Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65562 products of "Quinazoline and Quinoline Derivatives"
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Amantadine
CAS:Controlled Product<p>Applications Amantadine is useful in biology studies. Particularly it has been used for solid-state NMR and membrane protein studies.<br>References Shigeta, A., et al.: New Developments in NMR, 20, 457 (2019)<br></p>Formula:C10H17NColor and Shape:White To Off-WhiteMolecular weight:151.25Afatinib Dimaleate
CAS:Controlled Product<p>Applications Afatinib Dimaleate is a salt of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References D, Li. et al.: Oncogene., 27, 4702 (2008); Wang, X. et al.: Cancer Res., 74, 4431 (2014);<br></p>Formula:C24H25ClFN5O3·2C4H4O4Color and Shape:NeatMolecular weight:718.088-Bromo-3-methyl-7-(2-butynyl)-xanthine
CAS:Controlled ProductFormula:C10H9BrN4O2Color and Shape:NeatMolecular weight:297.108PTC-124
CAS:Controlled Product<p>Applications PTC-124 is a nonaminoglycoside that has been reported to induce ribosomes to read through premature nonsense stop signals on mRNA, allowing the production of full-length functional proteins,<br>References Yu, H. et al.: Int. J. Mol. Med., 33, 729 (2014); Aditya, S. et al.: J. Biomed. Pharm. Res., 2, 21 (2013);<br></p>Formula:C15H9FN2O3Color and Shape:White To Off-WhiteMolecular weight:284.24(E)-6-Iodo-3-[2-(pyridin-2-yl)ethenyl]-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
CAS:Controlled ProductFormula:C19H18IN3OColor and Shape:White To Light YellowMolecular weight:431.27Telmisartan
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Telmisartan is an angiotensin II receptor antagonist.<br>References Wienen, W., et al.: Brit. J. Pharmacol., 110, 245 (1993), Neutel, J.M., and Smith, D.H.G.: Adv. Ther., 15, 206 (1998)<br></p>Formula:C33H30N4O2Color and Shape:NeatMolecular weight:514.62cis-(Z)-Flupentixol Dihydrochloride
CAS:Controlled Product<p>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>Formula:C23H27Cl2F3N2OSColor and Shape:NeatMolecular weight:507.44Pericyazine
CAS:Controlled Product<p>Applications Psychotherapeutic phenothiazine. Antipsychotic.<br>References Schafer, et al.: Toxicol. Appl. Pharmacol., 21, 315 (1972), Kaye, J., et al.: Br. J. Clin. Pharmacol., 56, 569 (2003), Tschoner, A., et al.: Pharmacopsychiatry, 42, 29 (2009),<br></p>Formula:C21H23N3OSColor and Shape:Light Yellow To YellowMolecular weight:365.49Ondansetron
CAS:Controlled Product<p>Applications Ondansetron is a specific serotonin (5-HT3) receptor antagonist. Antiemetic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kris, M.G., et al.: J. Clin. Oncol., 6, 659 (1988); Faris, P..L., et al.: Lances, 355, 792 (2000)<br></p>Formula:C18H19N3OColor and Shape:White To Light BeigeMolecular weight:293.36rac-Praziquanamine
CAS:Controlled Product<p>Applications Praziquanamine, as the main intermediate for synthesizing antiparasitic agent Praziquantel (P702095).<br>References Dong, Y., et al.: Bioorg. Med. Chem. Lett., 20(8), 2481 (2010)<br></p>Formula:C12H14N2OColor and Shape:NeatMolecular weight:202.2524α-Ethyl Norepinephrine Hydrochloride (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications A bronchodilator.<br>References Daly, J. W., et al.: J. Med. Chem., 9(3), 273 (1966).<br></p>Formula:C10H15NO3·ClHColor and Shape:NeatMolecular weight:233.69Tert-Butyl 2-(pyridin-4-yl)acetate
CAS:Purity:95.0%Color and Shape:LiquidMolecular weight:193.24600219726562Letermovir
