Amino Acids (AA)

<p>Stability Light sensitive, Temperature Sensitive<br>Applications 3-Methyl-1,5-pentanediol Diacrylate is a useful chemical reagent.<br></p>

<p>Applications (1-Chlorocyclohexyl)cyclohexyl-methanone is a synthetic intermediate and a potential reagent for the synthesis of Dicyclomine Impurity A (B382435) and Dihexyverine Hydrochloride (D448200).<br>References Cramer, R., et al.: J. Med. Chem., 47, 6777 (2004); Vilar, S., et al.: J. Med. Chem., 49, 1118 (2006); Kopp, M., et al.: B. Soc. Chim. Fr., no vol., 84 (1952); Levy, J., et al.: CR. Soc. Biol., 144, 339 (1950)<br></p>

<p>Applications L-Glutamic acid 5-methyl ester is a protected form of L-Glutamic acid (G596960). L-Glutamic acid is a nonessential amino acid that is important to the mammalian central nervous system. L-Glutamic acid is also a neurotransmitter for cone photoreceptors in the human brain and is used as a treatment for patients who have liver disease accompanied by encephalopathy (a condition termed ‘hepatic coma’).<br>References Anderson, H., et al.: J. Nutr., 99, 82 (1969); Brandon, C. &amp; Lam, D.: Proc. Nat. Acad. Sci., 80, 5117 (1983); McDermott Jr, W., et al.: New Engl. J. Med., 253, 1093 (1955)<br></p>

<p>Applications 2-Amino-5-methylpyridine (cas# 1603-41-4) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Francotte, P., et al.: Bioorg. Med. Chem., 16, 9948 (2008), Sundaraganesan, N., et al.: J. Mol. Struc., 891, 284 (2008), Caleta, I., et al.: J. Med. Chem., 52, 1744 (2009),<br></p>

<p>Applications The urinary 1- and 3-methylhistidine (1- and 3-MH) metabolites as potential biomarkers of skeletal muscle toxicity. These metabolites were highly correlated to sex-, dose-, and time-dependent development of cerivastatin-induced myotoxicity. Natural but non-proteinogenic amino acid; employed as index of muscle protein breakdown.<br>References Berna, M., et al.: Anal. Chem., 79, 4199 (2007), Pritt, M., et al.: Toxicol. Sci., 103, 382 (2008), Tonomura, Y., et al.: Toxicology, 266, 48 (2009),<br></p>

<p>Stability Moisture Sensitive<br>Applications 1-Acetate 4-Methanesulfonate 1,4-Butanediol is used in the facile cleavage of ethers. A Busulfan Impurity<br>References Mazur, Y., et al.: J. Org. Chem., 36, 532 (1971);<br></p>

<p>Applications Labelled L-Citrulline. An amino acid, first isolated from the juice of watermelon, Citrullus vulgaris Schrad., Cucurbitaceae. Used in the treatment of asthenia.<br>References Kurtz, et al.: J. Biol. Chem., 122, 477 (1938), Rajantie, J., et al.: J. Pediatr., 97, 927 (1980), Carpenter, T.O., et al.: N. Engl. J. Med., 312, 290 (1985),<br></p>

<p>Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.<br></p>

<p>Applications Suberylglycine is one of the acylglycines, an important class of metabolites that have been used in the diagnosis of several inborn errors of metabolism (IEM).<br>References Costa, C., et al.: J. Pharmaceut. Biomed. Anal., 21, 1215 (2000), Garcia-Villoria, J., et al.: Clin. Biochem., 42, 2 (2009), Scalbert, A., et al.: Metabolomics, 5, 435 (2009),<br></p>

<p>Applications 7-Methoxy-4-(trifluoromethyl)coumarin is a biochemical for proteomics research.<br></p>

<p>Stability Hygroscopic<br>Applications Hexanoyl-L-carnitine-(N-methyl-d3) Chloride, is the labeled analogue of Hexanoyl-L-carnitine Hydrochloride (H294440), which is used as reactant in the synthesis of carnitine benzyl esters as prodrugs.<br>References Gong, X., et. al.: J. Chem. Res., 6, 327 (2008)<br></p>

