Amino Acids (AA)

<p>Impurity Ranitidine EP Impurity H<br>Applications N-Methylnitroacetamide (Ranitidine EP Impurity H) is a degradation product of Ranitidine (R120000).<br>References Sharma, N. et al.: Sci. Pharmac., 79, 309 (2011); Haywood, P.A. et al.: J. Chem. Soc., 5, 951 (1987);<br></p>

<p>Applications 1,2-Cyclohexanedicarboxylic Acid Mono 4-Methyloctan-1-ol Ester is a possible metabolite of the di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) monoester (MINCH).<br>References Koch, H., et al.: Arch. Toxicol., 87, 799 (2013)<br></p>

<p>Applications 4-Aminobutyl-d8 Guanidine is the labelled analog of the decarboxylation product of the amino acid arginine (A769500) and also an intermediate in polyamine biosynthesis.<br>References Golding, B.T., et al.: Biochem. Soc. Trans., 22, 391S (1994);<br></p>

<p>Stability Hygroscopic<br>Applications A potential inhibitor of glutamate carboxypeptidase.<br>References Wolcott, T.G., et al.: Biochem. Biophys. Res. Commun., 57, 709 (1974), Knowles, P.F., et al.: Eur. J. Biochem., 114, 139 (1981),<br></p>

<p>Applications A protected glutamic acid for use in peptide synthesis.<br>References Takahashi, M., et al.: J. Exp. Biol., 200, 401 (1997), Michaelis, E., et al.: Prog. Neurobiol., 54, 369 (1998), Koch, H., et al.: Mol. Pharmacol., 55, 1044 (1999), O'Kane, R., et al.: J. Biol. Chem., 274, 31891 (1999),<br></p>

<p>Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.<br>References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);<br></p>

<p>Applications Butyrylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications 1,2:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose is a reagent in the synthesis of antibacterial/antifungal monosaccaride esters. Also used in the synthesis of antihyperlipidemic novel compounds involving glycosyl fructose derivatives.<br>References Shen, Y. et al.: Molecules, 17, 8661 (2012); Tiwari, P. et al.: Bioorg. Med. Chem. Lett., 16, 6028 (2006);<br></p>

<p>Applications Intermediate in the preparation of Epinephrine metabolites<br>References Mizuta, H., et al.: Bioorg. Med. Chem., 10, 675 (2002),<br></p>

<p>Applications (3-Glycidoxypropyl)triethoxysilane is used in the fabric industry to treat and modify fabrics.<br>References Schramm, Christian, et al.: Coloration Tech., 133(3), 234-242 (2017);Grancaric, Ana Marija, et al.: Pro. in Org. Coatings, 103, 174-181 (2017); Yeo, Jun-Seok, et al.: J. of Ind. and Eng. Chem., 45, 301-306 (2017)<br></p>

<p>Stability Hygroscopic<br>Applications Oleoyl-L-carnitine is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Oleoyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Adams, S., et al.: J. Nutrition, 139, 1073 (2009); Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications 4-Methoxy-3-nitrobenzonitrile<br></p>

<p>Applications A non-essential amino acid found in food sources and dietary supplements. Its conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.<br>References Errico, F. et al.: J. Neurosci., 28, 10404 (2008); Denu, J.M. et al.: Biochem., 34, 3396 (1995); Chen, P.E. et al.: Mol. Pharmacol., 67, 1470 (2005);<br></p>

<p>Applications 2-(4-methylphenyl)propan-1-ol (cas# 4371-50-0) is a useful research chemical.<br></p>

<p>Applications A Boc-protected bifunctional linking reagent.<br>References Jimenez-Castells, C., et al.: Bioorg. Med. Chem. Lett., 17, 5155 (2007), Carmona, S., et al.: Mol. Pharm., 6, 706 (2009), Nagahori, N., et al.: Biochem., 48, 583 (2009),<br></p>

<p>Applications 5-Bromo-3-methyl-2(5H)-furanone is used as a reactant in the synthesis of strigolactone analogs.<br>References Artuso, Emma, et al.: J. of Nat. Products, 78(11), 2624-2633 (2015);Jia, Kun-Peng, et al.: Mol. Plant, 9(9), 1341-1344 (2016)<br></p>

<p>Stability Hygroscopic<br>Applications 3-Methyl-2-oxovaleric acid calcium salt (cas# 66872-75-1) is a useful research chemical.<br></p>

<p>Applications N-Carbobenzoxyglycine is used in the dipeptide synthesis.<br>References Hans, D., et al.: Med. Chem., 2, 627 (2006), Guzman, F., et al.: J. Biotechnol., 10, 279 (2007), Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010),<br></p>

