Aminoacids and derivatives

<p>Stability Hygroscopic<br>Applications Spermidine is a biogenic polyamine formed from putrescine. Spermidine is a precursor of Spermine. Spermidine is essential for both normal and neoplastic tissue growth.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abraham, A.K., et al.: Eur. J. Biochem., 106, 257 (1980), Mach, M., et al.: Biochem. J., 202, 153 (1982), Thyss, A., et al.: Eur. J. Cancer Clin. Oncol., 18, 611 (1982),<br></p>

<p>Stability Decomposes under acidic condition, Hygroscopic<br>Applications 1,1’-Ethylidenebis[L-tryptophan] is a L-tryptophan (T947210) contaminant found in the peripheral blood mononuclear cells from patients with functional somatic syndromes.<br>References Barth, H., et al.: Clin. Experiment. Inmmunol., 126, 187 (2001); Simat, T.J., et al.: Adv. Experi. Med. Biol., 467, 469 (1999);<br></p>

<p>Applications Potent crosslinking inhibitors.<br>References Sloan, J., et al.: J. Biol. Chem., 274, 23740 (1999).<br></p>

<p>Applications 2,5-Piperazinedione, can be used as an intermediate in the preparation of various pharmaceutical and biologically active compounds. It can be used in the synthesis of dipeptide isosteres by cross-metathesis.<br>References Enholm, J.E. et al.: Tetrahedron, 68, 6920 (2012);<br></p>

<p>Stability Very Hygroscopic, Moisture Sensitive<br>Applications 3,4-Dihydroxyphenylglycolaldehyde (Dopegal) is the monoamine oxidase metabolite of dopamine which is toxic of in a concentrated amount and may be a target for Alzheimer or Parkinson’s therapy.<br>References Burke, W. et al.: Neurotoxical., 25, 101 (2004);<br></p>

<p>Applications CEL and CML are two stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions.<br>References Fu, M.X., et al.: J. Biol. Chem., 271, 9982 (1996), Ahmed M.U., et al.: Biochem.J., 324, 565 (1997), Schleicher, E.D., et al.: J. Clin. Invest., 99, 457 (1997), Shibayama, R., et al.: Diabetes, 48, 1842 (1999),<br></p>

<p>Applications Baclofen-d4, is the labeled analogue of Baclofen (B108000), a specific GABA-B receptor agonist. Muscle relaxant (skeletal).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ahuja, S., et al.: Anal. Profiles Drug Subs., 14, 527 (1985), Brogden, R.N., et al.: Drugs, 8,1 (1974)<br></p>

<p>Applications An important metabolite of Benzene.<br></p>

<p>Applications Lacosamide impurity I: (R)-N-benzyl-2-(3-benzylureido)-3-methoxypropanamide is an impurity of lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br>References Lees, G., et al.: Brain Res., 612, 190 (1993), Kuo, C., et al.: Mol. Pharmacol., 51, 1077 (1997), Barton, M., et al.: Epilepsy Res., 47, 217 (2001), Beyreuther, B., et al.: Eur. J. Pharmacol., 539, 64 (2006), Beyreuther, B., et al.: CNS Drug Rev., 13, 21 (2007),<br></p>

<p>Applications Epi-Lacosamide is an impurity of Lacosamide (L098500), a medication used for the adjunctive treatment of partial-onset seizures and diabetic neuropathic pain. Lacosamide is a potent anticonvulsant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Choi, D., et al.: J. Med. Chem., 39, 1907 (1996), Morieux, P., et al.: Bioorg. Med. Chem., 16, 8968 (2008),<br></p>

<p>Applications 5-Aminolevulinic Acid Hydrochloride (cas# CAS:5451-09-2) is a useful research chemical.<br></p>

<p>Applications N-Methyl-N-nitroso-1-hexadecanamine is a compound found in a wide range of cosmetic products and cleaning emulsions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kamp, E.. et al.: Food. Chem. Toxicol., 29, 203 (1991); Lalljie, S. P. D., et al.: Adv. Mass. Spec., 14, 33790 (1998); Abidi, S.L., et al.: J. Chroma., 324, 209 (1985);<br></p>

<p>Applications 2-Hydroxy L-Tryptophan is a metabolic intermediate in the biosynthesis of the neurotransmitters serotonin and melatonin from Tryptophan.<br>References Southan, M.D., et al.: Med. Chem. Res., 6, 343 (1996);<br></p>

<p>Applications Labelled Tranexamic Acid (T714505). Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic.<br>References Andersson, et al.: Scand. J. Haematol. 2, 230 (1965), Melander, B., et al.: Acta Pharmacol. Toxicol., 22, 340 (1965), Bonnar, J., et al.: Br. Med. J., 313, 579 (1996), Dunn, C.J., et al.: Drugs, 57, 1005 (1999),<br></p>

<p>Applications D-Cysteine is a strong inhibitor of Escherichia coli growth and also functions to provide inorganic sulfates for the sulfation of xenobiotics. D-Cysteine is a non-physiological isomer of L-Cysteine (C995000), and is not involved in protein or glutathione synthesis.<br>References Glazenburg, E., et al.: Biochem. Pharm., 33, 625 (1984); Klassen, C. &amp; Boles, J.: FASEB J., 11, 404 (1997); Soutourina, J., et al.: J. Biol. Chem., 276, 40864 (2001);<br></p>

<p>Applications 6-(6-(6-Aminohexanamido)hexanamido)hexanoic Acid is used in the making of a preconjugate which serves as immunoreactive conjugate useful as a developer antigen in a competitive inhibition immunoassay for the polymorphic analyte. Also used in the efficient synthesis of a heterobifunctional coupling agent.<br>References Oh, C. S., et al.: PCT Int. Appl. (1994), WO 9416330 A1 19940721; Reddy, R. E., et al.: Bioconjug. Chem., 16, 1323 (2005)<br></p>

<p>Applications Benzylamine has been used as a reactant in the preparation of diacetylated benzylamide which has shown to induce a G1/G0 arrest in tumor cells and cytotoxicity against human ovarian cancer cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Siewert, B., et. al.: Bioorg. Med. Chem., 22, 594 (2014)<br></p>