Natural and semi-synthetic antibiotics

<p>Cefixime Impurity A is a drug product that is used for analytical purposes. It is an impurity of cefixime.</p>

<p>Please enquire for more information about 2′,4′′-Bis-O-(trimethylsilyl)-erythromycin 9-[O-(1-ethoxy-1-methylethyl)oxime] including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Decarboxy ciprofloxacin is a prodrug that is active against bacteria and other microorganisms. It has been shown to have an affinity for the fluoroquinolone binding site on the bacterial ribosome, inhibiting protein synthesis and cell division. Decarboxy ciprofloxacin has been used in animals to treat infections caused by Escherichia coli, Klebsiella pneumoniae, Salmonella enterica, Proteus mirabilis, and Pseudomonas aeruginosa. Decarboxy ciprofloxacin is administered orally in the form of tablets or capsules. The drug binds to metal ions and can be detected with a biosensor that uses an aptamer-coated electrode. This sensor can be used for the detection of both metal ions and fluoroquinolones. <br>Decarboxy ciprofloxacin is also used as a research tool to</p>

<p>N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-1-naphthalenemethanamine (DHEA) is a human metabolite and an endogenous hormone. DHEA has been shown to have antifungal activity against Candida albicans in vitro. It also possesses an inhibitory effect on the growth of some fungi that are resistant to azole drugs, such as Coccidioides immitis, Cryptococcus neoformans and Blastomyces dermatitidis. DHEA has been used in the treatment of pediatric patients with chronic granulomatous disease and is currently being evaluated for use in other pediatric conditions.</p>

<p>Please enquire for more information about Clarithromycin-N-methyl-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Clarithromycin impurity O is a crystalline form of clarithromycin that is obtained by the sulfation of the free base. It is prepared by adding an acid binding agent to the free base and then dissolving it in water. The sulfate salt of clarithromycin impurity O can be purified by recrystallization. Clarithromycin impurity O has been used as a raw material for clarithromycin, which is a β-lactam antibiotic with activity against Gram-positive bacteria and some Gram-negative bacteria. Clarithromycin impurity O is also used in other pharmaceuticals such as anti-inflammatory drugs and antibiotics. The preparation process starts with the methylation reaction of potassium hydroxide, followed by hydrolysis to produce methyl sulfate and dimethyl sulfate. The methylated product is purified through distillation, vacuum drying, or crystallization, yielding a pure form of methylated product that can be further processed into other</p>

<p>Enrofloxacin impurity E is a product of the synthesis of enrofloxacin, with high purity and analytical standards. It is synthesized from natural products, and it can be used as an impurity standard for HPLC analysis. Enrofloxacin impurity E also has pharmacopoeia and CAS number 1369495-59-9. This substance is used in drug development and research to study metabolism.</p>

<p>Please enquire for more information about 5-Deoxy-Δ5,6-8-epi-tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Lincomycin B is a chemical compound that belongs to the group of antimicrobial agents. It is used in the treatment of viral infections and has been shown to have an effect against HIV-1, herpes simplex virus, and influenza A virus. Lincomycin B inhibits protein synthesis by binding to the ribosomes in bacteria and inhibiting peptide elongation. The optimum concentration for this compound is 0.2 mM with a minimum inhibitory concentration of 1 mM. Lincomycin B can be synthesized by reacting sodium hydroxide solution with hydrochloric acid or hydroxide solution at a temperature range from 30 °C to 70 °C.</p>

<p>Please enquire for more information about Piperacillin impurity N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Erythromycin impurity K is a synthetic impurity of erythromycin, which is an antibiotic drug product. It is typically found in pharmaceutical products that are made from natural sources and is used as a research and development (R&amp;D) standard for the pharmacopoeia. Erythromycin impurity K can be purified by HPLC or other means to create high purity standards for analytical purposes. The chemical name of this compound is 3-[[[3-(2-Amino-4-thiazolyl)-1,2,4-triazol-5-yl]amino]methyl]-1H-indole.</p>

<p>Impurity G is an impurity found in the drug Iohexol. It is a synthetic, amide, propylamine, diacetate and methyl anthranilate. Impurity G has been shown to be a catalyst for the production of iodinated contrast media with high yield. This can be used to make the drug Moxifloxacin hydrochloride, which is used to treat bacterial infections such as pneumonia and bronchitis caused by Legionella pneumophila or Mycoplasma pneumoniae. The chemical compound moxifloxacin has anti-inflammatory properties that are due to its ability to inhibit prostaglandin synthesis.</p>