CAS:<p>Applications Letermovir acts as an orally or i.v administered cytomegalovirus terminus complex inhibitor, antiviral agent, used in the treatment of CMV infection which is prevalent in those with immunocompromised systems.<br>References Kropeit, D. et al.: Brit. J. Clin Pharmacol., 83, 2678 (2017); Kim, E. et al.: Drugs. 78, 147 (2018);<br></p>Formula:C29H28F4N4O4Color and Shape:NeatMolecular weight:572.551(R)-N-Desacryloyl N-Propionyl Ibrutinib
CAS:<p>Applications (R)-N-Desacryloyl N-Propionyl Ibrutinib is an inhibitor for bruton’s tyrosine kinase.<br>References Pan, Z., et al.: ChemMedChem (2007), 2(1), 58-61<br></p>Formula:C25H26N6O2Color and Shape:NeatMolecular weight:442.51S-(2-Guanidino-4-thiazolyl)methylisothiourea Dihydrochloride
CAS:Formula:C6H10N6S2·2ClHColor and Shape:NeatMolecular weight:303.236(E)-Chlorprothixene-d6 Hydrochloride
CAS:Controlled Product<p>Applications Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rudy, B.C., et al.: Anal. Profiles Drug Subs., 2, 63 (1973), Bagli, M., et al.: Arzneim.-Forsch., 46, 247 (1996),<br></p>Formula:C18H13D6Cl2NSColor and Shape:NeatMolecular weight:358.36Loxoprofen-d3
CAS:Controlled Product<p>Applications Loxoprofen-d3, is the labeled analogue of Loxoprofen (L472905), which is non-selective nonsteroidal anti-inflammatory drug (NSAID) that has been effective in reducing atherosclerosis in mice by reducing inflammation.<br>References Masahide H. et al.: J Clin Biochem Nutr., 47, 138 (2010); Noguchi, M. et al.: Biolog. Pharmac. Bull., 28, 2075 (2005); Hyun, J. et al.: Arch. Pharm. Res., 24, 541 (2001);<br></p>Formula:C15H15D3O3Color and Shape:NeatMolecular weight:249.32(R)-Lercanidipine-d3 Hydrochloride
CAS:Controlled ProductFormula:C36H39D3ClN3O6Color and Shape:NeatMolecular weight:651.21Atrazine
CAS:<p>Applications Selective herbicide. Potential symptoms of overexposure are irritation of eyes and skin; dermatitis, skin sensitization; dyspnea, weakness, incoordination, salivation; hypothermia; liver injury.This compound is a contaminant of emerging concern (CECs)<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dalgaard-Mikkelsen, S., et al.: Pharmacol. Rev., 14, 225 (1962), Muller, K., et al.: J. Environ. Qual., 31, 309 (2002), Backhaus, T., et al.: Environ. Toxicol. Chem., 23, 258 (2004),<br></p>Formula:C8H14ClN5Color and Shape:ColourlessMolecular weight:215.682-((7-(5-(Di-p-tolylamino)thiophen-2-yl)benzo[c][1,2,5]thiadiazol-4-yl)methylene)malononitrile
CAS:Purity:97%Molecular weight:489.6199951171875Desamino Chloroimiquimod
CAS:Controlled Product<p>Impurity Imiquimod USP Related Compound C<br>Applications Desamino Chloroimiquimod (Imiquimod USP Related Compound C) is a pharmacologically active compound related to Imiquimod (I475000), an immune response modifier. It stimulates the production of Interferon-a.<br>References Megyeri, K., et al.: Mol. Cell Biol., 15, 2207, (1995), Witt, P.L., et al.: Cancer Res., 53, 5176 (1993), Edwards, L., et al.: Arch. Dermatol., 134, 25 (1998); Gerster, J. et al.: J. Med. Chem., 48, 3481 (2005);<br></p>Formula:C14H14ClN3Color and Shape:NeatMolecular weight:259.73Nisoldipine
CAS:Controlled Product<p>Applications Dihydropyridine calcium channel blocker. Antihypertensive and antianginal.<br>References Kazda, S., et al.: Arzneimittel-Forsch., 30, 2144 (1980), Pasanisi, F., et al.: Eur. J. Clin. Pharmacol., 29, 21 (1985), Lam, J., et al.: J. Am. Col. Cardiol., 6, 447 (1985)<br></p>Formula:C20H24N2O6Color and Shape:YellowMolecular weight:388.413-Mercapto-2-methylpropanoic Acid
