Amino Acids (AA)

<p>Applications H-D-Ala-D-Leu-OH (cas# 67392-69-2) is a useful research chemical.<br></p>

<p>Applications AMMONIUM PERFLUORO(2-METHYL-3-OXAHEXANOATE) (cas# 62037-80-3) is a useful research chemical.<br></p>

<p>Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.<br>References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);<br></p>

<p>Stability Very Hygroscopic<br>Applications A component of elastin. It can be measured in all body fluids as biomarkers for in vivo degradation of matrix tissue elastin in man and animals.<br>References Sato, F., et al.: Clin. Biochem., 39, 746 (2006), Koenders, M., et al.: J. Pathol., 218, 446 (2009), Ma, S. et al.: J. Chrom. Anal. Tech. Biomed. Life Sci., 879, 1893 (2011),<br></p>

<p>Applications 3-Methylbutyl Acetate-d3 (CAS# 1219804-75-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2-(3-Methoxyphenoxy)propanoic acid<br></p>

<p>Applications N-Cbz-L-aspartic acid is an N-Cbz-protected form of L-Aspartic acid (A790024). L-Aspartic acid is a nonessential amino acid that is used to biosynthesize other amino acids within the human body. L-Aspartic acid also increases membrane conductance of mammalian neurons by voltage-dependent means, causing depolarization and nerve impulses that travel to key areas of the central nervous system.<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Honey, C., et al.: Neurosci. Lett., 61, 135 (1985); MacDonald, J., et al.: Brain Res., 237, 248 (1982)<br></p>

<p>Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Ferrous Bisglycinate is used in the fortification of infant formulations and foods.<br>References Fox, T. et al.: Am. J. Clin. Nutri., 67, 664 (1998); Heath, A. et al.: J. Am. Coll. Nutr., 20, 477 (2001);<br></p>

<p>Applications 5-methyl-2-(1H-pyrrol-1-yl)aniline (cas# 59194-21-7) is a useful research chemical.<br></p>

<p>Applications Useful for the synthesis of Biocytin containing peptides to study the mechanism of reactions catalyzed by biotin - containing enzymes.<br>References Bodanszky, M., and Fagan, D.T.: J. Am. Chem. Soc., 99, 235 (1977)<br></p>

<p>Applications L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Brandon, C. &amp; Lam, D.: Proc. Nat. Acad. Sci., 80, 5117 (1983); McDermott Jr, W., et al.: New Engl. J. Med., 253, 1093 (1955)<br></p>

<p>Applications 1-methoxypropan-2-amine hydrochloride (cas# 677743-83-8) is a useful research chemical.<br></p>

<p>Applications N-[(R)-1-Carbethoxybutyl]-(S)-alanine is an intermediate in the synthesis of Perindoprilat (P287530), an angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.<br>References Pascard, C., et al.: J. Med. Chem., 34, 663 (1991)<br></p>

<p>Applications D,L-o-Tyrosine is a metabolite of Phenylalanine (P319415). A precursor in the formation of catecholamines. Used as biomarkers of protein oxidative damage in β-thalassemia.<br>References Tsugita, A., et al.: Eur. J. Biochem., 124, 585 (1982), Nielsen, F., et al.: Clin. Chem., 43, 1209 (1997), Mates, J., et al.: Clin. Biochem., 32, 595 (1999),<br></p>

<p>Applications Ac-lys(ac)-oh was used in the reaction of HOCl with amino acids and peptides with ESR evidence for rapid rearrangement and fragmentation reactions of nitrogen-centered radicals.<br>References Hawkins, C., et al.: J. Chem. Soc. Perkin Trans. 2, 9, 1937 (1998);<br></p>

<p>Applications 3-Chloro-2-methyl-1-propene has been used in the synthesis of 2-S-substituted pyrimidines as antimetabolites of nucleic acid precursors for cancer therapy.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kaldrikyan, M.A., Melik-Ohanjanyan, R.G.: Hayastani Kimiakan Handes, 67, 321 (2014)<br></p>

