CAS 1046462-02-5

11-Cyclopropyl-5,11-dihydro-4-[[(methylsulfonyl)oxy]methyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one-d2

Kontrolliertes Produkt

CAS: 1046462-02-5

Applications 11-Cyclopropyl-5,11-dihydro-4-[[(methylsulfonyl)oxy]methyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one is an intermediate in synthesizing Nevirapine-d2 (N391276), an isotope labelled Nevirapine (N391275), which acts as a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral.
References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991); Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993); Guay, L.A., et al.: Lancet, 354, 795 (1999)

Formel: C₁₆H₁₄D₂N₄O₄S

Farbe und Form: Neat

Molekulargewicht: 362.4

Ref: TR-C992012

11-Cyclopropyl-5,11-dihydro-4-[[(methylsulfonyl)oxy]methyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one

Kontrolliertes Produkt

CAS: 1046462-02-5

Applications 11-Cyclopropyl-5,11-dihydro-4-[[(methylsulfonyl)oxy]methyl]-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one is an intermediate in synthesizing Nevirapine-d1 (N391279), an isotope labelled Nevirapine (N391275), which acts as a potent (IC50=84nM) and selective non-nucleoside inhibitor of HIV-1 reverse transcriptase. Antiviral.
References Hargrave, K.D., et al.: J. Med. Chem., 34, 2231 (1991); Cheeseman, S.H., et al.: Antimicrob. Agents Chemother., 37, 178 (1993); Guay, L.A., et al.: Lancet, 354, 795 (1999)

Formel: C₁₆H₁₆N₄O₄S

Farbe und Form: Light Yellow

Molekulargewicht: 360.39

Ref: TR-C992010