Amino Acids (AA)

<p>Applications Labelled Tiopronin. It is used as antidote against heavy metal poisoning; hepatoprotectant; mucolytic.<br>References Capasso, F., et al.: Agents Actions, 11, 741 (1981), Amor, B., et al.: Arthritis Rheum., 25, 698 (1982), Ichida, F., et al.: J. Int. Med. Res., 10, 325 (1982),<br></p>

<p>Applications Isotope labelled N-Isovalerylglycine is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isovalerylglycine is found in the urine of patients with isovaleric acidemia, an inborn error of leucine metabolism.<br>References Tanaka, K. et al.: J. Biol. Chem., 242, 2966 (1967); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000);<br></p>

<p>Applications 3-(methyl-d3)-1H-Indole-2,4,5,6,7-d5 is the labeled analogue of 3-Methylindole (M313470), a naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor; however in lower concentrations the compound has a pleasent aroma, giving orange blossoms and jasmine their pleasing scent. It is often a component of commercial fragrances and perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009), Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009), Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009), Naskar, S., et al.: J. Chem. Res., 3, 174 (2009), Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009),<br></p>

<p>Applications D-Tyrosine-d2 is deuterium labelled D-Tyrosine (T899970). D-Tyrosine, the stereoisomer to L-Tyrosine (T899975), is an amino acid used in various organic syntheses for antibiotics. It is used in the synthesis of (-)-anisomycin, as well as BATSI (boronic acid transition state inhibitors) which act on β-lactamases. It has also been studied as an inhibitor of microbial growth on surfaces, reducing microbial attachment to hydrophillic glass and hydrophobic polypropylene surfaces.<br>References Li, Ji. et al.: Chin. Chem. Lett., 23, 647 (2012); Xu, H. et al.: Water Res., 45, 5796 (2011); Ke, W. et al.: Antimicrob. Agents Chemother., 55, 174 (2011)<br></p>

<p>Applications Guaiacol-beta-D-glucopyranoside, is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications Cucumopine is used in biological studies to evaluate Agrobacterium rhizogenes cucumopine strain T-DNA ORF8 and its effects on transgenic tobacco root cultures.<br>References Bonfill, M., et al.: Curr. Top. Plant Biol., 3, 223 (2002);<br></p>

<p>Applications 1-(3,4-Dimethylphenyl)-3-methyl-1H-pyrazol-5(4H)-one is a reagent used in the enantioselective aminoalkylation of pyrazol-3-ones.<br>References Carceller-Ferrer, L. et al.: Org. Biomol. Chem., 17, 9859 (2019);<br></p>

<p>Applications N-Acetylglycine-d5 is an isotopic analog of N-Acetyl-glycine (A178260), a derivative of Glycine (G615990). It is an intermediate used to synthesize rac 3-O-Methyl DOPA (M303805) which is an impurity of Levodopa.<br>References Tabar, et al.: Pharmacol. Biochem. Behav., 33, 139 (1989), De Souza Silva, et al.: J. Neurochem., 68, 233 (1997), Feigin, A., et al.: Neurology, 57, 2083 (2001), Perera, A., et al.: J. Labelled Comp. Radiopharm., 46, 389 (2003),<br></p>

<p>Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105<br></p>

<p>Stability Hygroscopic<br>Applications Trigonelline-d3 HCl is deuterium labelled Trigonelline HCl. Trigonelline HCl has utility in developing site-specific system that delivers drugs to the brain. It has also been suggested as a potential anti-Alzheimer disease agent.<br>References Bodor, N., et al.: J. Med. Chem 26, 313 (1983); Makowska, J., et al.: J. Chromatogr. B 968, 101 (2014)<br></p>

<p>Applications N-(Carboxymethyl)-N-[2-[(carboxymethyl)amino]ethyl]-glycine Calcium Salt Hydrate is an intermediate used to prepare copper alkylenediaminetriacetic acid complexes.<br>References Matovic, Z., et al.: Inorganica Chimica Acta, 360, 2420 (2007)<br></p>

<p>Applications 2-Methyl-7-methylamino-8-nitro-quinoxaline (cas# 78411-55-9) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications 2-Methyl-2-propen-1-ol has been used in the synthesis of C2-methyl-1,2-di-O-hexadecylglycerophosphocholine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bittman, R., Witzke N.M.: Chem. Physics Lipid, 50, 99 (1989)<br></p>

<p>Applications Intermediate for the preparation of Naratriptan and other indole sulfonamide derivatives.<br></p>

<p>Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethametsulfuron-methyl Sodium Salt, a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Applications Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.<br>References Li, X., et. al.: Lett. Org. Chem., 12, 217 (2015); Vallu, V., et. al.: Anal. Chem. Indian J., 14, 339 (2014); Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993); Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003); Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005); Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005)<br></p>

<p>Applications N-(4-Bromo-2-methylphenyl)-2-chloroacetamide (cas# 96686-51-0) is a useful research chemical.<br></p>

<p>Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.<br></p>

<p>Applications L-Lysine L-Malate is used in the preparation of amino acid ionic liquids for use in food and medical field.<br></p>

<p>Stability Hygroscopic<br>Applications Used as a substrate for methionine adenosyltransferase from rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lombardini, J.B., et al.: Biochem. Pharmacol., 32(3), 489 (1983), Kajander, E., et al.: Cancer Res., 46 (6), 2866 (1986), Kajander, E., et al.: Biochem. J., 267 (3), 767 (1990)<br></p>

