Amino Acids (AA)

<p>Applications An antibody agent.<br>References Rowell, F. J., et al.: Immunochemistry, 13, 891 (1976),<br></p>

<p>Stability Volatile<br>Applications Labelled 3-Methylfuran (M305443). 3-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>

<p>Impurity Esomeprazol EP Impurity A/ Omeprazole EP Impurity A<br>Applications 5-Methoxy-2-mercaptobenzimidazole (Esomeprazol EP Impurity A) is used in the synthesis of COX-2 inhibitors<br>References Frechette, S., et al.: Bioorg. Med. Chem. Lett., 18, 1502 (2008), Zhang, R., et al.: Eur. J. Med. Chem., 44, 3771 (2009),<br></p>

<p>Applications β-Alanine-13C3,15N is the isotope labeled analogue of β-Alanine (A637320), which is a naturally occurring beta amino acid. β-Alanine is formed in vivo by the degradation of Dihydro Uracil (D449990) and Carnosine. β-Alanine is also the rate-limiting precursor of Carnosine, as a result supplementation with β-Alanine increases the concentration of Carnosine in muscles.<br>References Derave, W. et al.: J. Appl. Physiol., 103, 1736 (2007); Xia, J.-F. et al.: J. Chrom. B Anal. Technol. Biomed. Life Sci., 977, 1930 (2009); Artioli, G.G. et al.: Med. Sci. Sports Exer.,42, 1162 (2010);<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Norvaline, a hydrogen analogs of an amino acid, was found to be racemates from the Murchison meteorite show. Norvaline was used in chiral separation by electrokinetic chromatography.<br>References Cronin, J., et al.: Science, 275, 951 (1997); Pizzarello, S., et al.: Geochim. Cosmochim. Acta., 64, 329 (2000); Gerabe, S., et al.: J. Chromatogr., 480, 403 (1989);<br></p>

<p>Stability Hygroscopic<br>Applications 2-(N-Methyl-2-pyrrolidinyl)ethyl Chloride is an intermediate used in the synthesis of reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxcity.<br>References Zhu, S.J., et al.: Bioorg. Med. Chem., 14, 3131 (2006); Tanaka, N., et al.: Chem. Pharma. Bull., 48, 245 (2000);<br></p>

<p>Applications 2,3-Diethyl-5-methylpyrazine-N4-oxide (cas# 1076200-01-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.<br></p>

<p>Applications 2-(Acetylamino)-3-(phenylthio)propanoic acid is a useful chemical in research.<br></p>

<p>Applications 3-Methyl-2-furoic Acid-d is a deuterated version of 3-Methyl-2-furoic Acid (M219553), a useful reactant in the synthesis of therapeutic agents.<br>References Dragovich, Peter S., et al.: Bioorg. &amp; Med. Chem. Let., 24(3), 954-962 (2014);Garcia-Barrantes, Pedro M., et al.: J. of Med. Chem., 58(20), 7959-7971 (2015)<br></p>

<p>Applications 1-[1-(2-methoxyethyl)piperidin-3-yl]methanamine (cas# 936940-49-7) is a useful research chemical.<br></p>

<p>Applications Benzamide, 2,2'-dithiobis[N-methyl- (cas# 2527-58-4) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-2-methylaniline Hydrochloride (cas# 3165-93-3) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Methyldiethanolamine-13C,d3 Hydrochloride is isotopically labelled salt form of N-Methyldiethanolamine (M301625), which is used as a reagent in the synthesis of broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. It is also used as a reagent in the synthesis of dihydroxy quaternary ammonium salts with long chain alkyl bromides that can exhibit antibacterial and antifungal activity.<br>References Pascual, A., et al.: Biomacromolecules, 16, 1169 (2015); Liu, W., et al.: Chem. Biol. Drug Des., 85, 91 (2015);<br></p>

<p>Applications N-Methyl-p-tyramineúHCl (cas# 370-98-9) is a useful research chemical.<br></p>

<p>Applications 4-Methylfluorene is a polycyclic aromatic hydrocarbon that has been found to be emitted by wastewater treatment facilities.<br>References Zhang, W., et. al.: Sci. Total Environ., 432m 396 (2012)<br></p>

<p>Applications δ-Valerolactam-d4 is a labeled analog of δ-Valerolactam (V091440), which is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.<br>References Potts, K., et al. J. Org. Chem., 58, 5040 (1993); Klibanov, O., et al.: Curr. Opinion Invest. Drugs, 11, 940 (2010);<br></p>

<p>Applications 4-Chloro-2-methoxyphenol is used as a reagent in the synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonists which may be used in development of treatment against autoimmue diseases and viral infections. Also used in the synthesis of novel inhibtors of P. falciparum enoyl-ACP-reductase which may be used in treatment of malaria.<br>References Guerrero, M., et al.: Bioorg. Med. Chem. Lett., 22, 537 (2012); Belluti, F., et al.: J. Med. Chem., 56, 7516 (2013);<br></p>

<p>Applications 5'-O-Methylthymidine (cas# 14504-60-0) is a useful research chemical.<br></p>