<p>Applications 2-[4-(2-Methylpropenyl)phenyl]propionic Acid is a byproduct of Ibuprofen (I140000(P)), which is an anti-inflammatory drug.<br>References Sharma, K., et al.: Int. J. Environ. Sci. Tech., 16, 8315 (2019)<br></p>

<p>Applications N-Jasmonyl-L-Isoleucine (Mixture of Diastereomers) is a plant horomone.<br>References Chen, Y., Chen, Z.: J. Separation Sci., 36, 892 (2013)<br></p>

<p>Applications 4-Methoxyresorcinol (cas# 6100-60-3) is a compound useful in organic synthesis.<br></p>

<p>Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.<br>References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),<br></p>

<p>Applications N-Isobutyrylglycine detection is a useful diagnostic tool in the diagnosis of many organic acidemias and mitochondrial fatty acid β-oxidation defects. N-Isobutyrylglycine detection is also used in the diagnosis of isobutyryl-CoA dehydrogenase deficiency.<br>References Costa, C. G. et al.: J. Pharmac. Biomed. Anal., 21, 1215 (2000); Bonafe, L. et al.: Mol. Gen. Metab., 69, 311 (2000); Sass, J. et al.: J. Inher. Metab. Dis., 27, 741 (2004);<br></p>

<p>Applications 3-Methoxycatechol is used to prepare polyphenolic deoxybenzoins as potential antioxidants and tyrosinase inhibitors.<br>References Ng, L., et al.: Bioorg. Med. Chem., 17, 4360 (2009)<br></p>

<p>Applications Pipecolic acid is involved in synaptic transmission in the central nervous system.<br>References Nomura Y., et al.: Neurochem. Res., 6, 391 (1981),<br></p>

<p>Stability Moisture and Temperature Sensitive<br>Applications Galacto-PUGNAc is a highly selective inhibitor for β-hexosaminidases HEXA and HEXB is cell-permeable. Galacto-PUGNAc is able to modulate the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels in neuroblastoma cells<br>References Stubbs, K.A. et al.: Angew. Chem. Int. Ed., 48, 1300 (2009);<br></p>

<p>Applications DL-Histidine-alpha,beta,beta-d3 (CAS# 344299-50-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2-Dichloro-2-methylpropane (cas# 594-37-6) is a useful research chemical.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Moisture Sensitive<br>Applications 3-Glycidoxypropyltrimethoxysilane (cas# 2530-83-8) is a useful research chemical.<br></p>

<p>Applications N-Methyl-N-nitroso-1-octadecylamine was found to present in various hair-care products when investigated through thermal energy analyzer.<br>References Morrison, J.B., et al.: Food. Chem. Toxicol., 21, 69 (1983); Rainey, W.T., et al.: Biomed. Mass. Spec., 5, 395 (1978);<br></p>

<p>Stability Light Sensitive<br>Applications trans-β-Methylstyrene is an isomer of β-Methylstyrene (M301155), a styrene derivative that is used as a chemical intermediate in the manufacture of plasticizers, resins and polymers. trans-β-Methylstyrene is also produced from the combustion of methamphetamine (M258795).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lin, H., et al.: Tetrahedron, Asym., 22, 134 (2011); Hirata, T., et al.: Tetrahedron., 54, 15993 (1998);<br></p>

<p>Stability Hygroscopic<br>Applications β-Methylamino-L-alanine Hydrochloride is a useful intermediate in the synthesis of β-N-methylamino-L-alanine and other amino acid derivatives.<br>References Arevalo-Garcia, E. B., et al.: Tetrahedron Lett., 55, 2335 (2014); Sagiyan, A. S., et al.: Hayastani Kimiakan Handes, 61, 424 (2008); Sagiyan, A. S., et al.: Russ. Chem. Bull., 46, 483 (1997)<br></p>

<p>Applications N-Acetyl-L-tyrosine is an analogue of L-tyrosine which stimulate the transport of L-Tyr, mainly by the ASC system.<br>References Jara, J. et al.: Melanoma Res., 1, 15 (1991),<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications (4-Formyl-5-hydroxy-6-methylpyridin-3-yl)methyl dihydrogen phosphate hydrate (cas# 41468-25-1) is a useful research chemical.<br></p>

<p>Applications 2-Methyl-4,6-bis(octylsulfanylmethyl)phenol (cas# 110553-27-0) is a useful research chemical.<br></p>

<p>Applications 3’,5’-Diiodo-L-thyronine is a thyroid hormone that has been shown to increase malic enzyme activity, and the activity of glucose-6-phosphate dehydrogenase in teleost Anabas testudineus. Thus, showing short term effect on lipid metabolism.<br>References Davey, K.G.: Insect Biochem. Mol. Bio., 30, 877 (2000); Shameena, B., et. al.: Endocr. Res., 26, 431 (2000)<br></p>