CAS:Controlled Product<p>Impurity Captopril EP Impurity C<br>Applications 3-Mercapto-2-methylpropanoic Acid (Captopril EP Impurity C) is a useful synthetic intermediate.<br>References Lewis, S.N. et al.: J. Het. Chem., 8, 571-580 (1971)<br></p>Formula:C4H8O2SColor and Shape:NeatMolecular weight:120.176,7-Dimethoxy-2,3-dimethylquinoxaline
CAS:Purity:95.0%Color and Shape:Solid, Brown powderMolecular weight:218.25599670410156O-Desmethyl Carvedilol
CAS:Controlled Product<p>Applications A metabolite of Carvedilol (C184625), a nonselective β-adrenergic blocker with α1-blocking activity.<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., et al.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Clohs, L., et al.: J. Pharm. Biomed. Anal., 31, 407 (2003),<br></p>Formula:C23H24N2O4Color and Shape:NeatMolecular weight:392.45Rebamipide
CAS:Controlled Product<p>Applications Shows antiulcer activity in rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Uchida, M., et al.: Chem. Pharm. Bull., 33, 3775 (1985), Yamasaki, K., et al.: Eur. J. Pharmacol., 142, 23 (1987),<br></p>Formula:C19H15ClN2O4Color and Shape:Off-WhiteMolecular weight:370.795-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)-1H-benzo[d]imidazole
CAS:Controlled Product<p>Applications 5-Methoxy-2-(4-methoxy-3,5-dimethylpyridin-2-yl)-1H-benzo[d]imidazole is an impurity of Omeprazole (O635000), which binds covalently to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C16H17N3O2Color and Shape:NeatMolecular weight:283.33L-Phenylacetyl Carbinol
CAS:Controlled Product<p>Applications L-Phenylacetylcarbinol ( (L-PAC) obtained by biotransformation of benzaldehyde.<br>References Ellaiah, P., et al.: Ind. Drugs, 24, 192 (1987), Nikolova, P., et al.: Biotechnol. Bioeng., 38, 493 (1991), Shin, H., et al.: Biotechnol. Bioeng., 49, 52 (1996),<br></p>Formula:C9H10O2Color and Shape:NeatMolecular weight:150.17Gabapentin Related Compound A
CAS:Controlled Product<p>Impurity Gabapentin EP Impurity A; Gabapentin USP Related Compound A<br>Applications Gabapentin Lactam (Gabapentin EP Impurity A; Gabapentin USP Related Compound A) reduces protein aggregates and improves motor performance in a transgenic mouse model of Huntington’s disease. It opens mitochondrial ATP-dependent potassium channels.<br>References Zucker, B.,et al.: Naunyn Schmiedebergs Arch. Pharmacol., 370, 131 (2004)<br></p>Formula:C9H15NOColor and Shape:WhiteMolecular weight:153.22Intedanib
CAS:Controlled Product<p>Applications It is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases; an indolinone as triple angiokinase inhibitors. An antitumor agent.<br>References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)<br></p>Formula:C31H33N5O4Color and Shape:NeatMolecular weight:539.624-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde
CAS:<p>Impurity Bisoprolol EP Impurity L (Metoprolol EP Impurity C)<br>Stability Hygrscopic<br>Applications 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde (Bisoprolol EP Impurity L (Metoprolol EP Impurity C)) is a Metoprolol impurity .<br>References Baldwin, J.J. , et al.: J. Med. Chem., 29, 1065 (1986), Ravelet, C., et al.: J. Sep. Sci., 29, 1322 (2006),<br></p>Formula:C13H19NO3Color and Shape:NeatMolecular weight:237.293-(3,5-Dimethyl-pyrazol-1-yl)-benzoic acid
CAS:Formula:C12H12N2O2Purity:95.0%Color and Shape:SolidMolecular weight:216.24Tert-Butyl 1-oxo-4-(pyridin-3-yl)-2,8-diazaspiro[4.5]decane-8-carboxylate
CAS:Purity:98%Molecular weight:331.4159851074219N-Desmethyl Regorafenib (Pyridine)-N-oxide
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications N-Desmethyl Regorafenib (Pyridine)-N-oxide is a synthetic metabolite of Regorafenib (R143000) and is used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>Formula:C20H13ClF4N4O4Color and Shape:NeatMolecular weight:484.791-(4-Fluorophenyl)-4-(4-(pyridin-2-yl)piperazin-1-yl)butan-1-one