<p>Impurity Levothyroxine beta-Hydroxy Impurity / Levothyroxine beta-Hydroxy T4 Impurity<br>Applications It has been prepared for testing as possible antithyroid. It showed some thyromimetic activity.<br>References Wawzone, S., et al.: J. Med. Chem., 6, 442 (1963),<br></p>

<p>Applications 2-Methylbutyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several “inborn errors of metabolism” (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Stability Unstable in methanol solution<br>Applications 4-Chloro-2-methylphenol Sulfate Sodium Salt is a halogenated derivative of o-toluenesulfonate, present in landfill leachates. o-Toluenesulfonate is an analog of the strong organic acid p-Toluenesulfonate.<br>References Riediker, S. et al.: Environ. Sci. Tech., 34, 2156 (2000);<br></p>

<p>Applications Methyl 5-(Ethylsulfonyl)-2-methoxybenzoate (cas# 62140-67-4) is a useful research chemical.<br></p>

<p>Applications 3-Methylbutyric-2,2-d2 Acid (CAS# 95927-02-9) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications (S)-(+)-2-Methylbutyric Acid is a chiral starting reagent used in various synthetic preparations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neves, F., et al.: Beilstein. J. Org. Chem., 7, 1504 (2011); King, A.M., et al.: J. Medn. Chem., 54, 6432 (2011); Ferrarni, A., et al.: Chirality., 26, 9 (2011);<br></p>

<p>Applications A labelled metabolite of Crotonaldehyde.<br>References Gray, J.M., et al.: Xenobiotica, 1, 55 (1971), Chung, F., et al.: Mutat. Res., 424, 71 (1999), Smith, C., et al.: Food Chem. Toxicol., 38, 637 (2000), Pan, J., et al.: Chem. Res. Toxicol., 15, 367 (2002),<br></p>

<p>Applications N-t-Boc-2-bromoethylamine (Technical grade, ~90%) (cas# 39684-80-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Fmoc-L-cysteic acid (cas# 751470-47-0) is a useful research chemical for organic synthesis and other chemical processes.<br>References Dialer, L. O., et al.: J. Med. Chem., 56, 7552 (2013); Revell, J. D., et al.: Tetrahedron, 63, 8420, (2007)<br></p>

<p>Applications (±)-3-Amino-iso-butyric-2,3,3-d3 Acid is the labeled version of DL-3-Aminoisobutyric Acid (A603043(P)), which is a useful compound for suppressing atherosclerosis in apolipoprotein E-knockout mouse.<br>References Shimba, Y., et al.: Bio. Pharma. Bull., 43, 1016 (2020)<br></p>

<p>Applications Boc-4-azido-L-phenylalanine is used in the development of visible fluorogenic dyes for cellular imaging.<br>References Qi, Jianjun., et al.; Bioconjugate Chem., 22, 1758 (2011);<br></p>

<p>Applications 2,4-Dinitrophenylhydrazone (DNPH) derivative.<br>References Lindsay, R.C., et al.: J. Food Sci., 29, 266 (1964),<br></p>

<p>Applications 2-Amino-5-methylpyridine (cas# 1603-41-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Francotte, P., et al.: Bioorg. Med. Chem., 16, 9948 (2008), Sundaraganesan, N., et al.: J. Mol. Struc., 891, 284 (2008), Caleta, I., et al.: J. Med. Chem., 52, 1744 (2009),<br></p>

<p>Applications 3-(methyl-d3)-1H-Indole-2,4,5,6,7-d5 is the labeled analogue of 3-Methylindole (M313470), a naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor; however in lower concentrations the compound has a pleasent aroma, giving orange blossoms and jasmine their pleasing scent. It is often a component of commercial fragrances and perfumes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009), Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009), Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009), Naskar, S., et al.: J. Chem. Res., 3, 174 (2009), Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009),<br></p>

<p>Applications 1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester is a useful research chemical for organic synthesis and other chemical processes.<br>References Lewis, R. T., et al.: From PCT Int. Appl. (2017), WO 2017004359 A1 20170105<br></p>

<p>Applications Ethametsulfuron-methyl Sodium Salt, a regulator of the early steps of complement activation on mucosal surfaces. It can be used in combination treatment of ohmic heating with various essential oil components for inactivation of food-​borne pathogens in buffered peptone water and salsa.<br>References Kim, S. S., et al.: Food Control, 80, 29 (2017); Reichhardt, M. P., et al.: Front Immunol, 7, 85 (2016)<br></p>

<p>Stability Light Sensitive<br>Applications 4-Methoxyphenylhydrazine hydrochloride was used in the preparation of 5-cyano-3-(5-methoxy-2-methylindol-3-yl)-1,2,4-thiadiazole. It was also used to synthesize diarylpyrazoles as possible cyclooxygenase 2 ((COX-2)) inhibitors.<br>References Iwakawa, T., et al.: Chem. Pharm. Bull., 48, 160 (2000); Penning, T., et al.: J. Med. Chem., 40, 1347 (1997)<br></p>