<p>Applications 2-Methylindoline is an intermediate in the production of various indole derivatives<br>References Severino, B., et al.: Bioorg. Med. Chem., 16, 6009 (2008); Zlotos, D., et al.: J. Med. Chem., 52, 826 (2009);<br></p>

<p>Stability Moisture Sensitive<br>Applications N-Methyl-1H-imidazole-1-carboxamide is a useful Methyl Isocyanate (MIC) substitute.<br></p>

<p>Applications 4,4'-Methylene-d2-dianiline (CAS# 215590-72-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-[1-(2-methoxyethyl)piperidin-3-yl]methanamine (cas# 936940-49-7) is a useful research chemical.<br></p>

<p>Stability Volatile<br>Applications 1-Chloro-2-methylpropene is a reagent in the synthesis of pyrrolyl and indolyl diketo acids and esters as nucleotide-competitive non-nucleoside inhibitors of terminal deoxynucleotidyl transferase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costi, R., et al.: J. Med. Chem., 56, 7431 (2013);<br></p>

<p>Applications L-Lysine-3,3,4,4,5,5,6,6-d8 Dihydrochloride, is the labelled L-Lysine, a naturally occurring amino acid which is used in the labelling of human bone marrow mesenchymal stem cells for analysis.<br>References Rocha, B. et al.: J. Prot. Res., 11, 5350 (2012); Kumar, D. et al.: Polym. J., 45, 160 (2013);<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications This compound contains up to 25% of the two other regioisiomers.<br></p>

<p>Stability Light Sensitive<br>Applications α-Methacrylic acid is used in chemistry as a stabilizing agent, forming a thin capping layer on the surface of nanoparticles. α-Methacrylic acid is also used as a surfactant, so that control is maintained during nanocrystal growth. α-Methacrylic acid is also used as a chelating agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Peng, W., et al.: J. Cryst. Growth, 279, 454 (2005); Qu, S., et al.: Appl. Phys. Lett., 80, 3605 (2002); Zhao, G., et al.: Phys. C: Supercond., 468, 2317 (2008)<br></p>

<p>Applications 4-methyl-2-(piperidin-4-yl)pyridine (cas# 1260886-47-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Guaiacol-beta-D-glucopyranoside-d3, is a labeled analogue of Guaiacol-beta-D-glucopyranoside (G245565), a Guaiacol Conjugate, that has shown to present in fermentation of grapes that had been exposed to bushfire smoke and can potentially yield unpalatable, smoke-affected wine.<br>References Hayasaka, Y.m et al.: J. Arg. Food Chem., Vol. 58, Issue 4, P: 2076; 2081 (2010);<br></p>

<p>Applications Intermediate in the production of anti-cancer quinoline derivatives and antibacterial agents<br>References Zhao, H., et al.: Bioorg. Med. Chem. Lett., 12, 3105 (2002),<br></p>

<p>Applications 3-Methyl-2-hexanamine HCl Salt is more stable and easier to purify compared to the free base.<br></p>

<p>Applications The main labelled metabolite of o-xylene.<br>References Gregus, Z., et al.: Drug Metab. Dispos., 26, 1082 (1998), Gregus, Z., et al.: Xenobiotica, 29, 547 (1999), Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications 3,5-Diiodo-DL-tyrosine is used for diagnosis of hypothyroidism caused by DEHAL1 gene defects.<br>References Encinas, S., et al.: Chem. Res. Toxicol., 11, 946 (1998), Daneshvar, A., et al.: Chemosphere, 80, 301 (2010), Eriksson, J., et al.: Photochem. Photobiol., 86, 528 (2010),<br></p>

<p>Applications 2-Hydroxy-2-methylpropanamide (cas# 13027-88-8) is a useful research chemical.<br></p>

<p>Applications Bis(4-methylpentyl) Phthalate, is a phthalic acid ester (PAEs), widely used in many consumable products with potential carcinogenic properties. It is also the product of the fermentation of Streptomyces regnesis 099.<br></p>

<p>Applications 4-(4-Methoxyphenyl)-2-butanone is also used in the synthesis of novel axially chiral Rh-NHC complexes. Used to synthesize carbonyl complexes as novel traceless linkers.<br>References Duan, W. et al.: Chem. Comm., 23, 2916 (2003); Gibson, S. et al.: Tetrahedron. Lett., 40, 1417 (1999);<br></p>

<p>Applications 1-methoxypropan-2-amine hydrochloride (cas# 677743-83-8) is a useful research chemical.<br></p>

<p>Applications H-D-Ala-D-Leu-OH (cas# 67392-69-2) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications Ferrous Bisglycinate is used in the fortification of infant formulations and foods.<br>References Fox, T. et al.: Am. J. Clin. Nutri., 67, 664 (1998); Heath, A. et al.: J. Am. Coll. Nutr., 20, 477 (2001);<br></p>