CAS:Purity:95.0%Color and Shape:SolidMolecular weight:327.40301513671875rac-Mephenytoin
CAS:Controlled Product<p>Applications rac-Mephenytoin is an anticonvulsant agent.<br>References Shimada, et al.: Anal. Biochem., 147, 174 (1975), Dzhagatspanyan. IA., et al.: Pharm. Chem. J., 25, 181 (1991),<br></p>Formula:C12H14N2O2Color and Shape:White SolidMolecular weight:218.25Ezetimibe Phenoxy β-D-Glucuronide
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Phase-II metabolite of Ezetimibe, an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.This compound is very hygroscopic. Handle with care.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C30H29F2NO9Color and Shape:White To Light BrownMolecular weight:585.554-(4-Phenylbutoxy)benzoic Acid
CAS:Controlled Product<p>Applications 4-(4-PHENYLBUTOXY)BENZOIC ACID (cas# 30131-16-9) is a useful research chemical.<br></p>Formula:C17H18O3Color and Shape:NeatMolecular weight:270.325-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile
CAS:Controlled Product<p>Impurity Olanzapine EP Impurity A/ Olanzapene USP Related Compound A<br>Applications 5-Methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile (Olanzapine EP Impurity A) is an impurity of Olanzapine (O253750).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anon., et al.: Fed. Regist., 65, 83041 (2000), Yu, L., et al.: J. Phys. Chem., 106, 544 (2002),<br></p>Formula:C12H9N3O2SColor and Shape:NeatMolecular weight:259.28rac Fenfluramine-d5 Hydrochloride
CAS:Controlled Product<p>Applications Labelled Fenfluramine. Anorexic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),<br></p>Formula:C12D5H11F3N·ClHColor and Shape:NeatMolecular weight:272.75Hydroxy Dehydro Nifedipine Lactone
CAS:Controlled ProductFormula:C16H12N2O6Color and Shape:NeatMolecular weight:328.28TEMPO
CAS:Controlled Product<p>Applications TEMPO is a stable radical prepared through the oxidation of 2,2,6,6-tetramethylpiperidine. TEMPO has a wide range of applications including use as a free radical scavenger, a reagent in organic synthesis and as a structural probe in electron spin resonance spectroscopy. TEMPO can also be used as a mediator in free radical polymerization.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Seaton, T.A. et al.: Brain Res., 777, 110 (1997); Tanielyan, S.K. et al.: Top. Catal., 55, 556 (2012); Wolinska-Grabczyk, A. et al.: Polymer, 46, 2461 (2005); Keoshkerian, B. et al.: Polym. Prep., 35, 675 (1994);<br></p>Formula:C9H18NOColor and Shape:NeatMolecular weight:156.256-Methyl Risperidone
CAS:Controlled Product<p>Impurity Risperidone EP Impurity E<br>Applications 6-Methyl Risperidone (Risperidone EP Impurity E) is a Risperidone (R525000) impurity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>Formula:C24H29FN4O2Color and Shape:Light YellowMolecular weight:424.51Valsartan N1-Glucuronide
Controlled ProductFormula:C30H37N5O9Color and Shape:NeatMolecular weight:611.643Omeprazole
CAS:Controlled Product<p>Applications Omeprazole covalently binds to proton pump. It inhibits gastric secretion. Used as an anttiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983), Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984), Morii, M., et al.: J. Biol. chem., 268, 21553 (1993), Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>Formula:C17H19N3O3SColor and Shape:White To Light BrownMolecular weight:345.42Celecoxib Carboxylic Acid
