Quinazoline and Quinoline Derivatives
Quinazolines and quinolines are nitrogen-containing heterocyclic compounds with aromatic structures that play a key role in the synthesis of drugs with anticancer, antimicrobial, and anti-inflammatory activity. Their derivatives feature structural modifications that optimise bioavailability and selectivity, enabling the development of new active ingredients for various therapeutic applications. These compounds are used in the manufacture of APIs for the treatment of cancer, infections, neurodegenerative diseases, and cardiovascular conditions. Additionally, quinazoline and quinoline derivatives are essential in the research of enzyme inhibitors and the design of innovative bioactive molecules.
At CymitQuimica, we offer high-purity quinazoline and quinoline derivatives for applications in chemical synthesis, pharmaceutical development, and biotechnology.
Found 65562 products of "Quinazoline and Quinoline Derivatives"
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2-Acetoxy-N-(2-thiazolyl)benzamide
CAS:Controlled Product<p>Applications 2-Acetoxy-N-(2-thiazolyl)-benzamide is used in the synthesis of thiazolides as novel antiviral agents. Used in the inhibition of hepatitis C virus replication. Nitazoxanide Impurity<br>References Edwards, G. et al.: J. Med. Chem., 54, 8670 (2011);<br></p>Formula:C12H10N2O3SColor and Shape:Off-WhiteMolecular weight:262.281-Amino-3-adamantanol
CAS:Controlled Product<p>Applications Reagent used in the preparation of Vildagliptin.<br>References Fukushima, H., et al.: Bioorg. Med. Chem., 16, 4093 (2008), Anand, R., et al.: J. Med. Chem., 52, 1602 (2009),<br></p>Formula:C10H17NOColor and Shape:NeatMolecular weight:167.25Iloperidone-d3
CAS:Controlled Product<p>Applications Labelled Iloperidone. Combined dopamine (D2) and serotonin (5HT2) receptor antagonist. Antipsychotic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sainati, S.M., et al.: J. Clin. Pharmacol., 35, 713 (1995), Szewczak, M.R., et al.: J. Pharmacol. Exp. Ther., 274, 1404 (1995), Kongsamut, S., et al.: Eur. J. Pharmacol., 317, 417 (1996)<br></p>Formula:C24H24D3FN2O4Color and Shape:Light YellowMolecular weight:429.5γ-Aminobutyric Acid
CAS:<p>Applications An important inhibitory neurotransmitter. The foods contain γ-aminobutyric acid (GABA) at an amount that shows immediate effect of suppressing autonomic nerve activity related to blood pressure increase. Reacts with isothiocyanates to produce thioureas which have antifungal activity.<br>References Lowry, O., et al.: J. Biol. Chem., 193, 265 (1951), Gerlach, M., et al.: Brain Res., 741, 142 (1996), Choi, D., et al.: J Neurobiol 1992, 23, 1261<br></p>Formula:C4H9NO2Color and Shape:NeatMolecular weight:103.12Ilaprazole
CAS:Controlled Product<p>Applications Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer.<br>References Cao, S., et al.: Acta Pharmacol. Sin., 33, 1095 (2012); Wang, L., et al.: J. Clin. Gastroenterol., 45, 322 (2011)<br></p>Formula:C19H18N4O2SColor and Shape:NeatMolecular weight:366.44Piperonylic Acid
CAS:Controlled Product<p>Applications Piperonylic Acid is a compound closely mimicking the structure of transcinnamic acid involved in the phenylpropanoid pathway in plant physiology.<br>References Schalk, M. et al.: Plant Physiol., 118, 209 (1998);<br></p>Formula:C8H6O4Color and Shape:NeatMolecular weight:166.134-Chloro-benzoic Acid 1-(4-Methoxyphenyl)hydrazide Hydrochloride
CAS:<p>Applications 4-Chloro-benzoic Acid 1-(4-Methoxyphenyl)hydrazide Hydrochloride is a derivative of (4-Methoxyphenyl)hydrazine Hydrochloride (M265880). It is a useful synthetic intermediate for the preparation of Indomethacin (I641000); a potent, time-dependent, nonselective inhibitor of the cyclooxygenase enzymes COX-1 and COX-2.<br>References Blobaum, Anna L., et al.: ACS Med. Chem. Lett., 4(5), 486-490 (2013); Prusakiewicz, Jeffery J., et al.: Biochemistry, 43(49), 15439-15445 (2004)<br></p>Formula:C14H13ClN2O2·HClColor and Shape:NeatMolecular weight:313.18N-Nitrosooxprenolol
