CAS 1007358-76-0
:Ambrisentan R-Enantiomer ((R)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid)
CAS:Compounds containing a pyrimidine ring, whether or not hydrogenated, or piperazine ring in the structure, nesoiFormel:C22H22N2O4Farbe und Form:White Fine PowderMolekulargewicht:378.15796Avatrombopag Impurity 30
CAS:Formel:C16H21Cl2N3OFarbe und Form:White To Off-White SolidMolekulargewicht:342.26Avatrombopag Impurity 28
CAS:Formel:C14H8Cl2N4S4Farbe und Form:White To Off-White SolidMolekulargewicht:431.39(R)-Ambrisentan
CAS:Applications (R)-Ambrisentan is the R-isomer impurity of Ambrisentan (A575860), which is a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.
References Riechers, H., et al.: J. Med. Chem., 39, 2123 (1996); Billman, G.E., et al.: Curr. Opin. Invest. Drugs, 3, 1483 (2002); Vatter, H., et al.: Clin. Neuropharmacol., 26, 73 (2003);Formel:C22H22N2O4Farbe und Form:White To Off-WhiteMolekulargewicht:378.42(R)-Ambrisentan
CAS:(R)-Ambrisentan is an endothelin receptor antagonist, which is a pharmacological agent derived synthetically to target and inhibit specific cellular pathways. It is primarily utilized in the treatment of pulmonary arterial hypertension (PAH), where it plays a crucial role in modulating vascular function. The mode of action of (R)-Ambrisentan involves selective antagonism of the endothelin type A (ETA) receptors, which are responsible for vasoconstriction and proliferation of vascular smooth muscle cells. By blocking these receptors, it mitigates the effects of endothelin, a potent vasoconstrictor, thus reducing blood pressure and improving blood flow in pulmonary arteries.
Formel:C22H22N2O4Reinheit:Min. 95%Molekulargewicht:378.40 g/molRef: 3D-HQB35876
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