Carbohydrates and glycoconjugates

<p>Methylation is the addition of a methyl group to a molecule. The mannobiose-BSA is a methylated derivative of mannobiose, which has been modified by adding BSA. The modification of mannobiose-BSA with BSA facilitates its use in glycosylation reactions and as an intermediate in the synthesis of other complex carbohydrates. Methylation is also used to modify saccharides, polysaccharides, and oligosaccharides. Methyl groups are typically added using an organic chemical called dimethylamine or using an enzymatic reaction with SAM-dependent methyltransferases.</p>

<p>Sialyl-Lex-hexa-APD-HSA is a high purity synthetic glycosylation that is custom synthesized. It has been modified with fluorination, methylation, and click modification. Sialyl-Lex-hexa-APD-HSA can be used in the synthesis of complex carbohydrates and is available in CAS Number: 75869-57-3.</p>

<p>Lacto-N-difucohexaose I-APD-HSA is a custom synthesis of an oligosaccharide with a molecular weight of 5,000 Da. It is modified with fluorine and methyl groups at the C6 and C1 positions. Lacto-N-difucohexaose I-APD-HSA is synthesized by click chemistry and has been shown to be effective in inhibiting the growth of cancer cells. This sugar can be modified by glycosylation or carbohydrate modification.</p>

<p>6-O-Benzoyl-1,2,3-tri-O-benzyl-4-O-(2,3,4,6-tetra-O-benzyl-a -D-galactopyranosyl)-b -D -galactopyranoside is an oligosaccharide that has been custom synthesized by our company. It is a complex carbohydrate with a molecular weight of 1,216. The CAS number for this product is 105838-36-5. This product also has a high degree of purity and can be used in Click modification and Modification reactions. 6 O Benzoyl 1 2 3 tri O benzyl 4 O</p>

<p>Benzyl 2-acetamido-4-O-(2,3,4,6-tetra-O-acetyl-b-D-galactopyranosyl)-2-deoxy-b-D-galactopyranoside is a synthetic glycoside that has been modified with fluorination. It is an oligosaccharide sugar that has been synthesized from the monosaccharide galactose and the disaccharide maltose. The chemical formula for this compound is C14H22FNO6. This product can be used in custom synthesis or as a research reagent.</p>

<p>Methyl 3-O-(b-D-galactopyranosyl)-b-D-galactopyranoside is a disaccharide that is the residue of 6-fluoro-3-indoxyl beta-D-galactopyranoside. This product is a glycoside of methyl 3,6,3',6'-tetraacetate and b-D-galactose.</p>

<p>Varenicline N-oxide is a synthetic drug product. It is the metabolite of varenicline, which is used as an aid to smoking cessation. Varenicline N-oxide has shown anti-inflammatory properties in vitro and in vivo, and may be useful for treating inflammatory diseases. Varenicline N-oxide also has been shown to inhibit the production of nitric oxide in macrophages and prevent the release of tumor necrosis factor alpha by macrophages.</p>

<p>Lewis A tetrasaccharide-BSA is a synthetic oligosaccharide complex carbohydrate. It is a high purity custom synthesis that has been modified with click chemistry, methylation, and fluorination. Lewis A tetrasaccharide-BSA is a glycosylated polysaccharide that has been shown to have antiviral activity against human cytomegalovirus. This product can be used in research as a model for studying the structure of glycoproteins, including their interactions with other molecules in biological systems.</p>

<p>4-Methoxyphenyl 4-O-[3-O-(methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-a-D-galacto--2--nonulopyranosylonate)-2,6--di -O--benzyl b D galactopyranosyl]-2,3,6--tri -O benzyl b D glucopyranoside is a glycosylation product of the monosaccharide 4 methoxyphenol and 4 O-[3 O methyl 5 acetamido 4 7 8 9 tetra O acetyl 3 5 dideoxy D glycero 2 a D galacto 2 nonulopyranosylonate] 2 6 di O benzyl b D galactopyranoside. It has been modified by fluorination at the C1</p>