<p>Applications The main metabolite of o-xylene.<br>References Gregus, Z., et al.: Drug Metab. Dispos., 26, 1082 (1998), Gregus, Z., et al.: Xenobiotica, 29, 547 (1999), Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications 2,3-Dihydroxy-2-methylbutanoic Acid Sodium Salt is a useful research chemical.<br></p>

<p>Applications Methyl 4-Methyl-3-hydroxybenzoate is used in the preparation of potent antimalarial agents. Also used in the preparation of aromatic inhibtors of anthranilate synthase.<br>References Fattorusso, C. et al.: J. Med. Chem., 51, 1333 (2008); Payne, R. et al.: Org. biomol. Chem., 3, 3629 (2005);<br></p>

<p>Applications 4-Methyl-1-[3-nitro-5-(trifluoromethyl)phenyl]-1H-imidazole, is a 4-methyl-1H-imidazole (4-MEI) derivative.<br></p>

<p>Applications 1-[1-(2-methoxyethyl)piperidin-3-yl]methanamine (cas# 936940-49-7) is a useful research chemical.<br></p>

<p>Applications 2-Methylpropylamine is used in the synthesis of arylsulfonamide inhibitors that act upon afflictions of osteoarthritis. In addition, it is used in the synthesis of novel reservatrol amide derivatives that act as anti-tumor agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Yao, Ri-Sheng. et al.: Eur. J. Med. Chem. Lett., 62, 222 (2013); Nuti, E. et al.: Eur. j. Med. Chem., 62, 379 (2013)<br></p>

<p>Applications Dl-valine<br></p>

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Applications 2-Methoxypropanol is a susbtance used in the relative parameter sensitivity in prenatal toxicity studies with substances classified as developmental toxicants. Also applied in the studies for the analysis of volatile organic compounds in cigarette packaging materials by SPME-GC/MS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rorije, E., et al.: Reprod. Toxicol., 34, 284 (2012); Hong, W, et al.: Fujian Fenxi Ceshi, 19, 24 (2010)<br></p>

<p>Applications 4-Hydroxy-4-methylhepta-1,6-diene is a compound useful in organic synthesis.<br>References Ji, X., et al.: Xiangliao Xiangjing Huazhuangpin, 4, 6 (2011)<br></p>

<p>Applications N-Acetyl-S-(2,5-dimethylbenzene)-L-cysteine-d3 (cas# 1331909-07-9) is a compound useful in organic synthesis.<br>References Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Stability Volatile<br>Applications 2-Chloro-2-Methylpentane (cas# 4325-48-8) is a useful research chemical.<br></p>

<p>Applications A non-essential amino acid found in food sources and dietary supplements. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Impurity Iohexol EP Impurity K<br>Applications 5-Amino-2,4,6-triiodoisophthalic Acid (Iohexol EP Impurity K) is an intermediate for nonionic iodinated X-ray contrast agents.<br></p>

<p>Applications Labelled L-Citrulline. An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia.<br>References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Used in the methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins. Also used in the studies on the separation and photometric determination of antiepileptics.<br>References Quednow, B., et al.: Pharmazie, 34, 724 (1979),<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Stability Air Sensitive<br>Applications 4-Chloro-2-methylaniline<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications 3-Methylglutaconic acid is a glutarate which builds up in the urine in 3-methylglutaconic aciduria. 3-methylglutaconic aciduria is a term used to describe five different disorders that impair the functioning of energy-producing centers within cells (mitochondria)<br>References Walsh, R., et al.: J. Inherit. Metab. Dis., 22, 251 (1999); Gonzalez, I., et al.: Am J Med Genet A., 134, 409 (2005); MacKenzie, J., et al.: Biochim Biophys Acta., 1772, 509 (2007)<br></p>

<p>Applications 4-Methyl-5-thiazoleethanol is used in the synthesis of novel HldE kinase inhibitors used against gram negative bacteria. Also used in the synthesis of potential antimalarial agents from bis-thiazolium analogues.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Desroy, N. et al.: J. Med. CHem., 56, 1418 (2013); Caldarelli, S. et al.: J. Med. CHem., 496, (2013);<br></p>

