Amino Acids (AA)

<p>Applications Tetrahydro-5-methyl-2-furanol is an intermediate in synthesizing 2,3-Dihydro-2-methylfuran (D447355), which is a general reagent used in next generation of biofuels. Dihydrofuranyl derivative.<br>References Simmie, J. et al.: J. Phys Chem., 116, 4528 (2012);<br></p>

<p>Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.<br></p>

<p>Applications A well-known, highly active stimulant of cell divisions in plant tissue cultures.<br>References D.S. Letham: Phytochemistry, 12, 2445 (1973)<br></p>

<p>Applications 5-Methylfurfural is a common chemical reagent used in a wide variety of chemical reactions and organic synthesis. Polycyclic pyridazine based derivatives are synthesized with this compound to form antimicrobial agents. Also used in the preparation of antiinflammatory diarylpentanoid analogues.<br>References Deeb, A. et al.: Eur. Chem. Bull., 3, 897 (2014); Leong, S. et al.: Molecules, 19, 16058 (2014);<br></p>

<p>Applications Sodium 2,2'-Methylene-bis(4,6-di-tert-butylphenyl)phosphate is an organophosphate nucleating agent.<br>References Li, J., et al.: Suliao, 43, 47-50 (2014);<br></p>

<p>Applications 2-Amino-3-methylpyridine is used in the synthesis of ketones from aldehydes.<br>References Jun, C. et al.: J. Org. Chem., 62, 1200 (1997); Jun, C. et al.: Angew. Chem. Int. Ed., 37, 145 (1998);<br></p>

<p>Applications A derivative of imidazole used in the synthesis of heteroxanthine.<br>References Sarasin, J., et al.: Helv. Chim. Acta, 7, 713 (1924),<br></p>

<p>Applications N-PHENYL-4-METHOXYBENZYLAMINE (cas# 3526-43-0) is a useful research chemical.<br></p>

<p>Applications 2-Methoxytetrahydrofuran is a reactant in the preparation of ruthenium(III) chloro benzimidazolylmethylamine derivative complexes as oxidation catalysts.<br>References Murali, M., et. al.: Eur. J. Inorg. Chem., 22, 3238 (2009)<br></p>

<p>Applications An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia.<br>References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),<br></p>

<p>066621 - 5-Amino-4-oxopentanoic acid hydrochloride</p>

<p>Applications 3'-Methylacetophenone is a reagent that is used in the preparation of 3-aryl-6-phenylimidazo[2,1-b]thiazoles which has anticancer properties.<br>References Koppireddi, S., et al.: Bioorg. Med. Chem. Lett., 24, 5428 (2014);<br></p>

<p>Applications Threonine derivative used in the synthesis of peptide.<br>References Dekker, C.A., et al.: J. Biol. Chem., 180, 155 (1949),<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate (cas# 41468-25-1) is a useful research chemical.<br></p>

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled derivative of Dibarbituric acid.<br>References Hitchings, G.H., et al.: J. Biol. Chem., 177, 357 (1949),<br></p>

<p>Impurity Cyclobenzaprine USP Related Compound A<br>Applications 5-Hydroxy-N-methylprotriptyline acts as a reducing agent in chemical reactions. Cyclobenzaprine USP Related Compound A.<br>References Gribble, G. et al.: Synthesis., 3, 172 (1977);<br></p>

<p>Applications 2-Methoxybenzoic Acid is used in the preparation of benzohydroxamic acids as potent and selective anti-hepatitis C virus (HCV) agents.<br>References Kozlov, M.V., et al.: Bioorg. Med. Chem. Lett., 23, 5936 (2013)<br></p>

<p>Applications Used in the synthesis of DMPO-type spin traps.<br>References Konaka, R., et al.: Free Radical Res., 23, 15 (1995),<br></p>