CAS:Controlled ProductFormula:C17H12F3N3O4SColor and Shape:Off WhiteMolecular weight:411.362-(2,4-Dimethoxybenzoyl)-5-(1,3-dioxolan-2-yl)thiophene
CAS:Purity:97.0%Molecular weight:320.35998535156252-methyl-4-(2-(4-phenylcyclohexylidene)hydrazinyl)quinoline hydrochloride
CAS:Purity:95.0%Molecular weight:365.91000366210941-(tert-Butoxycarbonyl)-4-(1H-pyrazol-1-yl)piperidine-4-carboxylic acid
CAS:Purity:95%Molecular weight:295.33898925781257-Hydroxy Loxapine
CAS:Controlled Product<p>Applications 7-Hydroxy Loxapine is a metabolite of Loxapine (L472750), a neuroleptic medication used to treat patients with schizophrenia and obsessive compulsive disorder.<br>References Kapur, S., et al.: Am. J. Psychiatry, 154, 1525 (1997); Rivers-Bulkeley, N. & Hollender, M.: Am. J. Psychiat., 139, 1345 (1982)<br></p>Formula:C18H18ClN3O2Color and Shape:NeatMolecular weight:343.812-(Diphenylmethoxy)-N-methylethylamine
CAS:Controlled Product<p>Applications 2-(Diphenylmethoxy)-N-methylethylamine is used in the pereparation of H1 and H2 receptor antagonists containing Diphenhydramine (D486900) derivatives. Diphenhydramine is a H1-histamine receptor antagonist. Diphenhydramine (D486900) is categorized as an antihistaminic; sedative, hypnotic.<br>References Wolf, C. et al.: Archiv. de Pharm., 329, 87 (1996); Gruhzit, O.M., et al.: J. Pharmacol. Exp. Ther., 89, 227 (1947), Holcomb, I.J., et al.: Anal. Profiles Drug Subs., 3, 173 (1974), Scavone, J.M., et al.: J. Clin. Pharmacol., 38, 603 (1998),<br></p>Formula:C16H19NOColor and Shape:Light Yellow To YellowMolecular weight:241.33ABT 199 (Venetoclax)
CAS:Controlled Product<p>Applications ABT 199 is a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. It’s practical application is to treat chronic lymphocytic leukaemic cells and estrogen receptor-positive breast cancer.<br>References Davids, M. & Letai, A.: Cancer Cell, 23, 139 (2013); Souers, A.,et al.: Nat. Med., 19, 202 (2013); Vaillant, F., et al.: Cancer Cell, 24, 120 (2013); Vogler, M., et al.: Brit. J. Haematol., 163, 139 (2013);<br></p>Formula:C45H50ClN7O7SColor and Shape:Light Yellow To YellowMolecular weight:868.44Apalutamide
CAS:Controlled Product<p>Applications Apalutamide is a second-generation antiandrogen used in the treatment of prostate cancer.<br>References Li, Huifang, et al.: J. of Chem. Info. and Model., 53(1), 123-130 (2013);Joseph, James D., et al.: Cancer Disc., 3(9), 1020-1029 (2013)<br></p>Formula:C21H15F4N5O2SColor and Shape:White To Off-WhiteMolecular weight:477.43476-(trifluoromethyl)-1,2,3,4-tetrahydroquinazoline-2,4-dione
CAS:Purity:98%Molecular weight:230.14599609375N-Deshydroxyethyl Dasatinib-d8
CAS:Controlled ProductFormula:C21D8H15ClN6OSColor and Shape:White SolidMolecular weight:451.01Flibanserin N-Oxide
CAS:Controlled ProductFormula:C20H21F3N4O2Color and Shape:NeatMolecular weight:406.401Reboxetine-d5 Mesylate
CAS:Controlled ProductFormula:C20H22D5NO6SColor and Shape:Off White SolidMolecular weight:414.53Olanzapine-d3 N-Oxide
CAS:Controlled Product<p>Applications A labelled metabolite of Olanzapine.<br>References Jacobsen, E., et al.: Acta Pharmacol. Toxacol., 11, 135 (1955), Chakrabarti, J.K., et al.: J. Med. Chem., 23, 878 (1980), Luo, H., et al.: J. Pharm. Sci., 11, 1079 (1992), Moore, N.A., et al.: Curr. Opin. Invest. Drugs, 2, 281 (1993),<br></p>Formula:C17H17D3N4OSColor and Shape:NeatMolecular weight:331.45Etoricoxib-d3
CAS:Controlled Product<p>Applications A specific inhibitor of COX-2 .<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McGeer, P.L., et al.: Exp. Gerontol., 37, 925 (2002), Chenevard, R., et al.: Circulation, 107, 405 (2003)<br></p>Formula:C182H3H12ClN2O2SColor and Shape:NeatMolecular weight:361.86Loxapine-d8 Hydrochloride