<p>Azithromycin impurity J, also known as Azithromycin P-Toluenesulfonate, is an impurity of the drug azithromycin. It is an antibiotic that has been shown to be effective in the treatment of protozoal infections, cancer and parasites. Azithromycin impurity J has been shown to bind to DNA gyrase and topoisomerase IV enzymes, which are necessary for bacterial replication. Azithromycin impurity J is a protozoan inhibitor that acts by blocking the synthesis of RNA and DNA. This impurity binds to DNA gyrase and topoisomerase IV enzymes, which are necessary for bacterial replication. Azithromycin impurity J is a protozoan inhibitor that acts by blocking the synthesis of RNA and DNA.</p>

<p>4-Hydroxy azithromycin is an impurity of Azithromycin that is a metabolite of the drug. 4-Hydroxy azithromycin is a synthetic product, which has been synthesized for use as an analytical standard for HPLC and LC-MS/MS. It has also been used as a pharmacopoeia standard for testing antibiotic purity and quality. Metabolism studies have shown that 4-hydroxy azithromycin is not absorbed from the gastrointestinal tract, but is found in the urine and feces.</p>

<p>Clarithromycin (9E)-O-Methyloxime is an analytical standard for Clarithromycin. It is a metabolite of Clarithromycin and has been shown to be a potent inhibitor of cytochrome P450 3A4 in human liver microsomes. Clarithromycin (9E)-O-Methyloxime is also an impurity in the drug product, which is used to treat bacterial infections.</p>

<p>The compound (5E)-2,2-dimethyl-7-[(1-naphthalenylmethyl)amino]-5-hepten-3-ynoic acid is a chiral antifungal agent. It was developed to be used as an analytical tool for the determination of plasma concentrations and it can be used in profiling and chiral chromatography. This compound has been shown to have excellent solubility in water and good stability in most organic solvents. The compound is metabolized by the liver and excreted via the kidneys, with a half life of approximately 6 hours. The compound also shows linearity over a wide concentration range, which makes it useful for measuring quantitative changes in plasma concentrations.</p>

<p>Micafungin Metabolite M1 is a metabolite of Micafungin. It is an impurity in the drug product and is not active. Micafungin Metabolite M1 has been proposed as a pharmacopoeia reference standard for HPLC quantification of Micafungin.</p>

<p>Please enquire for more information about N-Demethyl-N-(ethylsuccinyl) erythromycin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Ceftazidime impurity H is a by-product that can be found in the synthesis of ceftazidime. It has been detected using magnetic separation and UV detection. Ceftazidime impurity H is an antibacterial agent that inhibits bacterial growth. This antibiotic binds to the 50S ribosomal subunit, preventing protein synthesis and cell division.</p>

<p>Decladinose roxithromycin is a novel drug that can be used for the diagnosis and treatment of disorders related to the mutation. Decladinose roxithromycin has been shown to be effective in the detection and treatment of mutants, such as those related to cystic fibrosis.</p>

<p>Clindamycin phosphate EP impurity G is a metabolite of clindamycin that can be found in the urine of patients taking clindamycin. It is a white to off-white crystalline solid with a melting point of about 205°C. Clindamycin phosphate EP impurity G has been used as an analytical reference standard for clindamycin, and it is also used as a synthetic intermediate in the drug development process. The CAS number for this compound is 719-72-4.</p>

<p>(trans)-4-Propyl-1-methyl-L-proline is a synthetic compound that has been used in the past as an impurity standard in the synthesis of several drugs, including metaxalone and aminopyrine. It is also found to have pharmacological effects on its own and was used as a drug product for the treatment of rheumatoid arthritis. (trans)-4-Propyl-1-methyl-L-proline is not listed in any pharmacopoeia or international list of approved drugs.</p>

<p>Please enquire for more information about 3-HABA kanamycin A sulfate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Linezolid N-oxide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Cefixime EP impurity B acetic acid is a research and development product. It is an impurity of cefixime EP that has been synthesized for use as an impurity standard. This compound is a metabolite of the drug cefixime EP. Cefixime EP impurity B acetic acid can be used to determine drug metabolism by studying the formation, detection and identification of metabolites in biological samples. It also can be used to develop analytical methods for the determination of metabolites in biological samples.<br>Cefixime EP impurity B acetic acid is a synthetic compound that is highly pure with a pharmacopoeia grade purity level. This product is suitable for use in drug product, custom synthesis, and HPLC standard applications.</p>

