Amino Acids (AA)

<p>Applications α-(2,3-Dimethylphenyl)-α-methyl-1H-imidazole-5-methanol is used as a reagent in the synthesis of Medetomidine (M203250); an α2-adrenergic agonist. Also a sedative and analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987); Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987); Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988); Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996); Chen, W., et al.: Faming Zhuanli Shenqing. CN 101921234 A 20101222. Dec 22, 2010<br></p>

<p>Applications Felypressin(Octapressin) is a vasopressin 1 agonist and a peptide containing eight amino acids including cystine. Felypressin is used as a vasoconstrictor.<br>References Boissonnas, G., et al.: Helv. Chim. Acta, 43, 190 (1960), Farkas, D., et al.: Curr. Drug Metab., 6, 111 (2005), Elferink, M., et al.: Toxicol. Appl. Pharmacol., 229, 300 (2008),<br></p>

<p>Applications 3-Ethyl-5-(2-hydroxyethyl)-4-methylthiazolium bromide is used in the novel synthesis of benzoin catalyzed by thiazolium salts.<br></p>

<p>Applications 5-Amino-6-methylbenzimidazolone<br></p>

<p>Applications Used in the methods of detecting nitrotyrosine and aminotyrosine residues of peptides and proteins. Also used in the studies on the separation and photometric determination of antiepileptics.<br>References Quednow, B., et al.: Pharmazie, 34, 724 (1979),<br></p>

<p>Applications N-Methyltaurine can be used as a counter ion in the formation of soaps.<br>References Miyahara, Reiji, et al.: J. of Oleo Sci., 50(10), 823-830 (2001)<br></p>

<p>Applications (3R)-Tetrahydrofuran-3-yl 4-Methylbenzenesulfonate is derived from (R)-(-)-3-Hydroxytetrahydrofuran (H957760), which is a versatile chemical reactant used in the synthesis of pharmaceutical agents.<br>References Hrapchak, M., et al.: J. Labelled. Comp. Radiopharm., 57, 687 (2014);<br></p>

<p>Applications 1-AMINO-2-METHYLNAPHTHALENE (cas# 2246-44-8) is a useful research chemical.<br></p>

<p>Applications L-Anserine Nitrate Salt (cas# 10030-52-1) is a compound useful in organic synthesis.<br></p>

<p>Applications Methylpropylnitrosamine is used in biological studies as human liver microsomal cytochrome P-450 enzymes which are involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TA 1535/pSK1002.<br>References Shimada, T., et al.: Cancer Res., 48, 3218 (1989);<br></p>

<p>Applications Potassium 2-hydroxy-4-methoxybenzoate (cas# 152312-71-5) is a useful research chemical.<br></p>

<p>Applications N-Boc-L-cis-4,5-Methanoprolineamide is an intermediate used to prepare methanoprolinenitrile-contg. dipeptide mimetics as DPP-IV inhibitors and as antidiabetic agents.<br>References Magnin, D., et al.: J. Med. Chem., 47, 2587 (2004)<br></p>

<p>Applications Substrate for TenA enzyme in the thiamin salvage pathway<br>References Jenkins, A., et al.: Nat. Chem. Biol., 3, 492 (2007), Jenkins, A., et al.: Bioorg. Chem., 36, 29 (2008),<br></p>

<p>Applications L-Lysine L-Malate is used in the preparation of amino acid ionic liquids for use in food and medical field.<br></p>

<p>Applications Threonine derivative used in the synthesis of peptide.<br>References Dekker, C.A., et al.: J. Biol. Chem., 180, 155 (1949),<br></p>

<p>Applications A labelled, essential amino acid.<br>References Liu, F., et al.: Bioorg. Med. Chem., 18, 4167 (2010), Kumar, R., et al.: Eur. J. Med. Chem., 45, 2265 (2010), Cai, W., et al.: Bioorg. Med. Chem., 18, 1899 (2010),<br></p>