<p>Applications D,L-β-Chloroalanine Methyl Ester Hydrochloride (cas# 33646-31-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 3-Ethyl-2-methyl-2-(3-methylbutyl)-oxazolidine is a oxazolidine-based moisture scavenger for use in urethane coatings, sealants and elastomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 2,6-Diaminopimelic Acid is useful in biological studies involving amino acids and amino sugars as molecular indicators of the origins of organic matter in buried tephra soils.<br>References Hobara, S., et al.: Geoderma, 373, 114449 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is used as a reagent in the synthesis of N-(2-acylaminobenzyl or 2-acylaminoheterocyclylmethyl)thiophene-2-carboxamide derivatives as antithrombotics. It is also used as a reagent in the synthesis of diamide derivatives as FXa inhibitors. 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic Acid Hydrochloride is an intermediate for Edoxaban (E555520).<br>References Mochizuki, A., et al.: Jpn. Kokai Tokkyo Koho. JP 2010120852 A 20100603. Jun 3, 2010; Mochizuki, A., et al.: PCT Int. Appl. WO 2008123017 A1 20081016. Oct 16, 2008<br></p>

<p>Applications Guaiacol-beta-D-glucopyranoside, is a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications N-Methyldiethanolamine-13C,d3 Hydrochloride is isotopically labelled salt form of N-Methyldiethanolamine (M301625), which is used as a reagent in the synthesis of broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. It is also used as a reagent in the synthesis of dihydroxy quaternary ammonium salts with long chain alkyl bromides that can exhibit antibacterial and antifungal activity.<br>References Pascual, A., et al.: Biomacromolecules, 16, 1169 (2015); Liu, W., et al.: Chem. Biol. Drug Des., 85, 91 (2015);<br></p>

<p>Applications 3-Methanesulfinylpropan-1-amine is used in preparation of Amide compounds as pesticides including acaricides, insecticides, and parasiticides.<br>References Furukawa, H., et al.: Jpn. Kokai Tokkyo Koho, (2018);<br></p>

<p>Applications 5-((2-Hydroxyethyl)amino)-2-methylphenol (cas# 55302-96-0) is a useful research chemical.<br></p>

<p>Applications N-(4-Bromo-2-methylphenyl)-2-chloroacetamide (cas# 96686-51-0) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications Labelled 3-Methylfuran (M305443). 3-Methylfuran is a volatile organic compound (VOCs) used as a potential non-intrusive tool for screening of lung cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References McWilliams, et al.: Curr. Oncol. Rep., 4, 487 (2002), Buszewski, B., et al.: Biomed. Chromatogr., 21, 553 (2007), Ligor, T., et al.: J. Breath. Res., 1, 1 (2007),<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Applications 7-Methoxy-3,4-dihydro-1-naphthalenyl-acetonitrile (cas# 861960-34-1) is a compound useful in organic synthesis.<br></p>

<p>Applications 4-(4-Chloro-2-methylphenoxy-d3)butyric Acid (CAS# 1219803-42-5) is a useful isotopically labeled research compound.<br></p>

<p>Stability Temperature Sensitive, Light Sensitive<br>Applications 2-Ethyl-4-methylpentyl Acrylate<br></p>

<p>Stability Hygroscopic<br>Applications Used in peptide N-terminal amino acid determination.<br>References Prota, G., et al.: Biochimie, 53, 51 (1971),<br></p>

<p>Applications N-Acetyl-DL-aspartic acid (cas# 2545-40-6) is a useful research chemical.<br></p>

<p>Applications 2-Furoylglycine is an intermediate used to prepare non-nucleoside inhibitors of HCV NS5b RNA polymerase. It is also used in the synthesis of benzimidazolylazabicyclooctylethylpiperidines as Ccr5 antagonists for the treatment of HIV infection.<br>References Antonysamy, S., et al.: Bioorg. Med. Chem. Lett., 18, 2990 (2008); Kazmierski, W., et al.: PCT Int. Appl. (2004), WO 2004054974 A2 20040701<br></p>

<p>Applications L-Lysine L-Malate is used in the preparation of amino acid ionic liquids for use in food and medical field.<br></p>