CAS:Controlled ProductFormula:C15H22N2O4Color and Shape:Light YellowMolecular weight:294.346Rimonabant Hydrochloride
CAS:Controlled Product<p>Applications Rimonabant Hydrochloride is a potent and selective CB1 cannabinoid antagonist used to investigate CB receptor properties (1). Rimonabant Hydrochloride is also an anti-obesity agent (2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Carai, M.A.M., et al.: Life Sci., 77, 2339 (2005) (2) Janiak, P., et al.: Kidney Int. 72, 1345 (2007)<br></p>Formula:C22H21Cl3N4O·ClHColor and Shape:White To Off-WhiteMolecular weight:500.25Propylthiouracil N-β-D-Glucuronide Sodium Salt
CAS:Controlled Product<p>Applications Salt of Propylthiouracil N-β-D-Glucuronide (P838315), also a metabolite of Propylthiouracil (P838310).<br>References Lindsay, R. H., et al.: J. Pharm. Sci., 63 1383 (1974)Taurog, A., et al.: Endocrinology, 122, 592 (1988),<br></p>Formula:C13H17N2NaO7SColor and Shape:NeatMolecular weight:368.34(R)-3-Aminopiperidine Dihydrochloride
CAS:Controlled Product<p>Applications (R)-3-Aminopiperidine Dihydrochloride has been used as a reactant for the preparation of dipeptidyl peptidase IV inhibitors derived from Alogliptin.<br>References Xie, Hui., et. al.: Eur. J. Med. Chem., 68, 312 (2013)<br></p>Formula:C5H14Cl2N2Color and Shape:NeatMolecular weight:173.08Deferiprone-d3
CAS:Controlled Product<p>Applications A chelator that could replace disferrioxamine. It is orally and parenterally effective in the removal of iron in vivo from rabbits and mice and also from transferrin and ferritin in vitro.<br>References Kontoghiorghes, G.J.: Lancet I, 817 (1985), Kontoghiorghes, G.J., et al.: Br. J. Haematol., 62, 607 (1986), Kontoghiorghes, G.J., et al.: Biochem. Biophys. Acta, 869, 141 (1986), Kontoghiorghes, G.J., et al.: Arzneim.-Forsch., 37, 1099 (1987),<br></p>Formula:C7H6D3NO2Color and Shape:White To Off-WhiteMolecular weight:142.17Nor Mianserin-d6 (Major)
Controlled Product<p>Applications Nor Mianserin-d6 (Major), is a labeled analogue of Nor Mianserin (N736800), an active metabolites of Miansein (M341500) in plasma, an antidepressant.<br>References Kent, J., et al.: Lancet, 355, 911 (2000), Maurer, H., et al.: Ther. Drug Monit., 24, 117 (2002),<br></p>Formula:C17H14D6N2Color and Shape:NeatMolecular weight:258.39Nadolol
CAS:Controlled Product<p>Applications β-Adrenergic blocker. Antihypertensive; antianginal.<br>References Dreyfuss, J., et al.: J. Clin. Pharmacol., 17, 300 (1977), Sibley, P.L., et al.: Toxicol. Appl. Pharmacol., 44, 379 (1978), Slusarek, L., et al.: Anal. Profiles Drug Subs., 9, 455 (1980),<br></p>Formula:C17H27NO4Color and Shape:Off-WhiteMolecular weight:309.4011-(4-Ethyl-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine Dihydrochloride
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications 11-(4-Ethyl-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine is an impurity of Quetiapine hemifumarate (Q510000), a dibenzothiazepine antipsychotic medication used in the treatment of schizophrenia.<br>References Kumar, K., et al.: Org. Chem.: An Indian Journal, 8, 164 (2012); Raju, I., et al.: Chromatographia, 70, 545 (2009)<br></p>Formula:C19H23Cl2N3SColor and Shape:NeatMolecular weight:396.38Nicorandil-d4
CAS:Controlled Product<p>Stability Unstable in Solution<br>Applications An antianginal.<br>References Yoneyama, F., et al.: Cardiovasc. Drugs Ther., 4, 1119 (1990), Purcell, H., et al.: Brit. J. Clin. Pract., 47, 150 (1993)<br></p>Formula:C82H4H5N3O4Color and Shape:NeatMolecular weight:215.20A77 1726 (E/Z) Mixture
CAS:Controlled Product<p>Impurity Leflunomide USP Related Compound B<br>Applications rac A77 1726 is the active metabolite of Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis. LEF-M interferes with dendritic cell function. The second Phase III study evaluating the efficacy of Genzyme’s teriflunomide therapy against relapsing forms of multiple sclerosis found the once-daily oral drug to be no less effective than injectable interferon beta 1a (Rebif®). Leflunomide USP Related Compound B.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kirsch, B.M., et al.: Arthritis Research and Therapy, 7, 3, R694, (2005)<br></p>Formula:C12H9F3N2O2Color and Shape:NeatMolecular weight:270.212-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzamide
CAS:Purity:95.0%Molecular weight:297.28900146484375N-Desmethyl Riociguat
CAS:Controlled Product<p>Applications N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.<br>References Mittendorf, J., et al.: ChemMedChem., 4, 853 (2009)<br></p>Formula:C19H17FN8O2Color and Shape:NeatMolecular weight:408.39N-Formyl Amlodipine
CAS:Controlled Product<p>Applications N-Fomyl Amlodipine acts as a reagent for the synthesis of dihydropyridine anti-ischemic and antihypertensive agents.<br>References Alker, D., et al.: Pat. Appl. (1984), EP 119050 A2 19840919<br></p>Formula:C21H25ClN2O6Color and Shape:White To Off-WhiteMolecular weight:436.886Astemizole
CAS:Controlled Product<p>Applications Nonsedating-type histamine H1-receptor antagonist. Potential for combination therapy with antivancer drugs such as doxorubicin in resistant leukemia. Antihistaminic.<br>References Wauquier, A., et al.: Eur. J. Pharmacol., 72, 245 (1981), Laduron, P.M., et al.: Mol. Pharmacol., 21, 294 (1982), Richards, D.M., et al.: Drugs, 28, 38 (1984), Al-Obaid, A.M., et al.: Anal. Profiles Drug Subs., 20, 173 (1991), Ishikawa, M., et al.: Biol. Pharm. Bull., 23, 112 (2000),<br></p>Formula:C28H31FN4OColor and Shape:White To Off-WhiteMolecular weight:458.57Deschloro Aripiprazole
CAS:Controlled Product<p>Impurity Aripiprazole EP Impurity C<br>Applications Deschloroaripiprazole (Aripiprazole EP Impurity C) is a derivative of Aripiprazole (A771000), a dopamine D2 receptor agonist. Antipsychotic.<br>References Chen, X. et al.: J. Med. Chem., 55, 7141 (2012); Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998), Oshiro, Y., et al.: J. Med. Chem., 41, 658 (1998),<br></p>Formula:C23H28ClN3O2Color and Shape:Off-WhiteMolecular weight:413.94Sertindole
CAS:Controlled Product<p>Applications Antipsychotic used in the treatment of schizophrenia.<br>References Nourian, Z., et al.: Eur. J. Pharmacol., 596, 32 (2008), Karczewski, J., et al.: Biochem. Pharmacol., 77, 1602 (2009), Isoherranen, N., et al.: Chem. Res. Toxicol., 22, 294 (2009), Goetghebeur, P., et al.: Psychopharmacol., 202, 287 (2009),<br></p>Formula:C24H26ClFN4OColor and Shape:NeatMolecular weight:440.943,4-Dihydro-7-(4-hydroxybutoxy)-2(1H)-quinolinone
CAS:Formula:C13H17NO3Color and Shape:NeatMolecular weight:235.28Empagliflozin α-Anomer
CAS:Controlled ProductFormula:C23H27ClO7Color and Shape:White To Off-WhiteMolecular weight:450.9092-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid
CAS:Controlled Product<p>Applications 2-[-2[(5-Nitro-2-furanyl)methylene]hydrazinyl]acetic Acid is an impurity of Nitrofurantoin (N493850), a nitrofuran antibiotic with low resistance potential that is rapidly metabolized by mammals.<br>References Cadwallader, D.E., et al.: Anal. Profiles Drug Subs., 5, 345 (1976); Rogers, R.G., et al.: Am. J. Obstr. Gynecol., 191, 182 (2004);<br></p>Formula:C7H7N3O5Color and Shape:NeatMolecular weight:213.1483-Hydroxyagomelatine
CAS:<p>Impurity Agomelatine Impurity 11/ Agomelatine 3-Hydroxy Impurity<br>Applications 3-Hydroxyagomelatine is an intermediate in the synthesis of 1-(aminoethyl)naphthalene derivative with potential binding affinity for melatonin receptors. Agomelatine Impurity 11<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simonin, G., et al.: J. Pharma. Biomed. Anal., 21, 591 (1999)<br></p>Formula:C15H17NO3Color and Shape:NeatMolecular weight:259.3(S)-5-Iodo Naproxen
CAS:Controlled ProductFormula:C14H13IO3Color and Shape:NeatMolecular weight:356.16N1-Ethylcarbamoyl Cabergoline (>90%)
CAS:Formula:C29H42N6O3Color and Shape:Off White SolidMolecular weight:522.68Baricitinib
CAS:Controlled Product<p>Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.<br>References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);<br></p>Formula:C16H17N7O2SColor and Shape:White SolidMolecular weight:371.42rac-Epinephrine-3-O-sulfate