<p>Impurity Ondansetron EP Impurity C<br>Applications 1,2,3,9-Tetrahydro-9-(methyl-d3)-4H-carbazol-4-one (Ondansetron EP Impurity C) is used in the preparation of 5-HT3 modulators useful in the treatment and prevention of 5-HT3 receptor-mediated diseases. 1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one is an impurity of Ondansetron (O655000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huang, W. et al.: Zhong. Yao. Dax. Xueb., 30, 1 (1999); Kim, M. et al.: Heterocycles, 45, 2041 (1997); Feng, R. et al.: Zhong. Yaox. Zaz., 46, 1436 (2011);<br></p>

<p>Stability Temperature Sensitive<br>Applications Precursor of Diazomethane. It has a cytotoxicity effect.This product contains an undetermined amount of water.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huggins, C., et al.: J. Exp. Med., 131, 321 (1970), Gullino, P.M., et al.: J. Natl. Cancer Inst., 54, 401 (1975),<br></p>

<p>Impurity Azathioprine EP Impurity C<br>Applications 5-Chloro-1-methyl-4-nitroimidazole (cas# 4897-25-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3,3’-Methylimino-di-propionitrile (cas# 1555-58-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications Isotope labelled 1,6-Anhydro-β-D-glucopyranose (A648100), an compound that have been proven to be a valuable synthon for the preparation of various biologically important and structurally diverse products (e.g. rifamycin S, indanomycin, thromboxane B2, (+)-biotin, tetrodotoxin, quinone, and macrolide antibiotics) as well as for modified sugars.<br>References Fraser-Reid, B., et al. J. Am. Chem. Soc. 106, 731 (1984); Edwards, M.P., et al. J. Org. Chem. 49, 3503 (1984); Kelly, A.G., and Roberts, J.S. J. Chem. Soc., Chem. Commun. 228, (1980); Ogawa, T., et al. Carbohydr. Res. 57, C31 (1977); Isobe, M., et al. Tetrahedron Lett. 28, 6485 (1987);<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol-13C3 is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues. Refer to M330235.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications 2,4-Dinitrophenylhydrazone (DNPH) derivative.<br>References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),<br></p>

<p>Applications L-Carnitine-d9 is the isotope labelled analog of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthesized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications: (3,5-Di-tert-butyl-4-methoxyphenyl)boronic acid (cas# 233584-42-4) is a useful research chemical.<br></p>

<p>Stability Light Sensitive, Volatile<br>Applications Labelled 2-Methylfuran (M305440). 2-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>

<p>Applications Labelled 2-Methylbutyrylglycine (M294340). 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications Fmoc-L-cysteic acid (cas# 751470-47-0) is a useful research chemical for organic synthesis and other chemical processes.<br>References Dialer, L. O., et al.: J. Med. Chem., 56, 7552 (2013); Revell, J. D., et al.: Tetrahedron, 63, 8420, (2007)<br></p>

<p>Stability Moisture Sensitive<br>Applications 4-chloro-5-fluoro-2-methoxypyrimidine (cas# 1801-06-5) is a useful research chemical.<br></p>

<p>Applications N-Methyl-L-alanine is a reactant used in the preparation of site-specific trastuzumab maytansinoid antibody-drug conjugates with improved therapeutic activity.<br>References Pillow, T.H., et. al.: J. Med. Chem., 57, 7890 (2014)<br></p>

<p>Applications 1-Methyl-2-pyrrolidinone-d9 is labeled 1-Methyl-2-pyrrolidinone (M326120), which is a versatile industrial solvent. NMP is currently approved for use only in veterinary pharmaceuticals. The determination of the disposition and metabolism of NMP in the rat will contribute toward understanding the toxicology of this exogenous chemical which man may likely be exposed to in increasing amounts.<br>References Southwell, D., et al.: J. Pharm. Pharmacol., 33, 3 (1981), Barry, W., et al.: J. Invest. Dermatol., 82, 49 (1984),<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications DL-Homocysteine-d4 is used in the detection of the biosynthetic pathway for the formation of volatile aroma compound 2-methyltetrahydrothiophen-3-one by the bacterium Chitinophaga.<br>References Nawrath, T., et al.: ChemBioChem., 11, 1914-1919 (2010)<br></p>