<p>Man-9-Glc N-Glycan is a synthetic carbohydrate that is a modification of the natural sugar, Man-9-GlcNAc. It can be used as an ingredient in pharmaceutical products, such as vaccines and other therapeutic agents. This product is a custom synthesis that can be produced to order.</p>

<p>Lipid A is a complex carbohydrate that is found in the outer membrane of Gram-negative bacteria. The lipid A molecule consists of a long chain of fatty acids linked to a phosphate group, with sugar and phosphate groups attached. Lipid A is important for the virulence of many Gram-negative bacteria, including Salmonella. Fluorination, monosaccharide, oligosaccharide and polysaccharide modifications are used to modify lipid A to increase its immunogenicity as an adjuvant or vaccine component. Click modification and methylation are also used to alter lipid A structure. This product has been custom synthesized in our lab using high purity ingredients.</p>

<p>6-O-(2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl)-1,2,3,4-tetra-O-benzyl-a-D-mannopyranoside is an oligosaccharide with a complex carbohydrate structure. This chemical is a custom synthesis and it has high purity. 6-O-(2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl)-1,2,3,4-- tetra--O--benzyl--A--mannopyranoside is used as an intermediate for the production of other compounds. The CAS number for this compound is</p>

<p>6'-Sulpho Lewisa-BSA is a carbohydrate that has been modified with sulphur and fluorine. It is used as a fluorescence probe for the detection of carbohydrates in solutions, such as glycoproteins, glycopeptides, and glycolipids. 6'-Sulpho Lewisa-BSA is a complex carbohydrate that can be synthesized from the reaction of d-glucose and D-alanine. It can also be custom synthesized to suit the needs of the customer. This product is high purity and can be methylated or glycosylated. 6'-Sulpho Lewisa-BSA also has been modified by click chemistry to incorporate fluorescent groups at specific sites on the sugar chain.</p>

<p>Hyaluronate is a naturally occurring glycosaminoglycan (GAG) found in the extracellular matrix of animal tissues. It is a linear polymer composed of alternating units of N-acetylglucosamine and glucuronic acid. The molecular weight of hyaluronate ranges from 10,000 Da to 1,000,000 Da. Hyaluronate has been modified by fluorination, methylation, and click modification reactions. These modifications affect the physical properties of hyaluronate, including its reactivity with other molecules. Click modification reactions are often used to link two different molecules together. This may include linking an oligosaccharide or saccharide to the hydroxyl groups on the glucuronic acid residues in hyaluronate.</p>

<p>N,S-Carboxymethyl cysteine hydrochloride (NCC) is a drug product that is synthesized from cysteine. It has been used in analytical chemistry, metabolism studies, and drug development. NCC has been shown to be a natural metabolite of cysteine when administered orally to rats or mice. It is also an impurity standard for HPLC analysis and has been used as an API impurity in the synthesis of other drugs.<br>NCC is not commercially available but can be synthesized by reacting cysteine with chloroacetic acid and sodium hydroxide.</p>

<p>Maltohexaose is a polysaccharide formed by 6 units of glucose and can be metabolised inside the cell to a substrate-based inhibitor of fucosyltransferases. It can also be converted to GDP-2-deoxy-2-fluoro-L-fucose, a competitive inhibitor of α-1,3-fucosyltransferase. Matohexaose is used as acceptor for measuring the activity of 4-Alpha-Glucanotransferase.</p>

<p>A antigen tetrasaccharide Type I I, possible use in antiviral development</p>

<p>A mixture of sodium trigalacturonate &amp; tetragalacturonate (α-1,4 sodium galacturonotriose + α-1,4 sodium galacturonotetraose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is a custom synthesis of an oligosaccharide. It is a complex carbohydrate that is composed of saccharides and has a CAS number. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside is modified with methylation, glycosylation and click modification. This product is also fluorinated. 8-Ethoxycarbonylheptyl N,N'-di-O-acetyl-b-chitobioside has high purity and can be used as a sugar in the synthesis of other compounds.</p>

<p>α-1,4-glucododecasaccharide derived from starch by hydrolysis and chromatography</p>