CAS:Formula:C9H13NO6SColor and Shape:White To Off-WhiteMolecular weight:263.268Rebamipide 3-Chloro Impurity (>80%)
CAS:Controlled Product<p>Applications Rebamipide 3-Chloro Impurity (CAS# 90098-05-8) is a useful research chemical compound.<br></p>Formula:C19H15ClN2O4Purity:>80%Color and Shape:White To Off-WhiteMolecular weight:370.78642-(1-Nitroso-4-piperidinyl)-1H-benzimidazole
CAS:Controlled ProductFormula:C12H14N4OColor and Shape:NeatMolecular weight:230.266(S)-(-)-4’-Hydroxyphenyl Carvedilol
CAS:Controlled Product<p>Applications An optically active metabolite of Carvedilol (C184625), a nonselective ß-adrenergic blocker with α1-blocking activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sponer, G., et al.: J. Cardiovasc. Pharmacol., 9, 317 (1987), Fujimaki, M., ET AL.: Xenobiotica, 20, 1025 (1990), Ruffolo, R., et al.: Eur. J. Clin. Pharmacol., 38, S82 (1990), Schaefer, W.H., et al.: Drug Metab. Dispos., 26, 10, 958 (1998),<br></p>Formula:C24H26N2O5Color and Shape:NeatMolecular weight:422.47Iso Sildenafil
CAS:Controlled Product<p>Applications Iso Sildenafil is the isomer of Sildenafil methylated at N-2 position of the pyrazolo[4,3-d]pyrimidin-7-one nucleus.<br>References Sheldrick, G., et al.: Acta Crystallogr., A46, 467 (1990), Terrett, N., et al.: Bioorg. Med. Chem. Lett., 6, 1819 (1996),<br></p>Formula:C22H30N6O4SColor and Shape:NeatMolecular weight:474.58N-Acetyldesloratadine
CAS:Controlled Product<p>Applications N-Acetyldesloratadine is an impurity in the synthesis of Desloratadine (D290250), Nonsedating-type histamine H1-receptor antagonist.<br>References Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000); Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000); Agrawal, D.K., et al.: Expert Opin. Invest. Drugs, 10, 547 (2001);<br></p>Formula:C21H21ClN2OColor and Shape:NeatMolecular weight:352.86Dasatinib Carboxylic Acid Ethyl Ester
CAS:Controlled Product<p>Applications Protected Dasatinib Carboxylic Acid (D193605). An oxidative metabolite of Dasatinib (M6 metabolite); used in the treatment of cancers and immune diseases. It is a COVID19-related research product.<br>References Jaworski, T., et al.: Xenobiotica, 21, 1451 (1991), Shah, N., et al.: Science, 305, 399 (2004), O'Hare, T., et al.: Cancer Res., 65, 4500 (2005), Das, J., et al.: J. Med. Chem., 49, 6819 (2006), Christopher, L., et al.: Drug Metab. Dispos., 36, 1341 (2008),<br></p>Formula:C24H28ClN7O3SColor and Shape:NeatMolecular weight:530.04Perphenazine Sulfoxide
CAS:Controlled Product<p>Impurity Perphenazine EP Impurity A<br>Applications Perphenazine Sulfoxide (Perphenazine EP Impurity A) acts as a D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro. Antipsychotic.<br>References Gaertner, H.J., et al.: Drug Metab. Dispos., 3, 437 (1975), O Brien, S., et al.: J. Med. Chem., 48, 1287 (2005), Briggs, K., et al.: Toxicology, 231, 113 (2007), Toga, T., et al.: J. Pharmacol. Sci., 105, 207 (2007),<br></p>Formula:C21H26ClN3O2SColor and Shape:NeatMolecular weight:419.97Ezetimibe-d4 β-D-Glucuronide, >85%
CAS:Controlled Product<p>Stability Hygroscopic<br>Applications Phase-II labelled metabolite of Ezetimibe, an antihyperlipoproteinemic. A cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>Formula:C30H25D4F2NO9Purity:>85%Color and Shape:NeatMolecular weight:589.57cis Lacidipine
CAS:Controlled Product<p>Stability Light Sensitive<br>Applications Z-Isomer of Lacidipine; a dihydropyridine calcium channel blocker. Antihypertensive.<br>References Safar, M., et al.: Clin. Pharmacol. Ther., 46, 94 (1989), Kharat, V.R., et al.: J. Pharm. Biomed. Anal., 28, 789 (2002), McCormack, A.J., et al.: Drugs, 63, 2327 (2003),<br></p>Formula:C26H33NO6Color and Shape:NeatMolecular weight:455.54Ezetimibe Diol Impurity
CAS:Controlled ProductFormula:C24H25F2NO3Color and Shape:NeatMolecular weight:413.46Levetiracetam-d3
CAS:Controlled ProductFormula:C8H11D3N2O2Color and Shape:White To Off-WhiteMolecular weight:173.23
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