<p>Applications 4-Methylmorpholine is used in the synthesis of novel and selective TYK2 inhibitors, used in the treatment of inflammatory diseases. Also used in the preparation of cathespin K inhibitors which are highly selective.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liang, J. et al.: Eur. J. Med. Chem., 67, 175 (2013); Yuan, X. et al.: Org. Biomol. Chem., 11, 5847 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications 3-Methyl-diazirine-3-propanoic Acid is a reagent used in crosslinking sugars and photoactivatable crosslinking.<br>References Tanaka, Y. et al.: J. Am. Chem. Soc., 130, 3278 (2008);<br></p>

<p>Applications Labelled DL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.<br>References Tanaka, M. et al.: Bioorg. Med. Chem., 21, 1159 (2013);<br></p>

<p>Applications Isopropyl 2-bromo-2-methylpropanoate (cas# 51368-55-9) is a useful research chemical.<br></p>

<p>Applications 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine is used to prepare ppGpp analogs as inhibitors of RelA from Gram-negative/-positive bacteria. It is also used to synthesize guanosine 5'-conjugates as initiator molecules for transcription priming.<br>References Wexselblatt, E., et al.: Bioorg. Med. Chem., 18, 4485 (2010); Wolf, J., et al.:Org. Biomol. Chem., 6, 899 (2008)<br></p>

<p>Applications 2-hydroxy-3-methylpentanoic acid (cas# 488-15-3) is a useful research chemical.<br></p>

<p>Applications 2-Hydroxy-2-methylpropanamide (cas# 13027-88-8) is a useful research chemical.<br></p>

<p>Applications Labelled Isoferulic Acid 3-O-β-D-Glucuronide, the glucuronide conjugate of Isoferulic Acid (H946180). Isoferulic Acid 3-O-β-D-Glucuronide is one of the circulating metabolites in human plasma after coffee consumption.<br>References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications 1-(2-Isopropylthiazol-4-yl)-N-methylmethanamine dihydrochloride (cas# 1185167-55-8) is a useful research chemical.<br></p>

<p>066621 - 5-Amino-4-oxopentanoic acid hydrochloride</p>

<p>Stability Very Hygroscopic<br>Applications A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells.<br>References Vallence, P., et al.: Lancet, 339, 572 (1992),<br></p>

<p>Stability Hygroscopic<br>Applications L-Ornithine is a non-essential amino acid for human development but is required intermediate in arginine biosynthesis. L-Ornithine is found in virtually all vertebrate tissues as well as incorporated into proteins, such as tyrocidine. Isolation from chicken excreta.<br>References Fattori, D., et al.: J. Med. Chem., 50, 550 (2007), Gomez-Alonso, S., et al.: J. Agric. Food Chem., 55, 608 (2007), Subramaniam, R., et al.: Bioorg. Med. Chem. Lett., 18, 3333 (2008),<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Glycidoxypropyltrimethoxysilane (cas# 2530-83-8) is a useful research chemical.<br></p>

<p>Applications D-Glutamic acid 1-tert-butyl ester is a protected form of D-Glutamic acid (G596965). D-Glutamic acid is an unnatural isomer of L-Glutamic acid (G596960), and is found in bacterial cell wall peptidoglycan of gram-positive and gram-negative bacteria. D-Glutamic acid also occurs as poly-gamma-Glutamic acid, which is a weak immunogen but is capable of acting as a hapten (a small molecule that induces the production of antibodies, as well as binding to them).<br>References Dougherty, T., et al.: J. Bacteriol., 175, 111 (1993); Goodman, J. &amp; Nitecki, D.: Immunology, 13, 577 (1967); Robinson, T.: Life Sci., 19, 1097 (1976)<br></p>

<p>Applications Perfluoro-3-methoxypropanoic acid (cas# 377-73-1) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Derivative of monoenoic and trienoic analogs of Sorbic Acid with antifungal activity.<br>References Guerin, J. et al.: Annales Pharmaceutiques Francaises 44, 373 (1987)<br></p>

<p>Applications cis-Propenylphosphonic Acid (R)-(+)-α-Methylbenzylamine Salt is used as a reagent in the microbial production of Fosfomycin (F727505); a compound used as an antibiotic in the treatment of urinary tract infections.<br>References Watanabe, M., et al.: Appl. Environ. Microb., 65, 1036 (1999); Itoh, N., et al.: Appl. Microbiol. Biot., 43, 394 (1995); White, R.F., et al.: Appl. Microbiol., 22, 55 (1971); Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013)<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>

<p>Applications 3-Methoxy-2',4',6',4-tetrahydroxychalcone piperidine complex (cas# 52218-19-6) is a useful research chemical.<br></p>

<p>Applications 2-Methoxytetrahydrofuran is a reactant in the preparation of ruthenium(III) chloro benzimidazolylmethylamine derivative complexes as oxidation catalysts.<br>References Murali, M., et. al.: Eur. J. Inorg. Chem., 22, 3238 (2009)<br></p>

<p>Applications 12-(t-Boc-amino)-1-dodecanol (cas# 67341-03-1) is a compound useful in organic synthesis.<br></p>