CAS:Controlled ProductFormula:C18H10D8ClN3O·xHClColor and Shape:Off-White To Light YellowMolecular weight:372.32Deracoxib
CAS:Controlled Product<p>Applications Deracoxib is a non-steroidal anti-inflammatory drug (NSAID) of the coxib class. Deracoxin is a selective cyclooxygenase-2 (COX-2) inhibitor used in the treatment of osteoarthritis in dogs. At low doses, adminsitartion of Deracoxin showed no factors associated with gastrointestinal tract perforation.<br>References Lascelles, B.D.X. et al.: J. Am. Vet. Med. Assoc., 227, 1112 (2005); Anderson, G.D. et al.: Inflam. Res., 58, 109 (2009); Brainard, B.M. et al.: Am. J. Vet. Res., 68, 251 (2007);<br></p>Formula:C17H14F3N3O3SColor and Shape:Light BrownMolecular weight:397.375’-[(Desloratadine)methyl] Rupatadine
CAS:Controlled Product<p>Applications 5’-[(Desloratidine)methyl] Rupatadine is an impurity of the antihistaminic drug Rupatadine (R701650).<br>References Wang, H. et al.: Yao. Fen. Zaz., 29, 791 (2009);<br></p>Formula:C45H43Cl2N5Color and Shape:NeatMolecular weight:724.762-methyl-2-(morpholin-4-yl)propanoic acid hydrochloride
CAS:Color and Shape:SolidMolecular weight:209.66999816894531-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications 1-(2,6-Dimethylphenyl)-1,5,6,7-tetrahydro-2H-azepin-2-one is an impurity of the local anesthetic Levobupivacaine (B689546).<br></p>Formula:C14H17NOColor and Shape:NeatMolecular weight:215.295-[[4-[3-(Aminocarbonyl)-1,4,5,7-tetrahydro-1-(4-methoxyphenyl)-7-oxo-6H-pyrazolo[3,4-c]pyridin-6-yl]phenyl]amino]pentanoic Acid
CAS:<p>Applications Apixaban Open chain Acid Is an open ring impurity of Apixaban (A726700). Apixaben is a potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.<br>References Luettgen, J.M. et al.: J. Enz. Inhib. Med. Chem., 26, 514 (2011); Glanis, T. et al.: J. Thromb. Thrombol., 31, 310 (2011); barrett, Y.C. et al.: Thromb. Haemos., 105, 181 (2011);<br></p>Formula:C25H27N5O5Color and Shape:Light YellowMolecular weight:477.514-Fluoro-3-chloroaniline
CAS:Controlled Product<p>Applications 4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reddy, D. R. S., et al.: Pharma Chemica., 5, 207 (2013);<br></p>Formula:C6H5ClFNColor and Shape:NeatMolecular weight:145.56N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib
CAS:Controlled Product<p>Impurity Celecoxib EP Impurity B<br>Applications N-De(4-sulfonamidophenyl)-N’-(4-sulfonamidophenyl) Celecoxib (Celecoxib EP Impurity B) is an isomeric impurity of Celecoxib (C251000) with selective inhibitory activity against human cyclooxygenase-2. USP Celecoxib Related Compound B<br>References Talley, J.J. et al.: Actual. Chim. Therap., 25, 123 (1999); Rao, R. et al.: Anal. Sci., 22, 1257 (2006);<br></p>Formula:C17H14F3N3O2SColor and Shape:NeatMolecular weight:381.37cis-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol
CAS:Controlled Product<p>Applications cis-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolane-4-methanol is a Ketoconazole (K186000) fragment that may have modulatory activity on the large conductance calcium-activated potassium channel (BKCa).<br>References Power, E.C. et al.: Bioorg. Med. Chem., 16, 887 (2006); Heeres, J. et al.: J. Med. Chem., 22, 1003 (1979);<br></p>Formula:C14H14Cl2N2O3Color and Shape:NeatMolecular weight:329.184-Defluoro-4-hydroxy Gefitinib
