), Hwamg. et al.: Neurosci. Lett., 265, 151 (1999), Ring, B.J., et al.: Drug Metab. Dispos., 30, 319 (2002),<br></p>

<p>Applications D,L-Venlafaxine-d10 Hydrochloride is the labeled analogue of D,L-Venlafaxine Hydrochloride (V120000), a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.<br>References Klamerus, K. J., et al.: J. Clin. PHarmacol., 32, 716 (1992); Gelenberg, A.J., et al.: J. Am. Med. Assoc., 283, 3082 (2000)<br></p>

<p>Duloxetine succinamide is a chromatographic, solid, acidic compound. It has been synthesized by reacting (S)-duloxetine hydrochloride with succinic anhydride in the presence of triethylamine and acetonitrile. The reaction mixture was purified by high-performance liquid chromatography to produce the desired product. The purity of the compound was confirmed by postulating that it should have a reversed-phase HPLC profile similar to that of duloxetine succinate. Duloxetine succinamide is not soluble in water and is insoluble in organic solvents such as acetone, chloroform, ether, or benzene. The compound is stable at room temperature but decomposes when heated at higher temperatures.<br>!--</p>

<p>N,N-Dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl) propanamine tartrate (DMNPA) is a synthetic compound with the molecular formula C14H17NO. DMNPA is used as an analytical reference standard for the quantification of N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2thienyl) propanamine HCl by HPLC. DMNPA has been shown to be a metabolite of the drug product, where it is formed from oxidation of the parent drug.</p>

<p>N-Methyl-3-(1-naphthalenyloxy)-3-(3-thienyl) propanamine tartrate is an impurity standard used for the quantitative analysis of norephedrine in pharmaceutical products. It is also a metabolite of methamphetamine, which has been shown to have anti-inflammatory activities.</p>

<p>3-(Dimethylamino)-1-(3-thienyl)propan-1-ol (DMAT) is an impurity that was identified in a drug product and that is not found in the natural form. DMAT is an intermediate of the synthesis of DMH, which is used as a research and development tool. DMAT has been shown to be metabolized by cytochrome P450 enzymes and other oxidative reactions, such as oxidation by cytochrome P450 enzymes or conjugation with glucuronic acid. DMAT also binds to markers expressed at high levels in Mycobacterium tuberculosis strains (e.g., ESX-1 secretion system protein) and inhibits cell growth in culture.</p>

<p>Ethyl 3-(dimethylamino)-2-(4-methoxyphenyl)propanoate is an impurity standard for drug product. It is a high purity, API impurity, HPLC standard and niche chemical that is found in the CAS No. 323176-93-8. This compound is used in drug development and analytical research. It is a synthetic compound that can be custom synthesized, natural or found in research and development.</p>

<p>2-(N-Methyl-propanamine)-3-(2-naphthyl) thiophene is a synthetic compound that has been used as an impurity standard for the drug product and API. It has also been used for the pharmacopoeia, research and development, and analytical purposes. This compound is a metabolite of erythromycin.</p>

<p>N-Methyl-3-(4-naphthol)-3-(2-thienyl) propanamine hydrochloride is a custom synthesis that has been shown to be a metabolite of naphthalene. It has been used as an impurity standard for N-methyl-3-(4-naphthol)-2-[(5-nitrofuran-2-yl)methyl] propanamine and in metabolism studies.</p>

<p>4-Methoxy-N,N-dimethylphenethylamine is a natural product that has been shown to inhibit the transfer of bacteria from the environment to food. It also has regulatory properties and can be used as a supplement in dietary drinks. 4-Methoxy-N,N-dimethylphenethylamine is an alkaloidal extract and has been shown to have antibacterial activity against Escherichia coli, Salmonella enterica, and Listeria monocytogenes. This compound was also found to have diffraction properties, which are related to its ability to bind DNA in bacterial cells.</p>

<p>Applications A labelled metabolite of Milnacipran.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bonnaud, B., et al.: J. Med. Chem., 30, 318 (1987), Kazuta, Y., et al.: Bioorg. Med. Chem., 10, 3829 (2002), Iversen, L., et al.: Br. J. Pharmacol., 147, S82 (2006),<br></p>