<p>Applications Methyl 4-Methyl-3-hydroxybenzoate is used in the preparation of potent antimalarial agents. Also used in the preparation of aromatic inhibtors of anthranilate synthase.<br>References Fattorusso, C. et al.: J. Med. Chem., 51, 1333 (2008); Payne, R. et al.: Org. biomol. Chem., 3, 3629 (2005);<br></p>

<p>Applications 3-Methyl-d3-indole has been used to prove that bioactivation of the pulmonary toxin 3-methylindole requires methyl carbon-hydrogen bond breakage in mice. 3-Methyl-d3-indole is the labeled analogue of 3-Methylindole (M313470), A naturally abundant pneumotoxin, found primarily in mammalian feces providing its strong fecal odor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Huijzer, J., et. al.: Toxicol. Appl. Pharm., 90, 60 (1987); Nakashima, T., et al.: Biol. Pharm. Bull., 32, 832 (2009); Xu, H., et al.: Chem. Pharm. Bull., 57, 321 (2009); Bodoor, K., et al.: J. Med. Chem., 52, 3753 (2009); Naskar, S., et al.: J. Chem. Res., 3, 174 (2009); Sollner, K., et al.: J. Agric. Food Chem., 57, 4319 (2009)<br></p>

<p>Applications 4-Methoxy-3-nitrobenzonitrile<br></p>

<p>Applications: Isotope labelled analogue of 2-Methoxyacetic Acid, a synthetic intermediate in the synthesis of dimethyl(alkyloxy)[(methylsulfonyl)phenyl]furanones as COX-2 inhibitors.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Leblanc, Y., et al.: Bioorg. Med. Chem. Lett., 9, 2207 (1999);<br></p>

<p>Applications 1,2-Bismethylphenidate is an impurity of methylphenidate (M325880), an CNS stimulant.<br>References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., Anal. Profiles Drug Subs., 10, 473 (1981), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),<br></p>

<p>Applications Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lu, R., et al.: J. Med. Chem., 52, 4481 (2009); Picard, F., et al.: J. Med. Chem., 45, 3406 (2002)<br></p>

<p>Applications N'-tert-Butyl-3-methoxy-2-methylbenzohydrazide is an intermediate used in the synthesis of methoxyfenozide; an active ingredient for the commercial production of certain insecticidal and pesticidal formulations.<br>References Shao, J., et al.: Xiandai Nongyao, 2, 12, (2003), Mao, W. T., et al.: Chin. Chem. Lett., 23, 1233 (2012)<br></p>

<p>Applications 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-guanosine is used to prepare ppGpp analogs as inhibitors of RelA from Gram-negative/-positive bacteria. It is also used to synthesize guanosine 5'-conjugates as initiator molecules for transcription priming.<br>References Wexselblatt, E., et al.: Bioorg. Med. Chem., 18, 4485 (2010); Wolf, J., et al.:Org. Biomol. Chem., 6, 899 (2008)<br></p>

<p>Applications: (3,5-Di-tert-butyl-4-methoxyphenyl)boronic acid (cas# 233584-42-4) is a useful research chemical.<br></p>

<p>Applications 4-Bromo-6-methyl-3H-1,3-benzodiazole<br></p>

<p>Applications 4-Methyl-d3-catechol (CAS# 83719-41-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Hydroxy-4-methoxycinnamic acid, trans-Isoferulic acid<br></p>

<p>Impurity Temozolomide USP Related Compound B<br>Applications N'-Methyl-N,N-diphenylurea is used in the stabilization of thermal propellants. Temozolomide USP Related Compound B.<br>References Bohn, M. et al.: Prop. Exp. Pyro.,et al.: 19, 266 (1994); Muthurajan, H. et al.: J. Hazard. Mat., 133, 30 (2006);<br></p>

<p>Applications N-Carbobenzoxyglycine is used in the dipeptide synthesis.<br>References Hans, D., et al.: Med. Chem., 2, 627 (2006), Guzman, F., et al.: J. Biotechnol., 10, 279 (2007), Vlieghe, P., et al.: Drug Discov. Today, 15, 40 (2010),<br></p>

<p>Applications 5-methoxypentanoic acid (cas# 70160-05-3) is a useful research chemical.<br></p>