<p>Applications 2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.<br>References Naveed S. et al.: Diab., 53, 11 (2004); Barlind, J. et al.: Bioorg. Med. Chem. Lett., 23, 2721 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Decanoyl-L-carnitine-d3 Chloride is the isotope labelled analog of Decanoyl-L-carnitine Chloride (D212580); a metabolite of L-Carnitine (C184110) which is an essential cofactor of fatty acid metabolism. Also required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications A labelled metabolite of Catecholamines.<br>References Kopin, I.J., et al.: J. Biol. Chem., 236, 2109 (1961), Short, F.W., et al.: J. Med. Pharm. Chem., 5, 642 (1962)<br></p>

<p>Applications A red azoic dye.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hoover, K., et al.: Chem. Res. Toxicol., 18, 1497 (2005), Altenburger, R., et al.: Environ. Toxicol. Chem., 24, 324 (2005), Gonzalez, M., et al.: Bioorg. Med. Chem., 13, 1775 (2005),<br></p>

<p>Applications 1-(2-METHOXYPHENETHYL)PIPERAZINE (cas# 6722-54-9) is a useful research chemical.<br></p>

<p>Applications N-Boc-piperazine (cas# 57260-71-6) is a compound useful in organic synthesis.<br></p>

<p>Applications L-Threonic acid calcium salt is the salt of L-Threonic acid, a naturally occurring compound that can be found in the leaves of Pelargonium crispum. L-Threonic acid is also the degradation product of Dehydroascorbate (DHA), a metabolite of Vitamin C (A786990).<br>References Helsper, J. &amp; Loewus, F.: Plant Phys., 69, 1365 (1982); Koch, C. &amp; Biaglow, J.: J. Cell. Phys., 94, 299 (1978); Nielsen J., et al.: J. Agr. Food Chem., 49, 2998 (2001)<br></p>

<p>Applications L-Glutamine (Alpha-15n, 98%) (cas# 80143-57-3) is a useful research chemical.<br></p>

<p>Applications L-Alanine-d7 (CAS# 74280-71-0) is a useful isotopically labeled research compound.<br></p>

<p>Stability Hygroscopic<br>Applications 4-Chloro-3-cyano-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline is a useful reagent to prepare benzofuranyl derivatives for treating solid tumours. It is also an impurity of Bosutinib.<br>References Hennequin, L. F. A. PCT Int. Appl. (2003), WO 2003047585 A1 20030612 (2003); Hennequin, L. F. A., Gibson, K. H., Foote, K. M. PCT Int. Appl. WO 2003047582 A1 20030612 (2003)<br></p>

<p>Applications N-Methyl-N-nitroso-ethenamine is used as research reagent for base induced fragmentation to give aldehydes or ketones and smaller alkylnitrosamine<br>References Leoppky, R.N., et al.: J Org. Chem, 23, 135(1982)<br></p>

<p>Stability Hygroscopic<br>Applications Dityrosine (DY), a tyrosine dimer formed by 3,3’-biaryl bond formation can be used as a biomarker to detect oxidative protein damage and selective proteolysis. Fluorescence intensity decays of Dityrosine are generally characterized by two decay components, one with a lifetime in the range of 150 to 800 ps and another between 2.5 and 4.5 ns.<br>References Libertini, L., et al.: Biophys. J., 47, 765 (1985), Huggins, T., et al.: J. Biol. Chem., 268, 12341 (1993), Malencik, D., et al.: Biochemistry, 35, 4375 (1996),<br></p>

<p>Applications 1-Methyl-1h-1,2,4-triazol-3-amine (cas# 49607-51-4) is a useful research chemical.<br></p>

<p>Applications 2-Amino-5-cyano-3-methylbenzoic Acid (cas# 871239-18-8) is a useful research chemical.<br></p>

<p>Impurity Rabeprazole EP Impurity G<br>Applications Used in the preparation of 2-[[(2-pyridyl)methyl]thio]-1H-benzimidazoles derivatives as anti helicobacter pylori agents.<br>References Kuehler, T. et al.: J. Med. Chem., 41, 1777 (1998)<br></p>

<p>Applications It can be degraded efficiently by the QL-degrading bacteria.<br>References Shukla, O., et al.: Microbios., 59, 47 (1989), Oh, Y; Biotechnol Bioeng 1994, 44, 533,,,<br></p>

<p>Stability Hygroscopic<br>Applications 4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine.<br>References Panten, U. et al.: Naun.-Schmied. Arch. Pharmacol., 291, 405 (1975); Vague, P. et al.: Diab. Metab., 1, 185 (1975); Francois, G. et al.: Lancet, 1, 858 (1984);<br></p>

<p>Applications 5,6-Dihydro-5-methyluridine (cas# 23067-10-9) is a useful research chemical.<br></p>