<p>Applications N-(2-Methyl-1-phenylpropan-2-yl)acetamide is a byproduct from the preparation of benzolactams by palladium-catalyzed carbonylation of arylethylamines and α-amino benzenepropanoates.<br>References Lopez, B., et al.: Chem. Commun., 47, 1054 (2011); Albert, J., et al.: Organometallics, 32, 649 (2013);<br></p>

<p>Applications L-Allo-isoleucine-d10 is a derivative compound of L-allo-isoleucine (A548200), which has been suggested to induce epithelial β-defensin expression. In addition, L-allo-isoleucine is utilized in the biosynthesis pathway for coronamic acid.<br>References Fehlbaum, P., et al.: Proc. Natl. Acad. Sci. USA 97, 12723 (2000); Parry, R. J., et al.: J. Am. Chem. Soc. 113, 1849 (1991)<br></p>

<p>Applications 2-Methoxyphenylsulfate is used in the analysis of alkylsulfatases and their kinetics.<br>References Bateman, T. et al.: Biochem. J., 236, 401 (1986);<br></p>

<p>Stability Hygroscopic<br>Applications A potential inhibitor of glutamate carboxypeptidase.<br>References Wolcott, T.G., et al.: Biochem. Biophys. Res. Commun., 57, 709 (1974), Knowles, P.F., et al.: Eur. J. Biochem., 114, 139 (1981),<br></p>

<p>Applications 3-Methoxypropanoic acid<br></p>

<p>Applications 2-amino-5-butyl-6-methylpyrimidin-4(3H)-one (cas# 4038-64-6) is a useful research chemical.<br></p>

<p>Applications Norvaline, a hydrogen analogs of an amino acid, was found to be racemates from the Murchison meteorite show. Norvaline was used in chiral separation by electrokinetic chromatography.<br>References Cronin, J., et al.: Science, 275, 951 (1997); Pizzarello, S., et al.: Geochim. Cosmochim. Acta., 64, 329 (2000); Gerabe, S., et al.: J. Chromatogr., 480, 403 (1989);<br></p>

<p>Applications alpha-Methylene-gamma-valerolactone (cas# 62873-16-9) is a useful research chemical.<br></p>

<p>Applications 4-Methyl-2(5H)-furanone (cas# 6124-79-4) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Labelled 3-Aminoisobutyric Acid (A611585). Substituted β-alanines. Used for preparation and isolation of D(-)-β-aminoisobutyric acid.<br>References Kakimoto, Y., et al.: J. Biol. Chem., 236, 3288 (1961),<br></p>

<p>Stability Hygroscopic<br>Applications A novel labelled metabolite of Butadiene monoepoxide (BMO), a mutagen and carcinogen compound.<br>References Cheng, X., et al.: Drug Metab. Dispos., 21, 121 (1993), Nieusma, J., et al.: Chem. Res. Toxicol., 10, 450 (1997),<br></p>

<p>Applications 2-Cyano-N-methylacetamide is used in the synthesis of pyridone compounds and benzimidazoles, for various pharmaceutical application.<br>References Mijin, D. et al.: Synth. Comm., 36, 193 (2006); Grimmett, M. et al.: Sci. Synth., 12, 529 (2002); Aggarwal, V. et al.: Synth. 3, 214 (1982);<br></p>

<p>Applications 6-Methyl-2-heptanol is an intermediate used to prepare tri- and tetrasubstituted imidazoles as highly potent and specific ATP-​mimetic inhibitors of p38 MAP kinase.<br>References Laufer, S., et al.: J. Med. Chem., 51, 4122 (2008)<br></p>