CAS 1067644-15-8

N-Methyl Naltrexone Glucuronide

CAS: 1067644-15-8

Formel: C₂₇H₃₃NO₁₀

Molekulargewicht: 531.56

Ref: 4Z-N-0126

N-Methyl Naltrexone Glucuronide

Kontrolliertes Produkt

CAS: 1067644-15-8

Applications N-Methyl Naltrexone Glucuronide is metabolite of Naltrexone (N285750). Methylnaltrexone (MNTX; M320350), a selective μ-opioid receptor (MOR) antagonist, functions as a peripherally acting receptor antagonist in tissues of the gastrointestinal tract. When opiates activate μ-opioid receptors (MORs) they trigger signaling pathways that lead to tolerance and hyperalgesia. Methylnaltrexone (M320350) is positively charged and therefore does not cross the blood brain barier. Mice given morphine with methylnaltrexone experienced pain relief without degeloping tolerance.
References Wall, M., et al.: Drug Metab. Dispos., 12, 677 (1984), Jones, D., et al.: .: Bioorg. Med. Chem., 13, 6727 ( 2005), Chen, T., et al.: Drugs Future, 32, 771 (2007); Chem. and Eng. News p.4 Jan. 23, (2017)

Formel: C₂₇H₃₄NO₁₀

Farbe und Form: Neat

Molekulargewicht: 532.56

Ref: TR-M493190