CAS:Controlled Product<p>Applications A metabolite of Gefitinib (G304000).<br>References Newton, D., et al.: Drug Metab. Dispos., 23, 154 (1995), Wakeling, A., et al.: Cancer Res., 62, 5749 (2002), McKillop, D., et al.: Xenobiotica, 34, 917 (2004),<br></p>Formula:C22H25ClN4O4Color and Shape:NeatMolecular weight:444.91TERT-BUTYL 4-(7-CHLOROQUINOLIN-4-YL)-4-CYANOPIPERIDINE-1-CARBOXYLATE
CAS:Purity:95.0%Molecular weight:371.86999511718752-(2-Methoxyphenoxy)ethylamine Hydrochloride
CAS:<p>Impurity Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E<br>Applications 2-(2-Methoxyphenoxy)ethylamine Hydrochloride (Carvedilol EP Impurity E; Carvedilol Impurity E; Carvedilol USP E) is an impurity of Carvedilol synthesis.<br>References Smith, L., et al.: J. Med. Chem., 20, 1653 (1977),<br></p>Formula:C9H13NO2·ClHColor and Shape:NeatMolecular weight:203.67Phenylephrone-d3 Hydrochloride
CAS:Controlled Product<p>Applications Labelled impurity C of Phenylephrine.<br>References Bodor, N., et al.: J. Med. Chem., 31, 100 (1988), Goskonda, V., et al.: J. Pharm. Sci., 88, 180 (1999),<br></p>Formula:C9H9D3ClNO2Color and Shape:NeatMolecular weight:204.674-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
CAS:Purity:98.0%Color and Shape:SolidMolecular weight:421.89999389648442-(4-(3-(2',8-Bis(trifluoromethyl)-10H-[3,10'-biphenothiazin]-10-yl)propyl)piperazin-1-yl)ethanol
Controlled ProductFormula:C35H32F6N4OS2Color and Shape:NeatMolecular weight:702.78Vortioxetine Hydrobromide-D8
CAS:Controlled Product<p>Applications Vortioxetine Hydrobromide-D8 is deuterium labeled Vortioxetine Hydrobromide (V766000), a multimodal serotonergic agent that inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT (1,2,3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Bang-Andersen, B., et al.: J. Med. Chem., 54, 3206 (2011)(2) Mørk, A., et al.: J. Pharmacol. Exp. Ther., 340, 666 (2012) (3) Mørk, A., et al.: Pharmacol. Biochem. Behav. 105C, 41 (2013)<br></p>Formula:C18D8H14N2S·BrHColor and Shape:Off White PowderMolecular weight:387.4069Amantadine-d15 Hydrochloride
CAS:Controlled Product<p>Applications NMDA-receptor antagonist. Antiviral; antiparkinsonian.<br>References Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969), Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983),<br></p>Formula:C102H15H2NColor and Shape:NeatMolecular weight:166.34Maltol
CAS:<p>Applications A fragrance molecule used in flavor enhancers and fragrances.<br>References Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010), Huang, Y., et al.: J. Food Sci., 75, C121 (2010), Tsuji, H., et al.: J. Food Sci., 75, C79 (2010),<br></p>Formula:C6H6O3Color and Shape:NeatMolecular weight:126.11rac Normetanephrine-d3 Hydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications A labelled metabolite of Epinephrine (E588585). A naturally occurring derivative of Epinephrine, found together with Metanephrine in urine and in certain tissues.<br>References Eisenhofer, G., et al.: J. Clin. Endocrinol. Metab., 82, 3864 (1997), Akiyama, T., et al.: Cardiovasc. Res., 49, 78 (2001), Burke, W., et al.: Brain Res., 891, 218 (2001),<br></p>Formula:C92H3H10NO3·ClHColor and Shape:BeigeMolecular weight:222.684’-Hydroxy Dutasteride
Controlled Product<p>Applications 4’-Hydroxy Dutasteride is an impurity of Dutasteride (D735000), a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.<br>References Bakshi, R.K., et al.: J. Med. Chem., 38, 3189 (1995), Gisleskog, P.O., et al.: Brit. J. Clin. Pharmacol., 47, 53 (1999), Djavan, B., et al.: Expert Opin. Pharmacother., 6, 311 (2005)<br></p>Formula:C27H30F6N2O3Color and Shape:NeatMolecular weight:544.532-Hydroxypropyl Nortadalafil (Mixture of Diastereomers)