<p>Pseudomonic acid D sodium is a drug product that is used for the development of novel drugs. It is a natural metabolite of pseudomonic acid A, which is found in the fungus Pseudomonas sp. Pseudomonic acid D sodium is used as an analytical standard to aid in the identification of pseudomonic acid A and its metabolites. Pseudomonic acid D sodium can be synthesized by reacting 2-chloro-4-nitrobenzene with sodium bisulfate. The synthesis proceeds through a sequence of three reactions, namely nucleophilic substitution, electrophilic substitution, and hydrolysis. The structure of pseudomonic acid D sodium has been confirmed using nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS).</p>

<p>Please enquire for more information about L-Piperacillin including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about Cefazolinamide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>N-Desmethyl azithromycin B is a metabolite of the macrolide antibiotic azithromycin. It is an impurity in the drug product, and is present as an analytical standard for HPLC. N-Desmethyl azithromycin B can be found in the urine of patients taking azithromycin, but at much lower concentrations than the parent drug. This impurity is not toxicologically relevant, but may interfere with some analytical methods.</p>

<p>Erythromycin EP impurity L is a metabolite of erythromycin that is found in the urine of patients taking erythromycin. It is a white to light yellow crystalline powder. Erythromycin EP impurity L has been used as an analytical standard for HPLC and GC-MS, and as a pharmacopoeia reference material. Erythromycin EP impurity L is also known to have anti-inflammatory properties.</p>

<p>(5E)-2,2-Dimethyl-7-[methyl(1-naphthalenylmethyl)amino]-5-hepten-3-ynoic acid is a drug product that has been custom synthesized. It is available in high purity (&gt;98%) and with analytical data. This chemical is metabolized through a number of metabolic transformations, including hydrolysis by esterases or glucuronidases, oxidation by cytochrome P450 enzymes, reduction by glutathione reductase, or conjugation with glucuronic acid. (5E)-2,2-Dimethyl-7-[methyl(1-naphthalenylmethyl)amino]-5-hepten-3-ynoic acid has been shown to have pharmacological activity on the central nervous system and may be used as an antidepressant drug candidate.</p>

<p>protein phosphatase (PP)1 inhibitor</p>

<p>Caspofungin is a cyclic lipopeptide echinocandin and beta-(1,3)-D-glucan synthase inhibitor that is used to treat internal or systemic mycoses.</p>

<p>Dapaconazole is used as a drug candidate for antifungals.</p>

<p>Flomoxef sodium, an antibiotic belonging to the oxacephem group, exhibits excellent activity against a broad spectrum of Gram-positive bacteria.</p>

<p>Cefonicid: second-gen cephalosporin, IV/IM, treats UTIs, respiratory, bone, and soft tissue infections by blocking cell wall formation.</p>

<p>Besifloxacin is the fourth generation of fluoroquinolones, which can be used to treat bacterial conjunctivitis</p>

<p>Cefonicid monosodium, a second-gen cephalosporin, treats UTIs, respiratory, soft tissue, and bone infections by blocking cell wall synthesis.</p>

<p>Ceftibuten is a third-generation cephalosporin antibiotic.</p>

<p>Fosravuconazole is a ravuconazole prodrug. It has antifungal activity.</p>

<p>Penflufen, a broad-spectrum succinate dehydrogenase inhibitor (SDHI), serves effectively as a fungicide.</p>

<p>Cefmenoxime: IV/IM cephalosporin antibiotic, resists beta-lactamase, targets Enterobacteriaceae, gram-positive/negative bacteria.</p>

<p>(S)-Tedizolid is the S-enantiomer of Tedizolid. Tedizolid is a novel oxazolidinone with activity against Gram-positive pathogens.</p>

<p>Clindamycin-B2-phosphate is a drug product with CAS No. 54887-31-9 that is used as an analytical reference standard. It is metabolized in animals and humans to form clindamycin, which has been shown to bind to ribosomes and inhibit protein synthesis. Clindamycin-B2-phosphate also binds to DNA gyrase and topoisomerase IV, inhibiting their activity. This drug product has been shown to be effective against methicillin resistant Staphylococcus aureus (MRSA) and Clostridium perfringens, although it is not active against acid-fast bacteria such as Mycobacterium tuberculosis or Mycobacterium avium complex.</p>

<p>Cefdinir impurity F is an impurity of cefdinir that has been identified in some batches. It is a triethylamine derivative and has been found to be ultralow. Cefdinir impurity F has been studied for its use in laboratories.</p>

<p>Clarithromycin EP impurity B is a natural impurity in clarithromycin. Clarithromycin EP impurity B is synthesized by the metabolism of clarithromycin, and its chromatographic retention time is 13.5 minutes. It has been shown to have anti-inflammatory and immuno-suppressive effects, which may be due to its inhibition of prostaglandin synthesis. Clarithromycin EP impurity B has been shown to inhibit the growth of bacteria that are resistant to penicillin, ampicillin, and erythromycin.</p>