<p>Applications 8-Methoxycarbonyloctanoic Acid (cas# 2104-19-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-Methylcatechol is a potent inducer of nerve growth factor (NGF) synthesis in vitro and in vivo.<br>References Kaechi, K., et al.: J. Pharmacol. Exp. Ther., 272, 1300 (1995); Hanaoka, Y., et al.: J. Neurol. Sci., 122, 28 (1994)<br></p>

<p>Applications N-Methyl-d3-formamide (CAS# 87955-92-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Bromo-5-methoxypyridine<br></p>

<p>Applications It is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications 2-(3,4-Diethoxyphenyl)ethanamine is a useful intermediate in the preparation of Drotaverine hydrochloride, an antispasmodic drug arising from papaverine class of biologically active compounds.<br>References Turks, M., et al.: Rigas Tehniskas Universitates Zinatniskie Raksti, Serija 1: Materialzinatne un Lietiska Kimija, 23, 107 (2011)<br></p>

<p>Stability Hygroscopic<br>Applications 1-(2-Methoxyphenyl)piperazine Hydrobromide is a useful reagent for improving the synthesis of Eapidil.<br>References Wang, H., et al.: Anhui Huagong, 37, 23 (2011)<br></p>

<p>Applications 2,6-Di-tert-butyl-4-methyl-d3-phenol (CAS# 86819-59-2) is a useful isotopically labeled research compound. This compound has been shown to significantly have lower toxic potency in mice compared to butylated hydroxytolune (BHT).<br>References Mizutani, T., et.al., Toxicol. Appl. Pharmacol. 69,283-290,(1983);<br></p>

<p>Applications L-Aspartyl-L-phenylalanine is an impurity of Thiamine (T344185). Thiamine Impurity B.<br>References Aluwihare, L., et al.: Science, 308, 1007 (2005), Koch, B., et al.: Anal. Chem., 79, 1758 (2007), Reemtsma, T., et al.: Environ. Sci. Technol., 42, 1430 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Chlorobutanol is used as a preservative and sedative. It has also been shown to exhibit antibacterial properties.<br>References Dutta, T., et al.: PCT Int. Appl., 22, (2020); Ibibia, E., et al.: Asian. J. Pharm. Clin. Res., 9, 179-182 (2016)<br></p>

<p>Applications 1-Methyl-1h-1,2,4-triazol-3-amine (cas# 49607-51-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline is a useful reagent to prepare benzofuranyl derivatives for treating solid tumours. It is also an impurity of Bosutinib.<br>References Hennequin, L. F. A. PCT Int. Appl. (2003), WO 2003047585 A1 20030612 (2003); Hennequin, L. F. A., Gibson, K. H., Foote, K. M. PCT Int. Appl. WO 2003047582 A1 20030612 (2003)<br></p>

<p>Applications 2-ethyl-6-methylpyrazine (cas# 13925-03-6) is a useful research chemical.<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Applications H-PRO-GLU-OH (cas# 67644-00-2) is a useful research chemical.<br></p>

<p>Applications 1-(4-Methoxyphenyl)piperazine (cas# 38212-30-5) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-Pentanoic acid is a useful building block for organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Labelled L-Glucose is the enantiomer of D-Glucose (G595000), a naturally occurring carbohydrate used in an abundance of cellular processes. L-Glucose is a synthetic sugar used in the formation of L-Glucose Pentaacetate (G596510), a potential therapeutic agent regarding type II diabetes. In addition, L-glucose can be used as a colon cleansing agent for before a colonoscopy procedure.<br>References Malaisse, W. et al.: Int. J. Mol. Med., 2, 383 (1998); Raymer, G. et al.: Gastrointest. Endosc., 58, 30 (2003); Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009),<br></p>

<p>Applications 1-Methyl-4-nitropyrrole-2-carboxylic Acid is used in the synthesis of Lexitropsin and distamycin analogs with antimicrobial activities.<br>References Anthony, N., et al.: J. Med. Chem., 50, 6116 (2007); Khalaf, A., et al.: J. Med. Chem., 47, 2133 (2004)<br></p>

<p>Applications 2-Methoxy-3-methylaniline is an important building block.<br></p>

<p>Applications Isotope labelled 2-Chloro-2-methylpropane is a starting molecule to carry out nucleophilic substitution reactions.<br>References Eyet, N., et al.: J. Phy. Chem. A., 117, 1136 (2013); Eyet, N., et al.: J. Am. Mass. Spec., 18, 1046 (2007);<br></p>

<p>Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>

<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications N-t-Boc-2-bromoethylamine (Technical grade, ~90%) (cas# 39684-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications (2E)-3-Methyl-1,3-benzothiazol-2(3H)-one Hydrazone Hydrochloride is used in method for synthesizing Methylbenzothiazolinone Hydrazone Hydrochloride Hydrate.<br>References Chen, W., et al.: Faming Zhuanli Shenqing, (2020);<br></p>

<p>Applications 4-methoxy-3-methylaniline (cas# 136-90-3) is a useful research chemical.<br></p>

<p>Applications 2-Oxo-3-methylbutanoic acid (cas# 759-05-7) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 1,3,5-Trimethoxy-2-methylbenzene AldrichCPR (cas# 14107-97-2) is a useful research chemical.<br></p>

<p>Applications Methyl 4-Methyl-3-hydroxybenzoate is used in the preparation of potent antimalarial agents. Also used in the preparation of aromatic inhibtors of anthranilate synthase.<br>References Fattorusso, C. et al.: J. Med. Chem., 51, 1333 (2008); Payne, R. et al.: Org. biomol. Chem., 3, 3629 (2005);<br></p>

<p>Applications 2-Methoxyresorcinol (cas# 29267-67-2) is a compound useful in organic synthesis.<br></p>