CAS:Controlled Product<p>Applications 2-Hydroxypropyl Nortadalafil is a derivative of Tadalafil (T004500), which is used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor.<br>References Carrier, S., et al.: Can. J. Urol., 10(1), 12 (2003), Doggrell, S.A., et al.: Expert Opin. Pharmacother., 6, 75 (2005), Forgue, S.T., et al.: Br. J. Clin. Pharmacol., 61, 280 (2005), Toomey, V. et al.: J. Pharm. Biomed. Anal., 59, 50 (2012);<br></p>Formula:C24H23N3O5Color and Shape:NeatMolecular weight:433.46Dihydroxy Moxonidine
CAS:Controlled Product<p>Impurity Moxonidine Impurity 1<br>Applications Dihydroxy Moxonidine (Moxonidine Impurity 1) is an impurity of Moxonidine (M745800).<br>References Diasio, R., et al.: Antimicrob. Agents Chemother., 14, 903 (1978), Yang, L., et al.: J. Pharm. Biomed. Anal., 22, 487 (2000),<br></p>Formula:C8H11N5O2Color and Shape:NeatMolecular weight:209.21Oclacitinib
CAS:<p>Applications Oclacitinib is a novel Janus kinase (JAK) inhibitor with activity against cytokines involved in allergy.<br>References Gonzales, A.J., et al.: J. Vet. Pharmacol. Ther., 37, 317 (2014)<br></p>Formula:C15H23N5O2SColor and Shape:NeatMolecular weight:337.44Rivastigmine-d4 Tartrate Salt
CAS:Controlled Product<p>Applications Rivastigmine-d4 Tartrate Salt, is the labeled analogue of Rivastigmine Tartrate Salt (R541000), a brain selective acetylcholinesterase inhibitor. Nootropic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rosler, M., et al.: Brit. Med. J., 318, 633 (1999), Enz, A., et al.: Prog. Brain Res., 98, 431 (1993),<br></p>Formula:C18H24D4N2O8Color and Shape:NeatMolecular weight:404.45N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine
CAS:Purity:95.0%Color and Shape:Solid, Light yellow crystalline powderMolecular weight:446.91000366210944-(2-Methoxyethyl)phenol
CAS:Controlled Product<p>Impurity Metoprolol EP Impurity B<br>Applications 4-(2-Methoxyethyl)phenol (Metoprolol EP Impurity B) is an impurity of Metoprolol.<br>References McGourty, J., et al.: Br. J. Clin. Pharmacol., 20, 555 (1985), Zhou, H., et al.: Clin. Pharmacol. Ther., 47, 686 (1990), Koyama, E., et al.: J. Pharmacol. Exp. Ther., 271, 860 (1994)<br></p>Formula:C9H12O2Color and Shape:NeatMolecular weight:152.19N-(4-Amino-6,7-dimethoxyquinazol-2-yl)-N-methylpropylenediamine Formamide Hydrochloride
CAS:Controlled Product<p>Impurity Alfuzosin Hydrochloride EP Impurity E<br>Applications Alfuzosin (A532000) impurity. Alfuzosin (A532000) is an α1-Adrenoceptor antagonist structurally similar to Prozosin. Antihypertensive. Used in treatment of benign prostatic hypertrophy. (Alfuzosin Hydrochloride EP Impurity E )<br>References Ramage, A.G., et al.: Eur. J. Pharmacol., 129, 307 (1986), Deering, A.H.,: Brit. J. Clin. Pharmacol., 25, 417 (1988), Priolo, L.D., et al.: Eur. J. Clin. Pharmacol., 35, 25 (1988),<br></p>Formula:C15H21N5O3·HClColor and Shape:White To Off-WhiteMolecular weight:319.37 + (36.46)1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-1H-pyrazol-5-amine
CAS:Purity:97%Molecular weight:213.244003295898445,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one Oxime Hydrochloride
CAS:Controlled Product<p>Impurity Ranitidine EP Impurity G<br>Stability Hygroscopic<br>Applications 5,6-Dihydro-3-(methylamino)-2H-1,4-thiazin-2-one Oxime Hydrochloride (Ranitidine EP Impurity G) is a Ranitidine HCl (R120000) impurity.<br>References Wu, V., et al.: Pharmazie, 55, 508 (2000), Salameh, A., et al.: J. Food Sci., 71, E10 (2006),<br></p>Formula:C5H9N3OS·ClHColor and Shape:NeatMolecular weight:195.67
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