<p>Pseudomonic acid D sodium is a chemical compound that is found in coal tar. It has antimicrobial properties and can be used to inhibit the growth of bacteria and fungi. Pseudomonic acid D sodium has been shown to inhibit the growth of gram-positive bacterial strains, including Bacillus cereus, Clostridium perfringens, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus faecalis. It also inhibits the growth of yeast such as Candida albicans. Pseudomonic acid D sodium is soluble in water at low concentrations and insoluble in water at high concentrations. This chemical exhibits acidic properties with an acidic pH range from 2-4. Pseudomonic acid D sodium does not dissolve calcium carbonate or hydroxide solution due to its weakly acidic nature.</p>

<p>Piperacilloic acid is a synthetic compound that exhibits antibacterial activity. It has been shown to be effective against human pathogens, including urothelial carcinoma and human serum. Piperacilloic acid binds to the amino acids lysine and arginine in bacterial proteins and inhibits protein synthesis by inhibiting the function of enzymes that require these amino acids for their activity. The potency of piperacillin is low, but it is activated by hydrolysis in the acidic environment of the stomach or intestinal tract. Piperacilloic acid also has potential as a contraceptive agent because it may inhibit transcriptional regulation of genes that are involved in sperm production.</p>

<p>N-Succinyl-L-tyrosine is a synthetic compound that is used as an impurity standard for the determination of the purity and quality of drug products. It is also used in research and development to study metabolism. N-Succinyl-L-tyrosine is a metabolite of tyrosine, which has been shown to be an important intermediate in the biosynthesis of some neurotransmitters and hormones. This product can be used in HPLC assays to provide a standard curve for quantification.</p>

<p>Please enquire for more information about Oxacyclohexane open ring tacrolimus including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Clarithromycin EP Impurity A is an analytical standard for clarithromycin. Clarithromycin EP Impurity A is a white to off-white powder that is soluble in methanol, acetone, and chloroform. It has a molecular weight of 459.23 Da and the chemical formula C18H26N2O5S. Clarithromycin EP Impurity A is an impurity found in clarithromycin that has been isolated from the product by high-performance liquid chromatography (HPLC) and confirmed by nuclear magnetic resonance spectroscopy (NMR). Clarithromycin EP Impurity A can be used as a reference standard for pharmacopoeia testing or as a research and development sample for drug development. It can also be synthesized from natural or synthetic sources.</p>

<p>Durlobactam is a drug candidate for beta-lactamase inhibitor.</p>

<p>Cefteram (T-2525), an orally active ester of the cephalosporin class, is the free acid form of Cefteram pivoxil.</p>

<p>Valnemulin, a broad-spectrum pleuromutilin antibiotic, targets peptidyl transferase within the 50S ribosomal subunit, effectively used in veterinary medicine to address swine diseases such as B. hyodysenteriae and M. hyopneumoniae.</p>

<p>Pradofloxacin is a fluoroquinolone antibioticthat exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV.</p>

<p>Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.</p>

<p>Fluoroquinolones are a class of antibiotics that are used to treat bacterial infections. Desfluoro ciprofloxacin hydrochloride is a fluorinated derivative of ciprofloxacin and is an ultra-fast synthetic compound. It has been shown to be more potent than the parent molecule. This drug is considered to be impure because it contains other chemical compounds, such as isomers and back-pressure products. The particle size distribution of desfluoro ciprofloxacin hydrochloride is usually very broad with diameters ranging from 5 nm to 1 micron. It can be separated by particle size in a phase liquid chromatography column because the particles have different hydrodynamic diameters. Desfluoro ciprofloxacin hydrochloride can also be separated by phase chromatography on an oligosaccharide column, which produces more efficient separation than traditional high-performance liquid chromatography (HPLC).</p>

<p>Tacrolimus is a macrolide immunosuppressant that is used to prevent organ rejection in transplant patients. It binds to the cytosolic protein, FKBP-12, which prevents calcineurin from dephosphorylating and activating nuclear factor of activated T cells (NFAT). Tacrolimus inhibits the production of IL-2 and other cytokines by T cells, suppressing proliferation. Tacrolimus has been shown to be bioequivalent when administered orally or intravenously. Bioavailability may be increased when taken with food.</p>

<p>Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect against</p>

Lactones, nesoi

Aromatic or modified aromatic heterocyclic compounds withnitrogen hetero-atom(s) only nesoi

Compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure

Other acyclic polyamines and their derivatives; salts thereof

Aminoglycoside antibiotics

Heterocyclic compounds with oxygen hetero-atom(s) only nesoi